Genetic studies of late diabetic complications: the overlooked importance of diabetes duration before complication onset.

abstract：:Increased abdominal obesity has been related to lower insulin sensitivity (SI), independent of overall obesity, but it has been suggested that this relationship may be weaker in non-whites. In the Insulin Resistance and Atherosclerosis Study (IRAS), SI was estimated using a minimal model analysis of the frequently sam...

journal_title：Diabetes

authors： Karter AJ,Mayer-Davis EJ,Selby JV,D'Agostino RB Jr,Haffner SM,Sholinsky P,Bergman R,Saad MF,Hamman RF

更新日期：1996-11-01 00:00:00

abstract：OBJECTIVE:Most pancreatic endocrine cells derive from Ptf1a-expressing progenitor cells. In humans, nonsense mutations in Ptf1a have recently been identified as a cause of permanent neonatal diabetes associated with pancreatic agenesis. The death of Ptf1a-null mice soon after birth has not allowed further insight into ...

journal_title：Diabetes

authors： Fukuda A,Kawaguchi Y,Furuyama K,Kodama S,Horiguchi M,Kuhara T,Kawaguchi M,Terao M,Doi R,Wright CV,Hoshino M,Chiba T,Uemoto S

更新日期：2008-09-01 00:00:00

abstract：:Insulin resistance associated with altered fat partitioning in liver and adipose tissues is a prediabetic condition in obese adolescents. We investigated interactions between glucose tolerance, insulin sensitivity, and the expression of lipogenic genes in abdominal subcutaneous adipose and liver tissue in 53 obese ado...

journal_title：Diabetes

authors： Kursawe R,Caprio S,Giannini C,Narayan D,Lin A,D'Adamo E,Shaw M,Pierpont B,Cushman SW,Shulman GI

更新日期：2013-03-01 00:00:00

abstract：:To examine the impact of diabetes and its treatment on plasma free-fatty acid (FFA) and oxidative fuel metabolism during hypoglycemia, we combined indirect calorimetry with [3-3H]glucose during a 4-h low-dose insulin infusion (plasma insulin approximately 2-fold above basal) in six poorly controlled and nine well-cont...

journal_title：Diabetes

authors： Caprio S,Amiel S,Tamborlane WV,Gelfand RA,Sherwin RS

更新日期：1990-02-01 00:00:00

abstract：:Mutations in the LMNA gene (encoding lamin A/C) underlie familial partial lipodystrophy, a syndrome of monogenic insulin resistance and diabetes. LMNA maps to the well-replicated diabetes-linkage region on chromosome 1q, and there are reported associations between LMNA single nucleotide polymorphisms (SNPs) (particula...

journal_title：Diabetes

authors： Owen KR,Groves CJ,Hanson RL,Knowler WC,Shuldiner AR,Elbein SC,Mitchell BD,Froguel P,Ng MC,Chan JC,Jia W,Deloukas P,Hitman GA,Walker M,Frayling TM,Hattersley AT,Zeggini E,McCarthy MI

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVE:Recent studies identified accumulation of reactive oxygen species (ROS) as a common pathway causing insulin resistance. However, whether and how the reduction of ROS levels improves insulin resistance remains to be elucidated. The present study was designed to define this mechanism. RESEARCH DESIGN AND METHO...

journal_title：Diabetes

authors： Kumashiro N,Tamura Y,Uchida T,Ogihara T,Fujitani Y,Hirose T,Mochizuki H,Kawamori R,Watada H

更新日期：2008-08-01 00:00:00

abstract：:Carbohydrate-responsive element-binding protein (ChREBP) is a glucose-sensing transcription factor required for glucose-stimulated proliferation of pancreatic β-cells in rodents and humans. The full-length isoform (ChREBPα) has a low glucose inhibitory domain (LID) that restrains the transactivation domain when glucos...

journal_title：Diabetes

authors： Zhang P,Kumar A,Katz LS,Li L,Paulynice M,Herman MA,Scott DK

更新日期：2015-12-01 00:00:00

abstract：:The mechanism of protection from type 1 diabetes conferred by regulatory T-cells induced by oral insulin treatment of NOD mice is not well understood. We demonstrate that oral insulin feeding of NOD mice induces the function of insulin B-chain reactive CD4+ regulatory T-cells, which compete with diabetogenic effector ...

journal_title：Diabetes

authors： Bergerot I,Arreaza GA,Cameron MJ,Burdick MD,Strieter RM,Chensue SW,Chakrabarti S,Delovitch TL

更新日期：1999-09-01 00:00:00

abstract：:Type 2 diabetes and skeletal muscle insulin resistance have been linked to accumulation of the intramyocellular lipid-intermediate diacylglycerol (DAG). However, recent animal and human studies have questioned such an association. Given that DAG appears in different stereoisomers and has different reactivity in vitro,...

journal_title：Diabetes

authors： Serup AK,Alsted TJ,Jordy AB,Schjerling P,Holm C,Kiens B

更新日期：2016-10-01 00:00:00

abstract：:Long-term insulin secretion was investigated in seven biohybrid capillary devices seeded with canine islets. Approximately 50,000 islets could be isolated from a single canine pancreas using collagenase digestion in conjunction with the recently described Velcro technique. Devices were perfused with tissue culture med...

journal_title：Diabetes

authors： Araki Y,Solomon BA,Basile RM,Chick WL

更新日期：1985-09-01 00:00:00

abstract：:Our aim was to isolate and determine the contribution of partial pancreatectomy, systemic delivery of pancreatic hormones, and duct obliteration to glucose regulation after segmental pancreas transplantation in dogs. Fasting, postprandial, and intravenous glucose-stimulated glucose, insulin, glucagon, pancreatic polyp...

journal_title：Diabetes

authors： van der Burg MP,Gooszen HG,Guicherit OR,Jansen JB,Frölich M,van Haastert FA,Lamers CB

更新日期：1989-09-01 00:00:00

abstract：:Complementary DNA encoding three catalytic subunits of protein phosphatase 1 (PP1 alpha, PP1 beta, and PP1 gamma) and the insulin-stimulated protein kinase 1 (ISPK-1) was analyzed for variations in the coding regions related to insulin-resistant glycogen synthesis in skeletal muscle of 30 patients with non-insulin-dep...

journal_title：Diabetes

authors： Bjørbaek C,Vik TA,Echwald SM,Yang PY,Vestergaard H,Wang JP,Webb GC,Richmond K,Hansen T,Erikson RL

更新日期：1995-01-01 00:00:00

abstract：:To define the mechanisms involved in the evolution of diabetes in the Zucker diabetic fatty (ZDF) rat, beta-cell mass and replication rates were determined by immunochemistry, point-counting morphometry, and 6-h 5-bromo-2'-deoxyuridine (BrdU) incorporation. The beta-cell mass in 5- to 7-week-old prediabetic ZDF rats (...

journal_title：Diabetes

authors： Pick A,Clark J,Kubstrup C,Levisetti M,Pugh W,Bonner-Weir S,Polonsky KS

更新日期：1998-03-01 00:00:00

abstract：OBJECTIVE:The G-protein-coupled receptor Gpr40 is expressed in beta-cells where it contributes to free fatty acid (FFA) enhancement of glucose-stimulated insulin secretion. However, other sites of Gpr40 expression, including the intestine, have been suggested. The transcription factor IPF1/PDX1 was recently shown to bi...

journal_title：Diabetes

authors： Edfalk S,Steneberg P,Edlund H

更新日期：2008-09-01 00:00:00

abstract：:Eight dogs with previously established kidney allografts, immunosuppressed with cyclosporin A, received islet allografts from their respective original kidney donors. The median islet-graft functional survival was only 10.5 days, significantly less than for six similarly immunosuppressed dogs receiving only islet allo...

journal_title：Diabetes

authors： Guy AJ,Griffin SM,Alderson D,Farndon JR

更新日期：1989-01-01 00:00:00

abstract：:Diabetes is generally diagnosed too late. Therefore, biomarkers indicating early stages of β-cell dysfunction and mass reduction would facilitate timely counteraction. Transgenic pigs expressing a dominant-negative glucose-dependent insulinotropic polypeptide receptor (GIPR(dn)) reveal progressive deterioration of glu...

journal_title：Diabetes

authors： Renner S,Römisch-Margl W,Prehn C,Krebs S,Adamski J,Göke B,Blum H,Suhre K,Roscher AA,Wolf E

更新日期：2012-08-01 00:00:00

abstract：:This is the third in a series of Perspectives on intracellular signaling pathways coupled to proliferation in pancreatic β-cells. We contrast the large knowledge base in rodent β-cells with the more limited human database. With the increasing incidence of type 1 diabetes and the recognition that type 2 diabetes is als...

journal_title：Diabetes

authors： Stewart AF,Hussain MA,García-Ocaña A,Vasavada RC,Bhushan A,Bernal-Mizrachi E,Kulkarni RN

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVE:To assess chemerin levels and regulation in sera and adipose tissue from women with polycystic ovary syndrome (PCOS) and matched control subjects. RESEARCH DESIGN AND METHODS:Real-time RT-PCR and Western blotting were used to assess mRNA and protein expression of chemerin. Serum chemerin was measured by enzy...

journal_title：Diabetes

authors： Tan BK,Chen J,Farhatullah S,Adya R,Kaur J,Heutling D,Lewandowski KC,O'Hare JP,Lehnert H,Randeva HS

更新日期：2009-09-01 00:00:00

abstract：:Because polyphenols may have beneficial effects on dyslipidemia, which accelerates atherosclerosis in diabetes, we examined the effect of polyphenols on hepatocellular AMP-activated protein kinase (AMPK) activity and lipid levels, as well as hyperlipidemia and atherogenesis in type 1 diabetic LDL receptor-deficient mi...

journal_title：Diabetes

authors： Zang M,Xu S,Maitland-Toolan KA,Zuccollo A,Hou X,Jiang B,Wierzbicki M,Verbeuren TJ,Cohen RA

更新日期：2006-08-01 00:00:00

abstract：:Platelet survival by 51chromium labeling was determined in six normal control subjects and in twelve patients with diabetes mellitus, before and after improved glucose control (mean HbA1c 10.5 +/- 2.2% and 7.1 +/- 1.8%, respectively). Mean platelet survival was 9.47 +/- 0.85 days for the normal subjects and 9.04 +/- 1...

journal_title：Diabetes

authors： Jones RL,Paradise C,Peterson CM

更新日期：1981-06-01 00:00:00

abstract：:The adrenocortical steroid, dehydroepiandrosterone, has been shown previously to produce an antidiabetic effect in C57BL/KsJ db/db mice. Preliminary clinical data suggest that this steroid may enhance insulin sensitivity in humans. The therapeutic use of dehydroepiandrosterone may be limited by its androgenic action. ...

journal_title：Diabetes

authors： Pashko LL,Schwartz AG

更新日期：1993-08-01 00:00:00

abstract：:The virtually fatless A-ZIP/F-1 mouse is profoundly insulin resistant, diabetic, and a good model for humans with severe generalized lipoatrophy. Like a number of other mouse models of diabetes, the A-ZIP/F-1 mouse has elevated serum corticosterone levels. Leptin infusion lowers the corticosterone levels, suggesting t...

journal_title：Diabetes

authors： Haluzik M,Dietz KR,Kim JK,Marcus-Samuels B,Shulman GI,Gavrilova O,Reitman ML

更新日期：2002-07-01 00:00:00

abstract：:The effect of strict glycemic control on retinal volumetric blood flow rate (Q) was investigated in 13 insulin-dependent diabetic patients with laser Doppler velocimetry and monochromatic fundus photography. Strict glycemic control was achieved by glucose monitoring and four daily insulin injections. Q was determined ...

journal_title：Diabetes

authors： Grunwald JE,Brucker AJ,Schwartz SS,Braunstein SN,Baker L,Petrig BL,Riva CE

更新日期：1990-05-01 00:00:00

abstract：:Sphingosine-1 phosphate (S1P) is a bioactive sphingolipid with the potential to mobilize Ca2+, to inhibit apoptosis, and to promote mitogenesis. Sphingosine kinase (SPHK) and S1P were characterized in INS-1 insulinoma cells and isolated rat islets of Langerhans. SPHK activity increased in INS-1 cell homogenates treate...

journal_title：Diabetes

authors： Mastrandrea LD,Sessanna SM,Laychock SG

更新日期：2005-05-01 00:00:00

abstract：:In skeletal muscle, the actin cytoskeleton-regulating GTPase, Rac1, is necessary for insulin-dependent GLUT4 translocation. Muscle contraction increases glucose transport and represents an alternative signaling pathway to insulin. Whether Rac1 is activated by muscle contraction and regulates contraction-induced glucos...

journal_title：Diabetes

authors： Sylow L,Jensen TE,Kleinert M,Mouatt JR,Maarbjerg SJ,Jeppesen J,Prats C,Chiu TT,Boguslavsky S,Klip A,Schjerling P,Richter EA

更新日期：2013-04-01 00:00:00

abstract：:The high-mobility group box transcription factor SOX4 is the most highly expressed SOX family protein in pancreatic islets, and mutations in Sox4 are associated with an increased risk of developing type 2 diabetes. We used an inducible β-cell knockout mouse model to test the hypothesis that Sox4 is essential for the m...

journal_title：Diabetes

authors： Xu EE,Sasaki S,Speckmann T,Nian C,Lynn FC

更新日期：2017-08-01 00:00:00

abstract：:Currently, the major indications for solitary islet transplantation are recurrent severe hypoglycemia and labile glucose control. Quantifying these problems remains subjective. We have developed a scoring system for both hypoglycemia and glycemic lability, established normative data, and used them in patients who have...

journal_title：Diabetes

authors： Ryan EA,Shandro T,Green K,Paty BW,Senior PA,Bigam D,Shapiro AM,Vantyghem MC

更新日期：2004-04-01 00:00:00

abstract：:We investigated the expression of Th1- and Th2-associated chemokine receptors on peripheral blood lymphocytes at diagnosis and in the first phase of type 1 diabetes. Peripheral blood mononuclear cells (PBMCs) of 25 patients with newly diagnosed type 1 diabetes, 10 patients with longstanding type 1 diabetes, and 35 hea...

journal_title：Diabetes

authors： Lohmann T,Laue S,Nietzschmann U,Kapellen TM,Lehmann I,Schroeder S,Paschke R,Kiess W

更新日期：2002-08-01 00:00:00

abstract：:Nonhuman primates have been used for a variety of studies on diabetes mellitus. Spontaneous, natural forms of diabetes have been well documented in several species; there are limited data on numerous other species that indicate diabetes or a diabetes-like syndrome. The causes and manifestations of spontaneous diabetes...

journal_title：Diabetes

authors： Howard CF Jr

更新日期：1982-01-01 00:00:00

abstract：:A major goal of the study was to assess the methodologies available for the quantification of retinal lesions suitable for application in trials of metabolic management. We describe the methods used for grading stereoscopic color fundus photographs. Overall retinopathy severity level for each eye ranging from normal (...

journal_title：Diabetes

authors： Davis MD,Hubbard LD,Trautman J,Klein R

更新日期：1985-08-01 00:00:00