Exercise and thiazolidinedione therapy normalize insulin action in the obese Zucker fatty rat.

abstract：:Hyperglycemia-induced alterations in mesangial (MES) cell function and extracellular matrix protein accumulation are seen in diabetic glomerulopathy. Recent studies have demonstrated that some of the effects of high glucose (HG) on cellular metabolism are mediated by the hexosamine biosynthesis pathway (HBP), in which...

journal_title：Diabetes

authors： Singh LP,Andy J,Anyamale V,Greene K,Alexander M,Crook ED

更新日期：2001-10-01 00:00:00

abstract：OBJECTIVE:Observations of elevated circulating concentrations of visfatin (PBEF/Nampt) in obesity and diabetes suggest that this recently described adipokine is involved in the regulation of body weight and metabolism. We examined in humans whether visfatin is found in cerebrospinal fluid (CSF) and, if so, how CSF visf...

journal_title：Diabetes

authors： Hallschmid M,Randeva H,Tan BK,Kern W,Lehnert H

更新日期：2009-03-01 00:00:00

abstract：:To ascertain whether the dawn phenomenon occurs in nondiabetic individuals and, if so, whether it is due to an increase in glucose production or a decrease in glucose utilization, we determined plasma concentrations of glucose, insulin, C-peptide, and counterregulatory hormones, as well as rates of glucose production,...

journal_title：Diabetes

authors： Bolli GB,De Feo P,De Cosmo S,Perriello G,Ventura MM,Calcinaro F,Lolli C,Campbell P,Brunetti P,Gerich JE

更新日期：1984-12-01 00:00:00

abstract：:Single "subdiabetogenic" doses of streptozotocin (SZ), when given to young male CD-1 mice, produced a delayed onset of hyperglycemia dependent on the dose of SZ and on the age of the mice. The effect was markedly reduced or absent in older mice given the same dose of SZ per kg of body weight. Histologic examination of...

journal_title：Diabetes

authors： Riley WJ,McConnell TJ,Maclaren NK,McLaughlin JV,Taylor G

更新日期：1981-09-01 00:00:00

abstract：:In renal transplant recipients (RTRs), new-onset diabetes after transplantation (NODAT) is a frequent and serious complication limiting survival of graft and patient. However, the underlying pathophysiology remains incompletely understood. In vitro and in preclinical models, HDL can preserve β-cell function, largely b...

journal_title：Diabetes

authors： Szili-Torok T,Annema W,Anderson JLC,Bakker SJL,Tietge UJF

更新日期：2019-10-01 00:00:00

abstract：:Low birth weight is a well-established risk factor for type 2 diabetes, but the risk at high birth weight levels remains uncertain. Potential sex differences in the associations are unexplored. We investigated whether sex influences the association of birth weight and adult type 2 diabetes, using a cohort of 113,801 m...

journal_title：Diabetes

authors： Zimmermann E,Gamborg M,Sørensen TI,Baker JL

更新日期：2015-12-01 00:00:00

abstract：:We tested 32 routine clinical parameters for their ability to discriminate between a high risk and a low risk of non-insulin-dependent diabetes mellitus (NIDDM) within 5-7 years after pregnancies complicated by gestational diabetes mellitus (GDM). Latino women (n = 671) with GDM who did not have diabetes 4-16 weeks af...

journal_title：Diabetes

authors： Kjos SL,Peters RK,Xiang A,Henry OA,Montoro M,Buchanan TA

更新日期：1995-05-01 00:00:00

abstract：:Despite intensive study, the relation between insulin's action on blood flow and glucose metabolism remains unclear. Insulin-induced changes in microvascular perfusion, independent from effects on total blood flow, could be an important variable contributing to insulin's metabolic action. We hypothesized that modest, ...

journal_title：Diabetes

authors： Coggins M,Lindner J,Rattigan S,Jahn L,Fasy E,Kaul S,Barrett E

更新日期：2001-12-01 00:00:00

abstract：:Patients with non-insulin-dependent diabetes mellitus (NIDDM) who have chronic hyperglycemia lose acute incremental insulin responses to glucose but are able to briskly respond to other beta-cell secretagogues. To investigate whether this is a defect specific for glucose or represents a more general phenomenon, we mea...

journal_title：Diabetes

authors： Karam JH,Sanz N,Salamon E,Nolte MS

更新日期：1986-12-01 00:00:00

abstract：:GLUT4 is necessary for acute insulin- and contraction-induced skeletal muscle glucose uptake, but its role in chronic muscle loading (overload)-induced glucose uptake is unknown. Our goal was to determine whether GLUT4 is required for overload-induced glucose uptake. Overload was induced in mouse plantaris muscle by u...

journal_title：Diabetes

authors： McMillin SL,Schmidt DL,Kahn BB,Witczak CA

更新日期：2017-06-01 00:00:00

abstract：:Six men with a low rate of insulin-stimulated, non-oxidative carbohydrate disposal (storage) and six with a high storage rate were recruited for study of the fate of insulin-stimulated glucose uptake. [3-3H]glucose was infused before and during a 4-h hyperinsulinemic euglycemic clamp procedure in a dosage regimen desi...

journal_title：Diabetes

authors： Young AA,Bogardus C,Wolfe-Lopez D,Mott DM

更新日期：1988-03-01 00:00:00

abstract：:The Clinical Islet Transplantation 07 (CIT07) protocol uses antithymocyte globulin and etanercept induction, islet culture, heparinization, and intensive insulin therapy with the same low-dose tacrolimus and sirolimus maintenance immunosuppression as in the Edmonton protocol. To determine whether CIT07 improves engraf...

journal_title：Diabetes

authors： Rickels MR,Liu C,Shlansky-Goldberg RD,Soleimanpour SA,Vivek K,Kamoun M,Min Z,Markmann E,Palangian M,Dalton-Bakes C,Fuller C,Chiou AJ,Barker CF,Luning Prak ET,Naji A

更新日期：2013-08-01 00:00:00

abstract：:AMPK is a widely expressed intracellular energy sensor that monitors and modulates energy expenditure. Transient receptor potential ankyrin 1 (TRPA1) channel is a widely recognized chemical and thermal sensor that plays vital roles in pain transduction. In this study, we discovered a functional link between AMPK and T...

journal_title：Diabetes

authors： Wang S,Kobayashi K,Kogure Y,Yamanaka H,Yamamoto S,Yagi H,Noguchi K,Dai Y

更新日期：2018-01-01 00:00:00

abstract：:Low plasma sex hormone-binding globulin (SHBG) levels are associated with obesity and predict the development of type 2 diabetes. The reason why obese individuals have low circulating SHBG has been attributed to hyperinsulinemia, but no mechanistic evidence has been described. The aim of the current study is to explor...

journal_title：Diabetes

authors： Simó R,Barbosa-Desongles A,Lecube A,Hernandez C,Selva DM

更新日期：2012-02-01 00:00:00

abstract：:Glucagon-like peptide 1 (GLP-1) is a potent glucose-lowering agent of potential interest for the treatment of type 2 diabetes. To evaluate actions of NN2211, a long-acting GLP-1 derivative, we examined 11 patients with type 2 diabetes, age 59 +/- 7 years (mean +/- SD), BMI 28.9 +/- 3.0 kg/m(2), HbA(1c) 6.5 +/- 0.6%, i...

journal_title：Diabetes

authors： Juhl CB,Hollingdal M,Sturis J,Jakobsen G,Agersø H,Veldhuis J,Pørksen N,Schmitz O

更新日期：2002-02-01 00:00:00

abstract：:In adipose tissue from both obese mice and humans, plasminogen activator inhibitor 1 (PAI-1) expression has been reported to be upregulated to levels of increased plasma PAI-1. This elevated expression has been shown to be partly controlled by tumor necrosis factor (TNF)-alpha in mice. In humans, increased PAI-1 expre...

journal_title：Diabetes

authors： Alessi MC,Bastelica D,Morange P,Berthet B,Leduc I,Verdier M,Geel O,Juhan-Vague I

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVE:Insulin resistance and other features of the metabolic syndrome have been causally linked to adipose tissue macrophages (ATMs) in mice with diet-induced obesity. We aimed to characterize macrophage phenotype and function in human subcutaneous and omental adipose tissue in relation to insulin resistance in obe...

journal_title：Diabetes

authors： Wentworth JM,Naselli G,Brown WA,Doyle L,Phipson B,Smyth GK,Wabitsch M,O'Brien PE,Harrison LC

更新日期：2010-07-01 00:00:00

abstract：:In type 1 diabetes, a lifelong autoimmune disease, T cells infiltrate the islets and the exocrine pancreas in high numbers. CD8+ T cells are the main cell type found in the insulitic lesion, and CD8+ T cells reactive against beta cell antigens have been detected in the periphery and in the pancreas of subjects with sh...

journal_title：Diabetes

authors： Rodriguez-Calvo T,Krogvold L,Amirian N,Dahl-Jørgensen K,von Herrath M

更新日期：2021-01-07 00:00:00

abstract：:To determine the role of prolactin in increasing junctional communication among islet beta-cells, we studied dye coupling in pancreatic islets exposed to elevated levels of prolactin in vivo and in vitro. Islets were isolated from rats immediately after lactation or from rats bearing mammosomatotropic tumors (MtTW15),...

journal_title：Diabetes

authors： Michaels RL,Sorenson RL,Parsons JA,Sheridan JD

更新日期：1987-10-01 00:00:00

abstract：:We studied the cross-sectional relationship between HbA1c and cardiovascular disease (CVD) in the survivors of the original cohort of the Framingham Heart Study (n = 1045). HbA1c was significantly related to prevalent CVD among women but not men. HbA1c was also related to hypertension and to the ratio of total to high...

journal_title：Diabetes

authors： Singer DE,Nathan DM,Anderson KM,Wilson PW,Evans JC

更新日期：1992-02-01 00:00:00

abstract：:Changes in intracellular Ca(2+) concentration play a key role in the regulation of insulin secretion by glucose and other secretagogues. Here, we explore the importance of the secretory pathway Ca(2+)-ATPase, plasma membrane-related Ca(2+)-ATPase-1 (PMR1; human orthologue ATP2C1) in intracellular Ca(2+) homeostasis in...

journal_title：Diabetes

authors： Mitchell KJ,Tsuboi T,Rutter GA

更新日期：2004-02-01 00:00:00

abstract：:In view of reports that accessory pathways of glucose oxidation are enhanced in the diabetic state, we have determined the levels of key enzymes of the glucuronate-xylulose cycle in the livers of diabetic mice and rats. Genetically diabetic mice (db/db) were found to have increased levels of two NADP-linked enzymes of...

journal_title：Diabetes

authors： Tulsiani DR,Touster O

更新日期：1979-09-01 00:00:00

abstract：:Insulin receptor substrate (IRS)-1 protein expression is markedly reduced in many insulin-resistant states, although the mechanism for this downregulation is unclear. In this study, we have investigated the early events in the insulin pathway that trigger the degradation of IRS-1. Incubation of the adipocytes with ins...

journal_title：Diabetes

authors： Pederson TM,Kramer DL,Rondinone CM

更新日期：2001-01-01 00:00:00

abstract：:Islet antigens associated with type 1 diabetes include a recently identified protein tyrosine phosphatase-like molecule IA-2, which contains the intracellular fragment IA-2ic. To determine whether combinations of antibodies including those to IA-2 characterize and predict type 1 diabetes, we studied antibodies to IA-2...

journal_title：Diabetes

authors： Hawa M,Rowe R,Lan MS,Notkins AL,Pozzilli P,Christie MR,Leslie RD

更新日期：1997-08-01 00:00:00

abstract：:Cultured bovine retinal capillary pericytes (BRP) were used to investigate the effect of an aldose reductase inhibitor, tolrestat, and an inhibitor of advanced glycation end products (AGE) formation, aminoguanidine, on glucose toxicity. Glucose at high concentration reduced the replicative activity of pericytes in a d...

journal_title：Diabetes

authors： Chibber R,Molinatti PA,Wong JS,Mirlees D,Kohner EM

更新日期：1994-06-01 00:00:00

abstract：:Type 1 diabetes is believed to be a Th1 lymphocyte-mediated disease, and both environmental and genetic factors play a role in its pathogenesis. It was recently found that interleukin (IL)-18 acts as a proinflammatory cytokine and, in synergy with IL-12, promotes development of Th1 lymphocyte response by induction of ...

journal_title：Diabetes

authors： Kretowski A,Mironczuk K,Karpinska A,Bojaryn U,Kinalski M,Puchalski Z,Kinalska I

更新日期：2002-11-01 00:00:00

abstract：:Pioglitazone is widely used for the treatment of diabetic patients with insulin resistance. The mechanism of pioglitazone to improve insulin sensitivity is not fully understood. Recent studies have shown that the induction of suppressor of cytokine signaling 3 (SOCS3) is related to the development of insulin resistanc...

journal_title：Diabetes

authors： Kanatani Y,Usui I,Ishizuka K,Bukhari A,Fujisaka S,Urakaze M,Haruta T,Kishimoto T,Naka T,Kobayashi M

更新日期：2007-03-01 00:00:00

abstract：:It is well established that patients with non-insulin-dependent diabetes mellitus (NIDDM) are resistant to insulin. However, the contribution of hepatic and extrahepatic tissues to insulin resistance remains controversial. The uncertainty may be at least in part due to errors introduced by the unknowing use in previou...

journal_title：Diabetes

authors： Butler PC,Kryshak EJ,Schwenk WF,Haymond MW,Rizza RA

更新日期：1990-02-01 00:00:00

abstract：:Diabetic hypoglycemia produces cognitive-motor slowing, which is assumed to increase risk of automobile crashes. This study investigated driving decrements during and after hypoglycemia, and the patients' awareness of driving decrements. We used a randomized, single-blind, crossover design and conducted the study at t...

journal_title：Diabetes

authors： Cox DJ,Gonder-Frederick L,Clarke W

更新日期：1993-02-01 00:00:00

abstract：:Altered muscle fatty acid (FA) metabolism may contribute to the presence of muscle insulin resistance in the genetically obese Zucker rat. To determine whether FA uptake and disposal are altered in insulin-resistant muscle, we measured palmitate uptake, oxidation, and incorporation into di- and triglycerides in isolat...

journal_title：Diabetes

authors： Turcotte LP,Swenberger JR,Zavitz Tucker M,Yee AJ

更新日期：2001-06-01 00:00:00