Abstract:
:The effect of strict glycemic control on retinal volumetric blood flow rate (Q) was investigated in 13 insulin-dependent diabetic patients with laser Doppler velocimetry and monochromatic fundus photography. Strict glycemic control was achieved by glucose monitoring and four daily insulin injections. Q was determined in a major retinal vein at baseline and then 5 days, 2 mo, and 6 mo after the institution of strict control. Level of retinopathy was assessed from stereocolor fundus photographs taken at baseline and 6 mo. After 6 mo of strict diabetic control, five eyes demonstrated progression (P) by one or more retinopathy levels, and eight eyes showed no progression (NP). At 5 days, there was a significant decrease in Q of 1.4 +/- 0.9 microliters/min (P less than 0.005) in NP eyes and a nonsignificant increase in Q of 1.2 +/- 1.7 microliters/min in P eyes. Changes in Q from baseline observed at 5 days were strongly correlated with changes in retinopathy level at 6 mo (r = 0.79, P less than 0.005). No significant changes in Q from baseline were observed at 2 and 6 mo. A lack of decrease in Q at 5 days was associated with the progression of retinopathy that occurs in some patients after the institution of strict glycemic control and may serve as a predictor for progression of retinopathy.
journal_name
Diabetesjournal_title
Diabetesauthors
Grunwald JE,Brucker AJ,Schwartz SS,Braunstein SN,Baker L,Petrig BL,Riva CEdoi
10.2337/diab.39.5.602subject
Has Abstractpub_date
1990-05-01 00:00:00pages
602-7issue
5eissn
0012-1797issn
1939-327Xjournal_volume
39pub_type
杂志文章相关文献
DIABETES文献大全abstract::The aim of this randomized double-blind study was to compare the within-subject variability of the glucose-lowering effect of a novel insulin analog, insulin detemir, with that of insulin glargine and NPH insulin in people with type 1 diabetes. Fifty-four subjects (32 males and 22 females, age 38 +/- 10 years [mean +/...
journal_title:Diabetes
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diabetes.53.6.1614
更新日期:2004-06-01 00:00:00
abstract::Glucokinase from rat liver or transplantable, radiation-induced insulinomas was partially purified by ion exchange chromatography using DEAE-Cibacron Blue F3GA agarose. Phosphorylation of alpha,beta-D-mannose by glucokinase occurred with cooperative rate dependence on mannose concentration (nH: 1.50). Half-maximal pho...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.32.12.1146
更新日期:1983-12-01 00:00:00
abstract::To elucidate the precise significance of pancreatic A-cell hypersecretion in the pathogenesis of diabetes mellitus, the change in the immunoreactive glucagon (IRG) response to intravenous arginine was studied in both nonobese, hypoinsulinemic non-insulin-dependent (NIDDM) and insulin-dependent diabetic (IDDM) subjects...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.29.9.762
更新日期:1980-09-01 00:00:00
abstract::In people with diabetes, the concentration of an individual lipoprotein or apolipoprotein can be highly variable and is totally different in the two major forms of the disease. Alterations in the concentrations of major lipids and lipoproteins are well characterized in both IDDM and NIDDM. In general, the lipoprotein ...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/diab.41.2.s12
更新日期:1992-10-01 00:00:00
abstract:OBJECTIVE:Glucagon-like peptide-1 (GLP-1) is a growth and differentiation factor for mature beta-cells and their precursors. However, the overall effect of GLP-1 on increasing beta-cell mass in both in vivo and in vitro conditions is relatively small, and augmenting this effect would be beneficial for the treatment or ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db07-1414
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:The ATP-binding cassette transporter A1 (ABCA1) R230C variant is associated with low HDL cholesterol levels, obesity, and the metabolic syndrome in Mexican-Mestizos. Because a pivotal role for ABCA1 in pancreatic beta-cell function was recently observed in the mouse model, we assessed the association of this ...
journal_title:Diabetes
pub_type: 杂志文章,多中心研究
doi:10.2337/db07-0484
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVE:Visceral obesity and elevated plasma free fatty acids are predisposing factors for type 2 diabetes. Chronic exposure to these lipids is detrimental for pancreatic beta-cells, resulting in reduced insulin content, defective insulin secretion, and apoptosis. We investigated the involvement in this phenomenon of...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db07-1252
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVE:Vaspin was identified as an adipokine with insulin-sensitizing effects, which is predominantly secreted from visceral adipose tissue in a rat model of type 2 diabetes. We have recently shown that vaspin mRNA expression in adipose tissue is related to parameters of obesity and glucose metabolism. However, the ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db07-1045
更新日期:2008-02-01 00:00:00
abstract::The high-mobility group box transcription factor SOX4 is the most highly expressed SOX family protein in pancreatic islets, and mutations in Sox4 are associated with an increased risk of developing type 2 diabetes. We used an inducible β-cell knockout mouse model to test the hypothesis that Sox4 is essential for the m...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db16-1074
更新日期:2017-08-01 00:00:00
abstract::The possible role of endothelial dysfunction in early stages of uncomplicated diabetes mellitus was investigated in porcine aortic endothelial cells. Prolonged exposure to various D-glucose concentrations resulted in concentration-dependent amplification of agonist-induced Ca2+ mobilization, whereas L-glucose and D-ma...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.42.10.1497
更新日期:1993-10-01 00:00:00
abstract::Postmortem studies have shown a relationship between diabetic state and atherosclerotic arterial lesions in adolescents. The aim of the present study was to determine the presence of increased subclinical atherosclerosis (measured as carotid intima-media thickness [IMT]) and its risk factors, including lipoprotein oxi...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.51.2.493
更新日期:2002-02-01 00:00:00
abstract::MDL 29311, an analogue of probucol, administered to rats as a 1% dietary admixture for 2 wk before and 5 days after intravenous injection of 40 mg/kg of ALX significantly (P < 0.05) reduced plasma glucose (6.9 +/- 0.3 vs. 19.2 +/- 1.3 mM) and serum triglyceride (0.17 +/- 0.01 vs. 1.82 +/- 0.39 mM) levels in overnight-...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.42.8.1179
更新日期:1993-08-01 00:00:00
abstract:OBJECTIVE:We examined the relationship between the expression of thrombospondin (TSP)1, an antiangiogenic factor and regulator of transforming growth factor-beta activity, obesity, adipose inflammation, and insulin resistance. RESEARCH DESIGN AND METHODS:TSP1 gene expression was quantified in subcutaneous adipose tiss...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db07-0840
更新日期:2008-02-01 00:00:00
abstract::Islet amyloid polypeptide (IAPP) or amylin is a newly identified 37-amino acid COOH-terminal-amidated polypeptide that is the major protein constituent of amyloid deposits in insulinomas and amyloid deposits in pancreatic islets of non-insulin-dependent (type II) diabetic humans and adult diabetic cats. IAPP is stored...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/diab.40.3.310
更新日期:1991-03-01 00:00:00
abstract::Leptin, a recently identified hormone, is believed to reduce appetite and maintain body weight. The mRNA of leptin is expressed only in mature adipose cells. To clarify the regulation of leptin gene expression in adipocytes, 3T3-L1 adipocytes were treated for 16 h with various agents known to modulate lipid metabolism...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.45.12.1744
更新日期:1996-12-01 00:00:00
abstract::We examined the hypothesis that imprinted genes may affect the propensity to type 2 diabetes and obesity in Pima Indians. Multipoint variance component methods were used to assess linkage of BMI (kg/m(2)) and age-adjusted diabetes to loci derived from either father (LOD(FA)) or mother (LOD(MO)) in a genome-wide scan. ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.50.12.2850
更新日期:2001-12-01 00:00:00
abstract::Advanced glycation end-products (AGEs) may play an important role in the pathogenesis and progression of cardiovascular and renal complications of diabetes. Four putative AGE receptors (RAGEs), AGE-R1, AGE-R2, and AGE-R3 have been described. In this study, we scanned the sequence of the genes encoding these AGE recept...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.50.5.1214
更新日期:2001-05-01 00:00:00
abstract:OBJECTIVE:To determine whether the obesity-related decrement in fatty acid oxidation (FAO) in primary human skeletal muscle cells (HSkMC) is linked with lower mitochondrial content and whether this deficit could be corrected via overexpression of peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db09-1704
更新日期:2010-06-01 00:00:00
abstract::Enhanced platelet functions have been demonstrated in patients with non-insulin-dependent diabetes mellitus (NIDDM). This study evaluated abnormalities in platelet signal transduction in diabetic patients, including turnover of phosphoinositides, mobilization of intracellular Ca2+, and phosphorylation of 20,000- and 4...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.39.12.1561
更新日期:1990-12-01 00:00:00
abstract::This article examines the role of the autonomic nervous system in mediating the increase of glucagon secretion observed during insulin-induced hypoglycemia (IIH). In the first section, we briefly review the importance of the alpha-cell response in recovery from hypoglycemia under both physiologic conditions and pathop...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/diabetes.47.7.995
更新日期:1998-07-01 00:00:00
abstract::Spleen cells from conventional BALB/c or athymic mice with streptozotocin (SZ)-induced hyperglycemia failed to raise blood sugar levels when injected into athymic or thymus-sufficient recipients. Passive transfer efforts were unsuccessful despite variations in donor-recipient pairs with respect to age, thymic function...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.29.2.146
更新日期:1980-02-01 00:00:00
abstract::We studied certain metabolic requirements for insulin-induced increases in phospholipids, and the relationship of phospholipid changes to the insulin-induced activation of pyruvate dehydrogenase, in rat adipocytes and fat pads in vitro. Increases in the contents of phosphatidylinositol and phosphatidylserine mass were...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.33.7.648
更新日期:1984-07-01 00:00:00
abstract::Because the pathogenetic understanding of diabetic vascular complications remains fragmentary, and even the best available interventions may prove insufficient to arrest the progression of certain lesions, new avenuses of investigation should be pursued. One of these should be the early in vivo investigation of the ce...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/diab.40.6.653
更新日期:1991-06-01 00:00:00
abstract::Adiponectin, an adipocyte protein important in insulin sensitization and cardioprotection, has a strong genetic component. We hypothesized that variants in the adiponectin gene (adipocyte collagen-domain containing [ACDC]) contribute to adiponectin levels in a biracial adolescent cohort. We genotyped 11 ACDC single nu...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.55.02.06.db05-0446
更新日期:2006-02-01 00:00:00
abstract::The effects of oral vanadate supplementation on intestinal morphometry and glucose transport were examined in STZ-induced diabetic and age-matched control male Sprague-Dawley rats. Animals received 0.1 mg/ml vanadium pentoxide in their drinking water over 14 days. Vanadate reduced intestinal glucose maximal transport ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.42.8.1126
更新日期:1993-08-01 00:00:00
abstract::The mechanism of protection from type 1 diabetes conferred by regulatory T-cells induced by oral insulin treatment of NOD mice is not well understood. We demonstrate that oral insulin feeding of NOD mice induces the function of insulin B-chain reactive CD4+ regulatory T-cells, which compete with diabetogenic effector ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.48.9.1720
更新日期:1999-09-01 00:00:00
abstract::The aim of this study was to investigate whether mutations in hepatocyte nuclear factor (HNF)-4gamma, a transcription factor homologous to HNF-4alpha, contribute to the etiology of early-onset type 2 diabetes. Linkage between diabetes and two polymorphic markers at the HNF-4gamma locus (D8S286 and D8S548) was evaluate...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.48.10.2099
更新日期:1999-10-01 00:00:00
abstract::Hypoglycemia causes substantial morbidity and some mortality in insulin-dependent diabetes mellitus (IDDM). It is often the limiting factor in attempts to achieve euglycemia. The prevention or correction of hypoglycemia normally involves both dissipation of insulin and activation of glucose counterregulatory systems. ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.38.9.1193
更新日期:1989-09-01 00:00:00
abstract::Antibodies to single stranded (SS-) and double stranded (DS-) DNA and RNA were determined by a passive microhemagglutination assay in sera from 80 children with juvenile-onset diabetes mellitus (JDM) and 129 children with asthma. The latter group was chosen for comparison with the JDM group because of their increased ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.27.11.1105
更新日期:1978-11-01 00:00:00
abstract::The molecular underpinnings of β-cell dysfunction and death leading to diabetes are not fully elucidated. The objective of the current study was to investigate the role of endoplasmic reticulum-associated degradation (ERAD) in pancreatic β-cells. Chemically induced ERAD deficiency in the rat insulinoma cell line INS-1...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db18-0624
更新日期:2019-04-01 00:00:00