Diabetic patients without vascular complications display enhanced basal platelet activation and decreased antioxidant status.

abstract：:Women with polycystic ovary syndrome (PCOS) have been shown to be less insulin sensitive compared with control (CON) women, independent of BMI. Training is associated with molecular adaptations in skeletal muscle, improving glucose uptake and metabolism in both healthy individuals and patients with type 2 diabetes. In...

journal_title：Diabetes

authors： Hansen SL,Bojsen-Møller KN,Lundsgaard AM,Hendrich FL,Nilas L,Sjøberg KA,Hingst JR,Serup AK,Olguín CH,Carl CS,Wernblad LF,Henneberg M,Lustrup KM,Hansen C,Jensen TE,Madsbad S,Wojtaszewski JFP,Richter EA,Kiens B

更新日期：2020-11-01 00:00:00

abstract：:Pancreatic beta-cell survival is critical in the setting of diabetes as well as in islet transplantation. Transgenic mice overexpressing parathyroid hormone-related protein (PTHrP) targeted to beta-cells using the rat insulin II promoter (RIP) display hyperinsulinemia, hypoglycemia, and islet hyperplasia, without a co...

journal_title：Diabetes

authors： Cebrian A,García-Ocaña A,Takane KK,Sipula D,Stewart AF,Vasavada RC

更新日期：2002-10-01 00:00:00

abstract：:Optimal immune-based therapies for type 1 diabetes (T1D) should restore self-tolerance without inducing chronic immunosuppression. CD4+Foxp3+ regulatory T cells (Tregs) are a key cell population capable of facilitating durable immune tolerance. However, clinical trials with expanded Tregs in T1D and solid-organ transp...

journal_title：Diabetes

authors： Cabello-Kindelan C,Mackey S,Sands A,Rodriguez J,Vazquez C,Pugliese A,Bayer AL

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:Vaspin was identified as an adipokine with insulin-sensitizing effects, which is predominantly secreted from visceral adipose tissue in a rat model of type 2 diabetes. We have recently shown that vaspin mRNA expression in adipose tissue is related to parameters of obesity and glucose metabolism. However, the ...

journal_title：Diabetes

authors： Youn BS,Klöting N,Kratzsch J,Lee N,Park JW,Song ES,Ruschke K,Oberbach A,Fasshauer M,Stumvoll M,Blüher M

更新日期：2008-02-01 00:00:00

abstract：:To investigate the temporal relationship of diabetes-induced renal growth and its associated metabolic alterations to the early development of renal hyperfunction, parallel functional and metabolic studies were performed shortly after the onset of diabetes in rats. Hyperglycemia and hypoinsulinemia were evident 18 h a...

journal_title：Diabetes

authors： Cortes P,Dumler F,Goldman J,Levin NW

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:The proinflammatory cytokines/adipokines produced from adipose tissue act in an autocrine and/or endocrine manner to perpetuate local inflammation and to induce peripheral insulin resistance. The present study investigates whether lipocalin-2 deficiency or replenishment with this adipokine has any impact on s...

journal_title：Diabetes

authors： Law IK,Xu A,Lam KS,Berger T,Mak TW,Vanhoutte PM,Liu JT,Sweeney G,Zhou M,Yang B,Wang Y

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVE:Exercise is an important strategy for the treatment of type 2 diabetes. This is due in part to an increase in glucose transport that occurs in the working skeletal muscles. Glucose transport is regulated by GLUT4 translocation in muscle, but the molecular machinery mediating this process is poorly understood....

journal_title：Diabetes

authors： Lauritzen HP,Galbo H,Toyoda T,Goodyear LJ

更新日期：2010-09-01 00:00:00

abstract：:Obesity is a strong risk factor for the development of type 2 diabetes. We have previously reported that in adipose tissue of obese (ob/ob) mice, the expression of adipogenic genes is decreased. When made genetically obese, the BTBR mouse strain is diabetes susceptible and the C57BL/6J (B6) strain is diabetes resistan...

journal_title：Diabetes

authors： Lan H,Rabaglia ME,Stoehr JP,Nadler ST,Schueler KL,Zou F,Yandell BS,Attie AD

更新日期：2003-03-01 00:00:00

abstract：:Endothelinlike immunoreactivity was detected by radioimmunoassay in medium conditioned by cultured endothelial cells obtained from bovine retinal microvessels (9.2 +/- 6.5 pM, n = 4). Sephadex G-25 column chromatography and fast-protein liquid chromatography revealed that most of the endothelinlike immunoreactivity wa...

journal_title：Diabetes

authors： Takahashi K,Brooks RA,Kanse SM,Ghatei MA,Kohner EM,Bloom SR

更新日期：1989-09-01 00:00:00

abstract：:We investigated the effects of non-insulin-dependent diabetes mellitus (NIDDM) on lipoprotein(a) (Lp[a]) and apolipoprotein(a) (apo[a]) in a population of Mexican-Americans. In plasma samples from 536 subjects, we measured Lp(a) concentrations, and we estimated apo(a) isoform sizes following immunostaining of plasma p...

journal_title：Diabetes

authors： Rainwater DL,MacCluer JW,Stern MP,VandeBerg JL,Haffner SM

更新日期：1994-07-01 00:00:00

abstract：OBJECTIVE:The involvement of proangiogenic factors such as vascular endothelial growth factor as well as the therapeutic efficacy of angiogenesis inhibitors in early diabetic nephropathy has been reported. Vasohibin-1 (VASH-1) is a unique endogenous angiogenesis inhibitor that is induced in endothelial cells by proangi...

journal_title：Diabetes

authors： Nasu T,Maeshima Y,Kinomura M,Hirokoshi-Kawahara K,Tanabe K,Sugiyama H,Sonoda H,Sato Y,Makino H

更新日期：2009-10-01 00:00:00

abstract：:The plasma concentration of 1,5-anhydro-D-glucitol (AG) was measured in 135 newly diagnosed patients who were referred for oral glucose tolerance tests. AG concentrations in the nondiabetic patients indicated that the mean value of normal AG concentration was 21.8 micrograms/ml (SD = 5.9 micrograms/ml, range 9.6-38.8 ...

journal_title：Diabetes

authors： Yamanouchi T,Akanuma H,Asano T,Konishi C,Akaoka I,Akanuma Y

更新日期：1987-06-01 00:00:00

abstract：OBJECTIVE:To characterize normal and malformed embryos within the same litters from control and diabetic rats for expression of genes related to metabolism of reactive oxygen species (ROS) or glucose as well as developmental genes. RESEARCH DESIGN AND METHODS:Embryos from nondiabetic and streptozotocin-induced diabeti...

journal_title：Diabetes

authors： Wentzel P,Gäreskog M,Eriksson UJ

更新日期：2008-12-01 00:00:00

abstract：:Under diabetic conditions, the Maillard reaction facilitates the production of reactive oxygen species, and the activity of antioxidant enzymes such as Cu,Zn-superoxide dismutase is decreased, resulting in a remarkable increase of oxidative stress. The oxidative stress attacks DNA, lipids, and proteins and is also tho...

journal_title：Diabetes

authors： Taniguchi N,Kaneto H,Asahi M,Takahashi M,Wenyi C,Higashiyama S,Fujii J,Suzuki K,Kayanoki Y

更新日期：1996-07-01 00:00:00

abstract：:Many common genetic polymorphisms are associated with glycemic traits and type 2 diabetes (T2D), but knowledge about genetic determinants of glycemic traits in pregnancy is limited. We tested genetic variants known to be associated with glycemic traits and T2D in the general population for associations with glycemic t...

journal_title：Diabetes

authors： Powe CE,Nodzenski M,Talbot O,Allard C,Briggs C,Leya MV,Perron P,Bouchard L,Florez JC,Scholtens DM,Lowe WL Jr,Hivert MF

更新日期：2018-12-01 00:00:00

abstract：:Insulin-dependent diabetes mellitus (IDDM) involves the destruction of the insulin-producing cells in the islets of Langerhans. One possible cure is by transplanting the islet cells; however, transplanted islets, even between identical twins, are subject to autoimmune destruction by the disease process, resulting in d...

journal_title：Diabetes

authors： Wang T,Singh B,Warnock GL,Rajotte RV

更新日期：1992-01-01 00:00:00

abstract：:Large glucagon immunoreactive substances, extracted from the fetal bovine pancreas and separated by gel filtration in the presence of 6 M guanidinium-hydrochloride, were submitted to lectin-sepharose affinity column chromatograph. Gel-filtered peak I (approximately 45 K delta) and peak II (approximately 10 K delta) in...

journal_title：Diabetes

authors： Tung AK,Cockburn E,Siu KP

更新日期：1982-11-01 00:00:00

abstract：:Hepatocyte nuclear factor 4alpha (HNF4A), the gene for the maturity-onset diabetes of the young type 1 monogenic form of type 2 diabetes, is within the type 2 diabetes-linked region on chromosome 20q12-q13.1 and, consequently, is a positional candidate gene for type 2 diabetes in the general population. Previous studi...

journal_title：Diabetes

authors： Bagwell AM,Bento JL,Mychaleckyj JC,Freedman BI,Langefeld CD,Bowden DW

更新日期：2005-04-01 00:00:00

abstract：:Transracial analysis provides a method of distinguishing primary associations between insulin-dependent diabetes mellitus (IDDM) and HLA class II alleles from those secondary to linkage disequilibrium. Blacks show DR-DQ relationships that are different from other races and are a useful group in which to investigate HL...

journal_title：Diabetes

authors： Mijovic CH,Jenkins D,Jacobs KH,Penny MA,Fletcher JA,Barnett AH

更新日期：1991-06-01 00:00:00

abstract：:The antidiabetic thiazolidinediones, which include troglitazone and rosiglitazone, are ligands for the nuclear receptor peroxisome proliferator-activated receptor (PPAR)-gamma and exert their antihyperglycemic effects by regulation of PPAR-gamma-responsive genes. We report here that PPAR-gamma activation by troglitazo...

journal_title：Diabetes

authors： Camp HS,Li O,Wise SC,Hong YH,Frankowski CL,Shen X,Vanbogelen R,Leff T

更新日期：2000-04-01 00:00:00

abstract：:Exosomes are important for intercellular communication, but the role of exosomes in the communication between adipose tissue (AT) and the liver remains unknown. The aim of this study is to determine the contribution of AT-derived exosomes in nonalcoholic fatty liver disease (NAFLD). Exosome components, liver fat conte...

journal_title：Diabetes

authors： Yan C,Tian X,Li J,Liu D,Ye D,Xie Z,Han Y,Zou MH

更新日期：2021-02-01 00:00:00

abstract：:Peripheral somatic and autonomic nerve function have been studied in 79 teenage (16-19 yr) diabetics and 20 age- and sex-matched normal controls. Almost three-quarters of the diabetics (72%) had abnormal peripheral somatic nerve function tests, and one-third (31%) had abnormal cardiac parasympathetic tests. Both motor...

journal_title：Diabetes

authors： Young RJ,Ewing DJ,Clarke BF

更新日期：1983-02-01 00:00:00

abstract：:The relationship between plasma C-peptide and the frequency and severity of diabetic retinopathy was examined in a population-based study in Wisconsin in 1984-1986. Individuals with younger- (n = 835) and older- (n = 940) onset diabetes were included. C-peptide was measured by radioimmunoassay with Heding's M1230 anti...

journal_title：Diabetes

authors： Klein R,Moss SE,Klein BE,Davis MD,DeMets DL

更新日期：1990-11-01 00:00:00

abstract：:The glucose-phosphorylating enzyme glucokinase has structural, kinetic, and molecular genetic features that are ideal for its primary role as glucose sensor in a network of neuro/endocrine sentinel cells that maintain glucose homeostasis in many vertebrates including humans. The glucokinase-containing, insulin-produci...

journal_title：Diabetes

authors： Matschinsky FM,Magnuson MA,Zelent D,Jetton TL,Doliba N,Han Y,Taub R,Grimsby J

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:Insulin resistance and other features of the metabolic syndrome have been causally linked to adipose tissue macrophages (ATMs) in mice with diet-induced obesity. We aimed to characterize macrophage phenotype and function in human subcutaneous and omental adipose tissue in relation to insulin resistance in obe...

journal_title：Diabetes

authors： Wentworth JM,Naselli G,Brown WA,Doyle L,Phipson B,Smyth GK,Wabitsch M,O'Brien PE,Harrison LC

更新日期：2010-07-01 00:00:00

abstract：:NIDDM has a substantial genetic component, but the nature of the genetic susceptibility is largely unknown. Maturity-onset diabetes of the young (MODY) is a genetically heterogeneous monogenic form of NIDDM characterized by an early age of onset and autosomal dominant inheritance, and linkage studies have identified g...

journal_title：Diabetes

authors： Shaw JT,Lovelock PK,Kesting JB,Cardinal J,Duffy D,Wainwright B,Cameron DP

更新日期：1998-11-01 00:00:00

abstract：:The objective of the U.K. Prospective Diabetes Study is to determine whether improved blood glucose control in type II diabetes will prevent the complications of diabetes and whether any specific therapy is advantageous or disadvantageous. The study will report in 1998, when the median duration from randomization will...

journal_title：Diabetes

authors：

更新日期：1995-11-01 00:00:00

abstract：:Insulin resistance is of pathogenic importance in several common human disorders including type 2 diabetes, hypertension, obesity and hyperlipidemia, but the underlying mechanisms are unknown. The spontaneously hypertensive rat (SHR) is a model of these human insulin resistance syndromes. Quantitative trait loci (QTLs...

journal_title：Diabetes

authors： Collison M,Glazier AM,Graham D,Morton JJ,Dominiczak MH,Aitman TJ,Connell JM,Gould GW,Dominiczak AF

更新日期：2000-12-01 00:00:00

abstract：:Long before reaching diagnostic cutoff levels for type 2 diabetes, fasting glucose can be a powerful risk marker for this disease. We conducted a genome-wide search for fasting glucose as a quantitative trait in 412 young European sib-pairs including obese children, with adjustment for sex, age, and BMI. We identified...

journal_title：Diabetes

authors： Fradin D,Heath S,Lathrop M,Bougnères P

更新日期：2007-06-01 00:00:00

abstract：:Obesity is associated with an increased risk for the development of type 2 diabetes and vascular complications. Advanced glycation end products are increased in adipose tissue and have been associated with insulin resistance, vascular dysfunction, and inflammation of adipose tissue. Here, we report that delayed interv...

journal_title：Diabetes

authors： Maessen DE,Brouwers O,Gaens KH,Wouters K,Cleutjens JP,Janssen BJ,Miyata T,Stehouwer CD,Schalkwijk CG

更新日期：2016-04-01 00:00:00