Label-retaining cells in the rat pancreas: location and differentiation potential in vitro.

abstract：:We explored the role of reactive oxygen species (ROS) in the pathogenesis of muscle insulin resistance. We assessed insulin action in vivo with a hyperinsulinemic-euglycemic clamp in mice expressing a mitochondrial-targeted catalase (MCAT) that were fed regular chow (RC) or a high-fat diet (HFD) or underwent an acute ...

journal_title：Diabetes

authors： Lee HY,Lee JS,Alves T,Ladiges W,Rabinovitch PS,Jurczak MJ,Choi CS,Shulman GI,Samuel VT

更新日期：2017-08-01 00:00:00

abstract：:Coxsackievirus B infections have been associated with clinical manifestation of insulin-dependent diabetes mellitus (IDDM) in several studies, but their initiating role in the slowly progressing beta-cell damage is not known. This is the first prospective study designed to assess the role of coxsackie B and other ente...

journal_title：Diabetes

authors： Hyöty H,Hiltunen M,Knip M,Laakkonen M,Vähäsalo P,Karjalainen J,Koskela P,Roivainen M,Leinikki P,Hovi T

更新日期：1995-06-01 00:00:00

abstract：:Recent data have suggested a key role for tumor necrosis factor (TNF)-alpha in the insulin resistance of obesity and non-insulin-dependent diabetes mellitus (NIDDM). TNF-alpha expression is elevated in the adipose tissue of multiple experimental models of obesity. Neutralization of TNF-alpha in one of these models imp...

journal_title：Diabetes

authors： Hotamisligil GS,Spiegelman BM

更新日期：1994-11-01 00:00:00

abstract：:Growing evidence suggests that epigenetic profile changes occurring during fetal development in response to in utero environment variations could be one of the mechanisms involved in the early determinants of adult chronic diseases. In this study, we tested whether maternal glycemic status is associated with the adipo...

journal_title：Diabetes

authors： Bouchard L,Hivert MF,Guay SP,St-Pierre J,Perron P,Brisson D

更新日期：2012-05-01 00:00:00

abstract：:Although hyperhomocysteinemia, an independent cardiovascular risk factor, is common in type 2 diabetes with nephropathy, the mechanism(s) of this alteration is not known. In healthy humans, hyperinsulinemia increases methionine transmethylation, homocysteine transsulfuration, and clearance. No such data exist in type ...

journal_title：Diabetes

authors： Tessari P,Coracina A,Kiwanuka E,Vedovato M,Vettore M,Valerio A,Zaramella M,Garibotto G

更新日期：2005-10-01 00:00:00

abstract：:Glucokinase is a critical component of the physiological glucose sensor found in cell types that are responsive to changes in plasma glucose levels. The acute regulation of glucokinase activity has been shown to occur via a regulatory protein found in liver parenchymal cells (Van Schaftingen E, Detheux M, Da Cunha MV....

journal_title：Diabetes

authors： Mookhtiar KA,Kalinowski SS,Brown KS,Tsay YH,Smith-Monroy C,Robinson GW

更新日期：1996-12-01 00:00:00

abstract：:Diabetes-induced alterations in heme and hemoproteins, as well as its relationship to drug-mediated induction of ALA Synthase (ALA-S), were examined in female Sprague-Dawley rats. Animals were rendered diabetic by a single i.v. injection of streptozotocin (STZ, 65 mg/kg) and measurements were made at various times aft...

journal_title：Diabetes

authors： Bitar M,Weiner M

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVE:Glucagon-like peptide-1 receptor (GLP-1R) agonists are used to treat type 2 diabetes, and transient GLP-1 administration improved cardiac function in humans after acute myocardial infarction (MI) and percutaneous revascularization. However, the consequences of GLP-1R activation before ischemic myocardial inju...

journal_title：Diabetes

authors： Noyan-Ashraf MH,Momen MA,Ban K,Sadi AM,Zhou YQ,Riazi AM,Baggio LL,Henkelman RM,Husain M,Drucker DJ

更新日期：2009-04-01 00:00:00

abstract：:Despite intensive study, the relation between insulin's action on blood flow and glucose metabolism remains unclear. Insulin-induced changes in microvascular perfusion, independent from effects on total blood flow, could be an important variable contributing to insulin's metabolic action. We hypothesized that modest, ...

journal_title：Diabetes

authors： Coggins M,Lindner J,Rattigan S,Jahn L,Fasy E,Kaul S,Barrett E

更新日期：2001-12-01 00:00:00

abstract：:Two major metabolic perturbations, increased polyol (sorbitol) pathway activity and reduced tissue myo-inositol content, are induced in peripheral nerve by hyperglycemia. Although they are commonly invoked as alternative biochemical pathogenetic mechanisms for diabetic neuropathy, their possible interrelationship has ...

journal_title：Diabetes

authors： Finegold D,Lattimer SA,Nolle S,Bernstein M,Greene DA

更新日期：1983-11-01 00:00:00

abstract：:Insulin is a short-lived species in the circulatory system. After binding to its receptor sites and transmission of its biological signals, bound insulin undergoes receptor-mediated endocytosis and consequent degradation. An inactive insulin derivative that is not recognized by the receptor has a longer circulation li...

journal_title：Diabetes

authors： Gershonov E,Shechter Y,Fridkin M

更新日期：1999-07-01 00:00:00

abstract：:There is an unexplained excess of type 1 diabetes and other organ-specific autoimmune diseases in children with Down's syndrome, but the immunogenetic characteristics of diabetes in Down's syndrome have not been investigated. We studied the frequency of islet autoantibodies in 106 children with Down's syndrome and no ...

journal_title：Diabetes

authors： Gillespie KM,Dix RJ,Williams AJ,Newton R,Robinson ZF,Bingley PJ,Gale EA,Shield JP

更新日期：2006-11-01 00:00:00

abstract：:When fed a high-energy (HE) diet, diabetes-prone (DP) Psammomys obesus develop type 2 diabetes with altered glucose-stimulated insulin secretion (GSIS). Beta-cell stimulus-secretion coupling was investigated in islets isolated from DP P. obesus fed a low-energy (LE) diet (DP-LE) and after 5 days on a HE diet (DP-HE). ...

journal_title：Diabetes

authors： Pertusa JA,Nesher R,Kaiser N,Cerasi E,Henquin JC,Jonas JC

更新日期：2002-08-01 00:00:00

abstract：OBJECTIVE:Preferential upper-body fat gain, a typical male pattern, is associated with a greater cardiometabolic risk. Regional differences in lipolysis and meal fat storage cannot explain sex differences in body fat distribution. We examined the potential role of the novel free fatty acid (FFA) storage pathway in dete...

journal_title：Diabetes

authors： Koutsari C,Ali AH,Mundi MS,Jensen MD

更新日期：2011-08-01 00:00:00

abstract：:Rapamycin is used frequently in both transplantation and oncology. Although historically thought to have little diabetogenic effect, there is growing evidence of β-cell toxicity. This Review draws evidence for rapamycin toxicity from clinical studies of islet and renal transplantation, and of rapamycin as an anticance...

journal_title：Diabetes

authors： Barlow AD,Nicholson ML,Herbert TP

更新日期：2013-08-01 00:00:00

abstract：:Because high D-glucose significantly stimulates endothelial cell death, we examined the molecular mechanisms of high D-glucose-induced endothelial apoptosis. Treatment of human aortic endothelial cells with high D-glucose (25 mmol/l), but not mannitol and L-glucose, resulted in a significant decrease in cell number an...

journal_title：Diabetes

authors： Nakagami H,Morishita R,Yamamoto K,Yoshimura SI,Taniyama Y,Aoki M,Matsubara H,Kim S,Kaneda Y,Ogihara T

更新日期：2001-06-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) has been suggested to play a role in the pathogenesis of diabetic vascular complications. In the present study, we investigated whether expression of monocyte chemoattractant protein-1 (MCP-1), a chemokine that has been proposed to recruit leukocytes to sites of inflammation, ...

journal_title：Diabetes

authors： Marumo T,Schini-Kerth VB,Busse R

更新日期：1999-05-01 00:00:00

abstract：:RIN-m cells, cultured from a rat insulinoma, not only bind and secrete but also degrade insulin (Diabetes 1982; 31:521-31). The insulin-degrading activity resides in the cytosol and is similar to the insulin-specific proteases previously described in muscle and other tissues. It has an apparent Km of 0.15 microM for p...

journal_title：Diabetes

authors： Bhathena SJ,Timmers KI,Oie HK,Voyles NR,Recant L

更新日期：1985-02-01 00:00:00

abstract：:It has been proposed that p38 mitogen-activated protein kinase (MAPK) isoforms sensitive to the pyridinylimidazole compounds SB 203580 and SB 202190 may participate in the acute insulin-dependent activation of glucose transporters recruited to the plasma membrane of adipocytes and skeletal muscle. Here, we explore whe...

journal_title：Diabetes

authors： Turban S,Beardmore VA,Carr JM,Sakamoto K,Hajduch E,Arthur JS,Hundal HS

更新日期：2005-11-01 00:00:00

abstract：:It is well established that patients with non-insulin-dependent diabetes mellitus (NIDDM) are resistant to insulin. However, the contribution of hepatic and extrahepatic tissues to insulin resistance remains controversial. The uncertainty may be at least in part due to errors introduced by the unknowing use in previou...

journal_title：Diabetes

authors： Butler PC,Kryshak EJ,Schwenk WF,Haymond MW,Rizza RA

更新日期：1990-02-01 00:00:00

abstract：OBJECTIVE:To evaluate the extent of pancreatic β-cell function in a large number of insulin-dependent diabetic patients with a disease duration of 50 years or longer (Medalists). RESEARCH DESIGN AND METHODS:Characterization of clinical and biochemical parameters and β-cell function of 411 Medalists with correlation wi...

journal_title：Diabetes

authors： Keenan HA,Sun JK,Levine J,Doria A,Aiello LP,Eisenbarth G,Bonner-Weir S,King GL

更新日期：2010-11-01 00:00:00

abstract：:Diabetes is generally diagnosed too late. Therefore, biomarkers indicating early stages of β-cell dysfunction and mass reduction would facilitate timely counteraction. Transgenic pigs expressing a dominant-negative glucose-dependent insulinotropic polypeptide receptor (GIPR(dn)) reveal progressive deterioration of glu...

journal_title：Diabetes

authors： Renner S,Römisch-Margl W,Prehn C,Krebs S,Adamski J,Göke B,Blum H,Suhre K,Roscher AA,Wolf E

更新日期：2012-08-01 00:00:00

abstract：:Previous cross-sectional studies show that puberty is associated with a reduction in insulin sensitivity (S(I)), but no longitudinal studies have examined this change in detail. This study is a longitudinal study in 60 children (33 male and 27 female subjects; 32 Caucasian and 28 African-American) examined at Tanner s...

journal_title：Diabetes

authors： Goran MI,Gower BA

更新日期：2001-11-01 00:00:00

abstract：:A polymorphism in the interleukin 12B gene was recently reported to be strongly associated with type 1 diabetes in 422 Australian and British families. We analyzed the same polymorphism in 470 Italian type 1 diabetic patients and 544 matched control subjects and found no evidence of association with the disease. ...

journal_title：Diabetes

authors： Nisticò L,Giorgi G,Giordano M,Galgani A,Petrone A,D'Alfonso S,Federici M,Di Mario U,Pozzilli P,Buzzetti R,Cascino I

更新日期：2002-05-01 00:00:00

abstract：:Clinical factors related to the development and progression of renal lesions were studied in twenty-three diabetics by the use of serial renal biopsies or autopsy. The results were as follows: Most of the juvenile and intermediate type diabetics were poorly controlled, with the glomerular lesion progressing rather rap...

journal_title：Diabetes

authors： Takazakura E,Nakamoto Y,Hayakawa H,Kawai K,Muramoto S

更新日期：1975-01-01 00:00:00

abstract：:Diabetic glomerulosclerosis is defined by increased glomerular extracellular matrix (ECM) that is mainly synthesized by mesangial cells that underwent an activation mediated by cytokines and growth factors from various cellular origins. In this study, we tested whether macrophages could infiltrate the glomeruli and in...

journal_title：Diabetes

authors： Sassy-Prigent C,Heudes D,Mandet C,Bélair MF,Michel O,Perdereau B,Bariéty J,Bruneval P

更新日期：2000-03-01 00:00:00

abstract：:Type 2 diabetes and skeletal muscle insulin resistance have been linked to accumulation of the intramyocellular lipid-intermediate diacylglycerol (DAG). However, recent animal and human studies have questioned such an association. Given that DAG appears in different stereoisomers and has different reactivity in vitro,...

journal_title：Diabetes

authors： Serup AK,Alsted TJ,Jordy AB,Schjerling P,Holm C,Kiens B

更新日期：2016-10-01 00:00:00

abstract：:The adipocyte-derived hormone adiponectin seems to protect from insulin resistance, a key factor in the pathogenesis of type 2 diabetes. Genome-wide scans have mapped a susceptibility locus for type 2 diabetes and the metabolic syndrome to chromosome 3q27, where the adiponectin gene is located. A common silent T-G exc...

journal_title：Diabetes

authors： Stumvoll M,Tschritter O,Fritsche A,Staiger H,Renn W,Weisser M,Machicao F,Häring H

更新日期：2002-01-01 00:00:00

abstract：:Isologous pancreatic islets were implanted into the portal vein of rats with streptozotocin-induced diabetes. At intervals of from one to 32 days after transplantation, the intrahepatic islet grafts were examined histologically and ultrastructurally, and their vascular supply was determined by later perfusion studies....

journal_title：Diabetes

authors： Griffith RC,Scharp DW,Hartman BK,Ballinger WF,Lacy PE

更新日期：1977-03-01 00:00:00

abstract：:Genetics, epigenetics, and environment may together affect the susceptibility for type 2 diabetes (T2D). Our aim was to dissect molecular mechanisms underlying T2D using genome-wide expression and DNA methylation data in adipose tissue from monozygotic twin pairs discordant for T2D and independent case-control cohorts...

journal_title：Diabetes

authors： Nilsson E,Jansson PA,Perfilyev A,Volkov P,Pedersen M,Svensson MK,Poulsen P,Ribel-Madsen R,Pedersen NL,Almgren P,Fadista J,Rönn T,Klarlund Pedersen B,Scheele C,Vaag A,Ling C

更新日期：2014-09-01 00:00:00