Insulin does not act by causing a change in membrane potential or intracellular free sodium and potassium concentration of adipocytes.

abstract：:Hepatocyte nuclear factor (HNF)-4alpha is a transcription factor known as a key molecule in the development and functions of the beta-cells. In a previously performed genome-wide scan of Japanese type 2 diabetic sibpairs, we observed linkage of type 2 diabetes to chromosome 20q12-q13, a region in which the HNF4A gene ...

journal_title：Diabetes

authors： Hara K,Horikoshi M,Kitazato H,Ito C,Noda M,Ohashi J,Froguel P,Tokunaga K,Tobe K,Nagai R,Kadowaki T

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:In the present study, we aimed to validate the type 2 diabetes susceptibility alleles identified in six recent genome-wide association studies in the HHEX/KIF11/IDE (rs1111875), CDKN2A/B (rs10811661), and IGF2BP2 (rs4402960) loci, as well as the intergenic rs9300039 variant. Furthermore, we aimed to character...

journal_title：Diabetes

authors： Grarup N,Rose CS,Andersson EA,Andersen G,Nielsen AL,Albrechtsen A,Clausen JO,Rasmussen SS,Jørgensen T,Sandbaek A,Lauritzen T,Schmitz O,Hansen T,Pedersen O

更新日期：2007-12-01 00:00:00

abstract：:Because the pathogenetic understanding of diabetic vascular complications remains fragmentary, and even the best available interventions may prove insufficient to arrest the progression of certain lesions, new avenuses of investigation should be pursued. One of these should be the early in vivo investigation of the ce...

journal_title：Diabetes

authors： Lorenzi M,Cagliero E

更新日期：1991-06-01 00:00:00

abstract：OBJECTIVE:Accumulation of glomerular matrix proteins is central to the pathogenesis of diabetic nephropathy, with resident mesangial cells (MCs) known to upregulate matrix protein synthesis in response to high glucose. Because activation of the GTPase RhoA has been implicated in matrix upregulation, we studied its role...

journal_title：Diabetes

authors： Peng F,Wu D,Gao B,Ingram AJ,Zhang B,Chorneyko K,McKenzie R,Krepinsky JC

更新日期：2008-06-01 00:00:00

abstract：:In an ongoing investigation of the effects of age on G protein-coupled receptor signaling in human atrial tissue, we have found that the density of atrial muscarinic acetylcholine receptor (mAChR) increases with age but reaches statistical significance only in patients with diabetes. Moreover, we find that in elderly ...

journal_title：Diabetes

authors： Richardson MD,Kilts JD,Kwatra MM

更新日期：2004-09-01 00:00:00

abstract：:Antibodies against islet cell antigens are used as predictive markers of type 1 diabetes, but it is unknown whether they reflect an ongoing autoimmune process in islet tissue. We investigated whether organs from adult donors that are positive for autoantibodies (aAbs) against islet cell antigens exhibit insulitis and/...

journal_title：Diabetes

authors： In't Veld P,Lievens D,De Grijse J,Ling Z,Van der Auwera B,Pipeleers-Marichal M,Gorus F,Pipeleers D

更新日期：2007-09-01 00:00:00

abstract：:The N6-methyladenosine (m6A) RNA modification is essential during embryonic development of various organs. However, its role in embryonic and early postnatal islet development remains unknown. Mice in which RNA methyltransferase-like 3/14 (Mettl3/14) were deleted in Ngn3+ endocrine progenitors (Mettl3/14 ...

journal_title：Diabetes

authors： Wang Y,Sun J,Lin Z,Zhang W,Wang S,Wang W,Wang Q,Ning G

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE:Glomerular filtration rate (GFR) is used to assess the progression of renal disease. We performed linkage analysis to localize genes that influence GFR using estimated GFR data from the San Antonio Family Diabetes/Gallbladder Study. We also examined the effect of genotype by diabetes interaction (G x DM) on t...

journal_title：Diabetes

authors： Puppala S,Arya R,Thameem F,Arar NH,Bhandari K,Lehman DM,Schneider J,Fowler S,Farook VS,Diego VP,Almasy L,Blangero J,Stern MP,Duggirala R,Abboud HE

更新日期：2007-11-01 00:00:00

abstract：:Diabetes mellitus developing in BALB/c ByJ mice infected with the M variant of encephalomyocarditis (EMC) virus is dependent on thymic immune mechanisms. We treated mice with the anti-T-lymphocyte monoclonal anti-L3T4 and anti-Lyt2.2 antibodies before virus inoculation and monitored the infection and occurrence of dia...

journal_title：Diabetes

authors： Haynes MK,Huber SA,Craighead JE

更新日期：1987-07-01 00:00:00

abstract：:Kinetic studies were carried out on liver glycogen synthase and phosphorylase isolated from genetically diabetic db/db mice. Glycogen synthase a and b enzymes from diabetic mice had Vmax values 30% and 20% lower, respectively, than the enzymes from normal mice. Glycogen synthase b from diabetic mice also had a 30% low...

journal_title：Diabetes

authors： Roesler WJ,Khandelwal RL

更新日期：1986-02-01 00:00:00

abstract：:The high-mobility group box transcription factor SOX4 is the most highly expressed SOX family protein in pancreatic islets, and mutations in Sox4 are associated with an increased risk of developing type 2 diabetes. We used an inducible β-cell knockout mouse model to test the hypothesis that Sox4 is essential for the m...

journal_title：Diabetes

authors： Xu EE,Sasaki S,Speckmann T,Nian C,Lynn FC

更新日期：2017-08-01 00:00:00

abstract：:Human fetal pancreatic glands were obtained from 12 consecutive prostaglandin-induced abortions. Explants cultured for 1 day were frozen at 0.3 degree C/min in a 1 M DMSO-containing medium and stored at -196 degrees C. After storage for 3-4 mo the frozen material was rapidly thawed and cultured 1 day before being test...

journal_title：Diabetes

authors： Sandler S,Andersson A,Hellerström C,Petersson B,Swenne I,Björkén C,Groth CG

更新日期：1982-03-01 00:00:00

abstract：:Pancreatogenic diabetes (PD), secondary either to chronic calcific pancreatitis or to pancreatectomy, is characterized by higher frequency of hypoglycemic events during insulin therapy in comparison with type I insulin-dependent diabetes (IDD). Not only glucagon deficiency, but an enhanced peripheral tissue sensitivit...

journal_title：Diabetes

authors： Nosadini R,del Prato S,Tiengo A,Duner E,Toffolo G,Cobelli C,Faronato PP,Moghetti P,Muggeo M

更新日期：1982-04-01 00:00:00

abstract：:A chromosome 1q25 variant (rs10911021) has been associated with coronary heart disease (CHD) in type 2 diabetes. In human umbilical vein endothelial cells (HUVECs), the risk allele "C" is associated with lower expression of the adjacent gene GLUL encoding glutamine synthase, converting glutamic acid to glutamine. To f...

journal_title：Diabetes

authors： Pipino C,Shah H,Prudente S,Di Pietro N,Zeng L,Park K,Trischitta V,Pennathur S,Pandolfi A,Doria A

更新日期：2020-10-01 00:00:00

abstract：:Fibroblast growth factor 1 (FGF1) has been shown to reverse hyperglycemia in diabetic rodent models through peripheral and central administration routes. Previous studies demonstrated that insulin is required for central and peripheral FGF1 metabolic improvements; however, it is unknown if FGF1 targets insulin secreti...

journal_title：Diabetes

authors： Tennant KG,Lindsley SR,Kirigiti MA,True C,Kievit P

更新日期：2019-07-01 00:00:00

abstract：:Obesity is one of the most serious threats to human health today. Although there is general agreement that environmental factors such as diet have largely caused the current obesity pandemic, the environmental changes have not affected all individuals equally. To model gene-by-environment interactions in a mouse model...

journal_title：Diabetes

authors： Ehrich TH,Hrbek T,Kenney-Hunt JP,Pletscher LS,Wang B,Semenkovich CF,Cheverud JM

更新日期：2005-06-01 00:00:00

abstract：:Recent work suggests that insulin may exert both positive and negative feedback directly on pancreatic beta-cells. To investigate the hypothesis that insulin modulates beta-cell metabolism, mouse islets and beta-cell clusters were loaded with rhodamine 123 to dynamically monitor mitochondrial membrane potential (Delta...

journal_title：Diabetes

authors： Nunemaker CS,Zhang M,Satin LS

更新日期：2004-07-01 00:00:00

abstract：:The effect of metabolic near-normalization, induced by continuous subcutaneous insulin infusion, on the exaggerated microalbuminuria of exercise was studied in eight insulin-dependent diabetic men selected for normal resting albuminuria. Patients were studied in randomized order during the ordinary glycemic control of...

journal_title：Diabetes

authors： Viberti G,Pickup JC,Bilous RW,Keen H,Mackintosh D

更新日期：1981-10-01 00:00:00

abstract：:To determine whether defects in the insulin signal transduction cascade are present in skeletal muscle from prediabetic individuals, we excised biopsies from eight glucose-intolerant male first-degree relatives of patients with type 2 diabetes (IGT relatives) and nine matched control subjects before and during a eugly...

journal_title：Diabetes

authors： Storgaard H,Song XM,Jensen CB,Madsbad S,Björnholm M,Vaag A,Zierath JR

更新日期：2001-12-01 00:00:00

abstract：:A strong genetic component of the beta-cell defect of type 2 diabetes is undisputed. We recently developed a modification of the classic hyperglycemic clamp to assess beta-cell function in response to various stimuli (10 mmol/l glucose, additional glucagon-like peptide [GLP]-1, and arginine). Subjects at risk for deve...

journal_title：Diabetes

authors： Stumvoll M,Fritsche A,Häring HU

更新日期：2002-02-01 00:00:00

abstract：:A new murine model of porcine islet-like cell cluster (ICC) xenograft rejection, avoiding interference of unspecific inflammation, was introduced and used to investigate rejection mechanisms. Athymic (nu/nu) mice were transplanted with syngeneic, allogeneic, or xenogeneic islets under the kidney capsule. After the ori...

journal_title：Diabetes

authors： Schmidt P,Krook H,Maeda A,Korsgren O,Benda B

更新日期：2003-05-01 00:00:00

abstract：:Islet transplantation for the treatment of autoimmune diabetes is more difficult because of the additional barrier presented by the autoimmunity. We tested the ability of hamster anti-rat CD154 to prevent recurrence of diabetes in renal subcapsular islet isografts in DR-BB (RT1uu) rats with established autoimmune diab...

journal_title：Diabetes

authors： Kover KL,Geng Z,Hess DM,Benjamin CD,Moore WV

更新日期：2000-10-01 00:00:00

abstract：:Brain lactate may be involved in the development of impaired awareness of hypoglycemia (IAH), a condition that affects approximately 25% of patients with type 1 diabetes and increases the risk of severe hypoglycemia. The aim of this study was to investigate the effect of acute hypoglycemia on brain lactate concentrati...

journal_title：Diabetes

authors： Wiegers EC,Rooijackers HM,Tack CJ,Heerschap A,de Galan BE,van der Graaf M

更新日期：2016-06-01 00:00:00

abstract：:Indoleamine 2,3 dioxygenase-1 (IDO1) is a powerful immunoregulatory enzyme that is deficient in patients with type 1 diabetes (T1D). In this study, we present the first systematic evaluation of IDO1 expression and localization in human pancreatic tissue. Although IDO1 was constitutively expressed in β-cells from donor...

journal_title：Diabetes

authors： Anquetil F,Mondanelli G,Gonzalez N,Rodriguez Calvo T,Zapardiel Gonzalo J,Krogvold L,Dahl-Jørgensen K,Van den Eynde B,Orabona C,Grohmann U,von Herrath MG

更新日期：2018-09-01 00:00:00

abstract：:Glucose-dependent insulin secretion (GDIS), reactive oxygen species (ROS) production, and oxidative stress in pancreatic beta-cells may be tightly linked processes. Here we suggest that the same pathways used in the activation of GDIS (increased glycolytic flux, ATP-to-ADP ratio, and intracellular Ca2+ concentration) ...

journal_title：Diabetes

authors： Fridlyand LE,Philipson LH

更新日期：2004-08-01 00:00:00

abstract：:The glycolytic enzyme glucokinase plays a primary role in the glucose-responsive secretion of insulin, and defects of this enzyme can cause NIDDM. As a step toward understanding the molecular basis of glucokinase (GK) gene regulation, we assessed the structure and regulation of the human GK gene beta-cell-type promote...

journal_title：Diabetes

authors： Watada H,Kajimoto Y,Umayahara Y,Matsuoka T,Kaneto H,Fujitani Y,Kamada T,Kawamori R,Yamasaki Y

更新日期：1996-11-01 00:00:00

abstract：:Glucose sensing is essential for the ability of pancreatic beta-cells to produce insulin in sufficient quantities to maintain blood glucose within the normal range. Stress causes the release of adrenergic hormones that increase circulating glucose by promoting glucose production and inhibiting insulin release. We have...

journal_title：Diabetes

authors： Gibson TB,Lawrence MC,Gibson CJ,Vanderbilt CA,McGlynn K,Arnette D,Chen W,Collins J,Naziruddin B,Levy MF,Ehrlich BE,Cobb MH

更新日期：2006-04-01 00:00:00

abstract：:Adiponectin is an abundant adipose tissue-derived protein with important metabolic effects. Plasma adiponectin levels are decreased in obese individuals, and low adiponectin levels predict insulin resistance and type 2 diabetes. Two variants in the adiponectin gene ACDC have been previously associated with plasma adip...

journal_title：Diabetes

authors： Vozarova de Courten B,Hanson RL,Funahashi T,Lindsay RS,Matsuzawa Y,Tanaka S,Thameem F,Gruber JD,Froguel P,Wolford JK

更新日期：2005-01-01 00:00:00

abstract：:One month following induction of diabetes with streptozotocin, one half of diabetic and control rats underwent unilateral nephrectomy. Subsequently, all animals were studied with respect to renal function and glomerular alterations of diabetes. Blood pressure levels were similar in all animals. Diabetic and control an...

journal_title：Diabetes

authors： Steffes MW,Brown DM,Mauer SM

更新日期：1978-01-01 00:00:00

abstract：:Acute insulin secretion determines the efficiency of glucose clearance. Moreover, impaired acute insulin release is characteristic of reduced glucose control in the prediabetic state. Incretin hormones, which increase β-cell cAMP, restore acute-phase insulin secretion and improve glucose control. To determine the phys...

journal_title：Diabetes

authors： Kaihara KA,Dickson LM,Jacobson DA,Tamarina N,Roe MW,Philipson LH,Wicksteed B

更新日期：2013-05-01 00:00:00