Invariant natural killer T-cell control of type 1 diabetes: a dendritic cell genetic decision of a silver bullet or Russian roulette.

abstract：:Growing evidence suggests that epigenetic profile changes occurring during fetal development in response to in utero environment variations could be one of the mechanisms involved in the early determinants of adult chronic diseases. In this study, we tested whether maternal glycemic status is associated with the adipo...

journal_title：Diabetes

authors： Bouchard L,Hivert MF,Guay SP,St-Pierre J,Perron P,Brisson D

更新日期：2012-05-01 00:00:00

abstract：:Rats from four experimental treatment groups, including fed controls, 24- to 30-h fasted, dexamethasone-treated, and intraperitoneal glucose-treated, were used to assess the effects of these treatments on the immunohistochemically detectable islet amyloid polypeptide (IAPP) content in the pancreatic islets. Isolated p...

journal_title：Diabetes

authors： O'Brien TD,Westermark P,Johnson KH

更新日期：1991-12-01 00:00:00

abstract：:A monoclonal islet cell antibody, HISL-19, reactive with human, bovine, and porcine pancreatic islets has been used to identify and characterize a novel group of islet cell proteins (p120, p69, p67, and p56). Besides the islets, HISL-19-reactive antigenic determinants are also expressed on selected cell types, namely,...

journal_title：Diabetes

authors： Srikanta S,Krisch K,Eisenbarth GS

更新日期：1986-03-01 00:00:00

abstract：:Human but not mouse islets transplanted into immunodeficient NSG mice effectively accumulate lipid droplets (LDs). Because chronic lipid exposure is associated with islet β-cell dysfunction, we investigated LD accumulation in the intact human and mouse pancreas over a range of ages and states of diabetes. Very few LDs...

journal_title：Diabetes

authors： Tong X,Dai C,Walker JT,Nair GG,Kennedy A,Carr RM,Hebrok M,Powers AC,Stein R

更新日期：2020-03-01 00:00:00

abstract：:The current view of diabetic kidney disease, based on meticulously acquired ultrastructural morphometry and the utility of measuring plasma creatinine and urinary albumin, has been almost entirely focused on the glomerulus. While clearly of great importance, changes in the glomerulus are not the major determinant of r...

journal_title：Diabetes

authors： Gilbert RE

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVE:Obesity causes insulin resistance, which has been interpreted as reduced downstream insulin signaling. However, changes in access of insulin to sensitive tissues such as skeletal muscle may also play a role. Insulin injected directly into skeletal muscle diffuses rapidly through the interstitial space to caus...

journal_title：Diabetes

authors： Kolka CM,Harrison LN,Lottati M,Chiu JD,Kirkman EL,Bergman RN

更新日期：2010-03-01 00:00:00

abstract：:Diabetes-induced oxidative stress can lead to protein misfolding and degradation by the ubiquitin-proteasome system. This study examined protein ubiquitination in pancreatic sections from Zucker diabetic fatty rats. We observed large aggregates of ubiquitinated proteins (Ub-proteins) in insulin-expressing beta-cells a...

journal_title：Diabetes

authors： Kaniuk NA,Kiraly M,Bates H,Vranic M,Volchuk A,Brumell JH

更新日期：2007-04-01 00:00:00

abstract：:Neonatal female rat pups that were raised artificially on a high-carbohydrate (HC) milk formula during their suckling period developed hyperinsulinemia immediately, maintained chronic hyperinsulinemia in the postweaning period on laboratory diet, and developed obesity in adulthood. Pups (second-generation HC [2-HC]) b...

journal_title：Diabetes

authors： Srinivasan M,Aalinkeel R,Song F,Patel MS

更新日期：2003-04-01 00:00:00

abstract：:Insulin signaling in vascular endothelial cells (ECs) is critical to maintain endothelial function but also to mediate insulin action on peripheral glucose disposal. However, gene knockout studies have reached disparate conclusions. Thus, insulin receptor inactivation in ECs does not impair insulin action, whereas ina...

journal_title：Diabetes

authors： Tsuchiya K,Accili D

更新日期：2013-05-01 00:00:00

abstract：:The transcription factor nuclear factor-κB (NF-κB) mediates inflammation and stress signals in cells. To test NF-κB in the control of hepatic insulin sensitivity, we inactivated NF-κB in the livers of C57BL/6 mice through deletion of the p65 gene, which was achieved by crossing floxed-p65 and Alb-cre mice to generate ...

journal_title：Diabetes

authors： Ke B,Zhao Z,Ye X,Gao Z,Manganiello V,Wu B,Ye J

更新日期：2015-10-01 00:00:00

abstract：:Beta,beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) consists of a nonmetabolizable long-chain fatty acid designed to probe the effect exerted by fatty acids on insulin sensitivity. The effect of MEDICA 16 was evaluated in insulin-resistant Zucker (fa/fa) rats in terms of liver, muscle, and adipose tissue re...

journal_title：Diabetes

authors： Mayorek N,Kalderon B,Itach E,Bar-Tana J

更新日期：1997-12-01 00:00:00

abstract：:We conducted autosomal genome scans to map loci for metabolic syndrome (MES) and related traits in the Hong Kong Family Diabetes Study. We selected 55 families with 137 affected members (121 affected relative pairs) for nonparametric linkage analysis on MES. We also selected 179 families with 897 members (2,127 relati...

journal_title：Diabetes

authors： Ng MC,So WY,Lam VK,Cockram CS,Bell GI,Cox NJ,Chan JC

更新日期：2004-10-01 00:00:00

abstract：:Insulin stimulation of adipose and muscle cells results in the translocation of GLUT4 from an intracellular location to the plasma membrane; this translocation is defective in insulin resistance. Studies have suggested an important role for synaptobrevin and syntaxin homologues in this event, particularly the v-solubl...

journal_title：Diabetes

authors： Maier VH,Melvin DR,Lister CA,Chapman H,Gould GW,Murphy GJ

更新日期：2000-04-01 00:00:00

abstract：:We have produced a monoclonal antibody 3A4 to the surface of islet cells by fusing spleen lymphocytes from nonobese diabetic (NOD) mice. To identify the molecular weight of specific target antigens reacting with 3A4, 125I-surface-labeled In-111 insulinoma cells were solubilized and extracts were absorbed with 3A4, and...

journal_title：Diabetes

authors： Hari J,Yokono K,Yonezawa K,Amano K,Yaso S,Shii K,Imamura Y,Baba S

更新日期：1986-05-01 00:00:00

abstract：:To test whether treatment with aminoguanidine, a drug known to prevent cross-linking between glycated proteins, is effective in improving reduced erythrocyte deformability in diabetes, we studied a group (n = 6) of ALX-induced long-term (12.7 +/- 2.2 mo of hyperglycemia) diabetic New Zealand white rabbits before and a...

journal_title：Diabetes

authors： Brown CD,Zhao ZH,De Alvaro F,Chan S,Friedman EA

更新日期：1993-04-01 00:00:00

abstract：:Increased hepatic gluconeogenesis maintains glycemia during fasting and has been considered responsible for elevated hepatic glucose output in type 2 diabetes. Glucose derived periportally via gluconeogenesis is partially taken up perivenously in perfused liver but not in adult rats whose mothers were protein-restrict...

journal_title：Diabetes

authors： Murphy HC,Regan G,Bogdarina IG,Clark AJ,Iles RA,Cohen RD,Hitman GA,Berry CL,Coade Z,Petry CJ,Burns SP

更新日期：2003-06-01 00:00:00

abstract：:Defects in insulin secretion, resulting from loss of function or destruction of pancreatic beta-cells, trigger diabetes. Interleukin (IL)-1beta is a proinflammatory cytokine that is involved in type 1 and type 2 diabetes development and impairs beta-cell survival and function. Because effective insulin signaling is re...

journal_title：Diabetes

authors： Emanuelli B,Glondu M,Filloux C,Peraldi P,Van Obberghen E

更新日期：2004-12-01 00:00:00

abstract：:The effects of glucose and diabetes on the high-affinity lofentanil-displaceable opiate-receptor binding in mouse brain membranes were studied to determine if the attenuation of opiate actions by hyperglycemia previously observed in our laboratory was due to a modification of receptor affinity or number. With membrane...

journal_title：Diabetes

authors： Brase DA,Han YH,Dewey WL

更新日期：1987-10-01 00:00:00

abstract：OBJECTIVE:Klotho is an antiaging hormone present in the kidney that extends the lifespan, regulates kidney function, and modulates cellular responses to oxidative stress. We investigated whether Klotho levels and signaling modulate inflammation in diabetic kidneys. RESEARCH DESIGN AND METHODS:Renal Klotho expression w...

journal_title：Diabetes

authors： Zhao Y,Banerjee S,Dey N,LeJeune WS,Sarkar PS,Brobey R,Rosenblatt KP,Tilton RG,Choudhary S

更新日期：2011-07-01 00:00:00

abstract：:In vivo studies were undertaken in rats to provide evidence of the neural nature, tentative localization and mode of excitation of the insulin-sensitive central nervous system (CSN) glucoregulator center. In rats under light barbiturate anesthesia minute amounts of insulin injected into the carotid artery resulted in ...

journal_title：Diabetes

authors： Szabo O,Szabo AJ

更新日期：1975-04-01 00:00:00

abstract：:Variation in the calpain 10 gene has recently been shown to be associated with type 2 diabetes by positional cloning. Since then, studies on calpain 10 have been started in correlation with diabetes and insulin-mediated signaling. In this review, the activation mechanism of calpain by calcium ions, which is essential ...

journal_title：Diabetes

authors： Suzuki K,Hata S,Kawabata Y,Sorimachi H

更新日期：2004-02-01 00:00:00

abstract：:Monogenic forms of obesity have been identified in ≤10% of severely obese European patients. However, the overall spectrum of deleterious variants (point mutations and structural variants) responsible for childhood severe obesity remains elusive. In this study, we genetically screened 225 severely obese children from ...

journal_title：Diabetes

authors： Saeed S,Arslan M,Manzoor J,Din SM,Janjua QM,Ayesha H,Ain QT,Inam L,Lobbens S,Vaillant E,Durand E,Derhourhi M,Amanzougarene S,Badreddine A,Berberian L,Gaget S,Khan WI,Butt TA,Bonnefond A,Froguel P

更新日期：2020-07-01 00:00:00

abstract：:The phenomenon of a discrepancy between glycated hemoglobin levels and other indicators of average glycemia may be due to many factors but can be measured as the glycation gap (GGap). This GGap is associated with differences in complications in patients with diabetes and may possibly be explained by dissimilarities in...

journal_title：Diabetes

authors： Dunmore SJ,Al-Derawi AS,Nayak AU,Narshi A,Nevill AM,Hellwig A,Majebi A,Kirkham P,Brown JE,Singh BM

更新日期：2018-01-01 00:00:00

abstract：:Although obesity rates are rapidly rising, caloric restriction remains one of the few safe therapies. Here we tested the hypothesis that obesity-associated disorders are caused by increased adipose tissue as opposed to excess dietary lipids. Fat mass (FM) of lean C57B6 mice fed a high-fat diet (HFD; FMC mice) was "cla...

journal_title：Diabetes

authors： Kirchner H,Hofmann SM,Fischer-Rosinský A,Hembree J,Abplanalp W,Ottaway N,Donelan E,Krishna R,Woods SC,Müller TD,Spranger J,Perez-Tilve D,Pfluger PT,Tschöp MH,Habegger KM

更新日期：2012-11-01 00:00:00

abstract：:New cellular-based reagents are needed to diagnose type I diabetes as well as to monitor the outcomes of clinical trials at early time points. Four new monoclonal antibodies (mAbs) have been shown to demonstrate reduced binding to lymphocytes from identical twins with long-term type I diabetes relative to that observe...

journal_title：Diabetes

authors： Pinies JA,Fu Y,Vazquez JA,Faustman D

更新日期：1997-03-01 00:00:00

abstract：:The effect of glyburide on glucose metabolism was examined in 10 non-insulin-dependent diabetic subjects (NIDDM) and 7 young, control subjects. After 3 mo of glyburide treatment in NIDDM, fasting plasma glucose declined from 198 to 141 mg/dl (P less than 0.01) without change in fasting insulin levels. Basal hepatic gl...

journal_title：Diabetes

authors： Simonson DC,Ferrannini E,Bevilacqua S,Smith D,Barrett E,Carlson R,DeFronzo RA

更新日期：1984-09-01 00:00:00

abstract：:Obesity is associated with an increased risk for the development of type 2 diabetes and vascular complications. Advanced glycation end products are increased in adipose tissue and have been associated with insulin resistance, vascular dysfunction, and inflammation of adipose tissue. Here, we report that delayed interv...

journal_title：Diabetes

authors： Maessen DE,Brouwers O,Gaens KH,Wouters K,Cleutjens JP,Janssen BJ,Miyata T,Stehouwer CD,Schalkwijk CG

更新日期：2016-04-01 00:00:00

abstract：:Impairment of suppressor-cell activity may be important in the pathogenesis and maintenance of insulin-dependent diabetes mellitus (IDDM). In 23 recent-onset IDDM patients, lymphocyte sensitivity in vitro to theophylline was tested both in basal conditions and after improvement of metabolic control. This pharmacologic...

journal_title：Diabetes

authors： Crosti F,Secchi A,Ferrero E,Falqui L,Inverardi L,Pontiroli AE,Ciboddo GF,Pavoni D,Protti P,Rugarli C

更新日期：1986-09-01 00:00:00

abstract：:Leptin administration has been shown to increase renal, adrenal, and lumbar sympathetic nerve activity. However, this generalized sympathoexcitatory activity is not always followed by an increase in arterial pressure. The present study tested the hypothesis that leptin induces a release of nitric oxide (NO) that oppos...

journal_title：Diabetes

authors： Frühbeck G

更新日期：1999-04-01 00:00:00

abstract：:The aim of this study was to compare the effects of insulin and the insulinomimetic agent, englitazone, on functional end points and putative mediators of insulin action in 3T3-L1 adipocytes. Cells were incubated with englitazone for 48 h or with insulin for 10 or 30 min, or both, and 2-deoxy-D-[3H]glucose (2DG) uptak...

journal_title：Diabetes

authors： Stevenson RW,Kreutter DK,Andrews KM,Genereux PE,Gibbs EM

更新日期：1998-02-01 00:00:00