Function and Mechanism of Long Noncoding RNAs in Adipocyte Biology.

abstract：:We examined the hypothesis that imprinted genes may affect the propensity to type 2 diabetes and obesity in Pima Indians. Multipoint variance component methods were used to assess linkage of BMI (kg/m(2)) and age-adjusted diabetes to loci derived from either father (LOD(FA)) or mother (LOD(MO)) in a genome-wide scan. ...

journal_title：Diabetes

authors： Lindsay RS,Kobes S,Knowler WC,Bennett PH,Hanson RL

更新日期：2001-12-01 00:00:00

abstract：:Mitochondrial ADP transport may represent a convergence point unifying two prominent working models for the development of insulin resistance, as reactive lipids (specifically palmitoyl-CoA [P-CoA]) can inhibit ADP transport and subsequently increase mitochondrial reactive oxygen species emissions. In the current stud...

journal_title：Diabetes

authors： Ludzki A,Paglialunga S,Smith BK,Herbst EA,Allison MK,Heigenhauser GJ,Neufer PD,Holloway GP

更新日期：2015-08-01 00:00:00

abstract：:Type 1 diabetes (T1D) results from T cell-mediated destruction of insulin-producing β-cells. Insulin represents a key self-antigen in disease pathogenesis, as recent studies identified proinsulin-responding T cells from inflamed pancreatic islets of organ donors with recent-onset T1D. These cells respond to an insulin...

journal_title：Diabetes

authors： Spanier JA,Sahli NL,Wilson JC,Martinov T,Dileepan T,Burrack AL,Finger EB,Blazar BR,Michels AW,Moran A,Jenkins MK,Fife BT

更新日期：2017-12-01 00:00:00

abstract：:In peripheral tissues, insulin signaling involves activation of the insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase (PI3K) enzyme system. In the hypothalamus, insulin functions with leptin as an afferent adiposity signal important for the regulation of body fat stores and hepatic glucose metabolism. To ...

journal_title：Diabetes

authors： Niswender KD,Morrison CD,Clegg DJ,Olson R,Baskin DG,Myers MG Jr,Seeley RJ,Schwartz MW

更新日期：2003-02-01 00:00:00

abstract：:Evidence exists for an essential role of beta-cell apoptosis in the pathology of type 1 and type 2 diabetes. Current methods for diabetes-associated apoptosis detection, however, suffer the drawbacks of relying on in situ-based strategies. In this study, we attempted to measure, both in vitro and ex vivo, levels of be...

journal_title：Diabetes

authors： Medarova Z,Bonner-Weir S,Lipes M,Moore A

更新日期：2005-06-01 00:00:00

abstract：:Cyclic nucleotide phosphodiesterase (PDE) 3B plays an important role in the antilipolytic action of insulin and, thereby, the release of fatty acids from adipocytes. Increased concentrations of circulating fatty acids as a result of elevated or unrestrained lipolysis cause insulin resistance. The lipolytic action of t...

journal_title：Diabetes

authors： Mei J,Holst LS,Landström TR,Holm C,Brindley D,Manganiello V,Degerman E

更新日期：2002-03-01 00:00:00

abstract：:A chromosome 1q25 variant (rs10911021) has been associated with coronary heart disease (CHD) in type 2 diabetes. In human umbilical vein endothelial cells (HUVECs), the risk allele "C" is associated with lower expression of the adjacent gene GLUL encoding glutamine synthase, converting glutamic acid to glutamine. To f...

journal_title：Diabetes

authors： Pipino C,Shah H,Prudente S,Di Pietro N,Zeng L,Park K,Trischitta V,Pennathur S,Pandolfi A,Doria A

更新日期：2020-10-01 00:00:00

abstract：:Glucose controls islet beta-cell mass and function at least in part through the phosphatidylinositol 3-kinase (PI3K)/Akt pathway downstream of insulin signaling. The Foxo proteins, transcription factors known in other tissues to be negatively regulated by Akt activation, affect proliferation and metabolism. In this st...

journal_title：Diabetes

authors： Martinez SC,Cras-Méneur C,Bernal-Mizrachi E,Permutt MA

更新日期：2006-06-01 00:00:00

abstract：:Improvement of glycemic status by insulin is associated with profound changes in amino acid metabolism in type 1 diabetes. In contrast, a dissociation of insulin effect on glucose and amino acid metabolism has been reported in type 2 diabetes. Type 2 diabetic patients are reported to have reduced muscle oxidative enzy...

journal_title：Diabetes

authors： Halvatsiotis P,Short KR,Bigelow M,Nair KS

更新日期：2002-08-01 00:00:00

abstract：:The mechanisms of marked increase in plasma leptin soon after ventromedial hypothalamus (VMH) lesions were investigated. Although rats did not gain body weight or parametrial fat-pad mass 24 h after the operation, the acute VMH-lesioned rats exhibited substantial five- and fourfold increases in plasma leptin levels co...

journal_title：Diabetes

authors： Suga A,Hirano T,Kageyama H,Kashiba M,Oka J,Osaka T,Namba Y,Tsuji M,Miura M,Adachi M,Inoue S

更新日期：1999-10-01 00:00:00

abstract：:The homeodomain-containing transcription factor pancreatic duodenal homeobox 1 (PDX-1) plays a key role in pancreas development and in beta-cell function. Upstream sequences of the gene up to about -6 kb show islet-specific activity in transgenic mice. Attempts to identify functional regulatory elements involved in th...

journal_title：Diabetes

authors： Melloul D,Marshak S,Cerasi E

更新日期：2002-12-01 00:00:00

abstract：:This study examined the role of p38 mitogen-activated protein (MAP) kinase in transducing high glucose into deficits in nerve conduction velocity (NCV) that are characteristic of diabetic neuropathy. p38 activation and NCV were measured in streptozocin-induced diabetic rats treated with a p38 inhibitor, an aldose redu...

journal_title：Diabetes

authors： Price SA,Agthong S,Middlemas AB,Tomlinson DR

更新日期：2004-07-01 00:00:00

abstract：:Insulin levels in humans were measured by a new assay, the isotope dilution assay (IDA), based on stable isotope dilution mass spectrometry. A known amount of a deuterated analog of insulin was used as an internal standard and added to the serum samples before sample processing. After isolation by immunoaffinity chrom...

journal_title：Diabetes

authors： Stöcklin R,Vu L,Vadas L,Cerini F,Kippen AD,Offord RE,Rose K

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:Skeletal muscle protein metabolism is resistant to the anabolic action of insulin in healthy, nondiabetic older adults. This defect is associated with impaired insulin-induced vasodilation and mTORC1 signaling. We hypothesized that, in older subjects, pharmacological restoration of insulin-induced capillary r...

journal_title：Diabetes

authors： Timmerman KL,Lee JL,Fujita S,Dhanani S,Dreyer HC,Fry CS,Drummond MJ,Sheffield-Moore M,Rasmussen BB,Volpi E

更新日期：2010-11-01 00:00:00

abstract：:Evidence from animal models suggests that natural killer (NK) cells can be important players in the development of type 1 diabetes, although data in humans are still sparse. We studied the frequency and activation state of blood NK cells at different stages of human type 1 diabetes, and whether genetic or phenotypic N...

journal_title：Diabetes

authors： Rodacki M,Svoren B,Butty V,Besse W,Laffel L,Benoist C,Mathis D

更新日期：2007-01-01 00:00:00

abstract：:The efficacy of gangliosides in enhancing axonal regeneration and maturation in the early stages of diabetic neuropathy was assessed by quantitative analysis of immunostained serial sections of the sciatic nerve. Sprague-Dawley rats were made diabetic with a single injection of alloxan (100 mg/kg). One week later they...

journal_title：Diabetes

authors： Triban C,Guidolin D,Fabris M,Marini P,Schiavinato A,Donà M,Bortolami MC,Di Giamberardino L,Fiori MG

更新日期：1989-08-01 00:00:00

abstract：:Disturbed immune regulation has been postulated to be crucial in the pathogenesis of IDDM and other autoimmune or allergic diseases. We therefore tested the hypothesis of a general bias in the peripheral immune system in patients with recent-onset IDDM or Graves' disease in comparison to healthy control subjects by st...

journal_title：Diabetes

authors： Kallmann BA,Hüther M,Tubes M,Feldkamp J,Bertrams J,Gries FA,Lampeter EF,Kolb H

更新日期：1997-02-01 00:00:00

abstract：:The early renal growth in streptozotocin (STZ)-induced diabetic rats is preceded by a transient rise in renal tissue insulin-like growth factor (IGF)-I concentration. Administration of the long-acting somatostatin analog octreotide to STZ diabetic rats inhibits the early increase in kidney IGF-I and the increase in ki...

journal_title：Diabetes

authors： Raz I,Rubinger D,Popovtzer M,Grønbaek H,Weiss O,Flyvbjerg A

更新日期：1998-06-01 00:00:00

abstract：:A reduced thermic effect of glucose in non-insulin-dependent diabetes mellitus (NIDDM) has been previously reported. To investigate whether this defect is related to 1) a decreased rate of glucose storage, 2) a reduced energy cost of glucose storage, or 3) a defect in the sympathetically mediated component of thermoge...

journal_title：Diabetes

authors： Ravussin E,Zawadzki JK

更新日期：1987-12-01 00:00:00

abstract：:Conjugated linoleic acid (CLA) isomers have a number of beneficial health effects, as shown in biomedical studies with animal models. Previously, we reported that a mixture of CLA isomers improved glucose tolerance in ZDF rats and activated peroxisome proliferator-activated receptor (PPAR)-gamma response elements in v...

journal_title：Diabetes

authors： Ryder JW,Portocarrero CP,Song XM,Cui L,Yu M,Combatsiaris T,Galuska D,Bauman DE,Barbano DM,Charron MJ,Zierath JR,Houseknecht KL

更新日期：2001-05-01 00:00:00

abstract：:Using an integrative approach in which genetic variation, gene expression, and clinical phenotypes are assessed in relevant tissues may help functionally characterize the contribution of genetics to disease susceptibility. We sought to identify genetic variation influencing skeletal muscle gene expression (expression ...

journal_title：Diabetes

authors： Keildson S,Fadista J,Ladenvall C,Hedman ÅK,Elgzyri T,Small KS,Grundberg E,Nica AC,Glass D,Richards JB,Barrett A,Nisbet J,Zheng HF,Rönn T,Ström K,Eriksson KF,Prokopenko I,MAGIC Consortium.,DIAGRAM Consortium.,MuTHER

更新日期：2014-03-01 00:00:00

abstract：:Fifty male rats were made diabetic by a single injection of streptozotocin and were killed at periods varying from 1 to 12 mo. Ten saline-injected rats and three rats treated with 3-O-methylglucose and streptozotocin served as controls. Intraluminal changes in retinal vessels were studied by electron microscopy. In di...

journal_title：Diabetes

authors： Ishibashi T,Tanaka K,Taniguchi Y

更新日期：1981-07-01 00:00:00

abstract：:Many common genetic polymorphisms are associated with glycemic traits and type 2 diabetes (T2D), but knowledge about genetic determinants of glycemic traits in pregnancy is limited. We tested genetic variants known to be associated with glycemic traits and T2D in the general population for associations with glycemic t...

journal_title：Diabetes

authors： Powe CE,Nodzenski M,Talbot O,Allard C,Briggs C,Leya MV,Perron P,Bouchard L,Florez JC,Scholtens DM,Lowe WL Jr,Hivert MF

更新日期：2018-12-01 00:00:00

abstract：:Impaired skeletal muscle fatty acid oxidation has been suggested to contribute to insulin resistance and glucose intolerance. However, increasing muscle fatty acid oxidation may cause a reciprocal decrease in glucose oxidation, which might impair insulin sensitivity and glucose tolerance. We therefore investigated wha...

journal_title：Diabetes

authors： Keung W,Ussher JR,Jaswal JS,Raubenheimer M,Lam VH,Wagg CS,Lopaschuk GD

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:Most pancreatic endocrine cells derive from Ptf1a-expressing progenitor cells. In humans, nonsense mutations in Ptf1a have recently been identified as a cause of permanent neonatal diabetes associated with pancreatic agenesis. The death of Ptf1a-null mice soon after birth has not allowed further insight into ...

journal_title：Diabetes

authors： Fukuda A,Kawaguchi Y,Furuyama K,Kodama S,Horiguchi M,Kuhara T,Kawaguchi M,Terao M,Doi R,Wright CV,Hoshino M,Chiba T,Uemoto S

更新日期：2008-09-01 00:00:00

abstract：:Blood T-cells from 28 patients with type I (insulin-dependent) diabetes (IDDM) of variable duration were examined for the Tac antigen by immunofluorescence, and for proliferation in the presence of interleukin 2 (IL 2). The mean percentage of Tac+ cells in patients whose IDDM was of less than 2-yr duration was 6.2% co...

journal_title：Diabetes

authors： Hayward AR,Herberger M

更新日期：1984-04-01 00:00:00

abstract：:Carbohydrate-responsive element-binding protein (ChREBP) is a glucose-sensing transcription factor required for glucose-stimulated proliferation of pancreatic β-cells in rodents and humans. The full-length isoform (ChREBPα) has a low glucose inhibitory domain (LID) that restrains the transactivation domain when glucos...

journal_title：Diabetes

authors： Zhang P,Kumar A,Katz LS,Li L,Paulynice M,Herman MA,Scott DK

更新日期：2015-12-01 00:00:00

abstract：:A growing body of evidence implicates ceramide and/or its glycosphingolipid metabolites in the pathogenesis of insulin resistance. We have developed a highly specific small molecule inhibitor of glucosylceramide synthase, an enzyme that catalyzes a necessary step in the conversion of ceramide to glycosphingolipids. In...

journal_title：Diabetes

authors： Aerts JM,Ottenhoff R,Powlson AS,Grefhorst A,van Eijk M,Dubbelhuis PF,Aten J,Kuipers F,Serlie MJ,Wennekes T,Sethi JK,O'Rahilly S,Overkleeft HS

更新日期：2007-05-01 00:00:00

abstract：:β-Cell function improves in patients with type 2 diabetes in response to an oral glucose stimulus after Roux-en-Y gastric bypass (RYGB) surgery. This has been linked to the exaggerated secretion of glucagon-like peptide 1 (GLP-1), but causality has not been established. The aim of this study was to investigate the rol...

journal_title：Diabetes

authors： Jørgensen NB,Dirksen C,Bojsen-Møller KN,Jacobsen SH,Worm D,Hansen DL,Kristiansen VB,Naver L,Madsbad S,Holst JJ

更新日期：2013-09-01 00:00:00

abstract：:Estrogen-related receptor γ (ERRγ) is a major positive regulator of hepatic gluconeogenesis. Its transcriptional activity is suppressed by phosphorylation signaled by insulin in the fed state, but whether posttranslational modification alters its gluconeogenic activity in the fasted state is not known. Metabolically a...

journal_title：Diabetes

authors： Misra J,Kim DK,Jung YS,Kim HB,Kim YH,Yoo EK,Kim BG,Kim S,Lee IK,Harris RA,Kim JS,Lee CH,Cho JW,Choi HS

更新日期：2016-10-01 00:00:00