Islet cell proteins defined by monoclonal islet cell antibody HISL-19.

abstract：:This study examines whether the loss of metabolic control in initially normalized islet transplants can result from the inadequate composition of the donor tissue. Streptozotocin-induced diabetic rats were followed for 64 weeks after the intraportal injection of islet isografts with different composition. The implanta...

journal_title：Diabetes

authors： Keymeulen B,Korbutt G,De Paepe M,Gorus F,Klöppel G,Pipeleers DG

更新日期：1996-12-01 00:00:00

abstract：OBJECTIVE:The gut environment modulates the pathogenesis of type 1 diabetes (T1D), but how it affects autoimmunity toward pancreatic β-cells, a self-tissue located outside the intestine, is still unclear. In the small intestine, lamina propria dendritic cells (LPDCs) induce peripheral differentiation of FoxP3(+) regula...

journal_title：Diabetes

authors： Badami E,Sorini C,Coccia M,Usuelli V,Molteni L,Bolla AM,Scavini M,Mariani A,King C,Bosi E,Falcone M

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE:The expansion of adipose tissue mass seen in obesity involves both hyperplasia and hypertrophy of adipocytes. However, little is known about how adipocytes, adipocyte precursors, blood vessels, and stromal cells interact with one another to achieve adipogenesis. RESEARCH DESIGN AND METHODS:We have developed ...

journal_title：Diabetes

authors： Nishimura S,Manabe I,Nagasaki M,Hosoya Y,Yamashita H,Fujita H,Ohsugi M,Tobe K,Kadowaki T,Nagai R,Sugiura S

更新日期：2007-06-01 00:00:00

abstract：:In adults, lower circulating levels of the adipocyte-derived hormone adiponectin are associated with obesity, type 2 diabetes, and cardiovascular disease risks. Its use as a risk marker in children is less clear. In 839 children aged 8 years from a representative birth cohort, circulating adiponectin levels were assoc...

journal_title：Diabetes

authors： Ong KK,Frystyk J,Flyvbjerg A,Petry CJ,Ness A,Dunger DB

更新日期：2006-05-01 00:00:00

abstract：:Infants with congenital hyperinsulinism owing to inactivating mutations in the K(ATP) channel (K(ATP)HI) who are unresponsive to medical therapy will require pancreatectomy to control the hypoglycemia. In preclinical studies, we showed that the GLP-1 receptor antagonist exendin-(9-39) suppresses insulin secretion and ...

journal_title：Diabetes

authors： Calabria AC,Li C,Gallagher PR,Stanley CA,De León DD

更新日期：2012-10-01 00:00:00

abstract：:The significance of the portohepatic glucosensors for counterregulation in deep hypoglycemia (i.e., glycemia < 2.8 mM) was studied in chronically cannulated male mongrel dogs in the conscious state. A total of 16 experiments were carried out on 6 dogs using the liver clamp technique under hyperinsulinemic conditions (...

journal_title：Diabetes

authors： Hamilton-Wessler M,Bergman RN,Halter JB,Watanabe RM,Donovan CM

更新日期：1994-08-01 00:00:00

abstract：:Fetuin-A interferes with insulin action in animal studies, but data on fetuin-A and diabetes risk in humans are sparse and the role of nonalcoholic fatty liver disease in this association is unknown. From 2000 to 2006, we prospectively identified 470 matched incident diabetes case-control pairs in the Nurses' Health S...

journal_title：Diabetes

authors： Sun Q,Cornelis MC,Manson JE,Hu FB

更新日期：2013-01-01 00:00:00

abstract：:In diabetic patients, elevated plasma levels of t-PA and PAI-1 accompany impaired fibrinolysis. To identify mechanisms for these abnormalities, we examined whether vascular endothelial cells exposed to high glucose upregulate t-PA and PAI-1 production and whether ambient PA activity is decreased concomitantly. In 17 c...

journal_title：Diabetes

authors： Maiello M,Boeri D,Podesta F,Cagliero E,Vichi M,Odetti P,Adezati L,Lorenzi M

更新日期：1992-08-01 00:00:00

abstract：:Heme oxygenase-1 (HO-1) exerts vasoprotective effects. Such benefit in diabetic vasculopathy, however, remains unclear. We hypothesize that bilirubin mediates HO-1-induced vascular benefits in diabetes. Diabetic db/db mice were treated with hemin (HO-1 inducer) for 2 weeks, and aortas were isolated for functional and ...

journal_title：Diabetes

authors： Liu J,Wang L,Tian XY,Liu L,Wong WT,Zhang Y,Han QB,Ho HM,Wang N,Wong SL,Chen ZY,Yu J,Ng CF,Yao X,Huang Y

更新日期：2015-05-01 00:00:00

abstract：:The aim of this study was to investigate whether mutations in hepatocyte nuclear factor (HNF)-4gamma, a transcription factor homologous to HNF-4alpha, contribute to the etiology of early-onset type 2 diabetes. Linkage between diabetes and two polymorphic markers at the HNF-4gamma locus (D8S286 and D8S548) was evaluate...

journal_title：Diabetes

authors： Plengvidhya N,Antonellis A,Wogan LT,Poleev A,Borgschulze M,Warram JH,Ryffel GU,Krolewski AS,Doria A

更新日期：1999-10-01 00:00:00

abstract：OBJECTIVE:Insulin resistance associated with obesity and diabetes is ameliorated by specific overexpression of GLUT4 in skeletal muscle. The molecular mechanisms regulating skeletal muscle GLUT4 expression remain to be elucidated. The purpose of this study was to examine these mechanisms. RESEARCH DESIGN AND METHODS A...

journal_title：Diabetes

authors： McGee SL,van Denderen BJ,Howlett KF,Mollica J,Schertzer JD,Kemp BE,Hargreaves M

更新日期：2008-04-01 00:00:00

abstract：:Tight glycemic control by intensive insulin therapy effectively delays the onset and slows the progression of diabetic complications but is associated with frequent dose adjustments and a high incidence of hypoglycemia. Successful pancreas transplantation corrects abnormal glucose metabolism but subjects patients to m...

journal_title：Diabetes

authors： Maki T,Otsu I,O'Neil JJ,Dunleavy K,Mullon CJ,Solomon BA,Monaco AP

更新日期：1996-03-01 00:00:00

abstract：:Type 2 diabetes (T2D) is hallmarked by insulin resistance, impaired insulin secretion, and increased hepatic glucose production. The worldwide increasing prevalence of T2D calls for efforts to understand its pathogenesis in order to improve disease prevention and management. Recent genome-wide association studies have...

journal_title：Diabetes

authors： Bantubungi K,Hannou SA,Caron-Houde S,Vallez E,Baron M,Lucas A,Bouchaert E,Paumelle R,Tailleux A,Staels B

更新日期：2014-10-01 00:00:00

abstract：:The ATP-sensitive K(+) channel (K(ATP) channel) in pancreatic beta-cells is a critical regulator in insulin secretion. We previously reported that transgenic mice expressing a dominant-negative form (Kir6.2G132S) of Kir6.2, a subunit of the K(ATP) channel, specifically in beta-cells develop severe hyperglycemia in adu...

journal_title：Diabetes

authors： Oyama K,Minami K,Ishizaki K,Fuse M,Miki T,Seino S

更新日期：2006-07-01 00:00:00

abstract：:Diabetes and obesity are two metabolic diseases characterized by insulin resistance and a low-grade inflammation. Seeking an inflammatory factor causative of the onset of insulin resistance, obesity, and diabetes, we have identified bacterial lipopolysaccharide (LPS) as a triggering factor. We found that normal endoto...

journal_title：Diabetes

authors： Cani PD,Amar J,Iglesias MA,Poggi M,Knauf C,Bastelica D,Neyrinck AM,Fava F,Tuohy KM,Chabo C,Waget A,Delmée E,Cousin B,Sulpice T,Chamontin B,Ferrières J,Tanti JF,Gibson GR,Casteilla L,Delzenne NM,Alessi MC,Burceli

更新日期：2007-07-01 00:00:00

abstract：:Women with polycystic ovary syndrome (PCOS) have been shown to be less insulin sensitive compared with control (CON) women, independent of BMI. Training is associated with molecular adaptations in skeletal muscle, improving glucose uptake and metabolism in both healthy individuals and patients with type 2 diabetes. In...

journal_title：Diabetes

authors： Hansen SL,Bojsen-Møller KN,Lundsgaard AM,Hendrich FL,Nilas L,Sjøberg KA,Hingst JR,Serup AK,Olguín CH,Carl CS,Wernblad LF,Henneberg M,Lustrup KM,Hansen C,Jensen TE,Madsbad S,Wojtaszewski JFP,Richter EA,Kiens B

更新日期：2020-11-01 00:00:00

abstract：:Glucose-dependent insulinotropic peptide (GIP) is known to be degraded by dipeptidyl peptidase IV (DPP IV), forming an inactive metabolite, but the extent of the enzyme's role in regulating the biological activity of GIP in vivo is still largely unknown. In nonfasted anesthetized pigs given an intravenous infusion of ...

journal_title：Diabetes

authors： Deacon CF,Danielsen P,Klarskov L,Olesen M,Holst JJ

更新日期：2001-07-01 00:00:00

abstract：:Kir6.2 is an inwardly rectifying potassium channel that is expressed in pancreatic beta-cells and cardiac and skeletal muscle. Expressed together with the high-affinity sulphonylurea receptor, it reconstitutes a sulphonylurea- and also ATP-sensitive potassium channel resembling the native beta-cell channel. The object...

journal_title：Diabetes

authors： Hansen L,Echwald SM,Hansen T,Urhammer SA,Clausen JO,Pedersen O

更新日期：1997-03-01 00:00:00

abstract：:Zucker (fa/fa) rats with defective leptin receptors are obese, hyperphagic, and hyperinsulinemic. For testing whether chronic activation of the central melanocortin pathway can bypass the defective leptin signaling and normalize altered energy homeostasis in these rats, recombinant adeno-associated virus encoding pro-...

journal_title：Diabetes

authors： Li G,Mobbs CV,Scarpace PJ

更新日期：2003-08-01 00:00:00

abstract：:The effect of three calcium antagonists (verapamil, diltiazem, and nifedipine) on insulin effects was investigated in isolated rat soleus muscles. Soleus muscles were incubated in the presence of insulin (100 microU/ml), a concentration that stimulates the rates of lactate formation and glycogen synthesis half-maximal...

journal_title：Diabetes

authors： Foot EA,Leighton B

更新日期：1994-01-01 00:00:00

abstract：:Islets of Langerhans are micro-organs scattered throughout the pancreas that contain insulin-producing cells, called beta-cells. Although new light has been recently shed on beta-cell development, information on the phenotype and location of beta-stem cells remains scarce. Here, we provide evidence that beta-stem cell...

journal_title：Diabetes

authors： Duvillié B,Attali M,Aiello V,Quemeneur E,Scharfmann R

更新日期：2003-08-01 00:00:00

abstract：:Analysis of conventional germ-line or tissue-specific gene manipulation in vivo is potentially confounded by developmental adaptation of animal physiology. We aimed to adapt the technique of in vivo electrotransfer (IVE) to alter local gene expression in skeletal muscle of rodents as a means of investigating the role ...

journal_title：Diabetes

authors： Cleasby ME,Davey JR,Reinten TA,Graham MW,James DE,Kraegen EW,Cooney GJ

更新日期：2005-09-01 00:00:00

abstract：:Low birth weight is a well-established risk factor for type 2 diabetes, but the risk at high birth weight levels remains uncertain. Potential sex differences in the associations are unexplored. We investigated whether sex influences the association of birth weight and adult type 2 diabetes, using a cohort of 113,801 m...

journal_title：Diabetes

authors： Zimmermann E,Gamborg M,Sørensen TI,Baker JL

更新日期：2015-12-01 00:00:00

abstract：:The relationship of plasma glucose levels to risk of death over a five-year follow-up period was studied in 2,770 male survivors of myocardial infarction in the placebo group of the Coronary Drug Project (CDP). In univariate analyses, a positive association was observed between mortality rates and both fasting and one...

journal_title：Diabetes

authors：

更新日期：1977-05-01 00:00:00

abstract：:Coxsackievirus B infections have been associated with clinical manifestation of insulin-dependent diabetes mellitus (IDDM) in several studies, but their initiating role in the slowly progressing beta-cell damage is not known. This is the first prospective study designed to assess the role of coxsackie B and other ente...

journal_title：Diabetes

authors： Hyöty H,Hiltunen M,Knip M,Laakkonen M,Vähäsalo P,Karjalainen J,Koskela P,Roivainen M,Leinikki P,Hovi T

更新日期：1995-06-01 00:00:00

abstract：:Because skeletal muscle plays a major role in glucose disposal, it may be the primary site of insulin resistance in non-insulin-dependent diabetes mellitus (NIDDM). Rates of glycogen synthesis (GS), glucose utilization via glycolysis, glycolytic utilization (GU), and glucose transport (GT) were studied in epitrochlear...

journal_title：Diabetes

authors： Karl IE,Gavin JR 3rd,Levy J

更新日期：1990-09-01 00:00:00

abstract：:Myo-Inositol depletion as a result of hyperglycemia is considered one of the leading contributors to chronic diabetic complications. We investigated the possible mechanisms through which elevated extracellular glucose levels affect the loss of intracellular myo-inositol in rat lens. Short-term incubation (up to 4 h) i...

journal_title：Diabetes

authors： Mistry KP,Beyer-Mears A,Diecke FP

更新日期：1993-12-01 00:00:00

abstract：:Obesity is usually associated with an increased risk of nonalcoholic fatty liver disease that is characterized by accumulation of excessive triglyceride (TG) in hepatocytes. However, the factors involved in the obesity-induced hepatosteatosis are poorly defined. Here, we report that SRY-box containing gene 4 (Sox4), a...

journal_title：Diabetes

authors： Jiao Y,Zhao J,Zhang Z,Li M,Yu X,Yang Y,Liu J,Liao S,Li D,Wang Y,Zhang D,Chen Y,Shi G,Liu B,Lu Y,Li X

更新日期：2018-11-01 00:00:00

abstract：:Somatostatin-like immunoreactivity (SLI) concentrations were determined in human peripheral plasma using affinity chromatography followed by radioimmunoassay. In normal subjects, fasting SLI ranged from 2.9 to 22.0 pg/ml with a mean +/- SE value of 10.2 +/- 2.1 pg/ml. In totally pancreatectomized or gastrectomized pat...

journal_title：Diabetes

authors： Tsuda K,Sakurai H,Seino Y,Seino S,Tanigawa K,Kuzuya H,Imura H

更新日期：1981-06-01 00:00:00

abstract：:Cyclic nucleotide phosphodiesterase (PDE) 3B plays an important role in the antilipolytic action of insulin and, thereby, the release of fatty acids from adipocytes. Increased concentrations of circulating fatty acids as a result of elevated or unrestrained lipolysis cause insulin resistance. The lipolytic action of t...

journal_title：Diabetes

authors： Mei J,Holst LS,Landström TR,Holm C,Brindley D,Manganiello V,Degerman E

更新日期：2002-03-01 00:00:00