Abstract:
:Two major metabolic perturbations, increased polyol (sorbitol) pathway activity and reduced tissue myo-inositol content, are induced in peripheral nerve by hyperglycemia. Although they are commonly invoked as alternative biochemical pathogenetic mechanisms for diabetic neuropathy, their possible interrelationship has never been adequately explored. Therefore, we studied the effect of polyol pathway blockade with sorbinil, a specific inhibitor of aldose reductase, on nerve myo-inositol content in acutely streptozotocin-diabetic rats. Sorbinil administration completely prevented the fall in nerve myo-inositol, thereby implicating increased polyol pathway activity as a likely factor in the fall in nerve myo-inositol content in experimental diabetes.
journal_name
Diabetesjournal_title
Diabetesauthors
Finegold D,Lattimer SA,Nolle S,Bernstein M,Greene DAdoi
10.2337/diab.32.11.988subject
Has Abstractpub_date
1983-11-01 00:00:00pages
988-92issue
11eissn
0012-1797issn
1939-327Xjournal_volume
32pub_type
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