Abstract:
OBJECTIVE:Vaspin was identified as an adipokine with insulin-sensitizing effects, which is predominantly secreted from visceral adipose tissue in a rat model of type 2 diabetes. We have recently shown that vaspin mRNA expression in adipose tissue is related to parameters of obesity and glucose metabolism. However, the regulation of vaspin serum concentrations in human obesity and type 2 diabetes is unknown. RESEARCH DESIGN AND METHODS:For the measurement of vaspin serum concentrations, we developed an enzyme-linked immunosorbent assay (ELISA). Using this ELISA, we assessed circulating vaspin in a cross-sectional study of 187 subjects with a wide range of obesity, body fat distribution, insulin sensitivity, and glucose tolerance and in 60 individuals with normal glucose tolerance (NGT), impaired glucose tolerance (IGT), or type 2 diabetes before and after a 4-week physical training program. RESULTS:Vaspin serum concentrations were significantly higher in female compared with male subjects. There was no difference in circulating vaspin between individuals with NGT and type 2 diabetes. In the normal glucose-tolerant group, circulating vaspin significantly correlated with BMI and insulin sensitivity. Moreover, physical training for 4 weeks resulted in significantly increased circulating vaspin levels. CONCLUSIONS:We found a sexual dimorphism in circulating vaspin. Elevated vaspin serum concentrations are associated with obesity and impaired insulin sensitivity, whereas type 2 diabetes seems to abrogate the correlation between increased circulating vaspin, higher body weight, and decreased insulin sensitivity. Low circulating vaspin correlates with a high fitness level, whereas physical training in untrained individuals causes increased vaspin serum concentrations.
journal_name
Diabetesjournal_title
Diabetesauthors
Youn BS,Klöting N,Kratzsch J,Lee N,Park JW,Song ES,Ruschke K,Oberbach A,Fasshauer M,Stumvoll M,Blüher Mdoi
10.2337/db07-1045subject
Has Abstractpub_date
2008-02-01 00:00:00pages
372-7issue
2eissn
0012-1797issn
1939-327Xpii
db07-1045journal_volume
57pub_type
杂志文章相关文献
DIABETES文献大全abstract::A cohort of 372 insulin-dependent diabetic children, diagnosed between October 1949 and December 1960, were followed-up until December 1976 by the same team of physicians. At the time of diagnosis all patients were under 16 yr of age and were given standardized treatment which did not change from 1949 to 1976. The the...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.30.3.175
更新日期:1981-03-01 00:00:00
abstract::The mechanisms responsible for painful and insensate diabetic neuropathy are not completely understood. Here, we have investigated sensory neuropathy in the Ins2+/Akita mouse, a hereditary model of diabetes. Akita mice become diabetic soon after weaning, and we show that this is accompanied by an impaired mechanical a...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db17-1306
更新日期:2018-08-01 00:00:00
abstract::Type 1 diabetes results from chronic autoimmune destruction of insulin-producing β-cells within pancreatic islets. Although insulin is a critical self-antigen in animal models of autoimmune diabetes, due to extremely limited access to pancreas samples, little is known about human antigenic targets for islet-infiltrati...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db16-1025
更新日期:2017-03-01 00:00:00
abstract::Microinflammation is a common major mechanism in the pathogenesis of diabetic vascular complications, including diabetic nephropathy. Macrophage scavenger receptor-A (SR-A) is a multifunctional receptor expressed on macrophages. This study aimed to determine the role of SR-A in diabetic nephropathy using SR-A-deficien...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db06-0359
更新日期:2007-02-01 00:00:00
abstract::We examined the effects of aldose reductase inhibition (ARI) on glomerular filtration rate (GFR), albuminuria, and kidney histology in partially insulin-treated streptozocin-induced diabetic (STZ-D) rats. After 1 mo of diabetes, GFR was elevated over control values in the STZ-D rats but was not affected by treatment w...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.38.8.981
更新日期:1989-08-01 00:00:00
abstract::Childhood obesity and its comorbidities continue to accelerate across the globe. Two-thirds of pregnant women are obese/overweight, as are 20% of preschoolers. Gestational diabetes mellitus (GDM) is escalating, affecting up to 1 in 5 pregnant women. The field of developmental origins of health and disease has begun to...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/dbi17-0011
更新日期:2018-11-01 00:00:00
abstract::Rapid and sustained stimulation of beta-cells with glucose induces biphasic insulin secretion. The two phases appear to reflect a characteristic of stimulus-secretion coupling in each beta-cell rather than heterogeneity in the time-course of the response between beta-cells or islets. There is no evidence indicating th...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/diabetes.51.2007.s60
更新日期:2002-02-01 00:00:00
abstract::Pancreatogenic diabetes (PD), secondary either to chronic calcific pancreatitis or to pancreatectomy, is characterized by higher frequency of hypoglycemic events during insulin therapy in comparison with type I insulin-dependent diabetes (IDD). Not only glucagon deficiency, but an enhanced peripheral tissue sensitivit...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.31.4.346
更新日期:1982-04-01 00:00:00
abstract::To investigate the pathophysiology of diabetic osteopenia, circulating levels and bone contents of bone gamma-carboxyglutamic acid-containing protein (BGP) were measured in streptozocin-induced diabetic rats . Plasma calcium and total protein were significantly decreased (P less than .01) in the diabetic group, and th...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.37.6.702
更新日期:1988-06-01 00:00:00
abstract::Genes play a role in many processes underlying late diabetic complications, but efforts to identify genetic variants have produced disappointing and contradictory results. Here, we evaluate whether the study designs and analytic methods commonly being used are optimal for finding susceptibility genes for diabetic comp...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/diabetes.51.6.1655
更新日期:2002-06-01 00:00:00
abstract::Diabetic glomerulosclerosis is defined by increased glomerular extracellular matrix (ECM) that is mainly synthesized by mesangial cells that underwent an activation mediated by cytokines and growth factors from various cellular origins. In this study, we tested whether macrophages could infiltrate the glomeruli and in...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.49.3.466
更新日期:2000-03-01 00:00:00
abstract::Susceptibility of mice to experimental insulin-dependent diabetes as induced by multiple subdiabetogenic doses of streptozotocin has been shown to be strongly gender-dependent, males being much more susceptible than females. We examined this gender difference further in two strains of genetically susceptible mice to d...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.31.8.724
更新日期:1982-08-01 00:00:00
abstract::Previous studies have provided evidence for the transcripts of Cx43 and Cx45 within pancreatic islets. As of yet, however, it has proven difficult to unambiguously demonstrate the expression of these proteins by islet cells. We have investigated whether Cx36, a new connexin species recently identified in mammalian bra...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.49.5.727
更新日期:2000-05-01 00:00:00
abstract::Infection of autoimmune New Zealand mice with the D variant of encephalomyocarditis (EMC) virus results in beta-cell damage and clinical diabetes. The induction of diabetes in parental NZB and NZW strains was independent of sex. However, the susceptibility to virus-induced diabetes in their F1 offspring was sex depend...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.32.8.755
更新日期:1983-08-01 00:00:00
abstract::Specific binding of [3H]SCH 23390 to dopamine D1 receptors in the striatum and olfactory tubercle in 14-day alloxan-induced diabetic rats was investigated. The Scatchard analysis revealed decreased D1 receptor density in the striatum (Bmax values were 548 +/- 23 fmol/mg protein for the control and 466 +/- 33 fmol/mg f...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.41.9.1119
更新日期:1992-09-01 00:00:00
abstract::We tested the hypothesis that dysfunction of vascular endothelium, indicated by an increase in plasma level of von Willebrand factor (vWF), is present in patients with insulin-dependent diabetes mellitus (IDDM) who develop diabetic nephropathy (DN). DN was classified as absent (urinary albumin excretion [UAE] rate les...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.40.8.971
更新日期:1991-08-01 00:00:00
abstract::Proinsulin folding within the endoplasmic reticulum (ER) remains incompletely understood, but it is clear that in mutant INS gene-induced diabetes of youth (MIDY), progression of the (three) native disulfide bonds of proinsulin becomes derailed, causing insulin deficiency, β-cell ER stress, and onset of diabetes. Here...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db15-1345
更新日期:2016-04-01 00:00:00
abstract::Insulin receptors from rat hepatoma cells (Fao) and human placenta were partially purified by detergent solubilization and lectin purification. The insulin receptor preparations were subjected to sodium dodecyl sulfate (SDS) polyacrylamide gel electrophoresis under reducing or nonreducing conditions. The proteins were...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.33.10.923
更新日期:1984-10-01 00:00:00
abstract::The success of the Edmonton Protocol for islet transplantation has provided new hope in the treatment of type 1 diabetes. This study reports on the assessment of 83 human islet grafts transplanted using the Edmonton Protocol since 1999. Cellular composition, as assessed by immunohistochemistry, showed a lower islet pu...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.53.12.3107
更新日期:2004-12-01 00:00:00
abstract::Parathyroid hormone-related protein (PTHrP) increases the content and mRNA level of insulin in a mouse beta-cell line, MIN6, and primary-cultured mouse islets. We examined the mechanism of PTHrP-induced insulin expression. The PTHrP effect was markedly augmented by SB203580, a mitogen-activated protein (MAP) kinase in...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.52.11.2720
更新日期:2003-11-01 00:00:00
abstract::Streptozocin-induced diabetic (STZ-D) mice have reduced brain concentrations of tryptophan, a precursor substance for 5-hydroxytryptamine, and show lengthened immobility in Porsolt's swim test, a putative animal model of depression. This study investigated whether tryptophan affects behavior in Porsolt's swim test in ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.40.12.1598
更新日期:1991-12-01 00:00:00
abstract::Vascular complications are the leading causes of morbidity and mortality in diabetic patients. The contribution of platelets to thromboembolic complications is well documented, but their involvement in the initiation of the atherosclerotic process is of rising interest. Thus, the aim of the present study was to evalua...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.53.4.1046
更新日期:2004-04-01 00:00:00
abstract::Orexins (hypocretins) are novel neuropeptides that appear to play a role in the regulation of energy balances. Orexin-A (OXA) increases food intake in rodents, and fasting activates OXA neurons in both the lateral hypothalamic area and gut. OXA is also found in the endocrine pancreas; however, little is known about it...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.52.1.111
更新日期:2003-01-01 00:00:00
abstract::p21(cip1), a regulatory molecule upstream of the G(1/0) checkpoint, is increased in beta-cells in response to mitogenic stimulation. Whereas p21(cip1) can variably stimulate or inhibit cell cycle progression, in vitro studies suggest that p21(cip1) acts as an inhibitor in the pancreatic beta-cell. To determine the fun...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db06-0627
更新日期:2006-12-01 00:00:00
abstract::There has been a prejudice that diabetes modulates the function of saphenous vein in a manner that predisposes to bypass graft failure, although most of the evidence accrues from animal studies. We have investigated the effect of diabetes on the vasodilator responses and ultrastructure of saphenous vein harvested from...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.46.1.113
更新日期:1997-01-01 00:00:00
abstract::The hormonal responses to low-level exercise in pregnancy have been studied in 13 insulin-requiring diabetic patients and 42 control subjects. We found no significant changes in plasma glucose, epinephrine, glucagon, or FFA with this level of exercise in the study group and control subjects; but plasma norepinephrine ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.34.2.s78
更新日期:1985-06-01 00:00:00
abstract::ATP is known to be coreleased with insulin from pancreatic beta-cells. To monitor insulin secretion from single beta-cells, a single beta-cell was surrounded in culture by Fura 2-loaded calf pulmonary artery endothelium (CPAE) cells, which can detect the ATP. CPAE cells did not respond with an elevation in cytoplasmic...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.44.10.1213
更新日期:1995-10-01 00:00:00
abstract::Neogenesis is crucial for the maintenance of beta-cell mass in the human pancreas and possibly for the outcome of clinical islet transplantation. To date, no studies have reported a stimulation of human beta-cell neogenesis in vivo. Therefore, we investigated whether human alpha-, beta-, and duct cell growth can be st...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.50.2.301
更新日期:2001-02-01 00:00:00
abstract::Low plasma sex hormone-binding globulin (SHBG) levels are associated with obesity and predict the development of type 2 diabetes. The reason why obese individuals have low circulating SHBG has been attributed to hyperinsulinemia, but no mechanistic evidence has been described. The aim of the current study is to explor...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db11-0727
更新日期:2012-02-01 00:00:00
abstract::We have recently reported successful 72-h preservation of the canine pancreas with a new cold-storage solution developed at the University of Wisconsin (UW solution). Over 10 mo, we performed 11 combined pancreas-kidney and 4 isolated-pancreas transplants with this solution. In situ cooling of the donor pancreas was p...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.38.1.s7
更新日期:1989-01-01 00:00:00