Liver-specific loss of lipolysis-stimulated lipoprotein receptor triggers systemic hyperlipidemia in mice.

abstract：:beta-Cell cycle progression and proliferation are critical to maintain beta-cell mass in adult mice. Of the cell cycle inhibitors, p27Kip1 is thought to be the primary modulator of the proliferative status in most cell types. p27 plays a role in beta-cell adaptation in genetic models of insulin resistance. To study th...

journal_title：Diabetes

authors： Rachdi L,Balcazar N,Elghazi L,Barker DJ,Krits I,Kiyokawa H,Bernal-Mizrachi E

更新日期：2006-12-01 00:00:00

abstract：:Dysfunctional T cells can mediate autoimmunity, but the inaccessibility of autoimmune tissues and the rarity of autoimmune T cells in the blood hinder their study. We describe a method to enrich and harvest autoimmune T cells in vivo by using a biomaterial scaffold loaded with protein antigens. In model antigen system...

journal_title：Diabetes

authors： Thelin MA,Kissler S,Vigneault F,Watters AL,White D,Koshy ST,Vermillion SA,Mooney DJ,Serwold T,Ali OA

更新日期：2017-08-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) is a transcriptional coactivator implicated in transcriptional programs of hepatic gluconeogenesis, oxidative phosphorylation, and insulin release by beta-cells. To study associations of the PGC-1alpha gene locus with carbohydrate metabolism an...

journal_title：Diabetes

authors： Oberkofler H,Linnemayr V,Weitgasser R,Klein K,Xie M,Iglseder B,Krempler F,Paulweber B,Patsch W

更新日期：2004-05-01 00:00:00

abstract：:Growth medium containing serum from young diabetic subjects caused a significant stimulation both of cell proliferation and of the outgrowth in cultures of rabbit aortic medial cells above that noted with normal human sera. The addition to the sera of guinea-pig human growth hormones antibody caused a marked inhibitio...

journal_title：Diabetes

authors： Ledet T

更新日期：1977-08-01 00:00:00

abstract：:Although epinephrine stimulates insulin release by activation of beta-adrenergic receptors, its dominant effect (mediated by stimulation of alpha-adrenergic receptors) is an inhibition of insulin secretion that is powerful enough to suppress the secretory activity of insulin's most potent stimulants. The insulin-secre...

journal_title：Diabetes

authors： Hiatt N,Davidson MB,Chapman LW,Sheinkopf JA

更新日期：1978-05-01 00:00:00

abstract：:Inhibition of glucose-stimulated insulin release by exogenous insulin has been demonstrated in pancreatic islets to be associated with a decrease of the NADPH/NADP ratio and the pentose-phosphate cycle activity. Batches of five islets were incubated for 15 and 90 minutes in 1 ml. of KRB buffer with 2 per cent albumin ...

journal_title：Diabetes

authors： Akhtar MS,Verspohl E,Hegner D,Ammon HP

更新日期：1977-09-01 00:00:00

abstract：OBJECTIVE:Glucagon-like peptide-1 (GLP-1) is a growth and differentiation factor for mature beta-cells and their precursors. However, the overall effect of GLP-1 on increasing beta-cell mass in both in vivo and in vitro conditions is relatively small, and augmenting this effect would be beneficial for the treatment or ...

journal_title：Diabetes

authors： Klinger S,Poussin C,Debril MB,Dolci W,Halban PA,Thorens B

更新日期：2008-03-01 00:00:00

abstract：:Association studies are a potentially powerful approach to identifying susceptibility variants for common multifactorial diseases such as type 1 diabetes, but the results are not always consistently reproducible. The IDDM5 locus has recently been narrowed to an approximately 200-kb interval on chromosome 6q25 by two i...

journal_title：Diabetes

authors： Noso S,Ikegami H,Fujisawa T,Kawabata Y,Asano K,Hiromine Y,Tsurumaru M,Sugihara S,Lee I,Kawasaki E,Awata T,Ogihara T

更新日期：2005-12-01 00:00:00

abstract：:Insulin-dependent diabetes mellitus (IDDM) involves the destruction of the insulin-producing cells in the islets of Langerhans. One possible cure is by transplanting the islet cells; however, transplanted islets, even between identical twins, are subject to autoimmune destruction by the disease process, resulting in d...

journal_title：Diabetes

authors： Wang T,Singh B,Warnock GL,Rajotte RV

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the extent of pancreatic β-cell function in a large number of insulin-dependent diabetic patients with a disease duration of 50 years or longer (Medalists). RESEARCH DESIGN AND METHODS:Characterization of clinical and biochemical parameters and β-cell function of 411 Medalists with correlation wi...

journal_title：Diabetes

authors： Keenan HA,Sun JK,Levine J,Doria A,Aiello LP,Eisenbarth G,Bonner-Weir S,King GL

更新日期：2010-11-01 00:00:00

abstract：:Diabetes diagnostic therapy and research would strongly benefit from noninvasive accurate imaging of the functional β-cells in the pancreas. Here, we developed an analysis of functional β-cell mass (BCM) by measuring manganese (Mn(2+)) uptake kinetics into glucose-stimulated β-cells by T1-weighted in vivo Mn(2+)-media...

journal_title：Diabetes

authors： Meyer A,Stolz K,Dreher W,Bergemann J,Holebasavanahalli Thimmashetty V,Lueschen N,Azizi Z,Khobragade V,Maedler K,Kuestermann E

更新日期：2015-06-01 00:00:00

abstract：:Bariatric surgery has proven to be the most effective treatment for controlling hyperglycemia in severely obese patients with diabetes. We show that fibroblast growth factor 19 (FGF19), a gut hormone, is rapidly induced by bariatric surgery in rodents and humans. Administration of FGF19 achieves diabetes remission ind...

journal_title：Diabetes

authors： DePaoli AM,Zhou M,Kaplan DD,Hunt SC,Adams TD,Learned RM,Tian H,Ling L

更新日期：2019-06-01 00:00:00

abstract：:The kinin B1 receptor (B1R) plays a role in inflammatory and metabolic processes. B1R deletion (B1-/-) protects mice from diet-induced obesity and improves insulin and leptin sensitivity. In contrast, genetic reconstitution of B1R exclusively in adipose tissue reverses the lean phenotype of B1-/- mice. To study the ce...

journal_title：Diabetes

authors： Sales VM,Gonçalves-Zillo T,Castoldi A,Burgos M,Branquinho J,Batista C,Oliveira V,Silva E,Castro CHM,Câmara N,Mori MA,Pesquero JB

更新日期：2019-08-01 00:00:00

abstract：:The TaqIB cholesteryl ester transfer protein (CETP) gene polymorphism (B1B2) is a determinant of HDL cholesterol in nondiabetic populations. Remarkably, this gene effect appears to be modified by environmental factors. We evaluated the effect of this polymorphism on HDL cholesterol levels and on the lipoprotein respon...

journal_title：Diabetes

authors： Dullaart RP,Hoogenberg K,Riemens SC,Groener JE,van Tol A,Sluiter WJ,Stulp BK

更新日期：1997-12-01 00:00:00

abstract：:Plasma glucagon response to glucose in diabetic subjects was observed before and after treatment. In normal subjects, plasma glucagon concentrations decreased substantially after an oral glucose load. In all diabetic patients before treatment, plasma glucagon was not suppressed and rather tended to rise paradoxically ...

journal_title：Diabetes

authors： Seino Y,Ikeda M,Kurahachi H,Taminato T,Sakurai H,Goto Y,Inoue Y,Kadowaki S,Mori K,Imura H

更新日期：1978-12-01 00:00:00

abstract：:The macro- and microvascular burden of type 2 diabetes is well established. A number of recent single risk factor intervention trials targeting hyperglycemia, dyslipidemia, hypertension, procoagulation, microalbumuria, and existing cardiovascular disorders have, however, shown major beneficial effects on long-term out...

journal_title：Diabetes

authors： Gaede P,Pedersen O

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVE:The aim of this analysis was to assess the prospective association of serum testosterone and dehydroepiandrosterone sulfate (DHEAS) levels with incident metabolic syndrome (MetS) in men. RESEARCH DESIGN AND METHODS:Data were obtained from the Study of Health in Pomerania (SHIP), a population-based prospectiv...

journal_title：Diabetes

authors： Haring R,Völzke H,Felix SB,Schipf S,Dörr M,Rosskopf D,Nauck M,Schöfl C,Wallaschofski H

更新日期：2009-09-01 00:00:00

abstract：:The significance of the portohepatic glucosensors for counterregulation in deep hypoglycemia (i.e., glycemia < 2.8 mM) was studied in chronically cannulated male mongrel dogs in the conscious state. A total of 16 experiments were carried out on 6 dogs using the liver clamp technique under hyperinsulinemic conditions (...

journal_title：Diabetes

authors： Hamilton-Wessler M,Bergman RN,Halter JB,Watanabe RM,Donovan CM

更新日期：1994-08-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are a group of signaling molecules that belong to the TGF-β superfamily. Initially discovered for their ability to induce bone formation, BMPs are known to play a diverse and critical array of biological roles. We here focus on recent evidence showing that BMP4 is an important regula...

journal_title：Diabetes

authors： Baboota RK,Blüher M,Smith U

更新日期：2021-02-01 00:00:00

abstract：:Type 2 diabetes is characterized by increased plasma triglyceride levels and a fourfold increase in ischemic heart disease, but the mechanism is unclear. CD36 is a receptor/transporter that binds fatty acids of lipoproteins. CD36 deficiency has been linked with insulin resistance. There is strong evidence of in vivo i...

journal_title：Diabetes

authors： Englyst NA,Taube JM,Aitman TJ,Baglin TP,Byrne CD

更新日期：2003-05-01 00:00:00

abstract：OBJECTIVE:Epidemiological and family studies have demonstrated that susceptibility genes play an important role in the etiology of diabetic nephropathy, defined as persistent proteinuria or end-stage renal disease (ESRD) in type 1 diabetes. RESEARCH DESIGN AND METHODS:To efficiently search for genomic regions harborin...

journal_title：Diabetes

authors： Rogus JJ,Poznik GD,Pezzolesi MG,Smiles AM,Dunn J,Walker W,Wanic K,Moczulski D,Canani L,Araki S,Makita Y,Warram JH,Krolewski AS

更新日期：2008-09-01 00:00:00

abstract：:Obesity is usually associated with an increased risk of nonalcoholic fatty liver disease that is characterized by accumulation of excessive triglyceride (TG) in hepatocytes. However, the factors involved in the obesity-induced hepatosteatosis are poorly defined. Here, we report that SRY-box containing gene 4 (Sox4), a...

journal_title：Diabetes

authors： Jiao Y,Zhao J,Zhang Z,Li M,Yu X,Yang Y,Liu J,Liao S,Li D,Wang Y,Zhang D,Chen Y,Shi G,Liu B,Lu Y,Li X

更新日期：2018-11-01 00:00:00

abstract：:Prophylactic insulin can prevent diabetes in the BB rat. We evaluated its use to prevent adoptive transfer of diabetes by activated splenocytes. ConA-activated spleen cells from acutely diabetic BB rats were divided into two equal aliquots and injected intravenously in paired diabetes-prone BB rat littermates. At the ...

journal_title：Diabetes

authors： Bertrand S,De Paepe M,Vigeant C,Yale JF

更新日期：1992-10-01 00:00:00

abstract：:Three hundred and seventy-seven children and adolescents aged 5-17 yr from the biracial (black-white) community of Bogalusa, Louisiana, were evaluated for Tanner stage of sexual development, plasma glucose, and insulin levels during an oral glucose tolerance test. Children of the two races were of similar age, weight,...

journal_title：Diabetes

authors： Svec F,Nastasi K,Hilton C,Bao W,Srinivasan SR,Berenson GS

更新日期：1992-03-01 00:00:00

abstract：OBJECTIVE:Evaluate if Erb B2 activation and the loss of caveolin-1 (Cav1) contribute to the pathophysiological progression of diabetic peripheral neuropathy (DPN). RESEARCH DESIGN AND METHODS:Cav1 knockout and wild-type C57BL/6 mice were rendered diabetic with streptozotocin, and changes in motor nerve conduction velo...

journal_title：Diabetes

authors： McGuire JF,Rouen S,Siegfreid E,Wright DE,Dobrowsky RT

更新日期：2009-11-01 00:00:00

abstract：:OKT3 has emerged as a highly effective antirejection therapy, but its efficacy in pancreas transplantation remains to be determined. During a 26-mo period, 46 vascularized pancreas transplants were performed with pancreaticoduodenocystostomy. Twenty-one patients (45.7%) were treated with OKT3. Indications for OKT3 use...

journal_title：Diabetes

authors： Stratta RJ,Sollinger HW,D'Alessandro AM,Pirsch JD,Kalayoglu M,Belzer FO

更新日期：1989-01-01 00:00:00

abstract：:Diabetes is associated with loss of functional pancreatic β-cells, and restoration of β-cells is a major goal for regenerative therapies. Endogenous regeneration of β-cells via β-cell replication has the potential to restore cellular mass; however, pharmacological agents that promote regeneration or expansion of endog...

journal_title：Diabetes

authors： Dhawan S,Dirice E,Kulkarni RN,Bhushan A

更新日期：2016-05-01 00:00:00

abstract：:Immune modulation of pancreatic inflammation induces recovery from type 1 diabetes (T1D), but remission was not durable, perhaps because of an inability to sustain the formation and function of new pancreatic β-cells. We have previously shown that Ig-GAD2, carrying GAD 206-220 peptide, induced in hyperglycemic mice im...

journal_title：Diabetes

authors： Wan X,Guloglu FB,Vanmorlan AM,Rowland LM,Zaghouani S,Cascio JA,Dhakal M,Hoeman CM,Zaghouani H

更新日期：2013-08-01 00:00:00

abstract：:Decreased uncoupling protein (UCP)3 is associated with insulin resistance in muscle of pre-diabetic and diabetic individuals, but the function of UCP3 remains unclear. Our goal was to elucidate mechanisms underlying the negative correlation between UCP3 and insulin resistance in muscle. We determined effects of physio...

journal_title：Diabetes

authors： MacLellan JD,Gerrits MF,Gowing A,Smith PJ,Wheeler MB,Harper ME

更新日期：2005-08-01 00:00:00

abstract：:Glucagonlike peptide I (7-37) [GLP-I-(7-37)], encoded with glucagon and glucagonlike peptide II and intervening peptide II in the rat and human glucagon gene, is processed from proglucagon in both pancreas and intestine and is a potent stimulator of insulin secretion. Unequivocal insulin release from the isolated perf...

journal_title：Diabetes

authors： Weir GC,Mojsov S,Hendrick GK,Habener JF

更新日期：1989-03-01 00:00:00