Disulfide Mispairing During Proinsulin Folding in the Endoplasmic Reticulum.

abstract：:Type 2 diabetes is characterized by increased plasma triglyceride levels and a fourfold increase in ischemic heart disease, but the mechanism is unclear. CD36 is a receptor/transporter that binds fatty acids of lipoproteins. CD36 deficiency has been linked with insulin resistance. There is strong evidence of in vivo i...

journal_title：Diabetes

authors： Englyst NA,Taube JM,Aitman TJ,Baglin TP,Byrne CD

更新日期：2003-05-01 00:00:00

abstract：:To investigate whether insulin reduces platelet aggregability through a modulation of the guanosine-3',5'-cyclic monophosphate (cGMP) concentrations, we determined by a radioimmunoassay the cGMP values in the platelet-rich plasma (PRP) obtained from 17 healthy volunteers and incubated for 3 min with different concentr...

journal_title：Diabetes

authors： Trovati M,Massucco P,Mattiello L,Mularoni E,Cavalot F,Anfossi G

更新日期：1994-08-01 00:00:00

abstract：:Studies were conducted to explore altered substrate utilization and metabolism in GLUT4 null mice. Liver fatty acid synthase mRNA and fatty acid synthesis rates were dramatically increased in GLUT4 null mice compared with control mice and were supported by increased rates of the pentose phosphate pathway oxidative pha...

journal_title：Diabetes

authors： Ranalletta M,Jiang H,Li J,Tsao TS,Stenbit AE,Yokoyama M,Katz EB,Charron MJ

更新日期：2005-04-01 00:00:00

abstract：:An in vivo microdialysis technique was used to study adrenal medullary function in 6 euglycemic and 6 hyperglycemic anesthetized Sprague-Dawley rats exposed to hypoxia. After stabilization of an adrenal dialysis probe, dialyzable adrenal epinephrine and norepinephrine were measured in response to 15 min of 7.8% oxygen...

journal_title：Diabetes

authors： Cohen WR,Deutsch J

更新日期：1994-05-01 00:00:00

abstract：:GLP-1 and incretin mimetics, such as exenatide, have been shown to attenuate hepatocyte steatosis in vivo and in vitro, but the specific underlying mechanism is unclear. SIRT1, an NAD(+)-dependent protein deacetylase, has been considered as a crucial regulator in hepatic lipid homeostasis by accumulated studies. Here,...

journal_title：Diabetes

authors： Xu F,Li Z,Zheng X,Liu H,Liang H,Xu H,Chen Z,Zeng K,Weng J

更新日期：2014-11-01 00:00:00

abstract：OBJECTIVE:Klotho is an antiaging hormone present in the kidney that extends the lifespan, regulates kidney function, and modulates cellular responses to oxidative stress. We investigated whether Klotho levels and signaling modulate inflammation in diabetic kidneys. RESEARCH DESIGN AND METHODS:Renal Klotho expression w...

journal_title：Diabetes

authors： Zhao Y,Banerjee S,Dey N,LeJeune WS,Sarkar PS,Brobey R,Rosenblatt KP,Tilton RG,Choudhary S

更新日期：2011-07-01 00:00:00

abstract：:Single "subdiabetogenic" doses of streptozotocin (SZ), when given to young male CD-1 mice, produced a delayed onset of hyperglycemia dependent on the dose of SZ and on the age of the mice. The effect was markedly reduced or absent in older mice given the same dose of SZ per kg of body weight. Histologic examination of...

journal_title：Diabetes

authors： Riley WJ,McConnell TJ,Maclaren NK,McLaughlin JV,Taylor G

更新日期：1981-09-01 00:00:00

abstract：:Bariatric surgery has proven to be the most effective treatment for controlling hyperglycemia in severely obese patients with diabetes. We show that fibroblast growth factor 19 (FGF19), a gut hormone, is rapidly induced by bariatric surgery in rodents and humans. Administration of FGF19 achieves diabetes remission ind...

journal_title：Diabetes

authors： DePaoli AM,Zhou M,Kaplan DD,Hunt SC,Adams TD,Learned RM,Tian H,Ling L

更新日期：2019-06-01 00:00:00

abstract：:The changes of the microvasculature of rat pancreas transplants during acute rejection were investigated and quantitatively analyzed. The vessels in pancreas transplants increased in caliber and decreased in density during acute rejection. These changes were marked in the exocrine pancreas, especially in central zones...

journal_title：Diabetes

authors： Nakai I,Aikawa I,Oka T

更新日期：1989-01-01 00:00:00

abstract：:The GK rat model of type 2 diabetes is especially convenient to dissect the pathogenic mechanism necessary for the emergence of overt diabetes because all adult rats obtained in our department (GK/Par colony) to date have stable basal mild hyperglycemia and because overt diabetes is preceded by a period of normoglycem...

journal_title：Diabetes

authors： Portha B,Giroix MH,Serradas P,Gangnerau MN,Movassat J,Rajas F,Bailbe D,Plachot C,Mithieux G,Marie JC

更新日期：2001-02-01 00:00:00

abstract：:Site differences in adipose tissue function may have implications for insulin-resistant conditions. In mature adipose tissue, subcutaneous adipocytes have higher leptin secretion, similar tumor necrosis factor (TNF)-alpha secretion, and lower catecholamine-stimulated lipolysis as compared with omental adipocytes. In t...

journal_title：Diabetes

authors： van Harmelen V,Dicker A,Rydén M,Hauner H,Lönnqvist F,Näslund E,Arner P

更新日期：2002-07-01 00:00:00

abstract：:The mechanisms responsible for painful and insensate diabetic neuropathy are not completely understood. Here, we have investigated sensory neuropathy in the Ins2+/Akita mouse, a hereditary model of diabetes. Akita mice become diabetic soon after weaning, and we show that this is accompanied by an impaired mechanical a...

journal_title：Diabetes

authors： Vastani N,Guenther F,Gentry C,Austin AL,King AJ,Bevan S,Andersson DA

更新日期：2018-08-01 00:00:00

abstract：:It is well described that excessive lipid metabolism can cause insulin resistance in both animals and humans, and this has been implicated as a causative factor in the development of insulin resistance and type 2 diabetes in humans. Recently, we have shown that intravenous lipid emulsion (liposyn) infusion during a 12...

journal_title：Diabetes

authors： Hevener A,Reichart D,Janez A,Olefsky J

更新日期：2002-06-01 00:00:00

abstract：:Rhesus monkeys frequently develop obesity and insulin resistance followed by type 2 diabetes when allowed free access to chow. This insulin resistance is partly due to defective glucose transport into skeletal muscle. In this study, we examined signaling factors required for insulin-stimulated glucose transport in mus...

journal_title：Diabetes

authors： Standaert ML,Ortmeyer HK,Sajan MP,Kanoh Y,Bandyopadhyay G,Hansen BC,Farese RV

更新日期：2002-10-01 00:00:00

abstract：OBJECTIVE:Chronic pancreatitis, characterized by pancreatic exocrine tissue destruction with initial maintenance of islets, eventually leads to insulin-dependent diabetes in most patients. Mice deficient for the transcription factors E2F1 and E2F2 suffer from a chronic pancreatitis-like syndrome and become diabetic. Su...

journal_title：Diabetes

authors： Tessem JS,Jensen JN,Pelli H,Dai XM,Zong XH,Stanley ER,Jensen J,DeGregori J

更新日期：2008-06-01 00:00:00

abstract：:Type 1 diabetes is caused by adaptive immune responses, but innate immunity is important because monocytes infiltrate islets. Activated monocytes express cyclooxygenase (COX)-2, promoting prostaglandin-E(2) (PGE(2)) secretion, whereas COX-1 expression is constitutive. We aimed to define monocyte COX expression in type...

journal_title：Diabetes

authors： Beyan H,Goodier MR,Nawroly NS,Hawa MI,Bustin SA,Ogunkolade WB,Londei M,Yousaf N,Leslie RD

更新日期：2006-12-01 00:00:00

abstract：:Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone with extrapancreatic effects beyond glycemic control. Here we demonstrate unexpected effects of GIP signaling in the vasculature. GIP induces the expression of the proatherogenic cytokine osteopontin (OPN) in mouse arteries via local release of ...

journal_title：Diabetes

authors： Berglund LM,Lyssenko V,Ladenvall C,Kotova O,Edsfeldt A,Pilgaard K,Alkayyali S,Brøns C,Forsblom C,Jonsson A,Zetterqvist AV,Nitulescu M,McDavitt CR,Dunér P,Stancáková A,Kuusisto J,Ahlqvist E,Lajer M,Tarnow L,Madsbad S

更新日期：2016-01-01 00:00:00

abstract：:Duct-occluded segmental-pancreas transplants develop progressive fibrotic atrophy, even though endocrine function seems to be unaffected. To determine end-stage size of the graft and to evaluate magnetic resonance imaging (MRI) and computed tomography (CT), these imaging techniques were applied in eight patients with ...

journal_title：Diabetes

authors： Schlumpf R,Marincek B,Von Schulthess G,Decurtins M,Largiadèr F

更新日期：1989-01-01 00:00:00

abstract：:The current study investigated the fate of a [U-(13)C]palmitate tracer extracted by forearm muscle in type 2 diabetic and control subjects. We studied seven healthy lean male subjects and seven obese male subjects with type 2 diabetes using the forearm muscle balance technique with continuous intravenous infusion of t...

journal_title：Diabetes

authors： Blaak EE,Wagenmakers AJ

更新日期：2002-03-01 00:00:00

abstract：:There has been great interest in the browning of fat for the treatment of obesity. Although β-lapachone (BLC) has potential therapeutic effects on obesity, the fat-browning effect and thermogenic capacity of BLC on obesity have never been demonstrated. Here, we showed that BLC stimulated the browning of white adipose ...

journal_title：Diabetes

authors： Choi WH,Ahn J,Jung CH,Jang YJ,Ha TY

更新日期：2016-09-01 00:00:00

abstract：:Type 1 diabetes (T1D) results from T cell-mediated destruction of insulin-producing β-cells. Insulin represents a key self-antigen in disease pathogenesis, as recent studies identified proinsulin-responding T cells from inflamed pancreatic islets of organ donors with recent-onset T1D. These cells respond to an insulin...

journal_title：Diabetes

authors： Spanier JA,Sahli NL,Wilson JC,Martinov T,Dileepan T,Burrack AL,Finger EB,Blazar BR,Michels AW,Moran A,Jenkins MK,Fife BT

更新日期：2017-12-01 00:00:00

abstract：:Embryonic stem (ES) cells display the ability to differentiate in vitro into a variety of cell lineages. Using a cell-trapping system, we have obtained an insulin-secreting cell clone from undifferentiated ES cells. The construction used allows the expression of a neomycin selection system under the control of the reg...

journal_title：Diabetes

authors： Soria B,Roche E,Berná G,León-Quinto T,Reig JA,Martín F

更新日期：2000-02-01 00:00:00

abstract：:Metformin is the most widely prescribed medication for the treatment of type 2 diabetes (T2D). However, gastrointestinal (GI) side effects develop in ~25% of patients treated with metformin, leading to the discontinuation of therapy in ~5% of cases. We hypothesized that reduced transport of metformin via organic catio...

journal_title：Diabetes

authors： Dujic T,Zhou K,Donnelly LA,Tavendale R,Palmer CN,Pearson ER

更新日期：2015-05-01 00:00:00

abstract：:There is growing interest in more widespread application of isolated islet transplantation for the treatment of type 1 diabetes; however, the sequelae of long-term islet residence within the liver are unknown. We report herein a consequence of intraportal islet transplantation, specifically the development of periport...

journal_title：Diabetes

authors： Markmann JF,Rosen M,Siegelman ES,Soulen MC,Deng S,Barker CF,Naji A

更新日期：2003-07-01 00:00:00

abstract：:Thiazolidinediones, such as pioglitazone, seem to exert direct antiatherosclerotic and antirestenotic effects on type 2 diabetes, in part due to an induction of vascular smooth muscle cell (VSMC) apoptosis. We aimed to study the role of transforming growth factor (TGF)-beta in rat aortic VSMC. Pioglitazone at 100 micr...

journal_title：Diabetes

authors： Redondo S,Ruiz E,Santos-Gallego CG,Padilla E,Tejerina T

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVE:To investigate if recurrent autoimmunity explained hyperglycemia and C-peptide loss in three immunosuppressed simultaneous pancreas-kidney (SPK) transplant recipients. RESEARCH DESIGN AND METHODS:We monitored autoantibodies and autoreactive T-cells (using tetramers) and performed biopsy. The function of auto...

journal_title：Diabetes

authors： Vendrame F,Pileggi A,Laughlin E,Allende G,Martin-Pagola A,Molano RD,Diamantopoulos S,Standifer N,Geubtner K,Falk BA,Ichii H,Takahashi H,Snowhite I,Chen Z,Mendez A,Chen L,Sageshima J,Ruiz P,Ciancio G,Ricordi C,Reij

更新日期：2010-04-01 00:00:00

abstract：:This study investigated changes in levels of mRNAs encoding the three neurofilament (NF) proteins NF-L (low), NF-M (medium), and NF-H (high) and two growth-associated proteins, GAP-43 and T alpha 1 alpha-tubulin, in lumbar dorsal root ganglia of control and streptozocin-induced diabetic rats. After 8 weeks of diabetes...

journal_title：Diabetes

authors： Mohiuddin L,Fernyhough P,Tomlinson DR

更新日期：1995-01-01 00:00:00

abstract：:The aim of this study was to investigate the effects of elevated D-glucose concentrations on vascular smooth muscle cell (VSMC) expression of the platelet-derived growth factor (PDGF)beta receptor and VSMC migratory behavior. Immunoprecipitation, immunofluorescent staining, and RT-PCR of human VSMCs showed that elevat...

journal_title：Diabetes

authors： Campbell M,Allen WE,Silversides JA,Trimble ER

更新日期：2003-02-01 00:00:00

abstract：:It is well established that patients with non-insulin-dependent diabetes mellitus (NIDDM) are resistant to insulin. However, the contribution of hepatic and extrahepatic tissues to insulin resistance remains controversial. The uncertainty may be at least in part due to errors introduced by the unknowing use in previou...

journal_title：Diabetes

authors： Butler PC,Kryshak EJ,Schwenk WF,Haymond MW,Rizza RA

更新日期：1990-02-01 00:00:00

abstract：:Rat islets contain the acid-labile activator of phosphofructokinase, fructose-2,6-bisphosphate. The islet content in activator is higher in islets exposed to glucose (16.7 mM) than in islets deprived of glucose. The islets display fructose-6-phosphate, 2-kinase activity with a Km for fructose-6-phosphate close to 0.08...

journal_title：Diabetes

authors： Malaisse WJ,Malaisse-Lagae F,Sener A

更新日期：1982-01-01 00:00:00