Glucose-induced [Ca2+]i abnormalities in human pancreatic islets: important role of overstimulation.

abstract：:Platelet survival by 51chromium labeling was determined in six normal control subjects and in twelve patients with diabetes mellitus, before and after improved glucose control (mean HbA1c 10.5 +/- 2.2% and 7.1 +/- 1.8%, respectively). Mean platelet survival was 9.47 +/- 0.85 days for the normal subjects and 9.04 +/- 1...

journal_title：Diabetes

authors： Jones RL,Paradise C,Peterson CM

更新日期：1981-06-01 00:00:00

abstract：:Sphingosine-1 phosphate (S1P) is a bioactive sphingolipid with the potential to mobilize Ca2+, to inhibit apoptosis, and to promote mitogenesis. Sphingosine kinase (SPHK) and S1P were characterized in INS-1 insulinoma cells and isolated rat islets of Langerhans. SPHK activity increased in INS-1 cell homogenates treate...

journal_title：Diabetes

authors： Mastrandrea LD,Sessanna SM,Laychock SG

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVE:Sarco-endoplasmic reticulum Ca(2+)-ATPase 2b (SERCA2b) and SERCA3 pump Ca(2+) in the endoplasmic reticulum (ER) of pancreatic β-cells. We studied their role in the control of the free ER Ca(2+) concentration ([Ca(2+)](ER)) and the role of SERCA3 in the control of insulin secretion and ER stress. RESEARCH DES...

journal_title：Diabetes

authors： Ravier MA,Daro D,Roma LP,Jonas JC,Cheng-Xue R,Schuit FC,Gilon P

更新日期：2011-10-01 00:00:00

abstract：:The effects of glucose and diabetes on the high-affinity lofentanil-displaceable opiate-receptor binding in mouse brain membranes were studied to determine if the attenuation of opiate actions by hyperglycemia previously observed in our laboratory was due to a modification of receptor affinity or number. With membrane...

journal_title：Diabetes

authors： Brase DA,Han YH,Dewey WL

更新日期：1987-10-01 00:00:00

abstract：:The molecular underpinnings of β-cell dysfunction and death leading to diabetes are not fully elucidated. The objective of the current study was to investigate the role of endoplasmic reticulum-associated degradation (ERAD) in pancreatic β-cells. Chemically induced ERAD deficiency in the rat insulinoma cell line INS-1...

journal_title：Diabetes

authors： Hu Y,Gao Y,Zhang M,Deng KY,Singh R,Tian Q,Gong Y,Pan Z,Liu Q,Boisclair YR,Long Q

更新日期：2019-04-01 00:00:00

abstract：:The Diabetes Association of greater Cleveland screened 307,000 individuals in the metropolitan area for diabetes with a 75-gm. oral load of carbohydrate. Of these subjects 12,600 (4.1 per cent) had a two-capillary blood glucose level of greater than 139 mg. per cent and were defined as positive. Seventy per cent of th...

journal_title：Diabetes

authors： Genuth SM,Houser HB,Carter JR Jr,Merkatz I,Price JW,Schumacher OP,Wieland RG

更新日期：1976-12-01 00:00:00

abstract：:Transgenic mice expressing the amyloidogenic human islet amyloid polypeptide (hIAPP) in their islet beta-cells are a model of islet amyloid formation as it occurs in type 2 diabetes. Our hIAPP transgenic mice developed islet amyloid when fed a breeder chow but not regular chow. Because the breeder chow contained incre...

journal_title：Diabetes

authors： Hull RL,Andrikopoulos S,Verchere CB,Vidal J,Wang F,Cnop M,Prigeon RL,Kahn SE

更新日期：2003-02-01 00:00:00

abstract：:Diabetic retinopathy is a potentially blinding eye disease that threatens the vision of one-ninth of patients with diabetes. Progression of the disease has long been attributed to an initial dropout of pericytes that enwrap the retinal microvasculature. Revealed through retinal vascular digests, a subsequent increase ...

journal_title：Diabetes

authors： Corliss BA,Ray HC,Doty RW,Mathews C,Sheybani N,Fitzgerald K,Prince R,Kelly-Goss MR,Murfee WL,Chappell J,Owens GK,Yates PA,Peirce SM

更新日期：2020-07-01 00:00:00

abstract：:The TaqIB cholesteryl ester transfer protein (CETP) gene polymorphism (B1B2) is a determinant of HDL cholesterol in nondiabetic populations. Remarkably, this gene effect appears to be modified by environmental factors. We evaluated the effect of this polymorphism on HDL cholesterol levels and on the lipoprotein respon...

journal_title：Diabetes

authors： Dullaart RP,Hoogenberg K,Riemens SC,Groener JE,van Tol A,Sluiter WJ,Stulp BK

更新日期：1997-12-01 00:00:00

abstract：:Mutations in the NeuroD/BETA2 gene have been shown to associate with type 2 diabetes. In the present study, we examined mutations in the NeuroD/BETA2 gene for association with either type 1 or 2 diabetes. Three variants were identified in patients with type 2 diabetes: Ala45Thr (allelic frequency 0.36, 95% CI 0.31-0.4...

journal_title：Diabetes

authors： Hansen L,Jensen JN,Urioste S,Petersen HV,Pociot F,Eiberg H,Kristiansen OP,Hansen T,Serup P,Nerup J,Pedersen O

更新日期：2000-05-01 00:00:00

abstract：:Insulin regulates heart metabolism through the regulation of insulin-stimulated glucose uptake. Studies have indicated that insulin can also regulate mitochondrial function. Relevant to this idea, mitochondrial function is impaired in diabetic individuals. Furthermore, the expression of Opa-1 and mitofusins, proteins ...

journal_title：Diabetes

authors： Parra V,Verdejo HE,Iglewski M,Del Campo A,Troncoso R,Jones D,Zhu Y,Kuzmicic J,Pennanen C,Lopez-Crisosto C,Jaña F,Ferreira J,Noguera E,Chiong M,Bernlohr DA,Klip A,Hill JA,Rothermel BA,Abel ED,Zorzano A,Lavandero S

更新日期：2014-01-01 00:00:00

abstract：:Birth weights of infants of 35 gestational diabetic mothers treated with calorie restriction alone (1200-1800 kcal) were compared with those of infants of 2337 nondiabetic women, including two control groups (A and B) matched for race, body mass index, age, and parity. All women were screened for gestational diabetes ...

journal_title：Diabetes

authors： Dornhorst A,Nicholls JS,Probst F,Paterson CM,Hollier KL,Elkeles RS,Beard RW

更新日期：1991-12-01 00:00:00

abstract：:Changes in intracellular Ca(2+) concentration play a key role in the regulation of insulin secretion by glucose and other secretagogues. Here, we explore the importance of the secretory pathway Ca(2+)-ATPase, plasma membrane-related Ca(2+)-ATPase-1 (PMR1; human orthologue ATP2C1) in intracellular Ca(2+) homeostasis in...

journal_title：Diabetes

authors： Mitchell KJ,Tsuboi T,Rutter GA

更新日期：2004-02-01 00:00:00

abstract：:The data being reported are part of an epidemiologic study of health and disease in an entire community, Tecumseh, Michigan. Approximately 1,300 males age 16-65 were classified into three groups on the basis of their habitual leisure and occupational physical activity. A blood sample was drawn one hour after a glucose...

journal_title：Diabetes

authors： Montoye HJ,Block WD,Metzner H,Keller JB

更新日期：1977-03-01 00:00:00

abstract：:Type 1 diabetes (T1D) remains a major health problem worldwide, with a steadily rising incidence yet no cure. Phosphoinositide 3-kinase-γ (PI3Kγ), a member of a family of lipid kinases expressed primarily in leukocytes, has been the subject of substantial research for its role in inflammatory diseases. However, the ro...

journal_title：Diabetes

authors： Azzi J,Moore RF,Elyaman W,Mounayar M,El Haddad N,Yang S,Jurewicz M,Takakura A,Petrelli A,Fiorina P,Ruckle T,Abdi R

更新日期：2012-06-01 00:00:00

abstract：:The effect of elevated glucagon concentrations on insulin requirements and on blood glucose concentrations was studied in five insulin-requiring diabetic subjects during feedback control of hyperglycemia with an automated glucose-controlled insulin infusion system (artificial endocrine pancreas) for six to eight hours...

journal_title：Diabetes

authors： Clarke WL,Santiago JV,Kipnis DM

更新日期：1978-06-01 00:00:00

abstract：:We examined the hypothesis that imprinted genes may affect the propensity to type 2 diabetes and obesity in Pima Indians. Multipoint variance component methods were used to assess linkage of BMI (kg/m(2)) and age-adjusted diabetes to loci derived from either father (LOD(FA)) or mother (LOD(MO)) in a genome-wide scan. ...

journal_title：Diabetes

authors： Lindsay RS,Kobes S,Knowler WC,Bennett PH,Hanson RL

更新日期：2001-12-01 00:00:00

abstract：OBJECTIVE:To investigate if recurrent autoimmunity explained hyperglycemia and C-peptide loss in three immunosuppressed simultaneous pancreas-kidney (SPK) transplant recipients. RESEARCH DESIGN AND METHODS:We monitored autoantibodies and autoreactive T-cells (using tetramers) and performed biopsy. The function of auto...

journal_title：Diabetes

authors： Vendrame F,Pileggi A,Laughlin E,Allende G,Martin-Pagola A,Molano RD,Diamantopoulos S,Standifer N,Geubtner K,Falk BA,Ichii H,Takahashi H,Snowhite I,Chen Z,Mendez A,Chen L,Sageshima J,Ruiz P,Ciancio G,Ricordi C,Reij

更新日期：2010-04-01 00:00:00

abstract：:Glucose-dependent insulin secretion (GDIS), reactive oxygen species (ROS) production, and oxidative stress in pancreatic beta-cells may be tightly linked processes. Here we suggest that the same pathways used in the activation of GDIS (increased glycolytic flux, ATP-to-ADP ratio, and intracellular Ca2+ concentration) ...

journal_title：Diabetes

authors： Fridlyand LE,Philipson LH

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVE:MBL2 encodes the mannose-binding lectin, which is a key player in the innate immune system and has recently been found to play a role in insulin resistance and development of type 1 diabetes and gestational diabetes mellitus. To assess the role of MBL2 in diabetes susceptibility, this gene was analyzed in the...

journal_title：Diabetes

authors： Muller YL,Hanson RL,Bian L,Mack J,Shi X,Pakyz R,Shuldiner AR,Knowler WC,Bogardus C,Baier LJ

更新日期：2010-08-01 00:00:00

abstract：:It has been suggested that the hemodynamic derangements present in diabetic ketoacidosis are the results not only of profound volume depletion but also of the effects of increased production of vasodilating prostaglandins (PGs), principally PGI2, released by adipose tissue. In animal and in vitro models, prostaglandin...

journal_title：Diabetes

authors： Avogaro A,Crepaldi C,Piarulli F,Milan D,Valerio A,Pavan P,Sacerdoti D,Calabrò A,Macdonald I,Crepaldi G,Scognamiglio R,Tiengo A

更新日期：1996-05-01 00:00:00

abstract：:The long-term success of pancreatic islet transplantation (Tx) as a cure for type 1 diabetes remains limited. Islet loss after Tx related to apoptosis, inflammation, and other factors continues to limit Tx efficacy. In this project, we demonstrate a novel approach aimed at protecting islets before Tx in nonhuman prima...

journal_title：Diabetes

authors： Pomposelli T,Wang P,Takeuchi K,Miyake K,Ariyoshi Y,Watanabe H,Chen X,Shimizu A,Robertson N,Yamada K,Moore A

更新日期：2020-11-01 00:00:00

abstract：:Results from experimental and gene-association studies suggest that IGF-II may influence body weight regulation and that individuals with low IGF-II levels may be more susceptible to weight gain and obesity. We therefore assessed the association between circulating concentrations of IGF-II and subsequent weight gain a...

journal_title：Diabetes

authors： Sandhu MS,Gibson JM,Heald AH,Dunger DB,Wareham NJ

更新日期：2003-06-01 00:00:00

abstract：:A role for glucose in the control of feeding has been proposed, but its precise physiological importance is unknown. Here, we evaluated feeding behavior in glut2-null mice, which express a transgenic glucose transporter in their beta-cells to rescue insulin secretion (ripglut1;glut2-/- mice). We showed that in the abs...

journal_title：Diabetes

authors： Bady I,Marty N,Dallaporta M,Emery M,Gyger J,Tarussio D,Foretz M,Thorens B

更新日期：2006-04-01 00:00:00

abstract：:We present a patient who developed insulin-requiring diabetes several years after the onset of symptoms of anterior hypopituitarism. It is likely that the hypopituitarism protected him against the development of diabetic retinopathy and glomerular basement membrane thickening but not against neuropathy and atheroma. T...

journal_title：Diabetes

authors： Greenwood RH,Ireland JT,Jones DH,Mahler RF

更新日期：1975-11-01 00:00:00

abstract：:Considerable evidence implicates cellular senescence in the biology of aging and chronic disease. Diet and exercise are determinants of healthy aging; however, the extent to which they affect the behavior and accretion of senescent cells within distinct tissues is not clear. Here we tested the hypothesis that exercise...

journal_title：Diabetes

authors： Schafer MJ,White TA,Evans G,Tonne JM,Verzosa GC,Stout MB,Mazula DL,Palmer AK,Baker DJ,Jensen MD,Torbenson MS,Miller JD,Ikeda Y,Tchkonia T,van Deursen JM,Kirkland JL,LeBrasseur NK

更新日期：2016-06-01 00:00:00

abstract：:Hypofibrinolysis caused by increased plasminogen activator inhibitor 1 (PAI-1) has been implicated in the vasculopathy of type 2 diabetes, typified by increased insulin, glucose, and triglycerides. However, short-term infusions of insulin have not increased PAI-1 in normal subjects. We hypothesized that induction of i...

journal_title：Diabetes

authors： Calles-Escandon J,Mirza SA,Sobel BE,Schneider DJ

更新日期：1998-02-01 00:00:00

abstract：:Pancreatic β-cells play a pivotal role in maintaining normoglycemia. Recent studies have revealed that the β-cell is not a homogeneous cell population but, rather, is heterogeneous in a number of properties such as electrical activity, gene expression, and cell surface markers. Identification of specific β-cell subpop...

journal_title：Diabetes

authors： Dybala MP,Hara M

更新日期：2019-06-01 00:00:00

abstract：:Na+-K+-ATPase or the Na+-K+ pump is essential for some specific properties of muscle and nerve tissue such as contractility and excitability. Previous studies have shown conflicting variations in Na+-K+-ATPase activity or Na+-K+ pump concentration of muscle cells in experimental diabetes. Our study demonstrates that e...

journal_title：Diabetes

authors： Kjeldsen K,Braendgaard H,Sidenius P,Larsen JS,Nørgaard A

更新日期：1987-07-01 00:00:00

abstract：:Mitochondrial injury is uniformly observed in several murine models as well as in individuals with diabetic kidney disease (DKD). Although emerging evidence has highlighted the role of key transcriptional regulators in mitochondrial biogenesis, little is known about the regulation of mitochondrial cytochrome c oxidase...

journal_title：Diabetes

authors： Horne SJ,Vasquez JM,Guo Y,Ly V,Piret SE,Leonardo AR,Ling J,Revelo MP,Bogenhagen D,Yang VW,He JC,Mallipattu SK

更新日期：2018-11-01 00:00:00