Formation of immunochemical advanced glycosylation end products precedes and correlates with early manifestations of renal and retinal disease in diabetes.

abstract：:Islet transplantation for the treatment of autoimmune diabetes is more difficult because of the additional barrier presented by the autoimmunity. We tested the ability of hamster anti-rat CD154 to prevent recurrence of diabetes in renal subcapsular islet isografts in DR-BB (RT1uu) rats with established autoimmune diab...

journal_title：Diabetes

authors： Kover KL,Geng Z,Hess DM,Benjamin CD,Moore WV

更新日期：2000-10-01 00:00:00

abstract：OBJECTIVE:To assess chemerin levels and regulation in sera and adipose tissue from women with polycystic ovary syndrome (PCOS) and matched control subjects. RESEARCH DESIGN AND METHODS:Real-time RT-PCR and Western blotting were used to assess mRNA and protein expression of chemerin. Serum chemerin was measured by enzy...

journal_title：Diabetes

authors： Tan BK,Chen J,Farhatullah S,Adya R,Kaur J,Heutling D,Lewandowski KC,O'Hare JP,Lehnert H,Randeva HS

更新日期：2009-09-01 00:00:00

abstract：:Some of the actions of leptin depend on cholecystokinin (CCK). However, it is unknown whether leptin modulates the release of CCK. Here, we demonstrate in vitro that leptin induces the phosphorylation of extracellular signal-related kinase (ERK)-1/2 proteins and increases CCK release (EC(50) = 0.23 nmol/l) in CCK-secr...

journal_title：Diabetes

authors： Guilmeau S,Buyse M,Tsocas A,Laigneau JP,Bado A

更新日期：2003-07-01 00:00:00

abstract：:The uptake of 2-deoxy-D-[1-14C]-glucose, in the presence and absence of insulin, was measured in adipocytes from normal and streptozotocin-diabetic animals, over a wide temperature range (25-45 degrees C). Optimum temperatures for uptake in the presence of maximally stimulating insulin concentrations occurred near phy...

journal_title：Diabetes

authors： Sauerheber RD,Kuhn CE,Hyslop PA

更新日期：1984-03-01 00:00:00

abstract：:ATP-sensitive potassium (K[ATP]) channels are an essential component of glucose-dependent insulin secretion in pancreatic islet beta-cells. These channels comprise the sulfonylurea receptor (SUR1) and Kir6.2, a member of the inward rectifier K+ channel family. Mutations in the SUR1 subunit are associated with familial...

journal_title：Diabetes

authors： Nestorowicz A,Inagaki N,Gonoi T,Schoor KP,Wilson BA,Glaser B,Landau H,Stanley CA,Thornton PS,Seino S,Permutt MA

更新日期：1997-11-01 00:00:00

abstract：:Fibroblast growth factor 1 (FGF1) has been shown to reverse hyperglycemia in diabetic rodent models through peripheral and central administration routes. Previous studies demonstrated that insulin is required for central and peripheral FGF1 metabolic improvements; however, it is unknown if FGF1 targets insulin secreti...

journal_title：Diabetes

authors： Tennant KG,Lindsley SR,Kirigiti MA,True C,Kievit P

更新日期：2019-07-01 00:00:00

abstract：:Adiponectin is an adipose tissue-specific protein with insulin-sensitizing and antiatherogenic properties. Therefore, the adiponectin gene is a promising candidate gene for type 2 diabetes. We investigated the single nucleotide polymorphisms (SNPs) +45T/G and +276G/T of the adiponectin gene as predictors for the conve...

journal_title：Diabetes

authors： Zacharova J,Chiasson JL,Laakso M,STOP-NIDDM Study Group.

更新日期：2005-03-01 00:00:00

abstract：:The flavonoid naringenin improves hyperlipidemia and hyperglycemia in streptozotocin-treated rats. In HepG2 human hepatoma cells, naringenin inhibits apolipoprotein B (apoB) secretion primarily by inhibiting microsomal triglyceride transfer protein and enhances LDL receptor (LDLr)-mediated apoB-containing lipoprotein ...

journal_title：Diabetes

authors： Borradaile NM,de Dreu LE,Huff MW

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:Suppression of Kinesin-1 by antisense oligonucleotides, or overexpression of dominant-negative acting kinesin heavy chain, has been reported to affect the sustained phase of glucose-stimulated insulin secretion in β-cells in vitro. In this study, we examined the in vivo physiological role of Kinesin-1 in β-ce...

journal_title：Diabetes

authors： Cui J,Wang Z,Cheng Q,Lin R,Zhang XM,Leung PS,Copeland NG,Jenkins NA,Yao KM,Huang JD

更新日期：2011-01-01 00:00:00

abstract：:Long-term insulin secretion was investigated in seven biohybrid capillary devices seeded with canine islets. Approximately 50,000 islets could be isolated from a single canine pancreas using collagenase digestion in conjunction with the recently described Velcro technique. Devices were perfused with tissue culture med...

journal_title：Diabetes

authors： Araki Y,Solomon BA,Basile RM,Chick WL

更新日期：1985-09-01 00:00:00

abstract：:We present a patient who developed insulin-requiring diabetes several years after the onset of symptoms of anterior hypopituitarism. It is likely that the hypopituitarism protected him against the development of diabetic retinopathy and glomerular basement membrane thickening but not against neuropathy and atheroma. T...

journal_title：Diabetes

authors： Greenwood RH,Ireland JT,Jones DH,Mahler RF

更新日期：1975-11-01 00:00:00

abstract：:In view of reports that accessory pathways of glucose oxidation are enhanced in the diabetic state, we have determined the levels of key enzymes of the glucuronate-xylulose cycle in the livers of diabetic mice and rats. Genetically diabetic mice (db/db) were found to have increased levels of two NADP-linked enzymes of...

journal_title：Diabetes

authors： Tulsiani DR,Touster O

更新日期：1979-09-01 00:00:00

abstract：:Clinical factors related to the development and progression of renal lesions were studied in twenty-three diabetics by the use of serial renal biopsies or autopsy. The results were as follows: Most of the juvenile and intermediate type diabetics were poorly controlled, with the glomerular lesion progressing rather rap...

journal_title：Diabetes

authors： Takazakura E,Nakamoto Y,Hayakawa H,Kawai K,Muramoto S

更新日期：1975-01-01 00:00:00

abstract：:IA-2, a member of the protein tyrosine phosphatase family, represents a major target autoantigen in type 1 diabetes. To study the regulation of IA-2 gene expression, we used INS-1 insulinoma cells to analyze beta-cell signal transduction pathways as well as the effect of metabolic and hormonal factors involved in the ...

journal_title：Diabetes

authors： Seissler J,Nguyen TB,Aust G,Steinbrenner H,Scherbaum WA

更新日期：2000-07-01 00:00:00

abstract：:IA-2 and IA-2beta are members of the transmembrane protein tyrosine phosphatase family located in dense core vesicles of neuroendocrine cells, including the beta-cells of pancreatic islets. In the present study, by mating C57BL/6Nci IA-2(+/-) with IA-2beta(+/-) mice, we generated double knockout mice (IA-2(-/-)/IA-2be...

journal_title：Diabetes

authors： Kubosaki A,Nakamura S,Notkins AL

更新日期：2005-12-01 00:00:00

abstract：:In the fasted rat, efficient glucose-stimulated insulin secretion (GSIS) is absolutely dependent on an elevated level of circulating free fatty acids (FFAs). To determine if this is also true in humans, nonobese volunteers were fasted for 24 h (n = 5) or 48 h (n = 5), after which they received an infusion of either sa...

journal_title：Diabetes

authors： Dobbins RL,Chester MW,Daniels MB,McGarry JD,Stein DT

更新日期：1998-10-01 00:00:00

abstract：:Wilson and coworkers (Wilson SB, Kent SC, Patton KT, Orban T, Jackson RA, Exley M, Porcelli S, Schatz DA, Atkinson MA, Balk SP, Strominger JL, Hafler DA: Extreme Th1 bias of invariant V alpha24J alpha Q T-cells in type 1 diabetes. Nature 391:177-181, 1998) have recently reported raised serum levels of interleukin-4 (I...

journal_title：Diabetes

authors： Redondo MJ,Gottlieb PA,Motheral T,Mulgrew C,Rewers M,Babu S,Stephens E,Wegmann DR,Eisenbarth GS

更新日期：1999-11-01 00:00:00

abstract：:Altered proteoglycan metabolism may play a role in the development of diabetic glomerulopathy. This study was conducted to examine the effects of glucose on the production and physical characteristics of proteoglycans generated by rat mesangial cells in culture. Rat mesangial cells were exposed to elevated glucose med...

journal_title：Diabetes

authors： Silbiger S,Schlondorff D,Crowley S,Rosenberg L,Choi H,Hatcher V,Gordon P

更新日期：1993-12-01 00:00:00

abstract：:The hyperglycemic patient remains persistently at risk for infectious complications. Whether ascribable to diabetes mellitus, to the administration of glucocorticoids, or to the infusion of hyperalimentation fluids, hyperglycemia may impair several mechanisms of humoral host defense, including such varied neutrophil f...

journal_title：Diabetes

authors： Hostetter MK

更新日期：1990-03-01 00:00:00

abstract：OBJECTIVE:The molecular mechanisms responsible for pancreatic β-cell dysfunction in type 2 diabetes remain unresolved. Increased expression of the helix-loop-helix protein Id1 has been found in islets of diabetic mice and in vitro models of β-cell dysfunction. Here, we investigated the role of Id1 in insulin secretion ...

journal_title：Diabetes

authors： Akerfeldt MC,Laybutt DR

更新日期：2011-10-01 00:00:00

abstract：:There is evidence from animal models of obesity and type 2 diabetes that increased parasympathetic vagal input to the pancreas contributes to hyperinsulinemia. Compared with Caucasians, Pima Indians have a high risk of type 2 diabetes and exhibit marked hyperinsulinemia and elevated plasma levels of pancreatic polypep...

journal_title：Diabetes

authors： Vozarova de Courten B,Weyer C,Stefan N,Horton M,DelParigi A,Havel P,Bogardus C,Tataranni PA

更新日期：2004-03-01 00:00:00

abstract：:Adiponectin is an abundant adipose tissue-derived protein with important metabolic effects. Plasma adiponectin levels are decreased in obese individuals, and low adiponectin levels predict insulin resistance and type 2 diabetes. Two variants in the adiponectin gene ACDC have been previously associated with plasma adip...

journal_title：Diabetes

authors： Vozarova de Courten B,Hanson RL,Funahashi T,Lindsay RS,Matsuzawa Y,Tanaka S,Thameem F,Gruber JD,Froguel P,Wolford JK

更新日期：2005-01-01 00:00:00

abstract：:A group of insulin-dependent diabetic patients was studied in order to determine the possible short-term regulatory effect of insulin and that of an antilipolytic drug on serum triglycerides. Subcutaneous crystalline insulin (one third of the usual morning dose of intermediate long-acting insulin, NPH) and an oral dos...

journal_title：Diabetes

authors： Alvarez-Reynolds M,Dominguez JM

更新日期：1977-07-01 00:00:00

abstract：:In diabetic patients, elevated plasma levels of t-PA and PAI-1 accompany impaired fibrinolysis. To identify mechanisms for these abnormalities, we examined whether vascular endothelial cells exposed to high glucose upregulate t-PA and PAI-1 production and whether ambient PA activity is decreased concomitantly. In 17 c...

journal_title：Diabetes

authors： Maiello M,Boeri D,Podesta F,Cagliero E,Vichi M,Odetti P,Adezati L,Lorenzi M

更新日期：1992-08-01 00:00:00

abstract：:Mutations in the melanocortin-4 receptor (MC4R) gene are the most frequent monogenic causes of severe obesity. Most mutations have been described as heterozygous with loss of function, suggesting that haploinsufficiency is the most likely mechanism of dominant inheritance. We detected a heterozygous mutation, D90N, in...

journal_title：Diabetes

authors： Biebermann H,Krude H,Elsner A,Chubanov V,Gudermann T,Grüters A

更新日期：2003-12-01 00:00:00

abstract：:In the transgenic mouse, a specific gene can be transduced or deleted to study its function and relation to human diseases. Recently, various lines of transgenic mice that overexpress or lack a specific gene have been established and are available to study the pathophysiology of human diseases, including atheroscleros...

journal_title：Diabetes

authors： Harada K,Shimano H,Ishibashi S,Yamada N

更新日期：1996-07-01 00:00:00

abstract：:This cross-sectional study evaluated the relationship between 1) functional and structural measurements of neurodegeneration in the initial stages of diabetic retinopathy (DR) and 2) the presence of neurodegeneration and early microvascular impairment. We analyzed baseline data of 449 patients with type 2 diabetes enr...

journal_title：Diabetes

authors： Santos AR,Ribeiro L,Bandello F,Lattanzio R,Egan C,Frydkjaer-Olsen U,García-Arumí J,Gibson J,Grauslund J,Harding SP,Lang GE,Massin P,Midena E,Scanlon P,Aldington SJ,Simão S,Schwartz C,Ponsati B,Porta M,Costa MÂ,Her

更新日期：2017-09-01 00:00:00

abstract：:Caloric restriction (CR) improves insulin sensitivity and reduces the incidence of diabetes in obese individuals. The underlying mechanisms whereby CR improves insulin sensitivity are not clear. We evaluated the effect of 16 weeks of CR on whole-body insulin sensitivity by pancreatic clamp before and after CR in 11 ob...

journal_title：Diabetes

authors： Johnson ML,Distelmaier K,Lanza IR,Irving BA,Robinson MM,Konopka AR,Shulman GI,Nair KS

更新日期：2016-01-01 00:00:00

abstract：:Impaired wound healing is one of the main causes of diabetic foot ulcerations. However, the exact mechanism of delayed wound healing in diabetes is not fully understood. Long noncoding RNAs (lncRNAs) are widely involved in a variety of biological processes and diseases, including diabetes and its associated complicati...

journal_title：Diabetes

authors： Hu M,Wu Y,Yang C,Wang X,Wang W,Zhou L,Zeng T,Zhou J,Wang C,Lao G,Yan L,Ren M

更新日期：2020-10-01 00:00:00

abstract：:To explore metabolic changes associated with the sorbitol accumulation and myo-inositol depletion observed in glomeruli of rats with experimental diabetes, we examined total and ouabain-inhibited adenosine triphosphatase (ATPase) activity in glomeruli isolated from control and streptozocin (STZ)-diabetic rats. Glomeru...

journal_title：Diabetes

authors： Cohen MP,Dasmahapatra A,Shapiro E

更新日期：1985-11-01 00:00:00