当前位置： SCI文献检索 > DIABETES期刊下所有文献 > Glucose potentiation of arginine-induced insulin secretion is impaired in subjects with a glucokinase Glu256Lys mutation.

Glucose potentiation of arginine-induced insulin secretion is impaired in subjects with a glucokinase Glu256Lys mutation.

Abstract：

:Insulin and glucagon release and insulin sensitivity were investigated in patients with glucokinase deficiency. Five subjects with a missense mutation (Glu256Lys) were studied. They were compared with six healthy subjects with low insulin response but normal glucose tolerance. Insulin and glucagon levels were measured at blood glucose 7.1 +/- 0.1 mmol/l and at 10.9 +/- 0.2 mmol/l with or without arginine (5 g i.v.). Insulin sensitivity was assessed as the ratio between infused glucose and the insulin level (M:I) during hyperglycemic clamps. Glu256Lys subjects were nonobese and had fasting blood glucose 6.7 +/- 0.1 mmol/l (P < 0.001 vs. control group). Insulin release was reduced in response to 11 mmol/l glucose (61% of control group, P < 0.05) as well as to arginine in the presence of 11 mmol/l glucose (54% of control group, P < 0.01). Also, the slope of potentiation, i.e., the enhancement of arginine-induced release as a function of prevailing glucose concentration, was reduced (delta insulin/delta glucose, 47% of control group, P < 0.05). As for glucagon release, the response to arginine was not inhibited normally by glucose, resulting in threefold higher levels at 11 mmol/l glucose versus control subjects. Insulin sensitivity, assessed as M:I, was significantly (P < 0.05) reduced (55% of control group). Glucokinase deficiency thus affects not only insulin responses to glucose per se but also glucose potentiation of responses to non-nutrient secretagogues. Abnormalities in glucagon release and insulin sensitivity coexist with attenuated insulin responses in glucokinase-deficient subjects.

journal_name

Diabetes

journal_title

Diabetes

authors

Wajngot A,Alvarsson M,Glaser A,Efendic S,Luthman H,Grill V

doi

10.2337/diab.43.12.1402

subject

Has Abstract

pub_date

1994-12-01 00:00:00

pages

1402-6

issue

12

eissn

0012-1797

issn

1939-327X

journal_volume

43

pub_type

杂志文章

相关文献

DIABETES文献大全
  • Comparison of alpha- and beta-cell secretory responses in islets isolated with collagenase and in the isolated perfused pancreas of rats.

    abstract：:The inhibitory actions of somatostatin (100 ng./ml.) on insulin release, stimulated by high glucose (20 mM), and on glucagon release, stimulated by arginine (15 mM), were studied with two in vitro systems: the isolated perifused rat islets prepared by the collagenase procedure and the isolated perfused rat pancreas. S...

    journal_title：Diabetes

    pub_type： 历史文章,杂志文章

    doi：10.2337/diab.24.11.961

    authors： Norfleet WT,Pagliara AS,Haymond MW,Matschinsky F

    更新日期：1975-11-01 00:00:00

  • The hemodynamic abnormalities in short-term insulin deficiency: the role of prostaglandin inhibition.

    abstract：:It has been suggested that the hemodynamic derangements present in diabetic ketoacidosis are the results not only of profound volume depletion but also of the effects of increased production of vasodilating prostaglandins (PGs), principally PGI2, released by adipose tissue. In animal and in vitro models, prostaglandin...

    journal_title：Diabetes

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.2337/diab.45.5.602

    authors： Avogaro A,Crepaldi C,Piarulli F,Milan D,Valerio A,Pavan P,Sacerdoti D,Calabrò A,Macdonald I,Crepaldi G,Scognamiglio R,Tiengo A

    更新日期：1996-05-01 00:00:00

  • Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine.

    abstract：:Accumulation of triosephosphates arising from high cytosolic glucose concentrations in hyperglycemia is the trigger for biochemical dysfunction leading to the development of diabetic nephropathy-a common complication of diabetes associated with a high risk of cardiovascular disease and mortality. Here we report that s...

    journal_title：Diabetes

    pub_type： 杂志文章

    doi：10.2337/diabetes.52.8.2110

    authors： Babaei-Jadidi R,Karachalias N,Ahmed N,Battah S,Thornalley PJ

    更新日期：2003-08-01 00:00:00

  • Fractalkine is a novel human adipochemokine associated with type 2 diabetes.

    abstract：OBJECTIVE:Leukocyte infiltration of adipose is a critical determinant of obesity-related metabolic diseases. Fractalkine (CX3CL1) and its receptor (CX3CR1) comprise a chemokine system involved in leukocyte recruitment and adhesion in atherosclerosis, but its role in adipose inflammation and type 2 diabetes is unknown. ...

    journal_title：Diabetes

    pub_type： 杂志文章

    doi：10.2337/db10-0956

    authors： Shah R,Hinkle CC,Ferguson JF,Mehta NN,Li M,Qu L,Lu Y,Putt ME,Ahima RS,Reilly MP

    更新日期：2011-05-01 00:00:00

  • Analysis of the mouse CD30 gene: a candidate for the NOD mouse type 1 diabetes locus Idd9.2.

    abstract：:Members of the tumor necrosis factor receptor superfamily play an important role in the initiation, expansion, and termination of an immune response. It has recently been demonstrated that one member of this family, CD30, plays a central role in maintaining peripheral tolerance by controlling the expansion of autoreac...

    journal_title：Diabetes

    pub_type： 杂志文章

    doi：10.2337/diabetes.49.9.1612

    authors： Siegmund T,Armitage N,Wicker LS,Peterson LB,Todd JA,Lyons PA

    更新日期：2000-09-01 00:00:00

  • The effect of oxidation on sorbitol pathway kinetics.

    abstract：:The rapid conversion of glucose to sorbitol by aldose reductase and the consequent hyperosmolarity of the cytoplasm has been shown to be the primary cause of the so-called "sugar" or "osmotic" cataract in many animal lenses. It is not as clear, however, that hyperosmolarity is the principal factor in the etiology of c...

    journal_title：Diabetes

    pub_type： 杂志文章

    doi：10.2337/diab.35.4.426

    authors： Barnett PA,González RG,Chylack LT Jr,Cheng HM

    更新日期：1986-04-01 00:00:00

  • Direct effects of glucagon on protein and amino acid metabolism in the isolated perfused rat liver. Interactions with insulin and dexamethasone in net synthesis of albumin and acute-phase proteins.

    abstract：:The isolated rat liver perfused for 12 hours at pH 7.10 with a suspension of bovine erythrocytes in Krebs-Ringer bicarbonate buffer containing 3 per cent bovine serum albumin has been used as a test system to study effects of glucagon and of dexamethasone in the presence and absence of insulin on net biosynthesis of r...

    journal_title：Diabetes

    pub_type： 杂志文章

    doi：

    authors： Miller LL

    更新日期：1976-01-01 00:00:00

  • Diabetic autonomic neuropathy in BB rat. Ultrastructural and morphometric changes in parasympathetic nerves.

    abstract：:Longitudinal electron-microscopic and morphometric studies of autonomic nerves containing predominantly parasympathetic fibers were undertaken in the spontaneously diabetic BB rat. Unmyelinated fibers of the diabetic vagus nerve and myelinated fibers of the penile nerve showed increased numbers of axonal glycogenosome...

    journal_title：Diabetes

    pub_type： 杂志文章

    doi：10.2337/diab.35.7.733

    authors： Yagihashi S,Sima AA

    更新日期：1986-07-01 00:00:00

  • Validation of 111In-Exendin SPECT for the Determination of the β-Cell Mass in BioBreeding Diabetes-Prone Rats.

    abstract：:The changes in β-cell mass (BCM) during the development and progression of diabetes could potentially be measured by radionuclide imaging using radiolabeled exendin. In this study, we investigated the potential of 111In-diethylenetriaminepentaacetic acid-exendin-3 (111In-exendin) in a rat model that closely mimics the...

    journal_title：Diabetes

    pub_type： 杂志文章

    doi：10.2337/db17-1312

    authors： Brom M,Joosten L,Frielink C,Peeters H,Bos D,van Zanten M,Boerman O,Gotthardt M

    更新日期：2018-10-01 00:00:00

  • Genetic Determinants of Glycemic Traits and the Risk of Gestational Diabetes Mellitus.

    abstract：:Many common genetic polymorphisms are associated with glycemic traits and type 2 diabetes (T2D), but knowledge about genetic determinants of glycemic traits in pregnancy is limited. We tested genetic variants known to be associated with glycemic traits and T2D in the general population for associations with glycemic t...

    journal_title：Diabetes

    pub_type： 杂志文章

    doi：10.2337/db18-0203

    authors： Powe CE,Nodzenski M,Talbot O,Allard C,Briggs C,Leya MV,Perron P,Bouchard L,Florez JC,Scholtens DM,Lowe WL Jr,Hivert MF

    更新日期：2018-12-01 00:00:00

  • Insulin receptor-related receptor is expressed in pancreatic beta-cells and stimulates tyrosine phosphorylation of insulin receptor substrate-1 and -2.

    abstract：:The receptor-type protein tyrosine kinases in murine pancreatic islets were screened to identify possible growth/differentiation factors in pancreatic beta-cells. The analysis revealed that insulin receptor-related receptor (IRR) is highly expressed in the islets as well as in several highly differentiated beta-cell l...

    journal_title：Diabetes

    pub_type： 杂志文章

    doi：10.2337/diabetes.48.6.1237

    authors： Hirayama I,Tamemoto H,Yokota H,Kubo SK,Wang J,Kuwano H,Nagamachi Y,Takeuchi T,Izumi T

    更新日期：1999-06-01 00:00:00

  • Regulated exocytosis and kiss-and-run of synaptic-like microvesicles in INS-1 and primary rat beta-cells.

    abstract：:We have applied cell-attached capacitance measurements to investigate whether synaptic-like microvesicles (SLMVs) undergo regulated exocytosis in insulinoma and primary pancreatic beta-cells. SLMV and large dense-core vesicle (LDCV) exocytosis was increased 1.6- and 2.4-fold upon stimulation with 10 mmol/l glucose in ...

    journal_title：Diabetes

    pub_type： 杂志文章

    doi：10.2337/diabetes.54.3.736

    authors： MacDonald PE,Obermüller S,Vikman J,Galvanovskis J,Rorsman P,Eliasson L

    更新日期：2005-03-01 00:00:00

  • A novel gene for neonatal diabetes maps to chromosome 10p12.1-p13.

    abstract：:We report a genomewide linkage analysis of a large consanguineous family segregating autosomal recessively inherited neonatal diabetes and the identification of a novel neonatal diabetes locus. Neonatal diabetes was characterized by low levels of circulating C-peptide with very low to undetectable levels of insulin in...

    journal_title：Diabetes

    pub_type： 杂志文章

    doi：10.2337/diabetes.52.10.2636

    authors： Sellick GS,Garrett C,Houlston RS

    更新日期：2003-10-01 00:00:00

  • RhoA/Rho-kinase contribute to the pathogenesis of diabetic renal disease.

    abstract：OBJECTIVE:Accumulation of glomerular matrix proteins is central to the pathogenesis of diabetic nephropathy, with resident mesangial cells (MCs) known to upregulate matrix protein synthesis in response to high glucose. Because activation of the GTPase RhoA has been implicated in matrix upregulation, we studied its role...

    journal_title：Diabetes

    pub_type： 杂志文章

    doi：10.2337/db07-1149

    authors： Peng F,Wu D,Gao B,Ingram AJ,Zhang B,Chorneyko K,McKenzie R,Krepinsky JC

    更新日期：2008-06-01 00:00:00

  • Development of early lesions of microangiopathy in chronically diabetic monkeys.

    abstract：:A chronic diabetic state was produced in Macaca fuscatus , and these diabetic monkeys were kept without insulin treatment for up to 25 mo. The metabolic derangements were characterized by hyperglycemia, insulinopenia, hyperglucagonemia, ketonemia, and hyperlipidemia. Significant thickening of the capillary basement me...

    journal_title：Diabetes

    pub_type： 杂志文章

    doi：10.2337/diab.33.5.415

    authors： Yasuda H,Harano Y,Kosugi K,Nakano T,Suzuki M,Tsuruoka Y,Taniguchi Y,Nishimori T,Kikkawa R,Shigeta Y

    更新日期：1984-05-01 00:00:00

  • Effects of acute, subacute, and chronic diabetes on carbohydrate and energy metabolism in rat sciatic nerve. Relation to mechanisms of peripheral neuropathy.

    abstract：:To address the problem of the pathogenesis of diabetic neuropathy, rats were made diabetic by alloxan administration, and sciatic nerves were sampled for electrolyte and water content and levels of selected carbohydrates and intermediates in energy metabolism at 3, 6, and 26 weeks. Significant increases were seen in t...

    journal_title：Diabetes

    pub_type： 杂志文章

    doi：10.2337/diab.44.2.190

    authors： Thurston JH,McDougal DB Jr,Hauhart RE,Schulz DW

    更新日期：1995-02-01 00:00:00

  • Handicaps to host defense. Effects of hyperglycemia on C3 and Candida albicans.

    abstract：:The hyperglycemic patient remains persistently at risk for infectious complications. Whether ascribable to diabetes mellitus, to the administration of glucocorticoids, or to the infusion of hyperalimentation fluids, hyperglycemia may impair several mechanisms of humoral host defense, including such varied neutrophil f...

    journal_title：Diabetes

    pub_type： 杂志文章,评审

    doi：10.2337/diab.39.3.271

    authors： Hostetter MK

    更新日期：1990-03-01 00:00:00

  • Habitual physical activity and glucose tolerance. Males age 16-64 in a total community.

    abstract：:The data being reported are part of an epidemiologic study of health and disease in an entire community, Tecumseh, Michigan. Approximately 1,300 males age 16-65 were classified into three groups on the basis of their habitual leisure and occupational physical activity. A blood sample was drawn one hour after a glucose...

    journal_title：Diabetes

    pub_type： 杂志文章

    doi：10.2337/diab.26.3.172

    authors： Montoye HJ,Block WD,Metzner H,Keller JB

    更新日期：1977-03-01 00:00:00

  • Mitochondrial respiration is decreased in skeletal muscle of patients with type 2 diabetes.

    abstract：:We tested the hypothesis of a lower respiratory capacity per mitochondrion in skeletal muscle of type 2 diabetic patients compared with obese subjects. Muscle biopsies obtained from 10 obese type 2 diabetic and 8 obese nondiabetic male subjects were used for assessment of 3-hydroxy-Acyl-CoA-dehydrogenase (HAD) and cit...

    journal_title：Diabetes

    pub_type： 杂志文章

    doi：10.2337/db06-0981

    authors： Mogensen M,Sahlin K,Fernström M,Glintborg D,Vind BF,Beck-Nielsen H,Højlund K

    更新日期：2007-06-01 00:00:00

  • Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome.

    abstract：:The insulin resistance syndrome is characterized by several risk factors for cardiovascular disease. Chronic chemical activation of AMP-activated protein kinase by the adenosine analog 5-aminoimidazole-4-carboxamide-1-beta -D-ribofuranoside (AICAR) has been shown to augment insulin action, upregulate mitochondrial enz...

    journal_title：Diabetes

    pub_type： 杂志文章

    doi：10.2337/diabetes.51.7.2199

    authors： Buhl ES,Jessen N,Pold R,Ledet T,Flyvbjerg A,Pedersen SB,Pedersen O,Schmitz O,Lund S

    更新日期：2002-07-01 00:00:00

  • Heritability of proliferative diabetic retinopathy.

    abstract：OBJECTIVE:Diabetic nephropathy clusters in families, suggesting that genetic factors play a role in its pathogenesis. We investigated whether similar clustering exists for proliferative retinopathy in families with two or more siblings with type 1 diabetes. RESEARCH DESIGN AND METHODS:The FinnDiane Study has character...

    journal_title：Diabetes

    pub_type： 杂志文章

    doi：10.2337/db07-1495

    authors： Hietala K,Forsblom C,Summanen P,Groop PH,FinnDiane Study Group.

    更新日期：2008-08-01 00:00:00

  • The effect of diabetes on expression of beta1-, beta2-, and beta3-adrenoreceptors in rat hearts.

    abstract：:Diabetic hearts exhibit decreased responsiveness to stimulation by beta-adrenoreceptor (beta-AR) agonists. This decrease in activity may be due to changes in expression and/or signaling of beta-AR. Recently we showed that right atrial strips from 14-week streptozotocin (STZ)-induced diabetic rat hearts exhibit decreas...

    journal_title：Diabetes

    pub_type： 杂志文章

    doi：10.2337/diabetes.50.2.455

    authors： Dinçer UD,Bidasee KR,Güner S,Tay A,Ozçelikay AT,Altan VM

    更新日期：2001-02-01 00:00:00

  • Hormone-sensitive lipase serine phosphorylation and glycerol exchange across skeletal muscle in lean and obese subjects: effect of beta-adrenergic stimulation.

    abstract：OBJECTIVE:Increased intramuscular triacylglycerol (IMTG) storage is a characteristic of the obese insulin-resistant state. We aimed to investigate whether a blunted fasting or beta-adrenergically mediated lipolysis contributes to this increased IMTG storage in obesity. RESEARCH DESIGN AND METHODS:Forearm skeletal musc...

    journal_title：Diabetes

    pub_type： 杂志文章

    doi：10.2337/db07-0857

    authors： Jocken JW,Roepstorff C,Goossens GH,van der Baan P,van Baak M,Saris WH,Kiens B,Blaak EE

    更新日期：2008-07-01 00:00:00

  • Islet autoimmunity in children with Down's syndrome.

    abstract：:There is an unexplained excess of type 1 diabetes and other organ-specific autoimmune diseases in children with Down's syndrome, but the immunogenetic characteristics of diabetes in Down's syndrome have not been investigated. We studied the frequency of islet autoantibodies in 106 children with Down's syndrome and no ...

    journal_title：Diabetes

    pub_type： 杂志文章

    doi：10.2337/db06-0856

    authors： Gillespie KM,Dix RJ,Williams AJ,Newton R,Robinson ZF,Bingley PJ,Gale EA,Shield JP

    更新日期：2006-11-01 00:00:00

  • Deficient axonal transport of substance P in streptozocin-induced diabetic rats. Effects of sorbinil and insulin.

    abstract：:This study measured the accumulation of substance P-like immunoreactivity (SPLI) proximal and distal to 12-h constricting ligatures applied to rat sciatic nerves. There were three separate experiments, and the baseline for each consisted of control and age-matched rats with 3 wk of untreated streptozocin-induced diabe...

    journal_title：Diabetes

    pub_type： 杂志文章

    doi：10.2337/diab.37.4.488

    authors： Tomlinson DR,Robinson JP,Willars GB,Keen P

    更新日期：1988-04-01 00:00:00

  • The rat T-cell surface protein RT6 is associated with src family tyrosine kinases and generates an activation signal.

    abstract：:RT6 is a glycosyl-phosphatidylinositol-linked surface molecule present on most mature rat T-cells. RT6+ T-cells can prevent the expression of autoimmune diabetes in the BB rat, but the mechanism is unknown. Because cross-linking of other glycosyl-phosphatidylinositol-linked T-cell proteins is known to activate T-cells...

    journal_title：Diabetes

    pub_type： 杂志文章

    doi：10.2337/diab.45.10.1419

    authors： Rigby MR,Bortell R,Greiner DL,Czech MP,Klarlund JK,Mordes JP,Rossini AA

    更新日期：1996-10-01 00:00:00

  • Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion.

    abstract：OBJECTIVE:The G-protein-coupled receptor Gpr40 is expressed in beta-cells where it contributes to free fatty acid (FFA) enhancement of glucose-stimulated insulin secretion. However, other sites of Gpr40 expression, including the intestine, have been suggested. The transcription factor IPF1/PDX1 was recently shown to bi...

    journal_title：Diabetes

    pub_type： 杂志文章

    doi：10.2337/db08-0307

    authors： Edfalk S,Steneberg P,Edlund H

    更新日期：2008-09-01 00:00:00

  • Prenatal programming of metabolic syndrome in the common marmoset is associated with increased expression of 11beta-hydroxysteroid dehydrogenase type 1.

    abstract：OBJECTIVE:Recent studies in humans and animal models of obesity have shown increased adipose tissue activity of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), which amplifies local tissue glucocorticoid concentrations. The reasons for this 11beta-HSD1 dysregulation are unknown. Here, we tested whether 11beta...

    journal_title：Diabetes

    pub_type： 杂志文章

    doi：10.2337/db09-0873

    authors： Nyirenda MJ,Carter R,Tang JI,de Vries A,Schlumbohm C,Hillier SG,Streit F,Oellerich M,Armstrong VW,Fuchs E,Seckl JR

    更新日期：2009-12-01 00:00:00

  • Insulin does not act by causing a change in membrane potential or intracellular free sodium and potassium concentration of adipocytes.

    abstract：:The influence of insulin on the intracellular free sodium and potassium ion concentrations ([Na+]i, [K+]i) and resting membrane potential of rat epididymal adipocytes was examined to determine its potential for mediating insulin's action on other cellular processes. Direct intracellular measurements of [Na+]i, [K+]i, ...

    journal_title：Diabetes

    pub_type： 杂志文章

    doi：10.2337/diab.29.12.1040

    authors： Stark RJ,Read PD,O'Doherty J

    更新日期：1980-12-01 00:00:00

  • Invariant natural killer T-cell control of type 1 diabetes: a dendritic cell genetic decision of a silver bullet or Russian roulette.

    abstract：OBJECTIVE:In part, activation of invariant natural killer T (iNKT)-cells with the superagonist alpha-galactosylceramide (alpha-GalCer) inhibits the development of T-cell-mediated autoimmune type 1 diabetes in NOD mice by inducing the downstream differentiation of antigen-presenting dendritic cells (DCs) to an immunotol...

    journal_title：Diabetes

    pub_type： 杂志文章

    doi：10.2337/db09-1116

    authors： Driver JP,Scheuplein F,Chen YG,Grier AE,Wilson SB,Serreze DV

    更新日期：2010-02-01 00:00:00