Abstract:
:We tested 32 routine clinical parameters for their ability to discriminate between a high risk and a low risk of non-insulin-dependent diabetes mellitus (NIDDM) within 5-7 years after pregnancies complicated by gestational diabetes mellitus (GDM). Latino women (n = 671) with GDM who did not have diabetes 4-16 weeks after delivery returned for at least one 75-g oral glucose tolerance test (OGTT) within 7.5 years. Multivariate analysis was used to identify parameters ascertained during or immediately after the index pregnancy that were independently associated with the development of diabetes during follow-up. Life table analysis revealed a 47% cumulative incidence rate of NIDDM 5 years after delivery for this cohort of patients who did not have diabetes at the initial postpartum examination. Four variables were identified as independent predictors of NIDDM: the area under the OGTT glucose curve at 4-16 weeks postpartum, the gestational age at the time of diagnosis of GDM, the area under the OGTT glucose curve during pregnancy, and the highest fasting serum glucose concentration during pregnancy. Examination of relative risks (RRs) of NIDDM between the highest and lowest quartiles of the cohort for each variable, adjusted for the other three variables, revealed that the postpartum OGTT provided the best discrimination between high-risk and low-risk individuals (adjusted RR = 11.5 [95% confidence interval 4.5-29.1] compared with adjusted RRs of only 0.5-2.5 for the other three variables).(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Diabetesjournal_title
Diabetesauthors
Kjos SL,Peters RK,Xiang A,Henry OA,Montoro M,Buchanan TAdoi
10.2337/diab.44.5.586subject
Has Abstractpub_date
1995-05-01 00:00:00pages
586-91issue
5eissn
0012-1797issn
1939-327Xjournal_volume
44pub_type
临床试验,杂志文章相关文献
DIABETES文献大全abstract::Sodium-glucose cotransporter 2 (SGLT2) inhibitors are the most recently approved class of diabetes drugs. Unlike other agents, SGLT2 inhibitors act on the kidney to promote urinary glucose excretion. SGLT2 inhibitors provide multiple benefits, including decreased HbA1c, body weight, and blood pressure. These drugs hav...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/dbi18-0006
更新日期:2019-06-01 00:00:00
abstract::Development of beta-cell lines for cell therapy of diabetes is hindered by functional deviations of the replicating cells from the normal beta-cell phenotype. In a recently developed cell line, denoted betaTC-tet, derived from transgenic mice expressing the SV40 T antigen (Tag) under control of the tetracycline (Tc) g...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.47.9.1419
更新日期:1998-09-01 00:00:00
abstract::A key pathophysiologic role for activated T-cells in mediating adipose inflammation and insulin resistance (IR) has been recently postulated. However, mechanisms underlying their activation are poorly understood. In this study, we demonstrated a previously unrecognized homeostatic role for the costimulatory B7 molecul...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db13-1094
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:Glucagon responses to hypoglycemia from islets transplanted in the liver are defective. To determine whether this defect is related to intrahepatic glycogen, islets from inbred Lewis rats were transplanted into the hepatic sinus (H group), peritoneal cavity (P group), omentum (O group), and kidney capsule (K ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db08-0137
更新日期:2008-06-01 00:00:00
abstract::Low birth weight is a well-established risk factor for type 2 diabetes, but the risk at high birth weight levels remains uncertain. Potential sex differences in the associations are unexplored. We investigated whether sex influences the association of birth weight and adult type 2 diabetes, using a cohort of 113,801 m...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db15-0494
更新日期:2015-12-01 00:00:00
abstract::Abdominal visceral fat (AVF), abdominal subcutaneous fat (ASF), and abdominal total fat (ATF) were measured using a computed tomography scan, both before (baseline) and after (post) a 20-week endurance exercise training protocol in the HERITAGE Family Study. Each of the baseline and response (post minus baseline) meas...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.51.3.848
更新日期:2002-03-01 00:00:00
abstract::The phenomenon of a discrepancy between glycated hemoglobin levels and other indicators of average glycemia may be due to many factors but can be measured as the glycation gap (GGap). This GGap is associated with differences in complications in patients with diabetes and may possibly be explained by dissimilarities in...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db17-0441
更新日期:2018-01-01 00:00:00
abstract::Hypoadiponectinemia has been widely observed in patients with gestational diabetes mellitus (GDM). To investigate the causal role of hypoadiponectinemia in GDM, adiponectin gene knockout (Adipoq-/- ) and wild-type (WT) mice were crossed to produce pregnant mouse models with or without adiponectin deficiency. Adenovira...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db16-1096
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVE:A major feature of type 1 diabetes is the appearance of islet autoantibodies before diagnosis. However, although the genetics of type 1 diabetes is advanced, the genetics of islet autoantibodies needs further investigation. The primary susceptibility loci in type 1 diabetes, the HLA class I and II genes, are ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db11-0131
更新日期:2011-10-01 00:00:00
abstract::Pancreatic beta-cell survival is critical in the setting of diabetes as well as in islet transplantation. Transgenic mice overexpressing parathyroid hormone-related protein (PTHrP) targeted to beta-cells using the rat insulin II promoter (RIP) display hyperinsulinemia, hypoglycemia, and islet hyperplasia, without a co...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.51.10.3003
更新日期:2002-10-01 00:00:00
abstract::The severe diabetic nephropathy that develops in the hypertensive transgenic (mRen-2)27 rat with streptozotocin (STZ) diabetes has previously been considered angiotensin II-dependent. Because metabolic pathways are also activated in the diabetic kidney, the present study aimed to determine whether renoprotection could...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.51.11.3283
更新日期:2002-11-01 00:00:00
abstract::The present study was performed to assess the potential relationship between the low T3 syndrome and hypothyroidism. Comparative studies were performed on the relative effects of diabetes and insulin on heparin-releasable adipose lipoprotein lipase (LPL) in the intact and hypothyroid rat. Hypothyroidism for 10 days (T...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.34.12.1266
更新日期:1985-12-01 00:00:00
abstract::The effect of muscular exertion of moderate intensity on blood sugar (BS), plasma levels of growth hormone (GH), glucagon, and cortisol (F) has been studied in endocrinologically normal children with short stature and compared with children with clinical diabetes mellitus and obese children with normal and diminished ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.24.8.758
更新日期:1975-08-01 00:00:00
abstract::Two sisters presented with severe insulin resistance and markedly decreased insulin binding to erythrocytes, cultured fibroblasts, and transformed lymphocytes. The dose-response curve of insulin-stimulated amino acid uptake in the fibroblasts was shifted to the right. The molecular weight of the insulin receptor on th...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.37.5.653
更新日期:1988-05-01 00:00:00
abstract::This study examined the role of p38 mitogen-activated protein (MAP) kinase in transducing high glucose into deficits in nerve conduction velocity (NCV) that are characteristic of diabetic neuropathy. p38 activation and NCV were measured in streptozocin-induced diabetic rats treated with a p38 inhibitor, an aldose redu...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.53.7.1851
更新日期:2004-07-01 00:00:00
abstract::We used hepatic balance and tracer ([3H]glucose) techniques to examine the impact of "breakfast" on hepatic glucose metabolism later in the same day. From 0-240 min, 2 groups of conscious dogs (n = 9 dogs/group) received a duodenal infusion of glucose (GLC) or saline (SAL), then were fasted from 240-360 min. Three dog...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db16-1308
更新日期:2017-05-01 00:00:00
abstract::The effects on N-acetylheparosan deacetylase (N-deacetylase) activity exerted by poorly and well-regulated diabetes and variation of genetic background were investigated in insulin-treated streptozocin-induced diabetic rats of two different strains (H and U). N-deacetylase plays a key role in heparan sulfate biosynthe...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.40.11.1449
更新日期:1991-11-01 00:00:00
abstract::The Diabetes Control and Complications Trial (DCCT) is a multicenter randomized clinical trial studying the effect of intensive insulin therapy on the early vascular and neurological complications of insulin-dependent diabetes mellitus (IDDM). During the feasibility phase of the DCCT, baseline neurological histories, ...
journal_title:Diabetes
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1988-04-01 00:00:00
abstract::In an ongoing investigation of the effects of age on G protein-coupled receptor signaling in human atrial tissue, we have found that the density of atrial muscarinic acetylcholine receptor (mAChR) increases with age but reaches statistical significance only in patients with diabetes. Moreover, we find that in elderly ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.53.9.2392
更新日期:2004-09-01 00:00:00
abstract::On its own, glucose is a major factor for proliferation of pancreatic beta-cells and is also an essential prerequisite for IGF-I and growth hormone-induced growth of these cells. p8 was originally identified as an emergency gene product upregulated in pancreatic acinar cells in response to acute pancreatitis. p8 was f...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.53.2007.s82
更新日期:2004-02-01 00:00:00
abstract::Diabetes is a common age-dependent complication of cystic fibrosis (CF) that is strongly influenced by modifier genes. We conducted a genome-wide association study in 3,059 individuals with CF (644 with CF-related diabetes [CFRD]) and identified single nucleotide polymorphisms (SNPs) within and 5' to the SLC26A9 gene ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db13-0510
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:In humans, it is unclear if insulin resistance at the monocyte level is associated with atherosclerosis in vivo. Here we have studied first-degree relatives of patients with type 2 diabetes to investigate whether a reduction in components of the insulin signal transduction pathways, such as the insulin recept...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db11-0162
更新日期:2011-12-01 00:00:00
abstract::Analysis of conventional germ-line or tissue-specific gene manipulation in vivo is potentially confounded by developmental adaptation of animal physiology. We aimed to adapt the technique of in vivo electrotransfer (IVE) to alter local gene expression in skeletal muscle of rodents as a means of investigating the role ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.54.9.2702
更新日期:2005-09-01 00:00:00
abstract::The effects of variations of glycemia from 1.7 to 35 mM on the activity of glycogen synthase and phosphorylase, on glycogen content, and on U-14C-glucose incorporation into glycogen in the liver of the near-term rat fetus were investigated. Hypoglycemia did not affect the activities of phosphorylase and synthase; tota...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.29.4.266
更新日期:1980-04-01 00:00:00
abstract::The time course of islet cell antibodies (ICA) and serum C-peptides responses (CPRs) to oral glucose tolerance tests (OGTTs) were studied prospectively up to 60 (mean 35) mo in 32 ICA-positive subjects [28 with non-insulin-dependent diabetes (NIDDM) and 4 subjects with impaired glucose tolerance (IGT); mean age 45 yr]...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.36.4.510
更新日期:1987-04-01 00:00:00
abstract::Peripheral somatic and autonomic nerve function have been studied in 79 teenage (16-19 yr) diabetics and 20 age- and sex-matched normal controls. Almost three-quarters of the diabetics (72%) had abnormal peripheral somatic nerve function tests, and one-third (31%) had abnormal cardiac parasympathetic tests. Both motor...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.32.2.142
更新日期:1983-02-01 00:00:00
abstract::Type 1 diabetes (T1D) results from a T cell-mediated destruction of pancreatic β-cells following the infiltration of leukocytes (including CD8(+), CD4(+), and CD20(+) cells) into and around pancreatic islets (insulitis). Recently, we reported that two distinct patterns of insulitis occur in patients with recent-onset ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db15-1615
更新日期:2016-05-01 00:00:00
abstract::Cultured skin fibroblasts from clinically normal offspring of two parents with non-insulin-dependent diabetes have demonstrated premature senescence as a decreased ability of cells to establish colonies when inoculated at low density (plating efficiency). The present study tested the hypothesis that there is an inhere...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.27.3.338
更新日期:1978-03-01 00:00:00
abstract::Long-term insulin secretion was investigated in seven biohybrid capillary devices seeded with canine islets. Approximately 50,000 islets could be isolated from a single canine pancreas using collagenase digestion in conjunction with the recently described Velcro technique. Devices were perfused with tissue culture med...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.34.9.850
更新日期:1985-09-01 00:00:00
abstract::The metabolic syndrome is a cluster of metabolic and inflammatory abnormalities including obesity, insulin resistance, type 2 diabetes, hypertension, dyslipidemia, and atherosclerosis. The fatty acid binding proteins aP2 (fatty acid binding protein [FABP]-4) and mal1 (FABP5) are closely related and both are expressed ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.52.2.300
更新日期:2003-02-01 00:00:00