Functional analysis of a conditionally transformed pancreatic beta-cell line.

abstract：:To examine the mechanism of the arginine-induced rise in blood glucose concentration, splanchnic glucose output (SGO) and precursor uptake were studied during i.v. infusion of arginine (30 g/30 min) with and without somatostatin infusion (500 microgram/h, 90 min) in postabsorptive and in 60-h fasted healthy subjects. ...

journal_title：Diabetes

authors： Bratusch-Marrain P,Björkman O,Hagenfeldt L,Waldhäusl W,Wahren J

更新日期：1979-02-01 00:00:00

abstract：:Hyperglycemia alters cardiac function and often leads to diabetic cardiomyopathy as cardiomyocyte apoptosis causes a hypertrophied heart to deteriorate to dilation and failure. Paradoxically, many short-term animal models of hyperglycemia protect against ischemia-induced damage, including apoptosis, by limiting Ca(2+)...

journal_title：Diabetes

authors： Pang Y,Hunton DL,Bounelis P,Marchase RB

更新日期：2002-12-01 00:00:00

abstract：:The association between clinical autonomic dysfunction and myocardial MIBG accumulation was investigated. The study groups comprised 6 male diabetic patients with autonomic neuropathy (ANP+ group), 6 male diabetic patients without autonomic neuropathy (ANP-group), and 6 male nondiabetic control subjects. The mean age ...

journal_title：Diabetes

authors： Mäntysaari M,Kuikka J,Mustonen J,Tahvanainen K,Vanninen E,Länsimies E,Uusitupa M

更新日期：1992-09-01 00:00:00

abstract：OBJECTIVE:Insulin resistance and other features of the metabolic syndrome have been causally linked to adipose tissue macrophages (ATMs) in mice with diet-induced obesity. We aimed to characterize macrophage phenotype and function in human subcutaneous and omental adipose tissue in relation to insulin resistance in obe...

journal_title：Diabetes

authors： Wentworth JM,Naselli G,Brown WA,Doyle L,Phipson B,Smyth GK,Wabitsch M,O'Brien PE,Harrison LC

更新日期：2010-07-01 00:00:00

abstract：:The relationship of plasma glucose levels to risk of death over a five-year follow-up period was studied in 2,770 male survivors of myocardial infarction in the placebo group of the Coronary Drug Project (CDP). In univariate analyses, a positive association was observed between mortality rates and both fasting and one...

journal_title：Diabetes

authors：

更新日期：1977-05-01 00:00:00

abstract：:The use of HIV protease inhibitors (PIs) has been associated with several metabolic changes, including lipodystrophy, hyperlipidemia, and insulin resistance. The etiology of these adverse effects remains unknown. PIs have recently been found to cause acute and reversible inhibition of GLUT4 activity in vitro. To deter...

journal_title：Diabetes

authors： Hruz PW,Murata H,Qiu H,Mueckler M

更新日期：2002-04-01 00:00:00

abstract：:Halofenate has been shown previously to lower triglycerides in dyslipidemic subjects. In addition, significant decreases in fasting plasma glucose were observed but only in type 2 diabetic patients. We hypothesized that halofenate might be an insulin sensitizer, and we present data to suggest that halofenate is a sele...

journal_title：Diabetes

authors： Allen T,Zhang F,Moodie SA,Clemens LE,Smith A,Gregoire F,Bell A,Muscat GE,Gustafson TA

更新日期：2006-09-01 00:00:00

abstract：:Diurnal variation in insulin sensitivity in patients with NIDDM has long been suspected but has been difficult to document mainly because of the interdependence of changes in glucose and insulin. Stable serum insulin levels during hyperglycemic clamping in patients with NIDDM in the present study provided the opportun...

journal_title：Diabetes

authors： Boden G,Chen X,Urbain JL

更新日期：1996-08-01 00:00:00

abstract：:The T-type Ca2+ channel is an important determinant of electrical activity and of Ca2+ influx in rat and human pancreatic beta-cells. We have identified and sequenced a cDNA encoding a T-type Ca2+ channel alpha1-subunit derived from INS-1, the rat insulin-secreting cell line. The sequence of the cDNA indicates a prote...

journal_title：Diabetes

authors： Zhuang H,Bhattacharjee A,Hu F,Zhang M,Goswami T,Wang L,Wu S,Berggren PO,Li M

更新日期：2000-01-01 00:00:00

abstract：:We performed a variance components linkage analysis of renal function, measured as glomerular filtration rate (GFR), in 63 extended families with multiple members with type 2 diabetes. GFR was estimated from serum concentrations of cystatin C and creatinine in 406 diabetic and 428 nondiabetic relatives. Results for cy...

journal_title：Diabetes

authors： Placha G,Poznik GD,Dunn J,Smiles A,Krolewski B,Glew T,Puppala S,Schneider J,Rogus JJ,Rich SS,Duggirala R,Warram JH,Krolewski AS

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVE:Elevated fasting glucose level is associated with increased carotid intima-media thickness (IMT), a measure of subclinical atherosclerosis. It is unclear if this association is causal. Using the principle of Mendelian randomization, we sought to explore the causal association between circulating glucose and I...

journal_title：Diabetes

authors： Rasmussen-Torvik LJ,Li M,Kao WH,Couper D,Boerwinkle E,Bielinski SJ,Folsom AR,Pankow JS

更新日期：2011-01-01 00:00:00

abstract：:AMPK is a widely expressed intracellular energy sensor that monitors and modulates energy expenditure. Transient receptor potential ankyrin 1 (TRPA1) channel is a widely recognized chemical and thermal sensor that plays vital roles in pain transduction. In this study, we discovered a functional link between AMPK and T...

journal_title：Diabetes

authors： Wang S,Kobayashi K,Kogure Y,Yamanaka H,Yamamoto S,Yagi H,Noguchi K,Dai Y

更新日期：2018-01-01 00:00:00

abstract：:Thiazolidinediones (TZDs) are peroxisome proliferator-activated receptor-gamma (PPARG) agonists used to treat type 2 diabetes. TZDs can also be used to reduce rates of type 2 diabetes in at-risk individuals. However, a large fraction of TZD-treated patients (30-40%) do not respond to TZD treatment with an improvement ...

journal_title：Diabetes

authors： Wolford JK,Yeatts KA,Dhanjal SK,Black MH,Xiang AH,Buchanan TA,Watanabe RM

更新日期：2005-11-01 00:00:00

abstract：OBJECTIVE:Obesity-associated insulin resistance is characterized by a state of chronic, low-grade inflammation that is associated with the accumulation of M1 proinflammatory macrophages in adipose tissue. Although different evidence explains the mechanisms linking the expansion of adipose tissue and adipose tissue macr...

journal_title：Diabetes

authors： Prieur X,Mok CY,Velagapudi VR,Núñez V,Fuentes L,Montaner D,Ishikawa K,Camacho A,Barbarroja N,O'Rahilly S,Sethi JK,Dopazo J,Orešič M,Ricote M,Vidal-Puig A

更新日期：2011-03-01 00:00:00

abstract：:Leptin resistance has recently been confirmed not only in animal obese models but in human obesity. Evidence is rapidly emerging that suggests that activation of histamine signaling in the hypothalamus may have substantial anti-obesity and antidiabetic actions, particularly in leptin-resistant states. To address this ...

journal_title：Diabetes

authors： Masaki T,Yoshimatsu H,Chiba S,Watanabe T,Sakata T

更新日期：2001-02-01 00:00:00

abstract：:Studies in 10 nonketotic diabetic subjects (five juvenile- and five adult-onset) before and after control of carbohydrate metabolism showed a high degree of correlation between hemoglobin AIc (HbAIc) concentrations and serum triglyceride levels. Serum triglyceride levels were found to correlate more closely with Hb AI...

journal_title：Diabetes

authors： Peterson CM,Koenig RJ,Jones RL,Saudek CD,Cerami A

更新日期：1977-05-01 00:00:00

abstract：OBJECTIVE:Atherosclerotic cardiovascular disease is the leading cause of death among people with diabetes. Generation of oxidized LDLs and reduced nitric oxide (NO) availability because of endothelial NO synthase (eNOS) dysfunction are critical events in atherosclerotic plaque formation. Biochemical mechanism leading f...

journal_title：Diabetes

authors： Tanaka J,Qiang L,Banks AS,Welch CL,Matsumoto M,Kitamura T,Ido-Kitamura Y,DePinho RA,Accili D

更新日期：2009-10-01 00:00:00

abstract：:The exposure of primary cultures of hepatocytes to insulin. 10(-8) M, for 16 h results in a decrease in high affinity insulin binding with no alterations in lower affinity binding. This is reflected in a decrease in the sensitivity, but normal responsiveness, of cultured hepatocytes to the acute effect of insulin on t...

journal_title：Diabetes

authors： Amatruda JM,Newmeyer HW,Chang CL

更新日期：1982-02-01 00:00:00

abstract：:We report on a 26-yr-old patient with an 11-yr history of insulin-dependent diabetes mellitus who exhibited insulin resistance with a requirement of up to 15,000 U of intravenous (i.v.) insulin/day. Attempts to diminish her insulin requirement by administration of sulfated insulin or Trasylol were unsuccessful, with t...

journal_title：Diabetes

authors： Blazar BR,Whitley CB,Kitabchi AE,Tsai MY,Santiago J,White N,Stentz FB,Brown DM

更新日期：1984-12-01 00:00:00

abstract：:A patient with functioning islet cell carcinoma is described who had amelioration of her hypoglycemia during the development of ectopic ACTH syndrome. Moon facies and hyperkalemic metabolic acidosis were also present in this patient, features uncommonly seen in the actopic ACTH syndrome. At autopsy, she was found to h...

journal_title：Diabetes

authors： Sadoff L,Gordon J,Goldman S

更新日期：1975-06-01 00:00:00

abstract：:The causes of the increased risk of severe COVID-19 in persons with diabetes are unclear. It has been speculated that renin angiotensin system (RAS) blockers may promote COVID-19 by increasing ACE2, which SARS-CoV-2 uses to enter host cells, along with the host protease TMPRSS2. Taking a reverse translational approach...

journal_title：Diabetes

authors： Batchu SN,Kaur H,Yerra VG,Advani SL,Kabir MG,Liu Y,Klein T,Advani A

更新日期：2020-12-11 00:00:00

abstract：:Site differences in adipose tissue function may have implications for insulin-resistant conditions. In mature adipose tissue, subcutaneous adipocytes have higher leptin secretion, similar tumor necrosis factor (TNF)-alpha secretion, and lower catecholamine-stimulated lipolysis as compared with omental adipocytes. In t...

journal_title：Diabetes

authors： van Harmelen V,Dicker A,Rydén M,Hauner H,Lönnqvist F,Näslund E,Arner P

更新日期：2002-07-01 00:00:00

abstract：:Type 1 diabetes (T1D) results from T cell-mediated destruction of insulin-producing β-cells. Insulin represents a key self-antigen in disease pathogenesis, as recent studies identified proinsulin-responding T cells from inflamed pancreatic islets of organ donors with recent-onset T1D. These cells respond to an insulin...

journal_title：Diabetes

authors： Spanier JA,Sahli NL,Wilson JC,Martinov T,Dileepan T,Burrack AL,Finger EB,Blazar BR,Michels AW,Moran A,Jenkins MK,Fife BT

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:Epidemiological and family studies have demonstrated that susceptibility genes play an important role in the etiology of diabetic nephropathy, defined as persistent proteinuria or end-stage renal disease (ESRD) in type 1 diabetes. RESEARCH DESIGN AND METHODS:To efficiently search for genomic regions harborin...

journal_title：Diabetes

authors： Rogus JJ,Poznik GD,Pezzolesi MG,Smiles AM,Dunn J,Walker W,Wanic K,Moczulski D,Canani L,Araki S,Makita Y,Warram JH,Krolewski AS

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:We have previously reported a highly diabetogenic CD8 T-cell clone, G9C8, in the nonobese diabetic (NOD) mouse, specific to low-avidity insulin peptide B15-23, and cells responsive to this antigen are among the earliest islet infiltrates. We aimed to study the selection, activation, and development of the dia...

journal_title：Diabetes

authors： Wong FS,Siew LK,Scott G,Thomas IJ,Chapman S,Viret C,Wen L

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVE:Anti-tissue transglutaminase (TG2) antibodies are the serological marker of celiac disease. Given the close association between celiac disease and type 1 diabetes, we investigated the production and deposition of anti-TG2 antibodies in the jejunal mucosa of type 1 diabetic children. RESEARCH DESIGN AND METHO...

journal_title：Diabetes

authors： Maglio M,Florian F,Vecchiet M,Auricchio R,Paparo F,Spadaro R,Zanzi D,Rapacciuolo L,Franzese A,Sblattero D,Marzari R,Troncone R

更新日期：2009-07-01 00:00:00

abstract：:The hexokinases, by converting glucose to glucose-6-phosphate, help maintain the downhill gradient that results in movement of glucose into cells through the facilitative glucose transporters. GLUT4 and hexokinase (HK) II are the major transporter and hexokinase isoforms in skeletal muscle, heart, and adipose tissue, ...

journal_title：Diabetes

authors： Osawa H,Printz RL,Whitesell RR,Granner DK

更新日期：1995-12-01 00:00:00

abstract：:Cultured skin fibroblasts from clinically normal offspring of two parents with non-insulin-dependent diabetes have demonstrated premature senescence as a decreased ability of cells to establish colonies when inoculated at low density (plating efficiency). The present study tested the hypothesis that there is an inhere...

journal_title：Diabetes

authors： Rosenbloom AL,Rosenbloom EK

更新日期：1978-03-01 00:00:00

abstract：:Recently, peptides with opioid-like activity have been demonstrated in peptic digests of dietary protein. The present study was designed to determine the effect of digested and undigested gluten on postprandial insulin and glucagon levels in conscious dogs. The intragastric instillation of digested gluten (25 g) elici...

journal_title：Diabetes

authors： Schusdziarra V,Henrichs I,Holland A,Klier M,Pfeiffer EF

更新日期：1981-04-01 00:00:00

abstract：:Although hyperhomocysteinemia, an independent cardiovascular risk factor, is common in type 2 diabetes with nephropathy, the mechanism(s) of this alteration is not known. In healthy humans, hyperinsulinemia increases methionine transmethylation, homocysteine transsulfuration, and clearance. No such data exist in type ...

journal_title：Diabetes

authors： Tessari P,Coracina A,Kiwanuka E,Vedovato M,Vettore M,Valerio A,Zaramella M,Garibotto G

更新日期：2005-10-01 00:00:00