The human GLP-1 analogs liraglutide and semaglutide: absence of histopathological effects on the pancreas in nonhuman primates.

abstract：:The high-mobility group box transcription factor SOX4 is the most highly expressed SOX family protein in pancreatic islets, and mutations in Sox4 are associated with an increased risk of developing type 2 diabetes. We used an inducible β-cell knockout mouse model to test the hypothesis that Sox4 is essential for the m...

journal_title：Diabetes

authors： Xu EE,Sasaki S,Speckmann T,Nian C,Lynn FC

更新日期：2017-08-01 00:00:00

abstract：:Pulsatile insulin secretion in vivo is believed to be derived, in part, from the intrinsic glucose-dependent intracellular calcium concentration ([Ca2+]i) pulsatility of individual islets. In isolation, islets display fast, slow, or mixtures of fast and slow [Ca2+]i oscillations. We show that the period of islet [Ca2+...

journal_title：Diabetes

authors： Nunemaker CS,Zhang M,Wasserman DH,McGuinness OP,Powers AC,Bertram R,Sherman A,Satin LS

更新日期：2005-12-01 00:00:00

abstract：:A chronic diabetic state was produced in Macaca fuscatus , and these diabetic monkeys were kept without insulin treatment for up to 25 mo. The metabolic derangements were characterized by hyperglycemia, insulinopenia, hyperglucagonemia, ketonemia, and hyperlipidemia. Significant thickening of the capillary basement me...

journal_title：Diabetes

authors： Yasuda H,Harano Y,Kosugi K,Nakano T,Suzuki M,Tsuruoka Y,Taniguchi Y,Nishimori T,Kikkawa R,Shigeta Y

更新日期：1984-05-01 00:00:00

abstract：:Evidence in rodents suggests that islet pretreatment to reduce islet immunogenicity will also require some form of immunosuppression of the recipient for islet allograft acceptance in highly reactive donor-recipient pairs. We attempted to ascertain whether outbred dogs would also require treatment of both donor islets...

journal_title：Diabetes

authors： Alejandro R,Latif Z,Noel J,Shienvold FL,Mintz DH

更新日期：1987-03-01 00:00:00

abstract：:A number of patients with type 2 diabetes are GAD antibody positive. A Diabetes Outcome Progression Trial (ADOPT) is a randomized, double-blind clinical trial in recently diagnosed drug-naive patients with type 2 diabetes that allows for the evaluation of GAD positivity in the context of anthropometric and biochemical...

journal_title：Diabetes

authors： Zinman B,Kahn SE,Haffner SM,O'Neill MC,Heise MA,Freed MI,ADOPT Study Group.

更新日期：2004-12-01 00:00:00

abstract：:A genome scan for B10-derived loci that reduce the frequency of diabetes and insulitis in NOD mice demonstrated a large region (34 cM) of linkage on the proximal end of chromosome 1. This locus was designated Idd5 and encompassed candidate genes including Il1r1, Il1r2, Stat1, Stat4, Nramp1, and Bcl2. In the current st...

journal_title：Diabetes

authors： Hill NJ,Lyons PA,Armitage N,Todd JA,Wicker LS,Peterson LB

更新日期：2000-10-01 00:00:00

abstract：:Impaired insulin secretion is a fundamental defect in type 2 diabetes. The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) in the genes regulating insulin secretion (SLC2A2 [encoding GLUT2], GCK, TCF1 [encoding HNF-1alpha], HNF4A, GIP, and GLP1R) are associated with the conversion f...

journal_title：Diabetes

authors： Laukkanen O,Lindström J,Eriksson J,Valle TT,Hämäläinen H,Ilanne-Parikka P,Keinänen-Kiukaanniemi S,Tuomilehto J,Uusitupa M,Laakso M,Finnish Diabetes Prevention Study.

更新日期：2005-07-01 00:00:00

abstract：:p21(cip1), a regulatory molecule upstream of the G(1/0) checkpoint, is increased in beta-cells in response to mitogenic stimulation. Whereas p21(cip1) can variably stimulate or inhibit cell cycle progression, in vitro studies suggest that p21(cip1) acts as an inhibitor in the pancreatic beta-cell. To determine the fun...

journal_title：Diabetes

authors： Cozar-Castellano I,Haught M,Stewart AF

更新日期：2006-12-01 00:00:00

abstract：:beta-Cell cycle progression and proliferation are critical to maintain beta-cell mass in adult mice. Of the cell cycle inhibitors, p27Kip1 is thought to be the primary modulator of the proliferative status in most cell types. p27 plays a role in beta-cell adaptation in genetic models of insulin resistance. To study th...

journal_title：Diabetes

authors： Rachdi L,Balcazar N,Elghazi L,Barker DJ,Krits I,Kiyokawa H,Bernal-Mizrachi E

更新日期：2006-12-01 00:00:00

abstract：:Nerve conduction and electromyography (EMG) of insulin-dependent (type 1) diabetic patients with end-stage nephropathy was studied before and up to 10 yr after kidney transplantation (KTx). A series of nondiabetic KTx patients served as a comparison group. Motor nerve conduction velocity (NCV) was measured in the ulna...

journal_title：Diabetes

authors： Van der Vliet JA,Navarro X,Kennedy WR,Goetz FC,Barbosa JJ,Sutherland DE,Najarian JS

更新日期：1988-09-01 00:00:00

abstract：:Type 2 diabetes (T2D) is associated with vascular dysfunction. We hypothesized that increased nuclear factor-κB (NF-κB) signaling contributes to vascular dysfunction in T2D. We treated type 2 diabetic (db(-)/db(-)) and control (db(-)/db(+)) mice with two NF-κB inhibitors (6 mg/kg dehydroxymethylepoxyquinomicin twice a...

journal_title：Diabetes

authors： Kassan M,Choi SK,Galán M,Bishop A,Umezawa K,Trebak M,Belmadani S,Matrougui K

更新日期：2013-06-01 00:00:00

abstract：:Resistin is a hormone secreted by adipocytes that acts on skeletal muscle myocytes, hepatocytes, and adipocytes themselves, reducing their sensitivity to insulin. In the present study, we investigated how the expression of resistin is affected by glucose and by mediators known to affect insulin sensitivity, including ...

journal_title：Diabetes

authors： Shojima N,Sakoda H,Ogihara T,Fujishiro M,Katagiri H,Anai M,Onishi Y,Ono H,Inukai K,Abe M,Fukushima Y,Kikuchi M,Oka Y,Asano T

更新日期：2002-06-01 00:00:00

abstract：:Stimulation of cardiomyocyte guanosine 3',5'-cyclic monophosphate (cyclic GMP) via endothelial-derived nitric oxide (NO) is an important mechanism by which bradykinin and ACE inhibitors prevent hypertrophy. Endothelial NO dysfunction and cardiac hypertrophy are morbid features of diabetes not entirely prevented by ACE...

journal_title：Diabetes

authors： Rosenkranz AC,Hood SG,Woods RL,Dusting GJ,Ritchie RH

更新日期：2003-09-01 00:00:00

abstract：:A role for glucose in the control of feeding has been proposed, but its precise physiological importance is unknown. Here, we evaluated feeding behavior in glut2-null mice, which express a transgenic glucose transporter in their beta-cells to rescue insulin secretion (ripglut1;glut2-/- mice). We showed that in the abs...

journal_title：Diabetes

authors： Bady I,Marty N,Dallaporta M,Emery M,Gyger J,Tarussio D,Foretz M,Thorens B

更新日期：2006-04-01 00:00:00

abstract：:The past decade has witnessed an exponential increase in our ability to search the genome for genetic factors predisposing to cardiovascular disease (CVD) and in particular coronary heart disease (CHD). Identifying these genes could lead to the development of innovative strategies to prevent the cardiovascular complic...

journal_title：Diabetes

authors： Doria A

更新日期：2019-03-01 00:00:00

abstract：:We tested the hypothesis that dysfunction of vascular endothelium, indicated by an increase in plasma level of von Willebrand factor (vWF), is present in patients with insulin-dependent diabetes mellitus (IDDM) who develop diabetic nephropathy (DN). DN was classified as absent (urinary albumin excretion [UAE] rate les...

journal_title：Diabetes

authors： Stehouwer CD,Stroes ES,Hackeng WH,Mulder PG,Den Ottolander GJ

更新日期：1991-08-01 00:00:00

abstract：:The incretin effect denominates the phenomenon that oral glucose elicits a higher insulin response than does intravenous glucose. The two hormones responsible for the incretin effect, glucose-dependent insulinotropic hormone (GIP) and glucagon-like peptide-1 (GLP-1), are secreted after oral glucose loads and augment i...

journal_title：Diabetes

authors： Nauck MA,Baller B,Meier JJ

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVE:C57Bl/6 mice develop obesity and mild hyperglycemia when fed a high-fat diet (HFD). Although diet-induced obesity (DIO) is a widely studied model of type 2 diabetes, little is known about beta-cell failure in these mice. RESEARCH DESIGN AND METHODS:DIO mice were separated in two groups according to body weig...

journal_title：Diabetes

authors： Peyot ML,Pepin E,Lamontagne J,Latour MG,Zarrouki B,Lussier R,Pineda M,Jetton TL,Madiraju SR,Joly E,Prentki M

更新日期：2010-09-01 00:00:00

abstract：:Marked improvement in glycemic control occurs in patients with type 2 diabetes mellitus shortly after Roux-en-Y gastric bypass surgery (RYGB) and before there is major weight loss. The objective of this study was to determine whether the magnitude of this change is primarily due to caloric restriction or is unique to ...

journal_title：Diabetes

authors： Jackness C,Karmally W,Febres G,Conwell IM,Ahmed L,Bessler M,McMahon DJ,Korner J

更新日期：2013-09-01 00:00:00

abstract：:The insulin receptor, an integral membrane glycoprotein, is synthesized as a single-chain precursor that is cleaved to produce two mature subunits, both of which contain N-linked oligosaccharide chains and covalently linked fatty acids. We report that the beta-subunit also contains O-linked oligosaccharides. The prore...

journal_title：Diabetes

authors： Collier E,Gorden P

更新日期：1991-02-01 00:00:00

abstract：:Transgenic mice expressing the amyloidogenic human islet amyloid polypeptide (hIAPP) in their islet beta-cells are a model of islet amyloid formation as it occurs in type 2 diabetes. Our hIAPP transgenic mice developed islet amyloid when fed a breeder chow but not regular chow. Because the breeder chow contained incre...

journal_title：Diabetes

authors： Hull RL,Andrikopoulos S,Verchere CB,Vidal J,Wang F,Cnop M,Prigeon RL,Kahn SE

更新日期：2003-02-01 00:00:00

abstract：:Pioglitazone is widely used for the treatment of diabetic patients with insulin resistance. The mechanism of pioglitazone to improve insulin sensitivity is not fully understood. Recent studies have shown that the induction of suppressor of cytokine signaling 3 (SOCS3) is related to the development of insulin resistanc...

journal_title：Diabetes

authors： Kanatani Y,Usui I,Ishizuka K,Bukhari A,Fujisaka S,Urakaze M,Haruta T,Kishimoto T,Naka T,Kobayashi M

更新日期：2007-03-01 00:00:00

abstract：:Endothelinlike immunoreactivity was detected by radioimmunoassay in medium conditioned by cultured endothelial cells obtained from bovine retinal microvessels (9.2 +/- 6.5 pM, n = 4). Sephadex G-25 column chromatography and fast-protein liquid chromatography revealed that most of the endothelinlike immunoreactivity wa...

journal_title：Diabetes

authors： Takahashi K,Brooks RA,Kanse SM,Ghatei MA,Kohner EM,Bloom SR

更新日期：1989-09-01 00:00:00

abstract：:Myoblasts from human skeletal muscle were isolated from needle biopsy samples of vastus lateralis and fused to differentiated multinucleated myotubes. Specific high-affinity insulin and insulin-like growth factor I (IGF-I) binding, glucose transporter proteins GLUT1 and GLUT4, glycogen synthase and pyruvate dehydrogen...

journal_title：Diabetes

authors： Henry RR,Abrams L,Nikoulina S,Ciaraldi TP

更新日期：1995-08-01 00:00:00

abstract：:Long before reaching diagnostic cutoff levels for type 2 diabetes, fasting glucose can be a powerful risk marker for this disease. We conducted a genome-wide search for fasting glucose as a quantitative trait in 412 young European sib-pairs including obese children, with adjustment for sex, age, and BMI. We identified...

journal_title：Diabetes

authors： Fradin D,Heath S,Lathrop M,Bougnères P

更新日期：2007-06-01 00:00:00

abstract：:Association studies are a potentially powerful approach to identifying susceptibility variants for common multifactorial diseases such as type 1 diabetes, but the results are not always consistently reproducible. The IDDM5 locus has recently been narrowed to an approximately 200-kb interval on chromosome 6q25 by two i...

journal_title：Diabetes

authors： Noso S,Ikegami H,Fujisawa T,Kawabata Y,Asano K,Hiromine Y,Tsurumaru M,Sugihara S,Lee I,Kawasaki E,Awata T,Ogihara T

更新日期：2005-12-01 00:00:00

abstract：OBJECTIVE:The liver plays a critical role in integrating and controlling glucose metabolism. Thus, it is important that the liver receive and react to signals from other tissues regarding the nutrient status of the body. Leptin, which is produced and secreted from adipose tissue, is a hormone that relays information re...

journal_title：Diabetes

authors： Huynh FK,Levi J,Denroche HC,Gray SL,Voshol PJ,Neumann UH,Speck M,Chua SC,Covey SD,Kieffer TJ

更新日期：2010-12-01 00:00:00

abstract：:We have suggested that altered maternal metabolism may affect the subsequent anthropometric and neuropsychological development of children who were in utero during disturbances in maternal fuel economy. This study reports the physical growth through 8 yr of age and the neuropsychological development through 4 yr of ag...

journal_title：Diabetes

authors： Silverman BL,Rizzo T,Green OC,Cho NH,Winter RJ,Ogata ES,Richards GE,Metzger BE

更新日期：1991-12-01 00:00:00

abstract：:Children with permanent diabetes are usually assumed to have type 1 diabetes. It has recently been shown that there are genetic subgroups of diabetes that are often diagnosed during the neonatal period but may present later. A recent Italian study proposed that type 1 diabetes is rare before 6 months of age. We aimed ...

journal_title：Diabetes

authors： Edghill EL,Dix RJ,Flanagan SE,Bingley PJ,Hattersley AT,Ellard S,Gillespie KM

更新日期：2006-06-01 00:00:00

abstract：:We conducted autosomal genome scans to map loci for metabolic syndrome (MES) and related traits in the Hong Kong Family Diabetes Study. We selected 55 families with 137 affected members (121 affected relative pairs) for nonparametric linkage analysis on MES. We also selected 179 families with 897 members (2,127 relati...

journal_title：Diabetes

authors： Ng MC,So WY,Lam VK,Cockram CS,Bell GI,Cox NJ,Chan JC

更新日期：2004-10-01 00:00:00