Abstract:
:Specific binding of [3H]SCH 23390 to dopamine D1 receptors in the striatum and olfactory tubercle in 14-day alloxan-induced diabetic rats was investigated. The Scatchard analysis revealed decreased D1 receptor density in the striatum (Bmax values were 548 +/- 23 fmol/mg protein for the control and 466 +/- 33 fmol/mg for the diabetic rats). No change was observed in the olfactory tubercle (Bmax; 299 +/- 27 fmol/mg for the control and 317 +/- 32 fmol/mg for the diabetic rats). Thus, specific binding of [3H]SCH 23390 to striatal and olfactory tubercle membranes showed region-specific changes of brain dopamine D1 receptors in alloxan diabetic rats.
journal_name
Diabetesjournal_title
Diabetesauthors
Salković M,Lacković Zdoi
10.2337/diab.41.9.1119subject
Has Abstractpub_date
1992-09-01 00:00:00pages
1119-21issue
9eissn
0012-1797issn
1939-327Xjournal_volume
41pub_type
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