Alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction.

abstract：:Childhood obesity and its comorbidities continue to accelerate across the globe. Two-thirds of pregnant women are obese/overweight, as are 20% of preschoolers. Gestational diabetes mellitus (GDM) is escalating, affecting up to 1 in 5 pregnant women. The field of developmental origins of health and disease has begun to...

journal_title：Diabetes

authors： Friedman JE

更新日期：2018-11-01 00:00:00

abstract：:Data based on the prospective study of Job et al. are reanalyzed while initial number of microaneurysms and duration of patient follow-up are controlled. The reported statistical difference in the rate of microaneurysm increase between the single- and the multiple-daily-injection groups may be due to a difference in a...

journal_title：Diabetes

authors： Ashikaga T,Borodic G,Sims EA

更新日期：1978-05-01 00:00:00

abstract：:Proliferation of vascular smooth muscle is thought to be involved in the major diabetic complication atherosclerosis. We have previously reported an increase of growth-promoting activity (GA) in platelets from insulin-dependent diabetics. In this study, GA was measured in the platelet extract (PE) from eight diabetic ...

journal_title：Diabetes

authors： Sugimoto H,Franks DJ,Lecavalier L,Chiasson JL,Hamet P

更新日期：1987-05-01 00:00:00

abstract：OBJECTIVE:Suppression of Kinesin-1 by antisense oligonucleotides, or overexpression of dominant-negative acting kinesin heavy chain, has been reported to affect the sustained phase of glucose-stimulated insulin secretion in β-cells in vitro. In this study, we examined the in vivo physiological role of Kinesin-1 in β-ce...

journal_title：Diabetes

authors： Cui J,Wang Z,Cheng Q,Lin R,Zhang XM,Leung PS,Copeland NG,Jenkins NA,Yao KM,Huang JD

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:Macrophages play an important role in the pathogenesis of insulin resistance via the production of proinflammatory cytokines. Our goal is to decipher the molecular linkage between proinflammatory cytokine production and insulin resistance in macrophages. RESEARCH DESIGN AND METHODS:We determined cytokine pro...

journal_title：Diabetes

authors： Su D,Coudriet GM,Hyun Kim D,Lu Y,Perdomo G,Qu S,Slusher S,Tse HM,Piganelli J,Giannoukakis N,Zhang J,Dong HH

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVE:The expansion of adipose tissue mass seen in obesity involves both hyperplasia and hypertrophy of adipocytes. However, little is known about how adipocytes, adipocyte precursors, blood vessels, and stromal cells interact with one another to achieve adipogenesis. RESEARCH DESIGN AND METHODS:We have developed ...

journal_title：Diabetes

authors： Nishimura S,Manabe I,Nagasaki M,Hosoya Y,Yamashita H,Fujita H,Ohsugi M,Tobe K,Kadowaki T,Nagai R,Sugiura S

更新日期：2007-06-01 00:00:00

abstract：:Fasting hypoglycemia occurred in a patient with a histologically benign mesothelioma; the serum insulin was low (2-4 muU./ml.), as was the glucose utilization rate. Splanchnic glucose output was markedly decreased on direct measurement (21 mg./min.; normal: 108-180 mg./min.). Splanchnic uptake of gluconeogenic substra...

journal_title：Diabetes

authors： Silbert CK,Rossini AA,Ghazvinian S,Widrich WC,Marks LJ,Sawin CT

更新日期：1976-03-01 00:00:00

abstract：:Brain lactate may be involved in the development of impaired awareness of hypoglycemia (IAH), a condition that affects approximately 25% of patients with type 1 diabetes and increases the risk of severe hypoglycemia. The aim of this study was to investigate the effect of acute hypoglycemia on brain lactate concentrati...

journal_title：Diabetes

authors： Wiegers EC,Rooijackers HM,Tack CJ,Heerschap A,de Galan BE,van der Graaf M

更新日期：2016-06-01 00:00:00

abstract：:To determine the effect of inhibition of gluconeogenesis on liver glycogen stores in patients with non-insulin-dependent diabetes mellitus (NIDDM) after a 3-day fast, 10% ethanol (EtOH) was administered intravenously to nine obese patients with NIDDM and six obese nondiabetic subjects. Rates of glucose appearance (3-[...

journal_title：Diabetes

authors： Clore JN,Blackard WG

更新日期：1994-02-01 00:00:00

abstract：:We previously described a prosthetic group methodology for incorporating 18F into peptides and showed that 18F-labeled insulin (18F-insulin) binds to insulin receptors on human cells (IM-9 lymphoblastoid cells) with affinity equal to that of native insulin (1). We now report studies using 18F-insulin with positron emi...

journal_title：Diabetes

authors： Eastman RC,Carson RE,Jacobson KA,Shai Y,Channing MA,Dunn BB,Bacher JD,Baas E,Jones E,Kirk KL

更新日期：1992-07-01 00:00:00

abstract：:Amylin, a 37-amino acid peptide hormone co-secreted with insulin, potently governs the rate of gastric emptying. Hypoglycemia, in the absence of agents such as amylin, is reported to accelerate gastric emptying. We asked whether hypoglycemia had a similar action on gastric emptying in the presence of amylin. In prelim...

journal_title：Diabetes

authors： Gedulin BR,Young AA

更新日期：1998-01-01 00:00:00

abstract：:Six men with a low rate of insulin-stimulated, non-oxidative carbohydrate disposal (storage) and six with a high storage rate were recruited for study of the fate of insulin-stimulated glucose uptake. [3-3H]glucose was infused before and during a 4-h hyperinsulinemic euglycemic clamp procedure in a dosage regimen desi...

journal_title：Diabetes

authors： Young AA,Bogardus C,Wolfe-Lopez D,Mott DM

更新日期：1988-03-01 00:00:00

abstract：:The responsiveness of the isolated perfused rat liver to different metabolic effects of insulin was investigated during recycling perfusion. Infusion of porcine insulin at rates of 6, 9, 16 and 33 mU/hr. resulted in stable perfusate insulin levels averaging 41, 72, 120 and 229 muU/ml., respectively. Since the portal v...

journal_title：Diabetes

authors： Mondon CE,Dolkas CB,Olefsky JM,Reaven GM

更新日期：1975-02-01 00:00:00

abstract：:Obesity is usually associated with an increased risk of nonalcoholic fatty liver disease that is characterized by accumulation of excessive triglyceride (TG) in hepatocytes. However, the factors involved in the obesity-induced hepatosteatosis are poorly defined. Here, we report that SRY-box containing gene 4 (Sox4), a...

journal_title：Diabetes

authors： Jiao Y,Zhao J,Zhang Z,Li M,Yu X,Yang Y,Liu J,Liao S,Li D,Wang Y,Zhang D,Chen Y,Shi G,Liu B,Lu Y,Li X

更新日期：2018-11-01 00:00:00

abstract：:Effects of epinephrine (Epi) infusion on the absorption of subcutaneously injected 125I-labeled soluble human insulin (10 U) from the thigh or the abdomen were studied in 16 healthy subjects and from the thigh in 10 insulin-dependent diabetic (IDDM) patients. Epi was infused at 0.3 (high dose) or 0.1 (low dose; health...

journal_title：Diabetes

authors： Fernqvist E,Gunnarsson R,Linde B

更新日期：1988-06-01 00:00:00

abstract：:Counterregulatory hormonal responses were studied in six patients after 4-18 mo treatment with a continuous subcutaneous insulin infusion pump. In response to insulin-induced hypoglycemia, significant increases in epinephrine, norepinephrine, cortisol, and growth hormone were measured in all subjects, while in five of...

journal_title：Diabetes

authors： Bergenstal RM,Polonsky KS,Pons G,Jaspan JB,Rubenstein AH

更新日期：1983-05-01 00:00:00

abstract：:Type 1 diabetes (T1D) results from the autoimmune destruction of insulin-producing β-cells in the pancreas. Thereby, the chemokine CXC-motif ligand 10 (CXCL10) plays an important role in the recruitment of autoaggressive lymphocytes to the islets of Langerhans. Transplantation of isolated islets as a promising therapy...

journal_title：Diabetes

authors： Bender C,Christen S,Scholich K,Bayer M,Pfeilschifter JM,Hintermann E,Christen U

更新日期：2017-01-01 00:00:00

abstract：:Apoptosis is a physiological form of cell death that occurs during normal development, and critical mediators of this process include caspases, reactive oxygen species, and Ca2+. Excessive apoptosis of the pancreatic beta-cell has been associated with diabetes. Consequently, apoptosis research has focused on how infil...

journal_title：Diabetes

authors： Chandra J,Zhivotovsky B,Zaitsev S,Juntti-Berggren L,Berggren PO,Orrenius S

更新日期：2001-02-01 00:00:00

abstract：:Ten young adult miniature swine from a line reported to be genetically selected for glucose intolerance and eight normal controls were obtained from Colorado State University. They were consecutively exposed to 4 mo of a high-fiber, low-fat standard swine diet; 4 mo of a high-sucrose, high-fat, low-fiber diabetogenic ...

journal_title：Diabetes

authors： Hand MS,Surwit RS,Rodin J,Van Order P,Feinglos MN

更新日期：1987-03-01 00:00:00

abstract：:In the oral glucose tolerance test (OGTT), divergent doses of glucose remain in use by virtue of the prevailing conviction that the size of the loading dose hardly affects the outcome of the test. We compared the results of OGTTs with 100-gm. and 50-gm. loads in 85 patients, who were selected for slightly impaired glu...

journal_title：Diabetes

authors： de Nobel E,van't Laar A

更新日期：1978-01-01 00:00:00

abstract：:The association between clinical autonomic dysfunction and myocardial MIBG accumulation was investigated. The study groups comprised 6 male diabetic patients with autonomic neuropathy (ANP+ group), 6 male diabetic patients without autonomic neuropathy (ANP-group), and 6 male nondiabetic control subjects. The mean age ...

journal_title：Diabetes

authors： Mäntysaari M,Kuikka J,Mustonen J,Tahvanainen K,Vanninen E,Länsimies E,Uusitupa M

更新日期：1992-09-01 00:00:00

abstract：:Ambulatory blood pressure (AMBP) measurements were obtained at 20-min intervals for 24 h in 25 subjects with insulin-dependent (type I) diabetes mellitus and 21 control subjects. The diabetic patients had normal kidney function (glomerular filtration rate 112.1 +/- 7.2 ml.min-1.1.73 m-2, renal plasma flow 459.0 +/- 23...

journal_title：Diabetes

authors： Wiegmann TB,Herron KG,Chonko AM,MacDougall ML,Moore WV

更新日期：1990-12-01 00:00:00

abstract：:To evaluate the correlation between heat-shock protein (HSP) and insulitis, we compared lymphocyte proliferative response to Mycobacterium leprae HSP65 of NOD mice with that of I-E alpha d transgenic NOD (I-E+NOD) mice, which show no insulitis. We found that splenocytes from 15-week-old NOD mice showed a more marked p...

journal_title：Diabetes

authors： Shimada A,Kasatani T,Takei I,Maruyama T,Nomaguchi H,Ozawa Y,Ishii M,Kasuga A,Tashiro F,Miyazaki J,Yamamura K,Saruta T

更新日期：1996-02-01 00:00:00

abstract：:The last two decades have witnessed an explosion of interest in adipocyte biology, coinciding with the upsurge of obesity and metabolic syndrome. Now we have new perspectives on the distinct developmental origins of white, brown, and beige adipocytes and their role in metabolic physiology and disease. Beyond fuel meta...

journal_title：Diabetes

authors： Sun L,Lin JD

更新日期：2019-05-01 00:00:00

abstract：:It has been proposed that insulin-mediated changes in muscle perfusion modulate insulin-mediated glucose uptake. However, the putative effects of insulin on the microcirculation that permit such modulation have not been studied in humans. We examined the effects of systemic hyperinsulinemia on skin microvascular funct...

journal_title：Diabetes

authors： Serné EH,IJzerman RG,Gans RO,Nijveldt R,De Vries G,Evertz R,Donker AJ,Stehouwer CD

更新日期：2002-05-01 00:00:00

abstract：:The data being reported are part of an epidemiologic study of health and disease in an entire community, Tecumseh, Michigan. Approximately 1,300 males age 16-65 were classified into three groups on the basis of their habitual leisure and occupational physical activity. A blood sample was drawn one hour after a glucose...

journal_title：Diabetes

authors： Montoye HJ,Block WD,Metzner H,Keller JB

更新日期：1977-03-01 00:00:00

abstract：:The virtually fatless A-ZIP/F-1 mouse is profoundly insulin resistant, diabetic, and a good model for humans with severe generalized lipoatrophy. Like a number of other mouse models of diabetes, the A-ZIP/F-1 mouse has elevated serum corticosterone levels. Leptin infusion lowers the corticosterone levels, suggesting t...

journal_title：Diabetes

authors： Haluzik M,Dietz KR,Kim JK,Marcus-Samuels B,Shulman GI,Gavrilova O,Reitman ML

更新日期：2002-07-01 00:00:00

abstract：:We previously showed that pancreatic beta-cells express a neuronal isoform of nitric oxide synthase (nNOS) that controls insulin secretion by exerting two enzymatic activities: nitric oxide (NO) production and cytochrome c reductase activity. We now bring evidence that two inhibitors of nNOS, N-omega-nitro-l-arginine ...

journal_title：Diabetes

authors： Lajoix AD,Pugnière M,Roquet F,Mani JC,Dietz S,Linck N,Faurie F,Ribes G,Petit P,Gross R

更新日期：2004-06-01 00:00:00

abstract：:Recent preclinical studies showed the potential of nicotinamide adenine dinucleotide (NAD(+)) precursors to increase oxidative phosphorylation and improve metabolic health, but human data are lacking. We hypothesize that the nicotinic acid derivative acipimox, an NAD(+) precursor, would directly affect mitochondrial f...

journal_title：Diabetes

authors： van de Weijer T,Phielix E,Bilet L,Williams EG,Ropelle ER,Bierwagen A,Livingstone R,Nowotny P,Sparks LM,Paglialunga S,Szendroedi J,Havekes B,Moullan N,Pirinen E,Hwang JH,Schrauwen-Hinderling VB,Hesselink MK,Auwerx J,Ro

更新日期：2015-04-01 00:00:00

abstract：:Low plasma sex hormone-binding globulin (SHBG) levels are associated with obesity and predict the development of type 2 diabetes. The reason why obese individuals have low circulating SHBG has been attributed to hyperinsulinemia, but no mechanistic evidence has been described. The aim of the current study is to explor...

journal_title：Diabetes

authors： Simó R,Barbosa-Desongles A,Lecube A,Hernandez C,Selva DM

更新日期：2012-02-01 00:00:00