FGF19 Analog as a Surgical Factor Mimetic That Contributes to Metabolic Effects Beyond Glucose Homeostasis.

abstract：:Rapid and sustained stimulation of beta-cells with glucose induces biphasic insulin secretion. The two phases appear to reflect a characteristic of stimulus-secretion coupling in each beta-cell rather than heterogeneity in the time-course of the response between beta-cells or islets. There is no evidence indicating th...

journal_title：Diabetes

authors： Henquin JC,Ishiyama N,Nenquin M,Ravier MA,Jonas JC

更新日期：2002-02-01 00:00:00

abstract：OBJECTIVE:Many of the effects of angiotensin (Ang) II are mediated through specific plasma membrane receptors. However, Ang II also elicits biological effects from the interior of the cell (intracrine), some of which are not inhibited by Ang receptor blockers (ARBs). Recent in vitro studies have identified high glucose...

journal_title：Diabetes

authors： Singh VP,Le B,Khode R,Baker KM,Kumar R

更新日期：2008-12-01 00:00:00

abstract：:In evaluating therapeutic interventions aimed at preventing diabetic neuropathy, choosing a suitable measure of neural function is difficult, partly because the relation between most available objective measures and the development of symptomatic neuropathy (SN) is unclear. Using data from 67 diabetic patients, we dev...

journal_title：Diabetes

authors： Weinberg CR,Pfeifer MA

更新日期：1986-08-01 00:00:00

abstract：:Recent studies have shown that two different voltage-dependent Ca2+ channels are expressed in pancreatic islets, the beta-cell/neuroendocrine-brain and the cardiac subtypes. The effects of chronic hyperglycemia on the levels in pancreatic islets of the mRNAs encoding the alpha 1-subunits of the beta-cell and cardiac s...

journal_title：Diabetes

authors： Iwashima Y,Pugh W,Depaoli AM,Takeda J,Seino S,Bell GI,Polonsky KS

更新日期：1993-07-01 00:00:00

abstract：:Expansion of pancreatic β-cells is a key goal of diabetes research, yet induction of adult human β-cell replication has proven frustratingly difficult. In part, this reflects a lack of understanding of cell cycle control in the human β-cell. Here, we provide a comprehensive immunocytochemical "atlas" of G1/S control m...

journal_title：Diabetes

authors： Fiaschi-Taesch NM,Kleinberger JW,Salim FG,Troxell R,Wills R,Tanwir M,Casinelli G,Cox AE,Takane KK,Scott DK,Stewart AF

更新日期：2013-07-01 00:00:00

abstract：:Specific allelic associations vary among ethnic groups. We studied the distribution of HLA-A,-B,-C, and -DR antigens in 34 Japanese juvenile-onset diabetic patients. The focus of our current work was HLS-DR antigens because there have been few studies of Japanese with this disease. A significant increase in the freque...

journal_title：Diabetes

authors： Sakurami T,Ueno Y,Nagaoka K,Kuno S,Iwaki Y,Park MS,Terasaki PI

更新日期：1982-02-01 00:00:00

abstract：:Beiging of white adipose tissue has potential antiobesity and antidiabetes effects, yet the underlying signaling mechanisms remain to be fully elucidated. Here we show that adipose-specific knockout of Rheb, an upstream activator of mechanistic target of rapamycin complex 1 (mTORC1), protects mice from high-fat diet-i...

journal_title：Diabetes

authors： Meng W,Liang X,Chen H,Luo H,Bai J,Li G,Zhang Q,Xiao T,He S,Zhang Y,Xu Z,Xiao B,Liu M,Hu F,Liu F

更新日期：2017-05-01 00:00:00

abstract：:The ATP-sensitive K(+) channel (K(ATP) channel) in pancreatic beta-cells is a critical regulator in insulin secretion. We previously reported that transgenic mice expressing a dominant-negative form (Kir6.2G132S) of Kir6.2, a subunit of the K(ATP) channel, specifically in beta-cells develop severe hyperglycemia in adu...

journal_title：Diabetes

authors： Oyama K,Minami K,Ishizaki K,Fuse M,Miki T,Seino S

更新日期：2006-07-01 00:00:00

abstract：:The clinical features of the experimental hyperosmolar diabetic (EHD) rat model resemble those seen in the human syndrome--extreme hyperglycemia without ketoacidosis is common to both. The absence of ketoacidosis in the syndrome has been ascribed to both substrate (free fatty acid) deficiency and to interference with ...

journal_title：Diabetes

authors： Gordon EE,Duga J

更新日期：1975-03-01 00:00:00

abstract：:In humans, the glucagon response to moderate-to-marked insulin-induced hypoglycemia (IIH) is largely mediated by the autonomic nervous system. Because this glucagon response is impaired early in type 1 diabetes, we sought to determine if these patients, like animal models of autoimmune diabetes, have an early and seve...

journal_title：Diabetes

authors： Mundinger TO,Mei Q,Foulis AK,Fligner CL,Hull RL,Taborsky GJ Jr

更新日期：2016-08-01 00:00:00

abstract：:Although hyperhomocysteinemia, an independent cardiovascular risk factor, is common in type 2 diabetes with nephropathy, the mechanism(s) of this alteration is not known. In healthy humans, hyperinsulinemia increases methionine transmethylation, homocysteine transsulfuration, and clearance. No such data exist in type ...

journal_title：Diabetes

authors： Tessari P,Coracina A,Kiwanuka E,Vedovato M,Vettore M,Valerio A,Zaramella M,Garibotto G

更新日期：2005-10-01 00:00:00

abstract：:This article is divided into two parts. A retrospective overview summarizes some of the work that provided the framework and tools of the more recent studies. The five novel areas of research are related to the indirect effects of insulin. Regulation of plasma glucose is of central importance in health and diabetes. U...

journal_title：Diabetes

authors： Vranic M

更新日期：1992-09-01 00:00:00

abstract：OBJECTIVE:Physical inactivity is a risk factor for type 2 diabetes and may be more detrimental in first-degree relative (FDR) subjects, unmasking underlying defects of metabolism. Using a positive family history of type 2 diabetes as a marker of increased genetic risk, the aim of this study was to investigate the impac...

journal_title：Diabetes

authors： Højbjerre L,Sonne MP,Alibegovic AC,Dela F,Vaag A,Meldgaard JB,Christensen KB,Stallknecht B

更新日期：2010-11-01 00:00:00

abstract：:Secondary hyperlipidemia is a major cardiovascular risk factor in individuals with type 2 diabetes. Increased hepatic production of apolipoprotein B (apoB)-containing lipoproteins contributes to the elevated plasma levels, but the mechanism is poorly understood. Recent results have established that microsomal triglyce...

journal_title：Diabetes

authors： Bartels ED,Lauritsen M,Nielsen LB

更新日期：2002-04-01 00:00:00

abstract：:Growing evidence suggests that epigenetic profile changes occurring during fetal development in response to in utero environment variations could be one of the mechanisms involved in the early determinants of adult chronic diseases. In this study, we tested whether maternal glycemic status is associated with the adipo...

journal_title：Diabetes

authors： Bouchard L,Hivert MF,Guay SP,St-Pierre J,Perron P,Brisson D

更新日期：2012-05-01 00:00:00

abstract：:In adult humans, insulin resistance is associated with relatively low proportions of polyunsaturated fatty acids (PUFAs) in muscle membrane structural lipid. The aim of the present study was to determine the relationship between young children's muscle membrane fatty acid (FA) composition and indices of insulin resist...

journal_title：Diabetes

authors： Baur LA,O'Connor J,Pan DA,Storlien LH

更新日期：1999-01-01 00:00:00

abstract：:Human fetal pancreatic glands were obtained from 12 consecutive prostaglandin-induced abortions. Explants cultured for 1 day were frozen at 0.3 degree C/min in a 1 M DMSO-containing medium and stored at -196 degrees C. After storage for 3-4 mo the frozen material was rapidly thawed and cultured 1 day before being test...

journal_title：Diabetes

authors： Sandler S,Andersson A,Hellerström C,Petersson B,Swenne I,Björkén C,Groth CG

更新日期：1982-03-01 00:00:00

abstract：:Impaired wound healing is one of the main causes of diabetic foot ulcerations. However, the exact mechanism of delayed wound healing in diabetes is not fully understood. Long noncoding RNAs (lncRNAs) are widely involved in a variety of biological processes and diseases, including diabetes and its associated complicati...

journal_title：Diabetes

authors： Hu M,Wu Y,Yang C,Wang X,Wang W,Zhou L,Zeng T,Zhou J,Wang C,Lao G,Yan L,Ren M

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:Short sleep duration is associated with impaired glucose tolerance and an increased risk of diabetes. The effects of sleep restriction on insulin sensitivity have not been established. This study tests the hypothesis that decreasing nighttime sleep duration reduces insulin sensitivity and assesses the effects...

journal_title：Diabetes

authors： Buxton OM,Pavlova M,Reid EW,Wang W,Simonson DC,Adler GK

更新日期：2010-09-01 00:00:00

abstract：:To assess the relationship between beta-cell function and the level and duration of hyperglycemia during generalized beta-cell impairment, we studied the effects of acute and prolonged infusion of somatostatin in seven normal men. Twenty minutes after beginning an acute infusion of somatostatin (200 microgram/h) plus ...

journal_title：Diabetes

authors： Ward WK,Halter JB,Best JD,Beard JC,Porte D Jr

更新日期：1983-10-01 00:00:00

abstract：:We studied the functional consequences of an enhanced polyol pathway activity, elicited with galactose feeding, on the peripheral nerve of transgenic mice expressing human aldose reductase. Nontransgenic littermate mice were used as controls. With a quantitative immunoassay, the expression level of human aldose reduct...

journal_title：Diabetes

authors： Yagihashi S,Yamagishi S,Wada R,Sugimoto K,Baba M,Wong HG,Fujimoto J,Nishimura C,Kokai Y

更新日期：1996-01-01 00:00:00

abstract：:The TaqIB cholesteryl ester transfer protein (CETP) gene polymorphism (B1B2) is a determinant of HDL cholesterol in nondiabetic populations. Remarkably, this gene effect appears to be modified by environmental factors. We evaluated the effect of this polymorphism on HDL cholesterol levels and on the lipoprotein respon...

journal_title：Diabetes

authors： Dullaart RP,Hoogenberg K,Riemens SC,Groener JE,van Tol A,Sluiter WJ,Stulp BK

更新日期：1997-12-01 00:00:00

abstract：:Glucose homeostasis, a defining characteristic of physiological glucose metabolism, is the result of complex feedback relationships with both genetic and environmental determinants that influence insulin sensitivity and beta-cell function. Relatively little is known about the genetic basis of glucose homeostasis pheno...

journal_title：Diabetes

authors： Palmer ND,Langefeld CD,Campbell JK,Williams AH,Saad M,Norris JM,Haffner SM,Rotter JI,Wagenknecht LE,Bergman RN,Rich SS,Bowden DW

更新日期：2006-04-01 00:00:00

abstract：:Diabetic states are characterized by a raised serum/islet level of triglycerides and a lowered EC50 (concentration at half-maximal stimulation) for glucose-induced insulin secretion. Culturing islets with long-chain fatty acids (FAs) replicates the basal insulin hypersecretion. In a previous study, we showed that the ...

journal_title：Diabetes

authors： Liu YQ,Tornheim K,Leahy JL

更新日期：1998-12-01 00:00:00

abstract：:Net hepatic glucose uptake (NHGU) is an important contributor to postprandial glycemic control. We hypothesized that NHGU is reduced during normal pregnancy and in a pregnant diet-induced model of impaired glucose intolerance/gestational diabetes mellitus (IGT/GDM). Dogs (n = 7 per group) that were nonpregnant (N), no...

journal_title：Diabetes

authors： Coate KC,Smith MS,Shiota M,Irimia JM,Roach PJ,Farmer B,Williams PE,Moore MC

更新日期：2013-03-01 00:00:00

abstract：:Mitochondrial injury is uniformly observed in several murine models as well as in individuals with diabetic kidney disease (DKD). Although emerging evidence has highlighted the role of key transcriptional regulators in mitochondrial biogenesis, little is known about the regulation of mitochondrial cytochrome c oxidase...

journal_title：Diabetes

authors： Horne SJ,Vasquez JM,Guo Y,Ly V,Piret SE,Leonardo AR,Ling J,Revelo MP,Bogenhagen D,Yang VW,He JC,Mallipattu SK

更新日期：2018-11-01 00:00:00

abstract：:To explain the contradictory data on the secretion of prostacyclin (PGI2) in clinical and experimental diabetes, we have investigated the effect of each of the major metabolic abnormalities in uncontrolled diabetes on vascular PGI2 synthesis. An increase in fatty acid concentrations caused a dose-dependent inhibition ...

journal_title：Diabetes

authors： Jeremy JY,Mikhailidis DP,Dandona P

更新日期：1983-03-01 00:00:00

abstract：:Development of beta-cell lines for cell therapy of diabetes is hindered by functional deviations of the replicating cells from the normal beta-cell phenotype. In a recently developed cell line, denoted betaTC-tet, derived from transgenic mice expressing the SV40 T antigen (Tag) under control of the tetracycline (Tc) g...

journal_title：Diabetes

authors： Fleischer N,Chen C,Surana M,Leiser M,Rossetti L,Pralong W,Efrat S

更新日期：1998-09-01 00:00:00

abstract：:Hypothalamic glucose sensing is involved in the control of feeding behavior and peripheral glucose homeostasis, and glial cells are suggested to play an important role in this process. Diazepam-binding inhibitor (DBI) and its processing product the octadecaneuropeptide (ODN), collectively named endozepines, are secret...

journal_title：Diabetes

authors： Lanfray D,Arthaud S,Ouellet J,Compère V,Do Rego JL,Leprince J,Lefranc B,Castel H,Bouchard C,Monge-Roffarello B,Richard D,Pelletier G,Vaudry H,Tonon MC,Morin F

更新日期：2013-03-01 00:00:00

abstract：:Decreased retinal blood flow has been measured in streptozotocin (STZ)-induced diabetes of 1 week's duration, and primary insulin intervention was effective in maintaining normal retinal blood flow in diabetic rats. Retinal blood-flow abnormalities precede clinical diabetic retinopathy in both diabetic animals and pat...

journal_title：Diabetes

authors： Higashi S,Clermont AC,Dhir V,Bursell SE

更新日期：1998-04-01 00:00:00