No evidence of amyloidosis in type I diabetics treated with continuous subcutaneous insulin infusion.

abstract：:Obesity and family history of diabetes are both risk factors for non-insulin-dependent diabetes mellitus (NIDDM), but it has been proposed that lean individuals with NIDDM have a greater load of diabetes susceptibility genes. If this is the case, one might expect a high prevalence of NIDDM in relatives of diabetic ind...

journal_title：Diabetes

authors： Hanson RL,Pettitt DJ,Bennett PH,Narayan KM,Fernandes R,de Courten M,Knowler WC

更新日期：1995-04-01 00:00:00

abstract：:Exciting new findings have been reported in the past few years that indicate that islets can be transplanted successfully across major histocompatibility barriers without the continuous use of immunosuppressive agents by techniques designed to eliminate passenger leukocytes. In vitro culture of donor islets either at ...

journal_title：Diabetes

authors： Faustman D,Lacy PE,Davie JM

更新日期：1982-08-01 00:00:00

abstract：:The transplantation of human fetal pancreas has been suggested as a means of treatment of insulin-dependent diabetes in man. We have obtained human fetal pancreata during the second trimester of pregnancy and transplanted 1-mm3 explants subcutaneously (s.c.) into both diabetic and nondiabetic nude mice, some of the ti...

journal_title：Diabetes

authors： Tuch BE,Ng AB,Jones A,Turtle JR

更新日期：1984-12-01 00:00:00

abstract：:The association between clinical autonomic dysfunction and myocardial MIBG accumulation was investigated. The study groups comprised 6 male diabetic patients with autonomic neuropathy (ANP+ group), 6 male diabetic patients without autonomic neuropathy (ANP-group), and 6 male nondiabetic control subjects. The mean age ...

journal_title：Diabetes

authors： Mäntysaari M,Kuikka J,Mustonen J,Tahvanainen K,Vanninen E,Länsimies E,Uusitupa M

更新日期：1992-09-01 00:00:00

abstract：OBJECTIVE:Increased intramuscular triacylglycerol (IMTG) storage is a characteristic of the obese insulin-resistant state. We aimed to investigate whether a blunted fasting or beta-adrenergically mediated lipolysis contributes to this increased IMTG storage in obesity. RESEARCH DESIGN AND METHODS:Forearm skeletal musc...

journal_title：Diabetes

authors： Jocken JW,Roepstorff C,Goossens GH,van der Baan P,van Baak M,Saris WH,Kiens B,Blaak EE

更新日期：2008-07-01 00:00:00

abstract：:There has been a prejudice that diabetes modulates the function of saphenous vein in a manner that predisposes to bypass graft failure, although most of the evidence accrues from animal studies. We have investigated the effect of diabetes on the vasodilator responses and ultrastructure of saphenous vein harvested from...

journal_title：Diabetes

authors： Hicks RC,Moss J,Higman DJ,Greenhalgh RM,Powell JT

更新日期：1997-01-01 00:00:00

abstract：:Isologous pancreatic islets were implanted into the portal vein of rats with streptozotocin-induced diabetes. At intervals of from one to 32 days after transplantation, the intrahepatic islet grafts were examined histologically and ultrastructurally, and their vascular supply was determined by later perfusion studies....

journal_title：Diabetes

authors： Griffith RC,Scharp DW,Hartman BK,Ballinger WF,Lacy PE

更新日期：1977-03-01 00:00:00

abstract：:This study addressed the controversial question of whether a negative-insulin-feedback loop exists in vivo. We utilized prehepatic insulin production, calculated by computerized deconvolution analysis of peripheral C-peptide concentration, as a measure of endogenous insulin secretion. Prehepatic insulin production was...

journal_title：Diabetes

authors： Argoud GM,Schade DS,Eaton RP

更新日期：1987-08-01 00:00:00

abstract：:Toll-like receptor 9 (TLR9) is highly expressed in B cells, and B cells are important in the pathogenesis of type 1 diabetes (T1D) development. However, the intrinsic effect of TLR9 in B cells on β-cell autoimmunity is not known. To fill this knowledge gap, we generated NOD mice with a B-cell-specific deficiency of TL...

journal_title：Diabetes

authors： Sha S,Pearson JA,Peng J,Hu Y,Huang J,Xing Y,Zhang L,Zhu Y,Zhao H,Wong FS,Chen L,Wen L

更新日期：2021-02-01 00:00:00

abstract：:The introduction of 13C magnetic resonance spectroscopy (MRS) has enabled noninvasive measurement of muscle glycogen synthesis in humans. Conclusions based on measurements by the MRS technique assume that glucose metabolism in gastrocnemius muscle is representative for all skeletal muscles and thus can be extrapolated...

journal_title：Diabetes

authors： Serlie MJ,de Haan JH,Tack CJ,Verberne HJ,Ackermans MT,Heerschap A,Sauerwein HP

更新日期：2005-05-01 00:00:00

abstract：:GLP-1 and incretin mimetics, such as exenatide, have been shown to attenuate hepatocyte steatosis in vivo and in vitro, but the specific underlying mechanism is unclear. SIRT1, an NAD(+)-dependent protein deacetylase, has been considered as a crucial regulator in hepatic lipid homeostasis by accumulated studies. Here,...

journal_title：Diabetes

authors： Xu F,Li Z,Zheng X,Liu H,Liang H,Xu H,Chen Z,Zeng K,Weng J

更新日期：2014-11-01 00:00:00

abstract：:A strong genetic component of the beta-cell defect of type 2 diabetes is undisputed. We recently developed a modification of the classic hyperglycemic clamp to assess beta-cell function in response to various stimuli (10 mmol/l glucose, additional glucagon-like peptide [GLP]-1, and arginine). Subjects at risk for deve...

journal_title：Diabetes

authors： Stumvoll M,Fritsche A,Häring HU

更新日期：2002-02-01 00:00:00

abstract：:Segmental pancreatic allografts with unligated ducts were transplanted intraperitoneally to five diabetic patients who had received renal allografts more than 2 yr earlier. One patient is alive with a functioning graft 10.5 mo later. Two patients rejected their grafts at approximately 2 and 3 mo but are alive 8--9 mo ...

journal_title：Diabetes

authors： Sutherland DE,Goetz FC,Najarian JS

更新日期：1980-01-01 00:00:00

abstract：:In the oral glucose tolerance test (OGTT), divergent doses of glucose remain in use by virtue of the prevailing conviction that the size of the loading dose hardly affects the outcome of the test. We compared the results of OGTTs with 100-gm. and 50-gm. loads in 85 patients, who were selected for slightly impaired glu...

journal_title：Diabetes

authors： de Nobel E,van't Laar A

更新日期：1978-01-01 00:00:00

abstract：:The aim of this randomized double-blind study was to compare the within-subject variability of the glucose-lowering effect of a novel insulin analog, insulin detemir, with that of insulin glargine and NPH insulin in people with type 1 diabetes. Fifty-four subjects (32 males and 22 females, age 38 +/- 10 years [mean +/...

journal_title：Diabetes

authors： Heise T,Nosek L,Rønn BB,Endahl L,Heinemann L,Kapitza C,Draeger E

更新日期：2004-06-01 00:00:00

abstract：:Platelet aggregation and related plasma factors have been studied in experimentally diabetic dogs, experimentally galactosemic dogs, and in normal dogs. Platelet aggregation, when induced in vitro by ADP (up to 22 microM) or collagen (up to 4 micrograms/ml), was not significantly different from normal in the diabetic ...

journal_title：Diabetes

authors： Kern TS,Engerman RL

更新日期：1984-09-01 00:00:00

abstract：:Nondiabetic obese humans adapt to insulin resistance by increasing beta-cell mass. In contrast, obese humans with type 2 diabetes have an approximately 60% deficit in beta-cell mass. Recent studies in rodents reveal that beta-cell mass is regulated, increasing in response to insulin resistance through increased beta-c...

journal_title：Diabetes

authors： Butler AE,Janson J,Soeller WC,Butler PC

更新日期：2003-09-01 00:00:00

abstract：:Insulin-dependent diabetes mellitus (IDDM) involves the destruction of the insulin-producing cells in the islets of Langerhans. One possible cure is by transplanting the islet cells; however, transplanted islets, even between identical twins, are subject to autoimmune destruction by the disease process, resulting in d...

journal_title：Diabetes

authors： Wang T,Singh B,Warnock GL,Rajotte RV

更新日期：1992-01-01 00:00:00

abstract：:To test whether treatment with aminoguanidine, a drug known to prevent cross-linking between glycated proteins, is effective in improving reduced erythrocyte deformability in diabetes, we studied a group (n = 6) of ALX-induced long-term (12.7 +/- 2.2 mo of hyperglycemia) diabetic New Zealand white rabbits before and a...

journal_title：Diabetes

authors： Brown CD,Zhao ZH,De Alvaro F,Chan S,Friedman EA

更新日期：1993-04-01 00:00:00

abstract：:The stimulatory effect of the sodium ionophore, veratridine (10, 25 and 50 microM), on glucagon and insulin secretion was investigated using monolayer cultures of newborn rat pancreas. The results suggest that intracellular accumulation of sodium modulates hormone secretion from both alpha- and beta-cells. The action ...

journal_title：Diabetes

authors： Kawazu S,Ikeuchi M,Kikuchi M,Kanazawa Y,Fujimoto WY,Kosaka K

更新日期：1981-05-01 00:00:00

abstract：:This study examines whether the loss of metabolic control in initially normalized islet transplants can result from the inadequate composition of the donor tissue. Streptozotocin-induced diabetic rats were followed for 64 weeks after the intraportal injection of islet isografts with different composition. The implanta...

journal_title：Diabetes

authors： Keymeulen B,Korbutt G,De Paepe M,Gorus F,Klöppel G,Pipeleers DG

更新日期：1996-12-01 00:00:00

abstract：OBJECTIVE:Sirtuin 1 (SIRT1) is implicated in the regulation of mitochondrial function, energy metabolism, and insulin sensitivity in rodents. No studies are available in humans to demonstrate that SIRT1 expression in insulin-sensitive tissues is associated with energy expenditure and insulin sensitivity. RESEARCH DESI...

journal_title：Diabetes

authors： Rutanen J,Yaluri N,Modi S,Pihlajamäki J,Vänttinen M,Itkonen P,Kainulainen S,Yamamoto H,Lagouge M,Sinclair DA,Elliott P,Westphal C,Auwerx J,Laakso M

更新日期：2010-04-01 00:00:00

abstract：:Plasma dopamine-beta-hydroxylase (pDBH) activity is markedly elevated in chronic experimental streptozotocin (STZ) diabetes in the rat. Several possible explanations, all potentially relevant to the pathophysiology of diabetes, could explain this observation. The objective of this paper was to further delineate the be...

journal_title：Diabetes

authors： Schmidt RE,Geller DM,Johnson EM Jr

更新日期：1981-05-01 00:00:00

abstract：:Hexokinase (HK) II plays an important role in intracellular glucose metabolism by catalyzing the conversion of glucose to glucose-6-phosphate. HKII is considered to be a promising candidate gene for non-insulin-dependent diabetes mellitus (NIDDM) and insulin resistance. Therefore, we investigated the frequency of vari...

journal_title：Diabetes

authors： Laakso M,Malkki M,Deeb SS

更新日期：1995-03-01 00:00:00

abstract：:The ATP-sensitive K(+) channel (K(ATP) channel) in pancreatic beta-cells is a critical regulator in insulin secretion. We previously reported that transgenic mice expressing a dominant-negative form (Kir6.2G132S) of Kir6.2, a subunit of the K(ATP) channel, specifically in beta-cells develop severe hyperglycemia in adu...

journal_title：Diabetes

authors： Oyama K,Minami K,Ishizaki K,Fuse M,Miki T,Seino S

更新日期：2006-07-01 00:00:00

abstract：:Increased pancreas mass and glucagon-positive adenomas have been suggested to be a risk associated with sitagliptin or exenatide therapy in humans. Novo Nordisk has conducted extensive toxicology studies, including data on pancreas weight and histology, in Cynomolgus monkeys dosed with two different human glucagon-lik...

journal_title：Diabetes

authors： Gotfredsen CF,Mølck AM,Thorup I,Nyborg NC,Salanti Z,Knudsen LB,Larsen MO

更新日期：2014-07-01 00:00:00

abstract：:A pancreatic alpha-like cell line has been established from a glucagonoma arising in transgenic mice expressing a hybrid gene consisting of the rat glucagon-promoter sequence fused to the sequence encoding the SV40 T-antigen oncoprotein. The alpha-tumor cell 1 (alpha TC1) line maintained many characteristics of differ...

journal_title：Diabetes

authors： Powers AC,Efrat S,Mojsov S,Spector D,Habener JF,Hanahan D

更新日期：1990-04-01 00:00:00

abstract：:Targeting of the GLP-1 receptor with (111)In-labeled exendin is an attractive approach to determine the β-cell mass (BCM). Preclinical studies as well as a proof-of-concept study in type 1 diabetic patients and healthy subjects showed a direct correlation between BCM and radiotracer uptake. Despite these promising ini...

journal_title：Diabetes

authors： Brom M,Joosten L,Frielink C,Boerman O,Gotthardt M

更新日期：2015-04-01 00:00:00

abstract：:Sphingosine-1 phosphate (S1P) is a bioactive sphingolipid with the potential to mobilize Ca2+, to inhibit apoptosis, and to promote mitogenesis. Sphingosine kinase (SPHK) and S1P were characterized in INS-1 insulinoma cells and isolated rat islets of Langerhans. SPHK activity increased in INS-1 cell homogenates treate...

journal_title：Diabetes

authors： Mastrandrea LD,Sessanna SM,Laychock SG

更新日期：2005-05-01 00:00:00

abstract：:Fibroblast growth factor 21 (FGF21) is increasingly recognized as an important metabolic regulator of glucose homeostasis. Here, we conducted an exome-chip association analysis by genotyping 5,169 Chinese individuals from a community-based cohort and two clinic-based cohorts. A custom Asian exome-chip was used to dete...

journal_title：Diabetes

authors： Cheung CYY,Tang CS,Xu A,Lee CH,Au KW,Xu L,Fong CHY,Kwok KHM,Chow WS,Woo YC,Yuen MMA,Cherny SS,Hai J,Cheung BMY,Tan KCB,Lam TH,Tse HF,Sham PC,Lam KSL

更新日期：2017-06-01 00:00:00