Abstract:
:To test whether treatment with aminoguanidine, a drug known to prevent cross-linking between glycated proteins, is effective in improving reduced erythrocyte deformability in diabetes, we studied a group (n = 6) of ALX-induced long-term (12.7 +/- 2.2 mo of hyperglycemia) diabetic New Zealand white rabbits before and after 20 wk of treatment with aminoguanidine (100 mg.kg-1 x day-1). The key findings were as follows: 1) at 12 wk of treatment with aminoguanidine, mean erythrocyte deformability normalized and remained within the normal reference range throughout the period of aminoguanidine administration; 2) 10 wk after discontinuing aminoguanidine in a subset of diabetic rabbits, mean erythrocyte deformability deteriorated by approximately 50%; 3) blood glucose and total GHb did not vary significantly during treatment with aminoguanidine nor after its discontinuation.
journal_name
Diabetesjournal_title
Diabetesauthors
Brown CD,Zhao ZH,De Alvaro F,Chan S,Friedman EAdoi
10.2337/diab.42.4.590subject
Has Abstractpub_date
1993-04-01 00:00:00pages
590-3issue
4eissn
0012-1797issn
1939-327Xjournal_volume
42pub_type
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