Diabetes decreases Na+-K+ pump concentration in skeletal muscles, heart ventricular muscle, and peripheral nerves of rat.

Abstract:

:Na+-K+-ATPase or the Na+-K+ pump is essential for some specific properties of muscle and nerve tissue such as contractility and excitability. Previous studies have shown conflicting variations in Na+-K+-ATPase activity or Na+-K+ pump concentration of muscle cells in experimental diabetes. Our study demonstrates that early untreated diabetes in rats induced by injection of streptozocin is associated with decreases in [3H]ouabain binding-site concentration of 24-48% in various skeletal muscles and 16% in peripheral nerves as well as a decrease in K+-dependent 3-O-methylfluorescein phosphatase activity of 21% in the heart ventricle. These effects could be prevented by insulin treatment. They probably represent a decrease in the concentration of Na+-K+ pumps. There was no evidence for more than one population of Na+-K+ pumps in intact samples of skeletal muscle and nerves from normal, diabetic, and insulin-treated animals. The decrease in Na+-K+ pump concentration in nerve cells may be due to atrophy of the axons. In skeletal muscles, myocardium, and peripheral nerves, the observed decrease in Na+-K+ pump concentration may be important for the pathophysiology of diabetes. We emphasize that quantification of Na+-K+-ATPase or the Na+-K+ pump in muscle and nerve tissue from diabetic animals should preferably be performed with either intact samples or crude homogenates of whole tissue.

journal_name

Diabetes

journal_title

Diabetes

authors

Kjeldsen K,Braendgaard H,Sidenius P,Larsen JS,Nørgaard A

doi

10.2337/diab.36.7.842

subject

Has Abstract

pub_date

1987-07-01 00:00:00

pages

842-8

issue

7

eissn

0012-1797

issn

1939-327X

journal_volume

36

pub_type

杂志文章

相关文献

DIABETES文献大全
  • Autocrine action of adiponectin on human fat cells prevents the release of insulin resistance-inducing factors.

    abstract::The adipocyte hormone adiponectin is negatively correlated with obesity and insulin resistance and may exert an important antidiabetes function. In this study, primary human skeletal muscle cells were cocultured with human fat cells or incubated with adipocyte-conditioned medium in the presence or absence of the globu...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diabetes.54.7.2003

    authors: Dietze-Schroeder D,Sell H,Uhlig M,Koenen M,Eckel J

    更新日期:2005-07-01 00:00:00

  • OKT3 rescue therapy in pancreas-allograft rejection.

    abstract::OKT3 has emerged as a highly effective antirejection therapy, but its efficacy in pancreas transplantation remains to be determined. During a 26-mo period, 46 vascularized pancreas transplants were performed with pancreaticoduodenocystostomy. Twenty-one patients (45.7%) were treated with OKT3. Indications for OKT3 use...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.38.1.s74

    authors: Stratta RJ,Sollinger HW,D'Alessandro AM,Pirsch JD,Kalayoglu M,Belzer FO

    更新日期:1989-01-01 00:00:00

  • The effect of oxidation on sorbitol pathway kinetics.

    abstract::The rapid conversion of glucose to sorbitol by aldose reductase and the consequent hyperosmolarity of the cytoplasm has been shown to be the primary cause of the so-called "sugar" or "osmotic" cataract in many animal lenses. It is not as clear, however, that hyperosmolarity is the principal factor in the etiology of c...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.35.4.426

    authors: Barnett PA,González RG,Chylack LT Jr,Cheng HM

    更新日期:1986-04-01 00:00:00

  • Glucose transporters of rat peripheral nerve. Differential expression of GLUT1 gene by Schwann cells and perineural cells in vivo and in vitro.

    abstract::Expression of GLUTs in rat peripheral nerve was first studied at the mRNA level with Northern transfer analysis with cDNAs specific for GLUT1, GLUT2, GLUT3, and GLUT4. GLUT1 mRNA was the only GLUT mRNA detectable in rat sciatic nerve. In situ hybridization localized this mRNA to the perineurium and to some endo- and e...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.41.12.1587

    authors: Muona P,Sollberg S,Peltonen J,Uitto J

    更新日期:1992-12-01 00:00:00

  • Changes in nerve conduction velocity after six weeks of glucoregulation with portable insulin infusion pumps.

    abstract::Near normal glucoregulation was maintained in 10 patients with insulin-dependent (type I) diabetes mellitus for 6 wk with preprogrammed continuous subcutaneous insulin infusion using a portable battery-powered infusion pump (CSII). This form of therapy resulted in a statistically significant increase in motor nerve co...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.29.8.668

    authors: Pietri A,Ehle AL,Raskin P

    更新日期:1980-08-01 00:00:00

  • Duodenal leptin stimulates cholecystokinin secretion: evidence of a positive leptin-cholecystokinin feedback loop.

    abstract::Some of the actions of leptin depend on cholecystokinin (CCK). However, it is unknown whether leptin modulates the release of CCK. Here, we demonstrate in vitro that leptin induces the phosphorylation of extracellular signal-related kinase (ERK)-1/2 proteins and increases CCK release (EC(50) = 0.23 nmol/l) in CCK-secr...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diabetes.52.7.1664

    authors: Guilmeau S,Buyse M,Tsocas A,Laigneau JP,Bado A

    更新日期:2003-07-01 00:00:00

  • Ciglitazone, a new hypoglycemic agent. I. Studies in ob/ob and db/db mice, diabetic Chinese hamsters, and normal and streptozotocin-diabetic rats.

    abstract::Ciglitazone, 5-[4-(1-methylcyclohexylmethoxy) benzyl]-thiazolidine-2,4-dione, is a new hypoglycemic agent orally active in the obese-hyperglycemic animal models. In C57BL/6J-ob/ob mice, treatment with 100 mg/kg ciglitazone for 2 days elicited a drastic fall in blood glucose. It also decreased plasma insulin, triglycer...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.32.9.830

    authors: Chang AY,Wyse BM,Gilchrist BJ,Peterson T,Diani AR

    更新日期:1983-09-01 00:00:00

  • Liver sinusoidal endothelial cells link hyperinsulinemia to hepatic insulin resistance.

    abstract::Insulin signaling in vascular endothelial cells (ECs) is critical to maintain endothelial function but also to mediate insulin action on peripheral glucose disposal. However, gene knockout studies have reached disparate conclusions. Thus, insulin receptor inactivation in ECs does not impair insulin action, whereas ina...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db12-1296

    authors: Tsuchiya K,Accili D

    更新日期:2013-05-01 00:00:00

  • Blood glucose lowering and glucagonostatic effects of glucagon-like peptide I in insulin-deprived diabetic dogs.

    abstract::To establish potential effects of glucagon-like peptide I (GLP-I) on blood glucose control in insulin-deficient states, GLP-I [GLP-I(7-36) amide; 10 pmol x kg(-1) x min(-1)] was infused intravenously in six fasting, canine C-peptide-negative, chronically diabetic dogs for 8 h. Blood samples were saved for the analysis...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.46.5.824

    authors: Freyse EJ,Becher T,El-Hag O,Knospe S,Göke B,Fischer U

    更新日期:1997-05-01 00:00:00

  • Common Polymorphisms in the Adiponectin Gene ACDC Are Not Associated With Diabetes in Pima Indians.

    abstract::Adiponectin is an abundant adipose tissue-derived protein with important metabolic effects. Plasma adiponectin levels are decreased in obese individuals, and low adiponectin levels predict insulin resistance and type 2 diabetes. Two variants in the adiponectin gene ACDC have been previously associated with plasma adip...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diabetes.54.1.284

    authors: Vozarova de Courten B,Hanson RL,Funahashi T,Lindsay RS,Matsuzawa Y,Tanaka S,Thameem F,Gruber JD,Froguel P,Wolford JK

    更新日期:2005-01-01 00:00:00

  • Developmental Programming of Obesity and Diabetes in Mouse, Monkey, and Man in 2018: Where Are We Headed?

    abstract::Childhood obesity and its comorbidities continue to accelerate across the globe. Two-thirds of pregnant women are obese/overweight, as are 20% of preschoolers. Gestational diabetes mellitus (GDM) is escalating, affecting up to 1 in 5 pregnant women. The field of developmental origins of health and disease has begun to...

    journal_title:Diabetes

    pub_type: 杂志文章,评审

    doi:10.2337/dbi17-0011

    authors: Friedman JE

    更新日期:2018-11-01 00:00:00

  • Reduction of glycemic and lipid levels in db/db diabetic mice by psyllium plant fiber.

    abstract::The soluble plant fiber psyllium significantly reduced fasting glucose and total cholesterol levels in the C57BL/KsJ db/db diabetic mouse relative to placebo-fed mice. Insulin levels were significantly higher in psyllium-fed than placebo-fed animals, indicating this fiber may delay the progression of diabetes in the a...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.38.12.1528

    authors: Watters K,Blaisdell P

    更新日期:1989-12-01 00:00:00

  • Quantitative and qualitative lipoprotein abnormalities in diabetes mellitus.

    abstract::In people with diabetes, the concentration of an individual lipoprotein or apolipoprotein can be highly variable and is totally different in the two major forms of the disease. Alterations in the concentrations of major lipids and lipoproteins are well characterized in both IDDM and NIDDM. In general, the lipoprotein ...

    journal_title:Diabetes

    pub_type: 杂志文章,评审

    doi:10.2337/diab.41.2.s12

    authors: Taskinen MR

    更新日期:1992-10-01 00:00:00

  • PTPN22 silencing in the NOD model indicates the type 1 diabetes-associated allele is not a loss-of-function variant.

    abstract::PTPN22 encodes the lymphoid tyrosine phosphatase (LYP) and is the second strongest non-HLA genetic risk factor for type 1 diabetes. The PTPN22 susceptibility allele generates an LYP variant with an arginine-to-tryptophan substitution at position 620 (R620W) that has been reported by several studies to impart a gain of...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db12-0929

    authors: Zheng P,Kissler S

    更新日期:2013-03-01 00:00:00

  • Insulin release. Demonstration of a priming effect of 3-isobutyl-1-methyl-xanthine (IBMX) on islets of Langerhans.

    abstract::Exposure of isolated rat pancreatic islets to 1 mM 3-isobutyl-1-methyl-xanthine (IBMX) resulted in a 5.7-fold increase in the rate of insulin release. After a 30-min rest period under basal conditions, reexposure of the islets to 1 mM IBMX resulted in an enhanced rate of release when compared with either a timed contr...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.30.9.754

    authors: Wiedenkeller DE,Sharp GW

    更新日期:1981-09-01 00:00:00

  • Altered monocyte cyclooxygenase response to lipopolysaccharide in type 1 diabetes.

    abstract::Type 1 diabetes is caused by adaptive immune responses, but innate immunity is important because monocytes infiltrate islets. Activated monocytes express cyclooxygenase (COX)-2, promoting prostaglandin-E(2) (PGE(2)) secretion, whereas COX-1 expression is constitutive. We aimed to define monocyte COX expression in type...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db06-0447

    authors: Beyan H,Goodier MR,Nawroly NS,Hawa MI,Bustin SA,Ogunkolade WB,Londei M,Yousaf N,Leslie RD

    更新日期:2006-12-01 00:00:00

  • Short-term effect of insulin and 5(3-piridyl) tetrazole on serum triglycerides in insulin-dependent diabetic patients.

    abstract::A group of insulin-dependent diabetic patients was studied in order to determine the possible short-term regulatory effect of insulin and that of an antilipolytic drug on serum triglycerides. Subcutaneous crystalline insulin (one third of the usual morning dose of intermediate long-acting insulin, NPH) and an oral dos...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.26.7.615

    authors: Alvarez-Reynolds M,Dominguez JM

    更新日期:1977-07-01 00:00:00

  • Evidence for rapamycin toxicity in pancreatic β-cells and a review of the underlying molecular mechanisms.

    abstract::Rapamycin is used frequently in both transplantation and oncology. Although historically thought to have little diabetogenic effect, there is growing evidence of β-cell toxicity. This Review draws evidence for rapamycin toxicity from clinical studies of islet and renal transplantation, and of rapamycin as an anticance...

    journal_title:Diabetes

    pub_type: 杂志文章,评审

    doi:10.2337/db13-0106

    authors: Barlow AD,Nicholson ML,Herbert TP

    更新日期:2013-08-01 00:00:00

  • Loss of IDO1 Expression From Human Pancreatic β-Cells Precedes Their Destruction During the Development of Type 1 Diabetes.

    abstract::Indoleamine 2,3 dioxygenase-1 (IDO1) is a powerful immunoregulatory enzyme that is deficient in patients with type 1 diabetes (T1D). In this study, we present the first systematic evaluation of IDO1 expression and localization in human pancreatic tissue. Although IDO1 was constitutively expressed in β-cells from donor...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db17-1281

    authors: Anquetil F,Mondanelli G,Gonzalez N,Rodriguez Calvo T,Zapardiel Gonzalo J,Krogvold L,Dahl-Jørgensen K,Van den Eynde B,Orabona C,Grohmann U,von Herrath MG

    更新日期:2018-09-01 00:00:00

  • Defects in β-cell Ca2+ dynamics in age-induced diabetes.

    abstract::Little is known about the molecular mechanisms underlying age-dependent deterioration in β-cell function. We now demonstrate that age-dependent impairment in insulin release, and thereby glucose homeostasis, is associated with subtle changes in Ca(2+) dynamics in mouse β-cells. We show that these changes are likely to...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db13-1855

    authors: Li L,Trifunovic A,Köhler M,Wang Y,Petrovic Berglund J,Illies C,Juntti-Berggren L,Larsson NG,Berggren PO

    更新日期:2014-12-01 00:00:00

  • Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells.

    abstract:OBJECTIVE:Posttranslational prenylation (e.g., farnesylation) of small G-proteins is felt to be requisite for cytoskeletal remodeling and fusion of secretory vesicles with the plasma membrane. Here, we investigated roles of protein farnesylation in the signaling steps involved in Raf-1/extracellular signal-related kina...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db09-1334

    authors: Kowluru A,Veluthakal R,Rhodes CJ,Kamath V,Syed I,Koch BJ

    更新日期:2010-04-01 00:00:00

  • Maternally inherited diabetes and deafness is a distinct subtype of diabetes and associates with a single point mutation in the mitochondrial tRNA(Leu(UUR)) gene.

    abstract::We have recently reported an A to G transition at nucleotide position 3243 in the mitochondrial DNA (mtDNA) tRNA(Leu(UUR)) gene in a large family with non-insulin-dependent diabetes mellitus (NIDDM). Characteristic was its maternal transmission and an associated sensorineural hearing loss. In a screening of a Dutch an...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.43.6.746

    authors: van den Ouweland JM,Lemkes HH,Trembath RC,Ross R,Velho G,Cohen D,Froguel P,Maassen JA

    更新日期:1994-06-01 00:00:00

  • Influence of circulating epinephrine on absorption of subcutaneously injected insulin.

    abstract::Effects of epinephrine (Epi) infusion on the absorption of subcutaneously injected 125I-labeled soluble human insulin (10 U) from the thigh or the abdomen were studied in 16 healthy subjects and from the thigh in 10 insulin-dependent diabetic (IDDM) patients. Epi was infused at 0.3 (high dose) or 0.1 (low dose; health...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.37.6.694

    authors: Fernqvist E,Gunnarsson R,Linde B

    更新日期:1988-06-01 00:00:00

  • Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion.

    abstract::Leptin, encoded for by the mouse ob gene, regulates feeding behavior and energy metabolism. Its receptor (Ob-R) is encoded by the mouse diabetic (db) gene and is mutated in the db/db mouse so that it lacks the cytoplasmic domain. We show that the full-length leptin receptor (Ob-Rb), which is believed to transmit the l...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.46.2.313

    authors: Emilsson V,Liu YL,Cawthorne MA,Morton NM,Davenport M

    更新日期:1997-02-01 00:00:00

  • Effects of insulin and IGF-I on vascular smooth muscle glucose and cation metabolism.

    abstract::Data is accumulating indicating that impaired insulin action predisposes to increased vascular smooth muscle (VSM) tone, the hallmark of hypertension associated with diabetes. During the last several years, it has been established that VSM is an insulin-sensitive tissue like skeletal muscle and adipocytes. Investigato...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.45.3.s47

    authors: Sowers JR

    更新日期:1996-07-01 00:00:00

  • The prognostic importance of plasma glucose levels and of the use of oral hypoglycemic drugs after myocardial infarction in men.

    abstract::The relationship of plasma glucose levels to risk of death over a five-year follow-up period was studied in 2,770 male survivors of myocardial infarction in the placebo group of the Coronary Drug Project (CDP). In univariate analyses, a positive association was observed between mortality rates and both fasting and one...

    journal_title:Diabetes

    pub_type: 临床试验,杂志文章

    doi:

    authors:

    更新日期:1977-05-01 00:00:00

  • Role for plasma membrane-related Ca2+-ATPase-1 (ATP2C1) in pancreatic beta-cell Ca2+ homeostasis revealed by RNA silencing.

    abstract::Changes in intracellular Ca(2+) concentration play a key role in the regulation of insulin secretion by glucose and other secretagogues. Here, we explore the importance of the secretory pathway Ca(2+)-ATPase, plasma membrane-related Ca(2+)-ATPase-1 (PMR1; human orthologue ATP2C1) in intracellular Ca(2+) homeostasis in...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diabetes.53.2.393

    authors: Mitchell KJ,Tsuboi T,Rutter GA

    更新日期:2004-02-01 00:00:00

  • Pioglitazone induces vascular smooth muscle cell apoptosis through a peroxisome proliferator-activated receptor-gamma, transforming growth factor-beta1, and a Smad2-dependent mechanism.

    abstract::Thiazolidinediones, such as pioglitazone, seem to exert direct antiatherosclerotic and antirestenotic effects on type 2 diabetes, in part due to an induction of vascular smooth muscle cell (VSMC) apoptosis. We aimed to study the role of transforming growth factor (TGF)-beta in rat aortic VSMC. Pioglitazone at 100 micr...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diabetes.54.3.811

    authors: Redondo S,Ruiz E,Santos-Gallego CG,Padilla E,Tejerina T

    更新日期:2005-03-01 00:00:00

  • Effect of insulin on glucose utilization in epitrochlearis muscle of rats with streptozocin-induced NIDDM.

    abstract::Because skeletal muscle plays a major role in glucose disposal, it may be the primary site of insulin resistance in non-insulin-dependent diabetes mellitus (NIDDM). Rates of glycogen synthesis (GS), glucose utilization via glycolysis, glycolytic utilization (GU), and glucose transport (GT) were studied in epitrochlear...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.39.9.1106

    authors: Karl IE,Gavin JR 3rd,Levy J

    更新日期:1990-09-01 00:00:00

  • Prevention of recurrence of IDDM in islet-transplanted diabetic NOD mice by adjuvant immunotherapy.

    abstract::Insulin-dependent diabetes mellitus (IDDM) involves the destruction of the insulin-producing cells in the islets of Langerhans. One possible cure is by transplanting the islet cells; however, transplanted islets, even between identical twins, are subject to autoimmune destruction by the disease process, resulting in d...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.41.1.114

    authors: Wang T,Singh B,Warnock GL,Rajotte RV

    更新日期:1992-01-01 00:00:00