Abstract:
:Key parameters of the endocrine pancreas, such as islet number, islet mass, beta-cell mass, and alpha-cell mass, were studied in different strains of inbred mice to investigate the impact of genetic background on the size and structure of the endocrine pancreas. Six mice from each of seven different strains of inbred mice were included in the study. For all parameters investigated, there was a pronounced interstrain variation. ANCOVA showed that only mouse strain was statistically significant as an explanatory parameter for the number of islets. Mouse strain, body weight, and pancreas mass reached statistical significance as explanatory parameters for the islet mass, with mouse strain as the most significant predictor. These data show that genetic background is the most important predictor of both the number of islets and total islet volume. We also conclude that inbred mice could be a valuable resource to identify the genes responsible for the size and structure of the endocrine pancreas.
journal_name
Diabetesjournal_title
Diabetesauthors
Bock T,Pakkenberg B,Buschard Kdoi
10.2337/diabetes.54.1.133subject
Has Abstractpub_date
2005-01-01 00:00:00pages
133-7issue
1eissn
0012-1797issn
1939-327Xpii
54/1/133journal_volume
54pub_type
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