Partial Disruption of Lipolysis Increases Postexercise Insulin Sensitivity in Skeletal Muscle Despite Accumulation of DAG.

abstract：OBJECTIVE:The catabasis of inflammation is an active process directed by n-3 derived pro-resolving lipid mediators. We aimed to determine whether high-fat (HF) diet-induced n-3 deficiency compromises the resolution capacity of obese mice and thereby contributes to obesity-linked inflammation and insulin resistance. RE...

journal_title：Diabetes

authors： White PJ,Arita M,Taguchi R,Kang JX,Marette A

更新日期：2010-12-01 00:00:00

abstract：:Both the coding and control regions of mitochondrial DNA (mtDNA) play roles in the generation of diabetes; however, no studies have thoroughly reported on the combined diabetogenic effects of variants in the two regions. We determined the mitochondrial haplogroup and the mtDNA sequence of the control region in 859 sub...

journal_title：Diabetes

authors： Liou CW,Chen JB,Tiao MM,Weng SW,Huang TL,Chuang JH,Chen SD,Chuang YC,Lee WC,Lin TK,Wang PW

更新日期：2012-10-01 00:00:00

abstract：:Adult, male ICR Swiss mice are susceptible to the diabetogenic effects of the D-variant of encephalomyocarditis virus (EMC-D) in contrast to adult C3H/HeJ male mice, which are relatively resistant. To date, experimental evidence suggests that the immune system plays a role in the pathogenesis of this infection. We hav...

journal_title：Diabetes

authors： Gould CL,McMannama KG,Bigley NJ,Giron DJ

更新日期：1985-12-01 00:00:00

abstract：:Type 1 diabetes is a major histocompatibility complex (MHC) class II-associated autoimmune disease mediated by beta-cell-specific T-cells and characterized by circulating autoantibodies to beta-cell molecules. In the BB/Wor diabetes-prone (DP) rat, type 1 diabetes develops spontaneously with an incidence of >90%. BB d...

journal_title：Diabetes

authors： Ellerman KE,Like AA

更新日期：1999-05-01 00:00:00

abstract：OBJECTIVE:ob/ob and db/db mice manifest myocardial hypertrophy, insulin resistance, altered substrate utilization, mitochondrial dysfunction, and lipid accumulation. This study was designed to determine the contribution of central and peripheral leptin signaling to myocardial metabolism and function in ob/ob and db/db ...

journal_title：Diabetes

authors： Sloan C,Tuinei J,Nemetz K,Frandsen J,Soto J,Wride N,Sempokuya T,Alegria L,Bugger H,Abel ED

更新日期：2011-05-01 00:00:00

abstract：:Hyperactivation of the mammalian target of rapamycin complex 1 (mTORC1) in β-cells is usually found as a consequence of increased metabolic load. Although it plays an essential role in β-cell compensatory mechanisms, mTORC1 negatively regulates autophagy. Using a mouse model with β-cell-specific deletion of Tsc2 (βTsc...

journal_title：Diabetes

authors： Bartolomé A,Kimura-Koyanagi M,Asahara S,Guillén C,Inoue H,Teruyama K,Shimizu S,Kanno A,García-Aguilar A,Koike M,Uchiyama Y,Benito M,Noda T,Kido Y

更新日期：2014-09-01 00:00:00

abstract：:To examine the impact of diabetes and its treatment on plasma free-fatty acid (FFA) and oxidative fuel metabolism during hypoglycemia, we combined indirect calorimetry with [3-3H]glucose during a 4-h low-dose insulin infusion (plasma insulin approximately 2-fold above basal) in six poorly controlled and nine well-cont...

journal_title：Diabetes

authors： Caprio S,Amiel S,Tamborlane WV,Gelfand RA,Sherwin RS

更新日期：1990-02-01 00:00:00

abstract：OBJECTIVE:This study aimed to estimate the current cumulative risk of end-stage renal disease (ESRD) due to diabetic nephropathy in a large, nationwide, population-based prospective type 1 diabetes cohort and specifically study the effects of sex and age at onset. RESEARCH DESIGN AND METHODS:In Sweden, all incident ca...

journal_title：Diabetes

authors： Möllsten A,Svensson M,Waernbaum I,Berhan Y,Schön S,Nyström L,Arnqvist HJ,Dahlquist G,Swedish Childhood Diabetes Study Group.,Diabetes Incidence Study in Sweden.,Swedish Renal Registry.

更新日期：2010-07-01 00:00:00

abstract：:One month following induction of diabetes with streptozotocin, one half of diabetic and control rats underwent unilateral nephrectomy. Subsequently, all animals were studied with respect to renal function and glomerular alterations of diabetes. Blood pressure levels were similar in all animals. Diabetic and control an...

journal_title：Diabetes

authors： Steffes MW,Brown DM,Mauer SM

更新日期：1978-01-01 00:00:00

abstract：:To investigate the pathophysiology of diabetic osteopenia, circulating levels and bone contents of bone gamma-carboxyglutamic acid-containing protein (BGP) were measured in streptozocin-induced diabetic rats . Plasma calcium and total protein were significantly decreased (P less than .01) in the diabetic group, and th...

journal_title：Diabetes

authors： Ishida H,Seino Y,Taminato T,Usami M,Takeshita N,Seino Y,Tsutsumi C,Moriuchi S,Akiyama Y,Hara K

更新日期：1988-06-01 00:00:00

abstract：:The identity of the cells responsible for beta-cell destruction in type I (insulin-dependent) diabetes is still uncertain. L3T4+ T-lymphocytes have a role in the initiation of insulitis and in damaging transplanted allogeneic islets in nonobese diabetic (NOD) mice. The role of L3T4+ T-lymphocytes in destruction of bet...

journal_title：Diabetes

authors： Charlton B,Mandel TE

更新日期：1988-08-01 00:00:00

abstract：:Canine pancreata obtained at total pancreatectomy were cannulated via the ducts and perfused with collagenase to prepare a tissue suspension that was isografted into the spleen (preparation congruent to 2 h, mean graft vol = 10 +/- 1 ml containing 24% of the B-cell mass/pancreas). In 13 dogs the tissue was implanted b...

journal_title：Diabetes

authors： Warnock GL,Rajotte RV,Procyshyn AW

更新日期：1983-05-01 00:00:00

abstract：:Three forms of disulfide-linked insulin receptor complexes are labeled by covalent cross-linking to receptor-bound 125I-insulin in native adipocyte or liver membranes. These receptors of Mr 350,000 Mr 320,000, and Mr 290,000 are composed of alpha (Mr 125,000), beta(Mr 90,000), and beta 1(Mr 49,000) subunits in stoichi...

journal_title：Diabetes

authors： Massaqué J,Czech MP

更新日期：1980-11-01 00:00:00

abstract：:Dispersed pancreatic endocrine cells (PECs) were recently shown to survive indefinitely in the brain of allogeneic diabetic rat recipients across the major histocompatibility barrier without immunosuppression. Purified PECs (2-3 X 10(6) cells) prepared from Wistar rat islets were transplanted in 10 different sites in ...

journal_title：Diabetes

authors： Tze WJ,Tai J

更新日期：1988-04-01 00:00:00

abstract：OBJECTIVE:Islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), now known as G6PC2, is a major target of autoreactive T cells implicated in the pathogenesis of type 1 diabetes in both mice and humans. This study aimed to determine whether suppression of G6p2 gene expression might therefore prev...

journal_title：Diabetes

authors： Oeser JK,Parekh VV,Wang Y,Jegadeesh NK,Sarkar SA,Wong R,Lee CE,Pound LD,Hutton JC,Van Kaer L,O'Brien RM

更新日期：2011-11-01 00:00:00

abstract：:Rapamycin is used frequently in both transplantation and oncology. Although historically thought to have little diabetogenic effect, there is growing evidence of β-cell toxicity. This Review draws evidence for rapamycin toxicity from clinical studies of islet and renal transplantation, and of rapamycin as an anticance...

journal_title：Diabetes

authors： Barlow AD,Nicholson ML,Herbert TP

更新日期：2013-08-01 00:00:00

abstract：:We have produced a monoclonal antibody 3A4 to the surface of islet cells by fusing spleen lymphocytes from nonobese diabetic (NOD) mice. To identify the molecular weight of specific target antigens reacting with 3A4, 125I-surface-labeled In-111 insulinoma cells were solubilized and extracts were absorbed with 3A4, and...

journal_title：Diabetes

authors： Hari J,Yokono K,Yonezawa K,Amano K,Yaso S,Shii K,Imamura Y,Baba S

更新日期：1986-05-01 00:00:00

abstract：:There has been a prejudice that diabetes modulates the function of saphenous vein in a manner that predisposes to bypass graft failure, although most of the evidence accrues from animal studies. We have investigated the effect of diabetes on the vasodilator responses and ultrastructure of saphenous vein harvested from...

journal_title：Diabetes

authors： Hicks RC,Moss J,Higman DJ,Greenhalgh RM,Powell JT

更新日期：1997-01-01 00:00:00

abstract：:Fasting hyperglycemia occurs when an excessive rate of endogenous glucose production (EGP) is not accompanied by an adequate compensatory increase in the rate of glucose disappearance (Rd). The situation following food ingestion is more complex as the amount of glucose that reaches the circulation for disposal is a fu...

journal_title：Diabetes

authors： Rizza RA,Toffolo G,Cobelli C

更新日期：2016-05-01 00:00:00

abstract：:In diabetic subjects, polyol pathway activity might inhibit neutrophil function and cause nerve damage. The effects of ponalrestat, an aldose reductase inhibitor, were assessed on neutrophil intracellular killing of Escherichia coli and on autonomic function in diabetic subjects in a randomized double-blind, placebo-c...

journal_title：Diabetes

authors： Boland OM,Blackwell CC,Clarke BF,Ewing DJ

更新日期：1993-02-01 00:00:00

abstract：:To investigate whether insulin reduces platelet aggregability through a modulation of the guanosine-3',5'-cyclic monophosphate (cGMP) concentrations, we determined by a radioimmunoassay the cGMP values in the platelet-rich plasma (PRP) obtained from 17 healthy volunteers and incubated for 3 min with different concentr...

journal_title：Diabetes

authors： Trovati M,Massucco P,Mattiello L,Mularoni E,Cavalot F,Anfossi G

更新日期：1994-08-01 00:00:00

abstract：:The effect of basal insulin on global and regional brain glucose uptake and metabolism in humans was studied using 18-fluorodeoxyglucose and positron emission tomography (FDG-PET). Eight healthy male volunteers aged 49.3 +/- 5.1 years were studied twice in random order. On each occasion, they received an infusion of 0...

journal_title：Diabetes

authors： Bingham EM,Hopkins D,Smith D,Pernet A,Hallett W,Reed L,Marsden PK,Amiel SA

更新日期：2002-12-01 00:00:00

abstract：:Nerve regeneration in diabetic animals is delayed and qualitatively impaired, but the mechanisms responsible for these defects have not been elucidated. The extracellular matrix protein laminin promotes the extension of neuronal processes, and recent studies have localized neurite-promoting activity to a lysine-contai...

journal_title：Diabetes

authors： Federoff HJ,Lawrence D,Brownlee M

更新日期：1993-04-01 00:00:00

abstract：:Beiging of white adipose tissue has potential antiobesity and antidiabetes effects, yet the underlying signaling mechanisms remain to be fully elucidated. Here we show that adipose-specific knockout of Rheb, an upstream activator of mechanistic target of rapamycin complex 1 (mTORC1), protects mice from high-fat diet-i...

journal_title：Diabetes

authors： Meng W,Liang X,Chen H,Luo H,Bai J,Li G,Zhang Q,Xiao T,He S,Zhang Y,Xu Z,Xiao B,Liu M,Hu F,Liu F

更新日期：2017-05-01 00:00:00

abstract：:The effect of cerebral intraventricular insulin on pancreatic insulin secretion was investigated. An extracorporeal pancreatic blood circuit was established after laparotomy to monitor blood flow and insulin concentration directly from the superior pancreaticoduodenal vein. Phentolamine was infused throughout (0.2 mg....

journal_title：Diabetes

authors： Chen M,Woods SC,Porte D Jr

更新日期：1975-10-01 00:00:00

abstract：CONTEXT:Circulating fatty acid synthase (FASN) is a biomarker of metabolically demanding human diseases. The aim of this study was to determine whether circulating FASN could be a biomarker of overnutrition-induced metabolic stress and insulin resistance in common metabolic disorders. RESEARCH DESIGN AND METHODS:Circu...

journal_title：Diabetes

authors： Fernandez-Real JM,Menendez JA,Moreno-Navarrete JM,Blüher M,Vazquez-Martin A,Vázquez MJ,Ortega F,Diéguez C,Frühbeck G,Ricart W,Vidal-Puig A

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:We hypothesized that intranasal insulin (I-I) delivery targets the nervous system while avoiding potential adverse systemic effects when compared with subcutaneous insulin (S-I) for experimental streptozotocin-induced diabetic peripheral neuropathy (DPN). RESEARCH DESIGN AND METHODS:I-I or S-I at 0.87 IU dai...

journal_title：Diabetes

authors： Francis G,Martinez J,Liu W,Nguyen T,Ayer A,Fine J,Zochodne D,Hanson LR,Frey WH 2nd,Toth C

更新日期：2009-04-01 00:00:00

abstract：:In the fasted rat, efficient glucose-stimulated insulin secretion (GSIS) is absolutely dependent on an elevated level of circulating free fatty acids (FFAs). To determine if this is also true in humans, nonobese volunteers were fasted for 24 h (n = 5) or 48 h (n = 5), after which they received an infusion of either sa...

journal_title：Diabetes

authors： Dobbins RL,Chester MW,Daniels MB,McGarry JD,Stein DT

更新日期：1998-10-01 00:00:00

abstract：:Diabetes is a common age-dependent complication of cystic fibrosis (CF) that is strongly influenced by modifier genes. We conducted a genome-wide association study in 3,059 individuals with CF (644 with CF-related diabetes [CFRD]) and identified single nucleotide polymorphisms (SNPs) within and 5' to the SLC26A9 gene ...

journal_title：Diabetes

authors： Blackman SM,Commander CW,Watson C,Arcara KM,Strug LJ,Stonebraker JR,Wright FA,Rommens JM,Sun L,Pace RG,Norris SA,Durie PR,Drumm ML,Knowles MR,Cutting GR

更新日期：2013-10-01 00:00:00

abstract：:We have examined the effects of underfeeding and obesity on the density of hypothalamic melanocortin MC3 and MC4 receptors (MC3-R and MC4-R, respectively), which may mediate the hypophagic effects of alpha-melanocyte-stimulating hormone (MSH) in the rat. MC3-R and MC4-R were measured by quantitative autoradiography in...

journal_title：Diabetes

authors： Harrold JA,Widdowson PS,Williams G

更新日期：1999-02-01 00:00:00