Insulin-induced alterations in insulin binding and insulin action in primary cultures of rat hepatocytes.

abstract：:Müller cells and macrophages/microglia are likely important for the development of diabetic retinopathy; however, the interplay between these cells in this disease is not well understood. An inflammatory process is linked to the onset of experimental diabetic retinopathy. CD40 deficiency impairs this process and preve...

journal_title：Diabetes

authors： Portillo JC,Lopez Corcino Y,Miao Y,Tang J,Sheibani N,Kern TS,Dubyak GR,Subauste CS

更新日期：2017-02-01 00:00:00

abstract：:Peripheral neuropathy and insensate limbs and digits cause significant morbidity in diabetic individuals. Previous studies showed that deletion of the receptor for advanced end-glycation products (RAGE) in mice was protective in long-term diabetic neuropathy. Here, we tested the hypothesis that RAGE suppresses effecti...

journal_title：Diabetes

authors： Juranek JK,Geddis MS,Song F,Zhang J,Garcia J,Rosario R,Yan SF,Brannagan TH,Schmidt AM

更新日期：2013-03-01 00:00:00

abstract：:Nine offspring of two diabetic parents and 18 normals were studied with two intravenous glucose loads (o.5 gm./kg. body weight), 60 minutes apart. By thus stressing the beta cell, subtle defects could be identified in the prediabetics: (1) An inverse relationship between insulin peak response and insulin concentration...

journal_title：Diabetes

authors： Koncz L,Soeldner JS,Otto H,Smith TM,Gleason RE

更新日期：1977-12-01 00:00:00

abstract：:The glycolytic enzyme glucokinase plays a primary role in the glucose-responsive secretion of insulin, and defects of this enzyme can cause NIDDM. As a step toward understanding the molecular basis of glucokinase (GK) gene regulation, we assessed the structure and regulation of the human GK gene beta-cell-type promote...

journal_title：Diabetes

authors： Watada H,Kajimoto Y,Umayahara Y,Matsuoka T,Kaneto H,Fujitani Y,Kamada T,Kawamori R,Yamasaki Y

更新日期：1996-11-01 00:00:00

abstract：:Recent preclinical studies showed the potential of nicotinamide adenine dinucleotide (NAD(+)) precursors to increase oxidative phosphorylation and improve metabolic health, but human data are lacking. We hypothesize that the nicotinic acid derivative acipimox, an NAD(+) precursor, would directly affect mitochondrial f...

journal_title：Diabetes

authors： van de Weijer T,Phielix E,Bilet L,Williams EG,Ropelle ER,Bierwagen A,Livingstone R,Nowotny P,Sparks LM,Paglialunga S,Szendroedi J,Havekes B,Moullan N,Pirinen E,Hwang JH,Schrauwen-Hinderling VB,Hesselink MK,Auwerx J,Ro

更新日期：2015-04-01 00:00:00

abstract：:Impaired wound healing is one of the main causes of diabetic foot ulcerations. However, the exact mechanism of delayed wound healing in diabetes is not fully understood. Long noncoding RNAs (lncRNAs) are widely involved in a variety of biological processes and diseases, including diabetes and its associated complicati...

journal_title：Diabetes

authors： Hu M,Wu Y,Yang C,Wang X,Wang W,Zhou L,Zeng T,Zhou J,Wang C,Lao G,Yan L,Ren M

更新日期：2020-10-01 00:00:00

abstract：:Retinal neovascularization is observed in progression of diabetic retinopathy. New vessels grow into the vitreous cavity in proliferative diabetic retinopathy, resulting in traction retinal detachment and vitreous hemorrhage. To overcome the catastrophic visual loss due to these complications, efforts have been focuse...

journal_title：Diabetes

authors： Lim Y,Jo DH,Kim JH,Ahn JH,Hwang YK,Kang DK,Chang SI,Yu YS,Yoon Y,Kim JH

更新日期：2012-06-01 00:00:00

abstract：:Somatostatin-like immunoreactivity (SLI) concentrations were determined in human peripheral plasma using affinity chromatography followed by radioimmunoassay. In normal subjects, fasting SLI ranged from 2.9 to 22.0 pg/ml with a mean +/- SE value of 10.2 +/- 2.1 pg/ml. In totally pancreatectomized or gastrectomized pat...

journal_title：Diabetes

authors： Tsuda K,Sakurai H,Seino Y,Seino S,Tanigawa K,Kuzuya H,Imura H

更新日期：1981-06-01 00:00:00

abstract：:It is well known that peripherally administered growth hormone (GH) results in decreased body fat mass. However, GH-deficient patients increase their food intake when substituted with GH, suggesting that GH also has an appetite stimulating effect. Transgenic mice with an overexpression of bovine GH in the central nerv...

journal_title：Diabetes

authors： Bohlooly-Y M,Olsson B,Bruder CE,Lindén D,Sjögren K,Bjursell M,Egecioglu E,Svensson L,Brodin P,Waterton JC,Isaksson OG,Sundler F,Ahrén B,Ohlsson C,Oscarsson J,Törnell J

更新日期：2005-01-01 00:00:00

abstract：:The secretory, metabolic, and signaling aspects of glucose/palmitate interaction on beta-cell function have been studied on rat islets. Palmitate potentiated the glucose-induced insulin response of perifused islets at suprathreshold (>3 mmol/l) sugar concentrations. This potentiating effect could be suppressed by 8-br...

journal_title：Diabetes

authors： Alcázar O,Qiu-yue Z,Giné E,Tamarit-Rodriguez J

更新日期：1997-07-01 00:00:00

abstract：OBJECTIVE:Offspring of mothers with type 1 diabetes (OT1DM) demonstrate increased fat deposition, hyperinsulinemia, and hyperleptinemia in utero. We examined the influence of maternal diabetes on cord lipids at birth and relationship to body composition, cord insulin, leptin, and other hormonal measures. RESEARCH DESI...

journal_title：Diabetes

authors： Nelson SM,Freeman DJ,Sattar N,Johnstone FD,Lindsay RS

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:This study aimed to estimate the current cumulative risk of end-stage renal disease (ESRD) due to diabetic nephropathy in a large, nationwide, population-based prospective type 1 diabetes cohort and specifically study the effects of sex and age at onset. RESEARCH DESIGN AND METHODS:In Sweden, all incident ca...

journal_title：Diabetes

authors： Möllsten A,Svensson M,Waernbaum I,Berhan Y,Schön S,Nyström L,Arnqvist HJ,Dahlquist G,Swedish Childhood Diabetes Study Group.,Diabetes Incidence Study in Sweden.,Swedish Renal Registry.

更新日期：2010-07-01 00:00:00

abstract：:Diabetic retinopathy is a potentially blinding eye disease that threatens the vision of one-ninth of patients with diabetes. Progression of the disease has long been attributed to an initial dropout of pericytes that enwrap the retinal microvasculature. Revealed through retinal vascular digests, a subsequent increase ...

journal_title：Diabetes

authors： Corliss BA,Ray HC,Doty RW,Mathews C,Sheybani N,Fitzgerald K,Prince R,Kelly-Goss MR,Murfee WL,Chappell J,Owens GK,Yates PA,Peirce SM

更新日期：2020-07-01 00:00:00

abstract：:RIN-m cells, cultured from a rat insulinoma, not only bind and secrete but also degrade insulin (Diabetes 1982; 31:521-31). The insulin-degrading activity resides in the cytosol and is similar to the insulin-specific proteases previously described in muscle and other tissues. It has an apparent Km of 0.15 microM for p...

journal_title：Diabetes

authors： Bhathena SJ,Timmers KI,Oie HK,Voyles NR,Recant L

更新日期：1985-02-01 00:00:00

abstract：:Type 1 diabetes appears to progress not as an uncontrolled autoimmune attack on the pancreatic islet beta-cells, but rather in a highly regulated manner. Leukocytic infiltration of the pancreatic islets by autoimmune cells, or insulitis, can persist for long periods of time before the terminal destruction of beta-cell...

journal_title：Diabetes

authors： Matos M,Park R,Mathis D,Benoist C

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:To examine the prospective association between objectively measured time spent sedentary and insulin resistance and whether this association is independent of moderate- and vigorous-intensity physical activity (MVPA) and other relevant confounders. RESEARCH DESIGN AND METHODS:This was a population-based stud...

journal_title：Diabetes

authors： Helmerhorst HJ,Wijndaele K,Brage S,Wareham NJ,Ekelund U

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVE:Glucagon responses to hypoglycemia from islets transplanted in the liver are defective. To determine whether this defect is related to intrahepatic glycogen, islets from inbred Lewis rats were transplanted into the hepatic sinus (H group), peritoneal cavity (P group), omentum (O group), and kidney capsule (K ...

journal_title：Diabetes

authors： Zhou H,Zhang T,Bogdani M,Oseid E,Parazzoli S,Vantyghem MC,Harmon J,Slucca M,Robertson RP

更新日期：2008-06-01 00:00:00

abstract：:Filtered proteins including insulin are absorbed in the proximal tubule by means of pinocytosis. The first step in this process is binding of the protein to brush border membrane. As it is not known whether absorption exhibits specificity, we set out to determine whether specific binding sites for insulin are present ...

journal_title：Diabetes

authors： Rabkin R,Petersen J,Mamelok R

更新日期：1982-07-01 00:00:00

abstract：OBJECTIVE:Pregnancy induces a state of immunological tolerance that aims at suppressing immune responses against the fetus and has been linked to temporal remission of preexisting autoimmune disorders. To understand the mechanisms of this reversible immune regulation, we investigated the role of a key pregnancy hormone...

journal_title：Diabetes

authors： Ueno A,Cho S,Cheng L,Wang J,Hou S,Nakano H,Santamaria P,Yang Y

更新日期：2007-06-01 00:00:00

abstract：:To investigate the early events in insulin signal transmission in liver, isolated rat hepatocytes were labeled with 32P, and proteins phosphorylated in response to insulin were detected by immunoprecipitation with anti-phosphotyrosine and anti-receptor antibodies and analyzed by sodium dodecyl sulfate (SDS)-polyacryla...

journal_title：Diabetes

authors： Okamoto M,Karasik A,White MF,Kahn CR

更新日期：1991-01-01 00:00:00

abstract：:The autoimmune disease type 1 diabetes is characterized by effector T-cell responses to pancreatic β-cell-derived peptides presented by HLA class I and class II molecules, leading ultimately to β-cell demise and insulin insufficiency. Although a given HLA molecule presents a vast array of peptides, only those recogniz...

journal_title：Diabetes

authors： James EA,Mallone R,Kent SC,DiLorenzo TP

更新日期：2020-07-01 00:00:00

abstract：:We have produced a monoclonal antibody 3A4 to the surface of islet cells by fusing spleen lymphocytes from nonobese diabetic (NOD) mice. To identify the molecular weight of specific target antigens reacting with 3A4, 125I-surface-labeled In-111 insulinoma cells were solubilized and extracts were absorbed with 3A4, and...

journal_title：Diabetes

authors： Hari J,Yokono K,Yonezawa K,Amano K,Yaso S,Shii K,Imamura Y,Baba S

更新日期：1986-05-01 00:00:00

abstract：:The interaction between insulin and its receptor was investigated using both monoclonal and polyclonal anti-insulin antibodies. After covalent cross-linking of 125I-insulin to the insulin receptor on cultured human lymphocytes (IM-9 cells) using disuccinimidyl suberate, we inquired whether the insulin-receptor complex...

journal_title：Diabetes

authors： Taylor SI,Schroer JA,Marcus-Samuels B,McElduff A,Bender TP

更新日期：1984-08-01 00:00:00

abstract：:A double-blind crossover study of fludrocortisone, 0,1 mg. twice daily, and placebo is reported in six diabetics with troublesome symptoms of postural hypotension due to autonomic neuropathy. During treatment with the active preparation there was an increase in the lying and tilted systolic blood pressure, a decrease ...

journal_title：Diabetes

authors： Campbell IW,Ewing DJ,Clarke BF

更新日期：1975-04-01 00:00:00

abstract：:O-linked N-acetylglucosamine transferase (OGT) catalyzes the attachment ofN-acetylglucosamine (GlcNAc) monosaccharides to the hydroxyl group of serine or threonine residues of intracellular proteins and may play an important role in the hexosamine pathway. Glucose-induced insulin resistance is mediated by increased ac...

journal_title：Diabetes

authors： Akimoto Y,Kreppel LK,Hirano H,Hart GW

更新日期：1999-12-01 00:00:00

abstract：:Diabetic cardiomyopathy is characterized by reduced cardiac contractility due to direct changes in heart muscle function independent of vascular disease. An important contributor to contractile dysfunction in the diabetic state is an impaired sarcoplasmic reticulum (SR) function, leading to disturbed intracellular cal...

journal_title：Diabetes

authors： Trost SU,Belke DD,Bluhm WF,Meyer M,Swanson E,Dillmann WH

更新日期：2002-04-01 00:00:00

abstract：:Counterregulatory hormonal responses were studied in six patients after 4-18 mo treatment with a continuous subcutaneous insulin infusion pump. In response to insulin-induced hypoglycemia, significant increases in epinephrine, norepinephrine, cortisol, and growth hormone were measured in all subjects, while in five of...

journal_title：Diabetes

authors： Bergenstal RM,Polonsky KS,Pons G,Jaspan JB,Rubenstein AH

更新日期：1983-05-01 00:00:00

abstract：:Both genetic and nongenetic factors contribute to the development of type 1 diabetes. Many investigations, including prospective studies of high-risk children, have implicated virus infections as predisposing environmental agents. We previously reported that basal activity of the key antiviral enzyme 2'5'-oligoadenyla...

journal_title：Diabetes

authors： Field LL,Bonnevie-Nielsen V,Pociot F,Lu S,Nielsen TB,Beck-Nielsen H

更新日期：2005-05-01 00:00:00

abstract：:The homeodomain-containing transcription factor pancreatic duodenal homeobox 1 (PDX-1) plays a key role in pancreas development and in beta-cell function. Upstream sequences of the gene up to about -6 kb show islet-specific activity in transgenic mice. Attempts to identify functional regulatory elements involved in th...

journal_title：Diabetes

authors： Melloul D,Marshak S,Cerasi E

更新日期：2002-12-01 00:00:00

abstract：:Tissue sensitivity to insulin was studied using the euglycemic insulin clamp technique (delta plasma insulin above basal 90 microU/ml) in eight patients with type I diabetes mellitus (IDDM) before and after 4-8 mo of continuous subcutaneous insulin infusion (CSII) and in 36 age-matched control subjects. Institution of...

journal_title：Diabetes

authors： Simonson DC,Tamborlane WV,Sherwin RS,Smith JD,DeFronzo RA

更新日期：1985-08-01 00:00:00