9-Alpha-fluorohydrocortisone in the treatment of postural hypotension in diabetic autonomic neuropathy.


:A double-blind crossover study of fludrocortisone, 0,1 mg. twice daily, and placebo is reported in six diabetics with troublesome symptoms of postural hypotension due to autonomic neuropathy. During treatment with the active preparation there was an increase in the lying and tilted systolic blood pressure, a decrease in orthostatic tachycardia, and in increase in the total plasma volume and body weight, but with no change in plasma or urine osmolality; The symptoms of postural hypotension improved in four patients, while two patients with a low serum albumin developed ankle edema during treatment with fludrocortisone. It is concluded that fludrocortisone is effective in diabetics with symptomatic postural hypotesnion, but should be used with caution in patients with a low serum albumin.






Campbell IW,Ewing DJ,Clarke BF




Has Abstract


1975-04-01 00:00:00














  • Body size and shape changes and the risk of diabetes in the diabetes prevention program.

    abstract::The researchers conducted this study to test the hypothesis that risk of type 2 diabetes is less following reductions in body size and central adiposity. The Diabetes Prevention Program (DPP) recruited and randomized individuals with impaired glucose tolerance to treatment with placebo, metformin, or lifestyle modific...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Fujimoto WY,Jablonski KA,Bray GA,Kriska A,Barrett-Connor E,Haffner S,Hanson R,Hill JO,Hubbard V,Stamm E,Pi-Sunyer FX,Diabetes Prevention Program Research Group.

    更新日期:2007-06-01 00:00:00

  • Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants.

    abstract:OBJECTIVE:Zinc ions are essential for the formation of hexameric insulin and hormone crystallization. A nonsynonymous single nucleotide polymorphism rs13266634 in the SLC30A8 gene, encoding the secretory granule zinc transporter ZnT8, is associated with type 2 diabetes. We describe the effects of deleting the ZnT8 gene...


    pub_type: 杂志文章


    authors: Nicolson TJ,Bellomo EA,Wijesekara N,Loder MK,Baldwin JM,Gyulkhandanyan AV,Koshkin V,Tarasov AI,Carzaniga R,Kronenberger K,Taneja TK,da Silva Xavier G,Libert S,Froguel P,Scharfmann R,Stetsyuk V,Ravassard P,Parker H,Gri

    更新日期:2009-09-01 00:00:00

  • Altered lysosomal glycohydrolase activities in juvenile diabetes mellitus.

    abstract::Studies have been carried out on activities of lysosomal beta-N-acetylhexosaminidase (hex), beta-galactosidase (beta-gal), alpha-glucosidase (alpha-glu), and acid phosphatase (AP) in serum and urine from patients with juvenile diabetes and matched controls. There is a large increase in blood and urinary hex activity (...


    pub_type: 杂志文章


    authors: Bomback FM,Nakagawa S,Kumin S,Nitowsky HM

    更新日期:1976-05-01 00:00:00

  • Relationships between angiotensin I converting enzyme gene polymorphism, plasma levels, and diabetic retinal and renal complications.

    abstract::Insulin-dependent diabetes mellitus (IDDM), cardiovascular morbidity, and vital prognosis are linked to diabetic nephropathy, which is probably determined by renal hemodynamic abnormalities and by a genetic predisposition. Angiotensin I converting enzyme (ACE) regulates systemic and renal circulations through angioten...


    pub_type: 杂志文章


    authors: Marre M,Bernadet P,Gallois Y,Savagner F,Guyene TT,Hallab M,Cambien F,Passa P,Alhenc-Gelas F

    更新日期:1994-03-01 00:00:00

  • Inactivation of NF-κB p65 (RelA) in Liver Improves Insulin Sensitivity and Inhibits cAMP/PKA Pathway.

    abstract::The transcription factor nuclear factor-κB (NF-κB) mediates inflammation and stress signals in cells. To test NF-κB in the control of hepatic insulin sensitivity, we inactivated NF-κB in the livers of C57BL/6 mice through deletion of the p65 gene, which was achieved by crossing floxed-p65 and Alb-cre mice to generate ...


    pub_type: 杂志文章


    authors: Ke B,Zhao Z,Ye X,Gao Z,Manganiello V,Wu B,Ye J

    更新日期:2015-10-01 00:00:00

  • Impact of lisinopril and atenolol on kidney function in hypertensive NIDDM subjects with diabetic nephropathy.

    abstract::Diabetic nephropathy is characterized by hypertension and a relentless decline in kidney function. Angiotensin-converting enzyme inhibitors have been claimed to preserve kidney function better than an equal blood pressure (BP) reduction with conventional antihypertensive treatment (renoprotection). We compared the eff...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Nielsen FS,Rossing P,Gall MA,Skøtt P,Smidt UM,Parving HH

    更新日期:1994-09-01 00:00:00

  • Pioglitazone induces vascular smooth muscle cell apoptosis through a peroxisome proliferator-activated receptor-gamma, transforming growth factor-beta1, and a Smad2-dependent mechanism.

    abstract::Thiazolidinediones, such as pioglitazone, seem to exert direct antiatherosclerotic and antirestenotic effects on type 2 diabetes, in part due to an induction of vascular smooth muscle cell (VSMC) apoptosis. We aimed to study the role of transforming growth factor (TGF)-beta in rat aortic VSMC. Pioglitazone at 100 micr...


    pub_type: 杂志文章


    authors: Redondo S,Ruiz E,Santos-Gallego CG,Padilla E,Tejerina T

    更新日期:2005-03-01 00:00:00

  • Insulin secretory profiles and C-peptide clearance kinetics at 6 months and 2 years after kidney-pancreas transplantation.

    abstract::Glucose, insulin secretion, and insulin secretory pulses were measured by deconvolution of peripheral C-peptide concentrations in 10 IDDM recipients of a combined kidney-pancreas allograft 6 mo post-transplantation and were compared with 10 matched nondiabetic control subjects. Seven of the 10 recipients were restudie...


    pub_type: 杂志文章


    authors: Blackman JD,Polonsky KS,Jaspan JB,Sturis J,Van Cauter E,Thistlethwaite JR

    更新日期:1992-10-01 00:00:00

  • Cotransplantation of Mesenchymal Stem Cells With Neonatal Porcine Islets Improve Graft Function in Diabetic Mice.

    abstract::Mesenchymal stem cells (MSCs) possess immunoregulatory, anti-inflammatory, and proangiogenic properties and, therefore, have the potential to improve islet engraftment and survival. We assessed the effect human bone marrow-derived MSCs have on neonatal porcine islets (NPIs) in vitro and determined islet engraftment an...


    pub_type: 杂志文章


    authors: Hayward JA,Ellis CE,Seeberger K,Lee T,Salama B,Mulet-Sierra A,Kuppan P,Adesida A,Korbutt GS

    更新日期:2017-05-01 00:00:00

  • Interaction of cooling rate, warming rate, and extent of permeation of cryoprotectant in determining survival of isolated rat islets of Langerhans during cryopreservation.

    abstract::Cryopreservation of islets of Langerhans offers a number of important benefits for attempts to cure diabetes by transplantation. In the published literature, a variety of cooling rates, ranging from 0.25 to 75 degrees C/min, in conjunction with warming rates of 4-200 degrees C/min have been proposed to give optimal pr...


    pub_type: 杂志文章


    authors: Taylor MJ,Benton MJ

    更新日期:1987-01-01 00:00:00

  • Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects.

    abstract::Mutations in the LMNA gene (encoding lamin A/C) underlie familial partial lipodystrophy, a syndrome of monogenic insulin resistance and diabetes. LMNA maps to the well-replicated diabetes-linkage region on chromosome 1q, and there are reported associations between LMNA single nucleotide polymorphisms (SNPs) (particula...


    pub_type: 杂志文章,meta分析


    authors: Owen KR,Groves CJ,Hanson RL,Knowler WC,Shuldiner AR,Elbein SC,Mitchell BD,Froguel P,Ng MC,Chan JC,Jia W,Deloukas P,Hitman GA,Walker M,Frayling TM,Hattersley AT,Zeggini E,McCarthy MI

    更新日期:2007-03-01 00:00:00

  • Diabetes decreases Na+-K+ pump concentration in skeletal muscles, heart ventricular muscle, and peripheral nerves of rat.

    abstract::Na+-K+-ATPase or the Na+-K+ pump is essential for some specific properties of muscle and nerve tissue such as contractility and excitability. Previous studies have shown conflicting variations in Na+-K+-ATPase activity or Na+-K+ pump concentration of muscle cells in experimental diabetes. Our study demonstrates that e...


    pub_type: 杂志文章


    authors: Kjeldsen K,Braendgaard H,Sidenius P,Larsen JS,Nørgaard A

    更新日期:1987-07-01 00:00:00

  • A monitor of secretion from single pancreatic beta-cells.

    abstract::ATP is known to be coreleased with insulin from pancreatic beta-cells. To monitor insulin secretion from single beta-cells, a single beta-cell was surrounded in culture by Fura 2-loaded calf pulmonary artery endothelium (CPAE) cells, which can detect the ATP. CPAE cells did not respond with an elevation in cytoplasmic...


    pub_type: 杂志文章


    authors: Kuromi H,Mizuno N,Seino S

    更新日期:1995-10-01 00:00:00

  • Physiological increases in uncoupling protein 3 augment fatty acid oxidation and decrease reactive oxygen species production without uncoupling respiration in muscle cells.

    abstract::Decreased uncoupling protein (UCP)3 is associated with insulin resistance in muscle of pre-diabetic and diabetic individuals, but the function of UCP3 remains unclear. Our goal was to elucidate mechanisms underlying the negative correlation between UCP3 and insulin resistance in muscle. We determined effects of physio...


    pub_type: 杂志文章


    authors: MacLellan JD,Gerrits MF,Gowing A,Smith PJ,Wheeler MB,Harper ME

    更新日期:2005-08-01 00:00:00

  • Beta-cell insensitivity to glucose in the GK rat, a spontaneous nonobese model for type II diabetes.

    abstract::In early 1988, a colony of GK rats was started in Paris with progenitors issued from F35 of the original colony reported by Goto and Kakisaki. When studied longitudinally up to 8 mo, GK rats showed as early as 1 mo (weaning) significantly higher basal plasma glucose (9 mM) and insulin levels (doubled), altered glucose...


    pub_type: 杂志文章


    authors: Portha B,Serradas P,Bailbé D,Suzuki K,Goto Y,Giroix MH

    更新日期:1991-04-01 00:00:00

  • B-type natriuretic peptide prevents acute hypertrophic responses in the diabetic rat heart: importance of cyclic GMP.

    abstract::Stimulation of cardiomyocyte guanosine 3',5'-cyclic monophosphate (cyclic GMP) via endothelial-derived nitric oxide (NO) is an important mechanism by which bradykinin and ACE inhibitors prevent hypertrophy. Endothelial NO dysfunction and cardiac hypertrophy are morbid features of diabetes not entirely prevented by ACE...


    pub_type: 杂志文章


    authors: Rosenkranz AC,Hood SG,Woods RL,Dusting GJ,Ritchie RH

    更新日期:2003-09-01 00:00:00

  • GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice.

    abstract:OBJECTIVE:Glucagon-like peptide-1 receptor (GLP-1R) agonists are used to treat type 2 diabetes, and transient GLP-1 administration improved cardiac function in humans after acute myocardial infarction (MI) and percutaneous revascularization. However, the consequences of GLP-1R activation before ischemic myocardial inju...


    pub_type: 杂志文章


    authors: Noyan-Ashraf MH,Momen MA,Ban K,Sadi AM,Zhou YQ,Riazi AM,Baggio LL,Henkelman RM,Husain M,Drucker DJ

    更新日期:2009-04-01 00:00:00

  • Complement-fixing islet cell antibodies in the spontaneously diabetic BB rat.

    abstract::Fourteen rats of the spontaneously diabetic BB line were bled from the retroorbital sinus approximately every 10 days. Sera taken from an early age up to 20 days after the onset of overt diabetes were assayed for complement-fixing antibodies against antigens of the surface of islet cells (CFA). Dispersed islet cells f...


    pub_type: 杂志文章


    authors: Martin DR,Logothetopoulos J

    更新日期:1984-01-01 00:00:00

  • Genetic architecture of the APM1 gene and its influence on adiponectin plasma levels and parameters of the metabolic syndrome in 1,727 healthy Caucasians.

    abstract::The associations of the adiponectin (APM1) gene with parameters of the metabolic syndrome are inconsistent. We performed a systematic investigation based on fine-mapped single nucleotide polymorphisms (SNPs) highlighting the genetic architecture and their role in modulating adiponectin plasma concentrations in a parti...


    pub_type: 杂志文章


    authors: Heid IM,Wagner SA,Gohlke H,Iglseder B,Mueller JC,Cip P,Ladurner G,Reiter R,Stadlmayr A,Mackevics V,Illig T,Kronenberg F,Paulweber B

    更新日期:2006-02-01 00:00:00

  • Insulin lispro in CSII: results of a double-blind crossover study.

    abstract::Insulin lispro is a human insulin analog that dissociates more rapidly than human regular insulin after subcutaneous injection, resulting in higher insulin levels at an earlier point in time and a shorter duration of action. The aim of the study was to evaluate if this pharmacokinetic difference would translate into b...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Zinman B,Tildesley H,Chiasson JL,Tsui E,Strack T

    更新日期:1997-03-01 00:00:00

  • Inhibition of Soluble Epoxide Hydrolase 2 Ameliorates Diabetic Keratopathy and Impaired Wound Healing in Mouse Corneas.

    abstract::EPHX2 (encoding soluble epoxide hydrolase [sEH]) converts biologically active epoxyeicosatrienoic acids (EETs), anti-inflammatory and profibrinolytic effectors, into the less biologically active metabolites, dihydroxyeicostrienoic acids. We sought to characterize the expression and the function of EPHX2 in diabetic co...


    pub_type: 杂志文章


    authors: Sun H,Lee P,Yan C,Gao N,Wang J,Fan X,Yu FS

    更新日期:2018-06-01 00:00:00

  • Diabetes-induced metabolic alterations in heme synthesis and degradation and various heme-containing enzymes in female rats.

    abstract::Diabetes-induced alterations in heme and hemoproteins, as well as its relationship to drug-mediated induction of ALA Synthase (ALA-S), were examined in female Sprague-Dawley rats. Animals were rendered diabetic by a single i.v. injection of streptozotocin (STZ, 65 mg/kg) and measurements were made at various times aft...


    pub_type: 杂志文章


    authors: Bitar M,Weiner M

    更新日期:1984-01-01 00:00:00

  • Functional Human Beige Adipocytes From Induced Pluripotent Stem Cells.

    abstract::Activation of thermogenic beige adipocytes has recently emerged as a promising therapeutic target in obesity and diabetes. Relevant human models for beige adipocyte differentiation are essential to implement such therapeutic strategies. We report a straightforward and efficient protocol to generate functional human be...


    pub_type: 杂志文章


    authors: Guénantin AC,Briand N,Capel E,Dumont F,Morichon R,Provost C,Stillitano F,Jeziorowska D,Siffroi JP,Hajjar RJ,Fève B,Hulot JS,Collas P,Capeau J,Vigouroux C

    更新日期:2017-06-01 00:00:00

  • Physiological increments in plasma insulin concentrations have selective and different effects on synthesis of hepatic proteins in normal humans.

    abstract::These studies tested the hypothesis that physiological increments in plasma insulin concentrations have selective effects on the synthesis of hepatic proteins in humans. Leucine kinetics and fractional synthetic rates of albumin, fibrinogen, antithrombin III, and apoB-100 were determined in 6 normal subjects, on two d...


    pub_type: 杂志文章


    authors: De Feo P,Volpi E,Lucidi P,Cruciani G,Reboldi G,Siepi D,Mannarino E,Santeusanio F,Brunetti P,Bolli GB

    更新日期:1993-07-01 00:00:00

  • Hyperlipoproteinemia in streptozotocin-treated rats.

    abstract::In order to study hyperlipidemia in diabetes mellitus, rats were made diabetic by administration of streptozotocin and the optimal conditions for production of severe and persistent hyperlipoprotenemia determined. Two groups of rats were compared: rats fed sucrose-rich diets and rats fed laboratory chow. The optimal d...


    pub_type: 杂志文章


    authors: Bar-On H,Roheim PS,Eder HA

    更新日期:1976-06-01 00:00:00

  • Pancreatic lipomatosis is a structural marker in nondiabetic children with mutations in carboxyl-ester lipase.

    abstract::Both pancreatic volume reduction and lipomatosis have been observed in subjects with diabetes. The underlying molecular and pathological mechanisms are, however, poorly known, and it has been speculated that both features are secondary to diabetes. We have recently described pancreatic atrophy and lipomatosis in diabe...


    pub_type: 杂志文章


    authors: Raeder H,Haldorsen IS,Ersland L,Grüner R,Taxt T,Søvik O,Molven A,Njølstad PR

    更新日期:2007-02-01 00:00:00

  • Factors in development of diabetic neuropathy. Baseline analysis of neuropathy in feasibility phase of Diabetes Control and Complications Trial (DCCT). The DCCT Research Group.

    abstract::The Diabetes Control and Complications Trial (DCCT) is a multicenter randomized clinical trial studying the effect of intensive insulin therapy on the early vascular and neurological complications of insulin-dependent diabetes mellitus (IDDM). During the feasibility phase of the DCCT, baseline neurological histories, ...


    pub_type: 临床试验,杂志文章,随机对照试验



    更新日期:1988-04-01 00:00:00

  • Sodium-Glucose Cotransporter 2 Inhibitors: A Case Study in Translational Research.

    abstract::Sodium-glucose cotransporter 2 (SGLT2) inhibitors are the most recently approved class of diabetes drugs. Unlike other agents, SGLT2 inhibitors act on the kidney to promote urinary glucose excretion. SGLT2 inhibitors provide multiple benefits, including decreased HbA1c, body weight, and blood pressure. These drugs hav...


    pub_type: 杂志文章,评审


    authors: Beitelshees AL,Leslie BR,Taylor SI

    更新日期:2019-06-01 00:00:00

  • Preferential stiffening of central over peripheral arteries in type 2 diabetes.

    abstract::Arterial stiffness affects cardiac functions, peripheral circulation, and cardiovascular mortality. We examined whether arterial stiffness in different regions is equally affected by diabetes and other factors. The subjects were 161 patients with type 2 diabetes and 129 healthy subjects comparable in age and sex. Arte...


    pub_type: 杂志文章


    authors: Kimoto E,Shoji T,Shinohara K,Inaba M,Okuno Y,Miki T,Koyama H,Emoto M,Nishizawa Y

    更新日期:2003-02-01 00:00:00

  • Diabetic glomerulopathy following unilateral nephrectomy in the rat.

    abstract::One month following induction of diabetes with streptozotocin, one half of diabetic and control rats underwent unilateral nephrectomy. Subsequently, all animals were studied with respect to renal function and glomerular alterations of diabetes. Blood pressure levels were similar in all animals. Diabetic and control an...


    pub_type: 杂志文章


    authors: Steffes MW,Brown DM,Mauer SM

    更新日期:1978-01-01 00:00:00