Increased Effector Memory Insulin-Specific CD4+ T Cells Correlate With Insulin Autoantibodies in Patients With Recent-Onset Type 1 Diabetes.

abstract：:The hyperglycemic patient remains persistently at risk for infectious complications. Whether ascribable to diabetes mellitus, to the administration of glucocorticoids, or to the infusion of hyperalimentation fluids, hyperglycemia may impair several mechanisms of humoral host defense, including such varied neutrophil f...

journal_title：Diabetes

authors： Hostetter MK

更新日期：1990-03-01 00:00:00

abstract：:Women gain weight and their diabetes risk increases as they transition through menopause; these changes can be partly reversed by hormone therapy. However, the underlying molecular mechanisms mediating these effects are unknown. A novel knock-in mouse line with the selective blockade of the membrane-initiated estrogen...

journal_title：Diabetes

authors： Ueda K,Takimoto E,Lu Q,Liu P,Fukuma N,Adachi Y,Suzuki R,Chou S,Baur W,Aronovitz MJ,Greenberg AS,Komuro I,Karas RH

更新日期：2018-08-01 00:00:00

abstract：:Fasting hyperglycemia occurs when an excessive rate of endogenous glucose production (EGP) is not accompanied by an adequate compensatory increase in the rate of glucose disappearance (Rd). The situation following food ingestion is more complex as the amount of glucose that reaches the circulation for disposal is a fu...

journal_title：Diabetes

authors： Rizza RA,Toffolo G,Cobelli C

更新日期：2016-05-01 00:00:00

abstract：:Precise timing of the teratogenic period in diabetic pregnancy is of clinical importance since correction of the glucose intolerance during this period may protect the offspring from malformations. An experimental approach to elucidate this problem with regard to skeletal development was made in groups of pregnant str...

journal_title：Diabetes

authors： Eriksson UJ,Dahlström E,Hellerström C

更新日期：1983-12-01 00:00:00

abstract：:Therapeutic engineering of glucagon-like peptide 1 (GLP-1) has enabled development of new medicines to treat type 2 diabetes. These injectable analogs achieve robust glycemic control by increasing concentrations of "GLP-1 equivalents" (∼50 pmol/L). Similar levels of endogenous GLP-1 occur after gastric bypass surgery,...

journal_title：Diabetes

authors： Briere DA,Bueno AB,Gunn EJ,Michael MD,Sloop KW

更新日期：2018-02-01 00:00:00

abstract：:Exogenous ghrelin reduces glucose-stimulated insulin secretion and endogenous ghrelin protects against hypoglycemia during starvation. Islet ε-cells produce ghrelin and δ-cells express growth hormone secretagogue receptor (GHSR), suggesting the possibility of a paracrine mechanism for islet ghrelin to reach high local...

journal_title：Diabetes

authors： Gray SM,Niu J,Zhang A,Svendsen B,Campbell JE,D'Alessio DA,Tong J

更新日期：2019-09-01 00:00:00

abstract：:Patients with type 2 diabetes respond poorly to treatments for peripheral arterial disease (PAD) and are more likely to present with the most severe manifestation of the disease, critical limb ischemia. The underlying mechanisms linking type 2 diabetes and the severity of PAD manifestation are not well understood. We ...

journal_title：Diabetes

authors： Ryan TE,Schmidt CA,Green TD,Spangenburg EE,Neufer PD,McClung JM

更新日期：2016-09-01 00:00:00

abstract：:The adipocyte hormone adiponectin is negatively correlated with obesity and insulin resistance and may exert an important antidiabetes function. In this study, primary human skeletal muscle cells were cocultured with human fat cells or incubated with adipocyte-conditioned medium in the presence or absence of the globu...

journal_title：Diabetes

authors： Dietze-Schroeder D,Sell H,Uhlig M,Koenen M,Eckel J

更新日期：2005-07-01 00:00:00

abstract：:Neogenesis is crucial for the maintenance of beta-cell mass in the human pancreas and possibly for the outcome of clinical islet transplantation. To date, no studies have reported a stimulation of human beta-cell neogenesis in vivo. Therefore, we investigated whether human alpha-, beta-, and duct cell growth can be st...

journal_title：Diabetes

authors： Tyrberg B,Ustinov J,Otonkoski T,Andersson A

更新日期：2001-02-01 00:00:00

abstract：:In adipose tissue from both obese mice and humans, plasminogen activator inhibitor 1 (PAI-1) expression has been reported to be upregulated to levels of increased plasma PAI-1. This elevated expression has been shown to be partly controlled by tumor necrosis factor (TNF)-alpha in mice. In humans, increased PAI-1 expre...

journal_title：Diabetes

authors： Alessi MC,Bastelica D,Morange P,Berthet B,Leduc I,Verdier M,Geel O,Juhan-Vague I

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVE:Offspring of mothers with type 1 diabetes (OT1DM) demonstrate increased fat deposition, hyperinsulinemia, and hyperleptinemia in utero. We examined the influence of maternal diabetes on cord lipids at birth and relationship to body composition, cord insulin, leptin, and other hormonal measures. RESEARCH DESI...

journal_title：Diabetes

authors： Nelson SM,Freeman DJ,Sattar N,Johnstone FD,Lindsay RS

更新日期：2007-11-01 00:00:00

abstract：:Key parameters of the endocrine pancreas, such as islet number, islet mass, beta-cell mass, and alpha-cell mass, were studied in different strains of inbred mice to investigate the impact of genetic background on the size and structure of the endocrine pancreas. Six mice from each of seven different strains of inbred ...

journal_title：Diabetes

authors： Bock T,Pakkenberg B,Buschard K

更新日期：2005-01-01 00:00:00

abstract：:Currently, the major indications for solitary islet transplantation are recurrent severe hypoglycemia and labile glucose control. Quantifying these problems remains subjective. We have developed a scoring system for both hypoglycemia and glycemic lability, established normative data, and used them in patients who have...

journal_title：Diabetes

authors： Ryan EA,Shandro T,Green K,Paty BW,Senior PA,Bigam D,Shapiro AM,Vantyghem MC

更新日期：2004-04-01 00:00:00

abstract：:The contribution of dietary amino acids and endogenous hyperinsulinemia to prandial protein anabolism still has not been established. To this end, leucine estimates ([1-14C]leucine infusion, plasma alpha-ketoisocaproic acid [KIC] specific activity [SA] as precursor pool SA) of whole-body protein kinetics and fractiona...

journal_title：Diabetes

authors： Volpi E,Lucidi P,Cruciani G,Monacchia F,Reboldi G,Brunetti P,Bolli GB,De Feo P

更新日期：1996-09-01 00:00:00

abstract：:The severe diabetic nephropathy that develops in the hypertensive transgenic (mRen-2)27 rat with streptozotocin (STZ) diabetes has previously been considered angiotensin II-dependent. Because metabolic pathways are also activated in the diabetic kidney, the present study aimed to determine whether renoprotection could...

journal_title：Diabetes

authors： Wilkinson-Berka JL,Kelly DJ,Koerner SM,Jaworski K,Davis B,Thallas V,Cooper ME

更新日期：2002-11-01 00:00:00

abstract：:It has been hypothesized that type 1 diabetes is initiated by neonatal physiological pancreatic beta-cell death, indicating that the early stages of this autoimmune response may reflect a dysregulated response to immune "danger" signals. One potential danger signal is ATP, high concentrations of which stimulate the pu...

journal_title：Diabetes

authors： Elliott JI,Higgins CF

更新日期：2004-08-01 00:00:00

abstract：:The regulation of insulin secretion from pancreatic beta-cells depends critically on the activities of their plasma membrane ion channels. ATP-sensitive K+ channels (K(ATP) channels) are present in many cells and regulate a variety of cellular functions by coupling cell metabolism with membrane potential. The activity...

journal_title：Diabetes

authors： Seino S,Iwanaga T,Nagashima K,Miki T

更新日期：2000-03-01 00:00:00

abstract：:Diabetogenic strains of Coxsackievirus B4 (CB4) produce a diabetes syndrome in susceptible mice that resembles insulin-dependent diabetes mellitus. To assess the possible role of autoimmunity, the expression of a 64,000-Mr islet antigen in SJL/J and CD1 mice infected with a diabetogenic strain of CB4 was monitored in ...

journal_title：Diabetes

authors： Gerling I,Nejman C,Chatterjee NK

更新日期：1988-10-01 00:00:00

abstract：:Lactate production, glucose utilization, glucose oxidation, and insulin release were studied in islets from rat and ob/ob mice. Lactate was determined with a highly sensitive method, based on esterification, subsequent separation, and quantitation with high-performance liquid chromatography. There was a significant la...

journal_title：Diabetes

authors： Tamarit-Rodriguez J,Idahl LA,Giné E,Alcazar O,Sehlin J

更新日期：1998-08-01 00:00:00

abstract：:The minor hemoglobins AIa, AIb, and AIc were studied in mice with either genetic or chemically induced diabetes. Hemoglobin AIc was elevated approximately twofold in all the phenotypically diabetic mice studied (C57BL/KsJ-db/db, C57BL/KsJ-ob/ob, C57BL/6J-db/db, and alloxan- and streptozotocin-treated mice). Elevation ...

journal_title：Diabetes

authors： Koenig RJ,Araujo DC,Cerami A

更新日期：1976-01-01 00:00:00

abstract：:Studies have been carried out on activities of lysosomal beta-N-acetylhexosaminidase (hex), beta-galactosidase (beta-gal), alpha-glucosidase (alpha-glu), and acid phosphatase (AP) in serum and urine from patients with juvenile diabetes and matched controls. There is a large increase in blood and urinary hex activity (...

journal_title：Diabetes

authors： Bomback FM,Nakagawa S,Kumin S,Nitowsky HM

更新日期：1976-05-01 00:00:00

abstract：:Leptin administration has been shown to increase renal, adrenal, and lumbar sympathetic nerve activity. However, this generalized sympathoexcitatory activity is not always followed by an increase in arterial pressure. The present study tested the hypothesis that leptin induces a release of nitric oxide (NO) that oppos...

journal_title：Diabetes

authors： Frühbeck G

更新日期：1999-04-01 00:00:00

abstract：:A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (coronavirus disease 2019 [COVID-19]) is now at global pandemic levels causing significant morbidity and mortality. Patients with diabetes are particularly vulnerable and more likely to get severe complications when infected with this vi...

journal_title：Diabetes

authors： Gianchandani R,Esfandiari NH,Ang L,Iyengar J,Knotts S,Choksi P,Pop-Busui R

更新日期：2020-10-01 00:00:00

abstract：:Neonatal rats injected with streptozocin (STZ, 100 mg/kg) at birth exhibited an acute diabetes followed by a spontaneous remission. We have previously shown that this recovery from neonatal diabetes is due to B-cell regeneration and reaccumulation of pancreatic insulin stores starting from 3 to 5 days after birth. The...

journal_title：Diabetes

authors： Portha B,Kergoat M

更新日期：1985-06-01 00:00:00

abstract：:It is accepted for insulin-secreting cells in culture that the closure of ATP-sensitive K+ channels causes the glucose-dependent depolarization of pancreatic beta-cells seen at subthreshold levels (less than 100 mg/dl) of glucose. The question remains for the more thoroughly studied beta-cells in freshly dissected int...

journal_title：Diabetes

authors： Cook DL,Ikeuchi M

更新日期：1989-04-01 00:00:00

abstract：OBJECTIVE:Since vascular dysfunction is a main trait of obese subjects, in the present study we evaluated the vascular impact of resistin, a recently discovered hormone markedly increased in obesity. RESEARCH DESIGN AND METHODS:We performed our analysis on aortic and mesenteric segments from young and old C57BL/6 mice...

journal_title：Diabetes

authors： Gentile MT,Vecchione C,Marino G,Aretini A,Di Pardo A,Antenucci G,Maffei A,Cifelli G,Iorio L,Landolfi A,Frati G,Lembo G

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:On the basis of the role of activin A in inflammation, atherogenesis, and glucose homeostasis, we investigated whether activin A could be related to glucometabolic abnormalities in patients with acute myocardial infarction (MI). RESEARCH DESIGN AND METHODS:Activin A measurement and oral glucose tolerance tes...

journal_title：Diabetes

authors： Andersen GØ,Ueland T,Knudsen EC,Scholz H,Yndestad A,Sahraoui A,Smith C,Lekva T,Otterdal K,Halvorsen B,Seljeflot I,Aukrust P

更新日期：2011-05-01 00:00:00

abstract：:Leptin resistance has recently been confirmed not only in animal obese models but in human obesity. Evidence is rapidly emerging that suggests that activation of histamine signaling in the hypothalamus may have substantial anti-obesity and antidiabetic actions, particularly in leptin-resistant states. To address this ...

journal_title：Diabetes

authors： Masaki T,Yoshimatsu H,Chiba S,Watanabe T,Sakata T

更新日期：2001-02-01 00:00:00

abstract：:The aim of this study was to test the hypothesis that plasma leptin concentrations contributed to the pathophysiology of NIDDM by decreasing both insulin-mediated glucose disposal and glucose-stimulated insulin secretion. The study was performed in 60 women with normal oral glucose tolerance. Differences in insulin-me...

journal_title：Diabetes

authors： Carantoni M,Abbasi F,Azhar S,Chen YD,Klebanov M,Wang PW,Warmerdam F,Reaven GM

更新日期：1998-02-01 00:00:00

abstract：:Highly angiogenic bone marrow mononuclear cell-derived spheroids (BM-spheroids), formed by selective proliferation of the CD31+CD14+CD34+ monocyte subset via three-dimensional (3D) culture, have had robust angiogenetic capacity in rodent syngeneic renal subcapsular islet transplantation. We wondered whether the effica...

journal_title：Diabetes

authors： Oh BJ,Jin SM,Hwang Y,Choi JM,Lee HS,Kim G,Kim G,Park HJ,Kim P,Kim SJ,Kim JH

更新日期：2018-03-01 00:00:00