Hypoglycemia overrides amylin-mediated regulation of gastric emptying in rats.

abstract：:GAD autoantibodies (GADAs) are sensitive markers of islet autoimmunity and type 1 diabetes. They form the basis of robust prediction models and are widely used for the recruitment of subjects at high risk of type 1 diabetes to prevention trials. However, GADAs are also found in many individuals at low risk of diabetes...

journal_title：Diabetes

authors： Williams AJ,Lampasona V,Schlosser M,Mueller PW,Pittman DL,Winter WE,Akolkar B,Wyatt R,Brigatti C,Krause S,Achenbach P,Participating Laboratories.

更新日期：2015-09-01 00:00:00

abstract：:Hepatocyte nuclear factor 4alpha (HNF4A), the gene for the maturity-onset diabetes of the young type 1 monogenic form of type 2 diabetes, is within the type 2 diabetes-linked region on chromosome 20q12-q13.1 and, consequently, is a positional candidate gene for type 2 diabetes in the general population. Previous studi...

journal_title：Diabetes

authors： Bagwell AM,Bento JL,Mychaleckyj JC,Freedman BI,Langefeld CD,Bowden DW

更新日期：2005-04-01 00:00:00

abstract：:Segmental pancreatic allografts with unligated ducts were transplanted intraperitoneally to five diabetic patients who had received renal allografts more than 2 yr earlier. One patient is alive with a functioning graft 10.5 mo later. Two patients rejected their grafts at approximately 2 and 3 mo but are alive 8--9 mo ...

journal_title：Diabetes

authors： Sutherland DE,Goetz FC,Najarian JS

更新日期：1980-01-01 00:00:00

abstract：OBJECTIVE:Visceral obesity and elevated plasma free fatty acids are predisposing factors for type 2 diabetes. Chronic exposure to these lipids is detrimental for pancreatic beta-cells, resulting in reduced insulin content, defective insulin secretion, and apoptosis. We investigated the involvement in this phenomenon of...

journal_title：Diabetes

authors： Lovis P,Roggli E,Laybutt DR,Gattesco S,Yang JY,Widmann C,Abderrahmani A,Regazzi R

更新日期：2008-10-01 00:00:00

abstract：:Toll-like receptor 9 (TLR9) is highly expressed in B cells, and B cells are important in the pathogenesis of type 1 diabetes (T1D) development. However, the intrinsic effect of TLR9 in B cells on β-cell autoimmunity is not known. To fill this knowledge gap, we generated NOD mice with a B-cell-specific deficiency of TL...

journal_title：Diabetes

authors： Sha S,Pearson JA,Peng J,Hu Y,Huang J,Xing Y,Zhang L,Zhu Y,Zhao H,Wong FS,Chen L,Wen L

更新日期：2021-02-01 00:00:00

abstract：:Insulin lispro is a human insulin analog that dissociates more rapidly than human regular insulin after subcutaneous injection, resulting in higher insulin levels at an earlier point in time and a shorter duration of action. The aim of the study was to evaluate if this pharmacokinetic difference would translate into b...

journal_title：Diabetes

authors： Zinman B,Tildesley H,Chiasson JL,Tsui E,Strack T

更新日期：1997-03-01 00:00:00

abstract：:The transmission behavior of insulin-dependent juvenile diabetes mellitus (JDM) has been studied with respect to its frequency in the relatives of JDM probands and its possible linkage to the HLA complex. Mathematical analysis shows that under a single locus hypothesis a very restricted range of incidence rates is pos...

journal_title：Diabetes

authors： Suarez B,Hodge SE,Reich T

更新日期：1979-06-01 00:00:00

abstract：OBJECTIVE:Heart failure is a major cause of mortality in diabetes and may be causally associated with altered metabolism. Recent reports indicate a role of inflammation in peripheral insulin resistance, but the impact of inflammation on cardiac metabolism is unknown. We investigated the effects of diet-induced obesity ...

journal_title：Diabetes

authors： Ko HJ,Zhang Z,Jung DY,Jun JY,Ma Z,Jones KE,Chan SY,Kim JK

更新日期：2009-11-01 00:00:00

abstract：:Hypofibrinolysis caused by increased plasminogen activator inhibitor 1 (PAI-1) has been implicated in the vasculopathy of type 2 diabetes, typified by increased insulin, glucose, and triglycerides. However, short-term infusions of insulin have not increased PAI-1 in normal subjects. We hypothesized that induction of i...

journal_title：Diabetes

authors： Calles-Escandon J,Mirza SA,Sobel BE,Schneider DJ

更新日期：1998-02-01 00:00:00

abstract：:In an ongoing investigation of the effects of age on G protein-coupled receptor signaling in human atrial tissue, we have found that the density of atrial muscarinic acetylcholine receptor (mAChR) increases with age but reaches statistical significance only in patients with diabetes. Moreover, we find that in elderly ...

journal_title：Diabetes

authors： Richardson MD,Kilts JD,Kwatra MM

更新日期：2004-09-01 00:00:00

abstract：:Low-grade sustained inflammation links obesity to insulin resistance and nonalcoholic fatty liver disease (NAFLD). However, therapeutic approaches to improve systemic energy balance and chronic inflammation in obesity are limited. Pharmacological activation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) allevia...

journal_title：Diabetes

authors： Nagata N,Xu L,Kohno S,Ushida Y,Aoki Y,Umeda R,Fuke N,Zhuge F,Ni Y,Nagashimada M,Takahashi C,Suganuma H,Kaneko S,Ota T

更新日期：2017-05-01 00:00:00

abstract：:In skeletal muscle, the actin cytoskeleton-regulating GTPase, Rac1, is necessary for insulin-dependent GLUT4 translocation. Muscle contraction increases glucose transport and represents an alternative signaling pathway to insulin. Whether Rac1 is activated by muscle contraction and regulates contraction-induced glucos...

journal_title：Diabetes

authors： Sylow L,Jensen TE,Kleinert M,Mouatt JR,Maarbjerg SJ,Jeppesen J,Prats C,Chiu TT,Boguslavsky S,Klip A,Schjerling P,Richter EA

更新日期：2013-04-01 00:00:00

abstract：:Glucagonlike peptide I (7-37) [GLP-I-(7-37)], encoded with glucagon and glucagonlike peptide II and intervening peptide II in the rat and human glucagon gene, is processed from proglucagon in both pancreas and intestine and is a potent stimulator of insulin secretion. Unequivocal insulin release from the isolated perf...

journal_title：Diabetes

authors： Weir GC,Mojsov S,Hendrick GK,Habener JF

更新日期：1989-03-01 00:00:00

abstract：:Type 1 diabetes (T1D) results from a T cell-mediated destruction of pancreatic β-cells following the infiltration of leukocytes (including CD8(+), CD4(+), and CD20(+) cells) into and around pancreatic islets (insulitis). Recently, we reported that two distinct patterns of insulitis occur in patients with recent-onset ...

journal_title：Diabetes

authors： Leete P,Willcox A,Krogvold L,Dahl-Jørgensen K,Foulis AK,Richardson SJ,Morgan NG

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVE:Vaspin was identified as an adipokine with insulin-sensitizing effects, which is predominantly secreted from visceral adipose tissue in a rat model of type 2 diabetes. We have recently shown that vaspin mRNA expression in adipose tissue is related to parameters of obesity and glucose metabolism. However, the ...

journal_title：Diabetes

authors： Youn BS,Klöting N,Kratzsch J,Lee N,Park JW,Song ES,Ruschke K,Oberbach A,Fasshauer M,Stumvoll M,Blüher M

更新日期：2008-02-01 00:00:00

abstract：:Ciglitazone, 5-[4-(1-methylcyclohexylmethoxy) benzyl]-thiazolidine-2,4-dione, is a new hypoglycemic agent orally active in the obese-hyperglycemic animal models. In C57BL/6J-ob/ob mice, treatment with 100 mg/kg ciglitazone for 2 days elicited a drastic fall in blood glucose. It also decreased plasma insulin, triglycer...

journal_title：Diabetes

authors： Chang AY,Wyse BM,Gilchrist BJ,Peterson T,Diani AR

更新日期：1983-09-01 00:00:00

abstract：:Plasma glucagon response to glucose in diabetic subjects was observed before and after treatment. In normal subjects, plasma glucagon concentrations decreased substantially after an oral glucose load. In all diabetic patients before treatment, plasma glucagon was not suppressed and rather tended to rise paradoxically ...

journal_title：Diabetes

authors： Seino Y,Ikeda M,Kurahachi H,Taminato T,Sakurai H,Goto Y,Inoue Y,Kadowaki S,Mori K,Imura H

更新日期：1978-12-01 00:00:00

abstract：:Pancreatic beta-cells are more sensitive to several toxins (e.g., streptozotocin, alloxan, cytokines) than the other three endocrine cell types in the islets of Langerhans. Cytokine-induced free radicals in beta-cells may be involved in beta-cell-specific destruction in type 1 diabetes. To investigate if this sensitiv...

journal_title：Diabetes

authors： Nielsen K,Karlsen AE,Deckert M,Madsen OD,Serup P,Mandrup-Poulsen T,Nerup J

更新日期：1999-12-01 00:00:00

abstract：:The present study was performed to assess the potential relationship between the low T3 syndrome and hypothyroidism. Comparative studies were performed on the relative effects of diabetes and insulin on heparin-releasable adipose lipoprotein lipase (LPL) in the intact and hypothyroid rat. Hypothyroidism for 10 days (T...

journal_title：Diabetes

authors： Gavin LA,McMahon F,Moeller M

更新日期：1985-12-01 00:00:00

abstract：:The primary objective of this study was to assess whether the topical administration of two neuroprotective drugs (brimonidine and somatostatin) could prevent or arrest retinal neurodysfunction in patients with type 2 diabetes. For this purpose, adults aged between 45 and 75 years with a diabetes duration ≥5 years and...

journal_title：Diabetes

authors： Simó R,Hernández C,Porta M,Bandello F,Grauslund J,Harding SP,Aldington SJ,Egan C,Frydkjaer-Olsen U,García-Arumí J,Gibson J,Lang GE,Lattanzio R,Massin P,Midena E,Ponsati B,Ribeiro L,Scanlon P,Lobo C,Costa MÂ,Cunha-

更新日期：2019-02-01 00:00:00

abstract：:Dynamic aspects of whole body alanine and glycine metabolism have been explored in insulin-dependent (type I) diabetic subjects. Using a primed, continuous intravenous (i.v.) infusion of [2H3]alanine and [15N]glycine given simultaneously with [1-13C]leucine, whole body alanine and glycine fluxes and their rates of de ...

journal_title：Diabetes

authors： Robert JJ,Beaufrere B,Koziet J,Desjeux JF,Bier DM,Young VR,Lestradet H

更新日期：1985-01-01 00:00:00

abstract：:Type 1 diabetes results from chronic autoimmune destruction of insulin-producing β-cells within pancreatic islets. Although insulin is a critical self-antigen in animal models of autoimmune diabetes, due to extremely limited access to pancreas samples, little is known about human antigenic targets for islet-infiltrati...

journal_title：Diabetes

authors： Michels AW,Landry LG,McDaniel KA,Yu L,Campbell-Thompson M,Kwok WW,Jones KL,Gottlieb PA,Kappler JW,Tang Q,Roep BO,Atkinson MA,Mathews CE,Nakayama M

更新日期：2017-03-01 00:00:00

abstract：:Association studies are a potentially powerful approach to identifying susceptibility variants for common multifactorial diseases such as type 1 diabetes, but the results are not always consistently reproducible. The IDDM5 locus has recently been narrowed to an approximately 200-kb interval on chromosome 6q25 by two i...

journal_title：Diabetes

authors： Noso S,Ikegami H,Fujisawa T,Kawabata Y,Asano K,Hiromine Y,Tsurumaru M,Sugihara S,Lee I,Kawasaki E,Awata T,Ogihara T

更新日期：2005-12-01 00:00:00

abstract：:In pancreatic β-cells, closure of the ATP-sensitive K(+) (K(ATP)) channel is an initial process triggering glucose-stimulated insulin secretion. In addition, constitutive opening of background nonselective cation channels (NSCCs) is essentially required to effectively evoke depolarization as a consequence of K(ATP) ch...

journal_title：Diabetes

authors： Yosida M,Dezaki K,Uchida K,Kodera S,Lam NV,Ito K,Rita RS,Yamada H,Shimomura K,Ishikawa SE,Sugawara H,Kawakami M,Tominaga M,Yada T,Kakei M

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVE:The presence of autoantibodies to islet antigens GAD and/or tyrosine phosphatase 2 (IA-2) in type 2 diabetic patients (latent autoimmune diabetes in adults [LADA]) identifies subjects at high risk to develop insulin dependency. The aim of this study was to dissect humoral anti-IA-2 immune response in Caucasia...

journal_title：Diabetes

authors： Tiberti C,Giordano C,Locatelli M,Bosi E,Bottazzo GF,Buzzetti R,Cucinotta D,Galluzzo A,Falorni A,Dotta F

更新日期：2008-05-01 00:00:00

abstract：:We have shown previously that palmitate treatment of C2C12 skeletal muscle myotubes causes inhibition of the protein kinase B (PKB) pathway and hence reduces insulin-stimulated glycogen synthesis through the elevation of intracellular ceramide levels. Ceramide is known to activate both atypical protein kinase C (aPKC)...

journal_title：Diabetes

authors： Cazzolli R,Carpenter L,Biden TJ,Schmitz-Peiffer C

更新日期：2001-10-01 00:00:00

abstract：:Autoantibodies to glutamic acid decarboxylase (GAD) are frequent at or before the onset of insulin-dependent diabetes mellitus (IDDM). We have developed a simple, reproducible, and quantitative immunoprecipitation radioligand assay using as antigen in vitro transcribed and translated [35S]methionine-labeled human isle...

journal_title：Diabetes

authors： Petersen JS,Hejnaes KR,Moody A,Karlsen AE,Marshall MO,Høier-Madsen M,Boel E,Michelsen BK,Dyrberg T

更新日期：1994-03-01 00:00:00

abstract：:The vascular endothelial growth factor (VEGF) family of cytokines are important regulators of angiogenesis that have emerged as important targets for the treatment of obesity. While serum VEGF levels rise during obesity, recent studies using genetic models provide conflicting evidence as to whether VEGF prevents or ac...

journal_title：Diabetes

authors： Wu LE,Meoli CC,Mangiafico SP,Fazakerley DJ,Cogger VC,Mohamad M,Pant H,Kang MJ,Powter E,Burchfield JG,Xirouchaki CE,Mikolaizak AS,Stöckli J,Kolumam G,van Bruggen N,Gamble JR,Le Couteur DG,Cooney GJ,Andrikopoulos S,Ja

更新日期：2014-08-01 00:00:00

abstract：:Thiazolidinediones and exercise are both known to improve insulin action independently. Therefore, we determined whether combined therapy could normalize insulin action in the Zucker fatty (ZF) rat. Rats were fed troglitazone as a 0.2% food admixture over a 3-week exercise training period (treadmill running 5 days/wee...

journal_title：Diabetes

authors： Hevener AL,Reichart D,Olefsky J

更新日期：2000-12-01 00:00:00

abstract：:Impaired wound healing is one of the main causes of diabetic foot ulcerations. However, the exact mechanism of delayed wound healing in diabetes is not fully understood. Long noncoding RNAs (lncRNAs) are widely involved in a variety of biological processes and diseases, including diabetes and its associated complicati...

journal_title：Diabetes

authors： Hu M,Wu Y,Yang C,Wang X,Wang W,Zhou L,Zeng T,Zhou J,Wang C,Lao G,Yan L,Ren M

更新日期：2020-10-01 00:00:00