NeuroD/BETA2 gene variability and diabetes: no associations to late-onset type 2 diabetes but an A45 allele may represent a susceptibility marker for type 1 diabetes among Danes. Danish Study Group of Diabetes in Childhood, and the Danish IDDM Epidemiolog

abstract：OBJECTIVE:Sirtuin 1 (SIRT1) is implicated in the regulation of mitochondrial function, energy metabolism, and insulin sensitivity in rodents. No studies are available in humans to demonstrate that SIRT1 expression in insulin-sensitive tissues is associated with energy expenditure and insulin sensitivity. RESEARCH DESI...

journal_title：Diabetes

authors： Rutanen J,Yaluri N,Modi S,Pihlajamäki J,Vänttinen M,Itkonen P,Kainulainen S,Yamamoto H,Lagouge M,Sinclair DA,Elliott P,Westphal C,Auwerx J,Laakso M

更新日期：2010-04-01 00:00:00

abstract：:Activity of the vascular large conductance Ca(2+)-activated K(+) (BK) channel is tightly regulated by its accessory β(1) subunit (BK-β(1)). Downregulation of BK-β(1) expression in diabetic vessels is associated with upregulation of the forkhead box O subfamily transcription factor-3a (FOXO-3a)-dependent F-box-only pro...

journal_title：Diabetes

authors： Lu T,Chai Q,Yu L,d'Uscio LV,Katusic ZS,He T,Lee HC

更新日期：2012-07-01 00:00:00

abstract：:We present a patient who developed insulin-requiring diabetes several years after the onset of symptoms of anterior hypopituitarism. It is likely that the hypopituitarism protected him against the development of diabetic retinopathy and glomerular basement membrane thickening but not against neuropathy and atheroma. T...

journal_title：Diabetes

authors： Greenwood RH,Ireland JT,Jones DH,Mahler RF

更新日期：1975-11-01 00:00:00

abstract：:Considerable evidence implicates cellular senescence in the biology of aging and chronic disease. Diet and exercise are determinants of healthy aging; however, the extent to which they affect the behavior and accretion of senescent cells within distinct tissues is not clear. Here we tested the hypothesis that exercise...

journal_title：Diabetes

authors： Schafer MJ,White TA,Evans G,Tonne JM,Verzosa GC,Stout MB,Mazula DL,Palmer AK,Baker DJ,Jensen MD,Torbenson MS,Miller JD,Ikeda Y,Tchkonia T,van Deursen JM,Kirkland JL,LeBrasseur NK

更新日期：2016-06-01 00:00:00

abstract：:Livers from 9-10-wk-old genetically obese and hyperinsulinemic (fa/fa) rats contained more DNA, proteins, and lipids than livers of age-matched controls. Actually, the increase in liver mass of fa/fa rats was mainly due to an increased cell number. On perfusion with insulin (1.75-16 nM), livers of obese fa/fa rats rem...

journal_title：Diabetes

authors： Karakash C,Jeanrenaud B

更新日期：1983-07-01 00:00:00

abstract：:Diabetic states are characterized by a raised serum/islet level of triglycerides and a lowered EC50 (concentration at half-maximal stimulation) for glucose-induced insulin secretion. Culturing islets with long-chain fatty acids (FAs) replicates the basal insulin hypersecretion. In a previous study, we showed that the ...

journal_title：Diabetes

authors： Liu YQ,Tornheim K,Leahy JL

更新日期：1998-12-01 00:00:00

abstract：:The Dio2 gene encodes the type 2 deiodinase (D2) that activates thyroxine (T4) to 3,3',5-triiodothyronine (T3), the disruption of which (Dio2(-/-)) results in brown adipose tissue (BAT)-specific hypothyroidism in an otherwise euthyroid animal. In the present studies, cold exposure increased Dio2(-/-) BAT sympathetic s...

journal_title：Diabetes

authors： Christoffolete MA,Linardi CC,de Jesus L,Ebina KN,Carvalho SD,Ribeiro MO,Rabelo R,Curcio C,Martins L,Kimura ET,Bianco AC

更新日期：2004-03-01 00:00:00

abstract：:A group of insulin-dependent diabetic patients was studied in order to determine the possible short-term regulatory effect of insulin and that of an antilipolytic drug on serum triglycerides. Subcutaneous crystalline insulin (one third of the usual morning dose of intermediate long-acting insulin, NPH) and an oral dos...

journal_title：Diabetes

authors： Alvarez-Reynolds M,Dominguez JM

更新日期：1977-07-01 00:00:00

abstract：:Body weight is tightly regulated by food intake and energy dissipation, and obesity is related to decreased energy expenditure (EE). Herein, we show that nucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2, autotaxin) is an adipose-derived, secreted enzyme that controls adipose expansion, brown adipose tissue (BAT) ...

journal_title：Diabetes

authors： Nishimura S,Nagasaki M,Okudaira S,Aoki J,Ohmori T,Ohkawa R,Nakamura K,Igarashi K,Yamashita H,Eto K,Uno K,Hayashi N,Kadowaki T,Komuro I,Yatomi Y,Nagai R

更新日期：2014-12-01 00:00:00

abstract：:When fed a high-energy (HE) diet, diabetes-prone (DP) Psammomys obesus develop type 2 diabetes with altered glucose-stimulated insulin secretion (GSIS). Beta-cell stimulus-secretion coupling was investigated in islets isolated from DP P. obesus fed a low-energy (LE) diet (DP-LE) and after 5 days on a HE diet (DP-HE). ...

journal_title：Diabetes

authors： Pertusa JA,Nesher R,Kaiser N,Cerasi E,Henquin JC,Jonas JC

更新日期：2002-08-01 00:00:00

abstract：:The pancreatic and duodenal homeobox factor-1 (PDX-1), also known as IDX-1/STF-1/IPF1, a homeodomain-containing transcription factor, plays a central role in regulating pancreatic development and insulin gene transcription. Furthermore, even in adults, PDX-1 is associated with islet neogenesis and differentiation of i...

journal_title：Diabetes

authors： Noguchi H,Kaneto H,Weir GC,Bonner-Weir S

更新日期：2003-07-01 00:00:00

abstract：:The fa-gene was transferred from the Zucker rat (13 M strain) to the Wistar Kyoto (WKY) rat. The survey, performed at the 10th generation of backcrossing, showed that Wistar fatty rats (fa/fa), a congenic strain of WKY, developed obesity and obesity-related features, such as hyperinsulinemia and hyperlipemia, in the s...

journal_title：Diabetes

authors： Ikeda H,Shino A,Matsuo T,Iwatsuka H,Suzuoki Z

更新日期：1981-12-01 00:00:00

abstract：:Platelet survival by 51chromium labeling was determined in six normal control subjects and in twelve patients with diabetes mellitus, before and after improved glucose control (mean HbA1c 10.5 +/- 2.2% and 7.1 +/- 1.8%, respectively). Mean platelet survival was 9.47 +/- 0.85 days for the normal subjects and 9.04 +/- 1...

journal_title：Diabetes

authors： Jones RL,Paradise C,Peterson CM

更新日期：1981-06-01 00:00:00

abstract：:Type 1 diabetes (T1D) is an autoimmune disease leading to β-cell destruction. MicroRNAs (miRNAs) are small noncoding RNAs that control gene expression and organ formation. They participate in the pathogenesis of several autoimmune diseases, but the nature of miRNAs contributing to β-cell death in T1D and their target ...

journal_title：Diabetes

authors： Grieco FA,Sebastiani G,Juan-Mateu J,Villate O,Marroqui L,Ladrière L,Tugay K,Regazzi R,Bugliani M,Marchetti P,Dotta F,Eizirik DL

更新日期：2017-01-01 00:00:00

abstract：:There is controversy over the extent to which fatty acids (FAs) derived from plasma free FAs (FFAs) or from hydrolysis of plasma triglycerides (TGFAs) form communal or separate pools and what the contribution of each FA source is to cellular FA metabolism. Chylomicrons and lipid emulsions were labeled with [(3)H]triol...

journal_title：Diabetes

authors： Teusink B,Voshol PJ,Dahlmans VE,Rensen PC,Pijl H,Romijn JA,Havekes LM

更新日期：2003-03-01 00:00:00

abstract：:The mechanisms of marked increase in plasma leptin soon after ventromedial hypothalamus (VMH) lesions were investigated. Although rats did not gain body weight or parametrial fat-pad mass 24 h after the operation, the acute VMH-lesioned rats exhibited substantial five- and fourfold increases in plasma leptin levels co...

journal_title：Diabetes

authors： Suga A,Hirano T,Kageyama H,Kashiba M,Oka J,Osaka T,Namba Y,Tsuji M,Miura M,Adachi M,Inoue S

更新日期：1999-10-01 00:00:00

abstract：OBJECTIVE:The molecular mechanisms responsible for pancreatic β-cell dysfunction in type 2 diabetes remain unresolved. Increased expression of the helix-loop-helix protein Id1 has been found in islets of diabetic mice and in vitro models of β-cell dysfunction. Here, we investigated the role of Id1 in insulin secretion ...

journal_title：Diabetes

authors： Akerfeldt MC,Laybutt DR

更新日期：2011-10-01 00:00:00

abstract：:With the aim of investigating glucose-mediated glucose disposal (glucose effectiveness [GE]) in 15 (3 female and 12 male subjects) insulin-resistant normoglycemic relatives of patients with type 2 diabetes (DM2), and 15 age-, sex-, and BMI-matched control subjects without a family history of DM2, we performed 2 studie...

journal_title：Diabetes

authors： Henriksen JE,Levin K,Thye-Rønn P,Alford F,Hother-Nielsen O,Holst JJ,Beck-Nielsen H

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVE:The gene encoding the alpha2 Heremans-Schmid glycoprotein (AHSG) is a credible biological and positional candidate gene for type 2 diabetes and the metabolic syndrome, and previous attempts to relate AHSG variation with type 2 diabetes and obesity in Swedish and French Caucasians have been largely successful....

journal_title：Diabetes

authors： Andersen G,Burgdorf KS,Sparsø T,Borch-Johnsen K,Jørgensen T,Hansen T,Pedersen O

更新日期：2008-05-01 00:00:00

abstract：:Mitochondrial injury is uniformly observed in several murine models as well as in individuals with diabetic kidney disease (DKD). Although emerging evidence has highlighted the role of key transcriptional regulators in mitochondrial biogenesis, little is known about the regulation of mitochondrial cytochrome c oxidase...

journal_title：Diabetes

authors： Horne SJ,Vasquez JM,Guo Y,Ly V,Piret SE,Leonardo AR,Ling J,Revelo MP,Bogenhagen D,Yang VW,He JC,Mallipattu SK

更新日期：2018-11-01 00:00:00

abstract：:This study investigated changes in levels of mRNAs encoding the three neurofilament (NF) proteins NF-L (low), NF-M (medium), and NF-H (high) and two growth-associated proteins, GAP-43 and T alpha 1 alpha-tubulin, in lumbar dorsal root ganglia of control and streptozocin-induced diabetic rats. After 8 weeks of diabetes...

journal_title：Diabetes

authors： Mohiuddin L,Fernyhough P,Tomlinson DR

更新日期：1995-01-01 00:00:00

abstract：:Production of reactive oxygen species (ROS) is a key instigator of β-cell dysfunction in diabetes. The pleiotropic cytokine interleukin 6 (IL-6) has previously been linked to β-cell autophagy but has not been studied in the context of β-cell antioxidant response. We used a combination of animal models of diabetes and ...

journal_title：Diabetes

authors： Marasco MR,Conteh AM,Reissaus CA,Cupit JE 5th,Appleman EM,Mirmira RG,Linnemann AK

更新日期：2018-08-01 00:00:00

abstract：:Fed male Wistar rats were eviscerated by two procedures. The first group of eviscerated rats were left with a nonfunctional liver in situ while the second group were eviscerated by a newer technic, developed in this laboratory, that preserves liver function. The animals were maintained on a regimen of saline and antib...

journal_title：Diabetes

authors： Penhos JC,Ezequiel M,Lepp A,Ramey ER

更新日期：1975-07-01 00:00:00

abstract：:Insulin stimulation of adipose and muscle cells results in the translocation of GLUT4 from an intracellular location to the plasma membrane; this translocation is defective in insulin resistance. Studies have suggested an important role for synaptobrevin and syntaxin homologues in this event, particularly the v-solubl...

journal_title：Diabetes

authors： Maier VH,Melvin DR,Lister CA,Chapman H,Gould GW,Murphy GJ

更新日期：2000-04-01 00:00:00

abstract：:Impaired insulin secretion is a fundamental defect in type 2 diabetes. The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) in the genes regulating insulin secretion (SLC2A2 [encoding GLUT2], GCK, TCF1 [encoding HNF-1alpha], HNF4A, GIP, and GLP1R) are associated with the conversion f...

journal_title：Diabetes

authors： Laukkanen O,Lindström J,Eriksson J,Valle TT,Hämäläinen H,Ilanne-Parikka P,Keinänen-Kiukaanniemi S,Tuomilehto J,Uusitupa M,Laakso M,Finnish Diabetes Prevention Study.

更新日期：2005-07-01 00:00:00

abstract：:These studies of a rat model for non-insulin-dependent diabetes mellitus (NIDDM) were performed to determine whether hyperglycemia occurs when capacity to synthesize insulin is exceeded. The neonatal streptozocin (STZ)-treated rat has acute hyperglycemia with marked destruction of pancreatic beta-cells, followed by gr...

journal_title：Diabetes

authors： Giddings SJ,Orland MJ,Weir GC,Bonner-Weir S,Permutt MA

更新日期：1985-03-01 00:00:00

abstract：:A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (coronavirus disease 2019 [COVID-19]) is now at global pandemic levels causing significant morbidity and mortality. Patients with diabetes are particularly vulnerable and more likely to get severe complications when infected with this vi...

journal_title：Diabetes

authors： Gianchandani R,Esfandiari NH,Ang L,Iyengar J,Knotts S,Choksi P,Pop-Busui R

更新日期：2020-10-01 00:00:00

abstract：:The BB rat spontaneously develops autoimmune abnormalities such as insulin-dependent diabetes mellitus and thyroiditis. The autoimmunity of the BB rat is controlled in part by genes of the major histocompatibility complex (MHC), known as the RT1 complex in the rat, and accumulating evidence suggests the involvement of...

journal_title：Diabetes

authors： Holowachuk EW,Greer MK,Martin DR

更新日期：1988-12-01 00:00:00

abstract：:Kir6.2 is an inwardly rectifying potassium channel that is expressed in pancreatic beta-cells and cardiac and skeletal muscle. Expressed together with the high-affinity sulphonylurea receptor, it reconstitutes a sulphonylurea- and also ATP-sensitive potassium channel resembling the native beta-cell channel. The object...

journal_title：Diabetes

authors： Hansen L,Echwald SM,Hansen T,Urhammer SA,Clausen JO,Pedersen O

更新日期：1997-03-01 00:00:00

abstract：:One subtype of maturity-onset diabetes of the young (MODY)-3 results from mutations in the gene encoding hepatocyte nuclear factor (HNF)-1 alpha. We generated transgenic mice expressing a naturally occurring dominant-negative form of human HNF-1 alpha (P291fsinsC) in pancreatic beta-cells. A progressive hyperglycemia ...

journal_title：Diabetes

authors： Yamagata K,Nammo T,Moriwaki M,Ihara A,Iizuka K,Yang Q,Satoh T,Li M,Uenaka R,Okita K,Iwahashi H,Zhu Q,Cao Y,Imagawa A,Tochino Y,Hanafusa T,Miyagawa J,Matsuzawa Y

更新日期：2002-01-01 00:00:00