Proximal Tubulopathy: Prime Mover and Key Therapeutic Target in Diabetic Kidney Disease.

abstract：:Near normal glucoregulation was maintained in 10 patients with insulin-dependent (type I) diabetes mellitus for 6 wk with preprogrammed continuous subcutaneous insulin infusion using a portable battery-powered infusion pump (CSII). This form of therapy resulted in a statistically significant increase in motor nerve co...

journal_title：Diabetes

authors： Pietri A,Ehle AL,Raskin P

更新日期：1980-08-01 00:00:00

abstract：OBJECTIVE:Preferential upper-body fat gain, a typical male pattern, is associated with a greater cardiometabolic risk. Regional differences in lipolysis and meal fat storage cannot explain sex differences in body fat distribution. We examined the potential role of the novel free fatty acid (FFA) storage pathway in dete...

journal_title：Diabetes

authors： Koutsari C,Ali AH,Mundi MS,Jensen MD

更新日期：2011-08-01 00:00:00

abstract：:Long-term insulin secretion was investigated in seven biohybrid capillary devices seeded with canine islets. Approximately 50,000 islets could be isolated from a single canine pancreas using collagenase digestion in conjunction with the recently described Velcro technique. Devices were perfused with tissue culture med...

journal_title：Diabetes

authors： Araki Y,Solomon BA,Basile RM,Chick WL

更新日期：1985-09-01 00:00:00

abstract：:Neonatal female rat pups that were raised artificially on a high-carbohydrate (HC) milk formula during their suckling period developed hyperinsulinemia immediately, maintained chronic hyperinsulinemia in the postweaning period on laboratory diet, and developed obesity in adulthood. Pups (second-generation HC [2-HC]) b...

journal_title：Diabetes

authors： Srinivasan M,Aalinkeel R,Song F,Patel MS

更新日期：2003-04-01 00:00:00

abstract：:Development of beta-cell lines for cell therapy of diabetes is hindered by functional deviations of the replicating cells from the normal beta-cell phenotype. In a recently developed cell line, denoted betaTC-tet, derived from transgenic mice expressing the SV40 T antigen (Tag) under control of the tetracycline (Tc) g...

journal_title：Diabetes

authors： Fleischer N,Chen C,Surana M,Leiser M,Rossetti L,Pralong W,Efrat S

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVE:FUT2 encodes the α(1,2) fucosyltransferase that determines blood group secretor status. Homozygotes (A/A) for the common nonsense mutation rs601338A>G (W143X) are nonsecretors and are unable to express histo-blood group antigens in secretions and on mucosal surfaces. This mutation has been reported to provide...

journal_title：Diabetes

authors： Smyth DJ,Cooper JD,Howson JM,Clarke P,Downes K,Mistry T,Stevens H,Walker NM,Todd JA

更新日期：2011-11-01 00:00:00

abstract：:Evidence exists for an essential role of beta-cell apoptosis in the pathology of type 1 and type 2 diabetes. Current methods for diabetes-associated apoptosis detection, however, suffer the drawbacks of relying on in situ-based strategies. In this study, we attempted to measure, both in vitro and ex vivo, levels of be...

journal_title：Diabetes

authors： Medarova Z,Bonner-Weir S,Lipes M,Moore A

更新日期：2005-06-01 00:00:00

abstract：:Syngeneic pancreatic islet grafts in diabetic NOD mice are infiltrated by mononuclear leukocytes, beta-cells are selectively destroyed, and autoimmune diabetes recurs. This model was used to identify islet graft-infiltrating mononuclear leukocytes associated with beta-cell destruction and diabetes recurrence. We compa...

journal_title：Diabetes

authors： Suarez-Pinzon W,Rajotte RV,Mosmann TR,Rabinovitch A

更新日期：1996-10-01 00:00:00

abstract：:Diabetic nephropathy (DN) is the major life-threatening complication of diabetes. Abnormal permselectivity of glomerular basement membrane (GBM) plays an important role in DN pathogenesis. Heparanase is the predominant enzyme that degrades heparan sulfate (HS), the main polysaccharide of the GBM. Loss of GBM HS in dia...

journal_title：Diabetes

authors： Gil N,Goldberg R,Neuman T,Garsen M,Zcharia E,Rubinstein AM,van Kuppevelt T,Meirovitz A,Pisano C,Li JP,van der Vlag J,Vlodavsky I,Elkin M

更新日期：2012-01-01 00:00:00

abstract：:The Na+-pumping activity of the erythrocyte plasma membrane in diabetic subjects was studied together with the lipid composition. Insulin-dependent diabetes mellitus (IDDM) patients (n = 25) were divided into young (28.1 +/- 7.4 yr old, mean +/- SD; n = 16) and old (7.17 +/- 9.8 yr old; n = 10) subjects; the age of no...

journal_title：Diabetes

authors： Baldini P,Incerpi S,Lambert-Gardini S,Spinedi A,Luly P

更新日期：1989-07-01 00:00:00

abstract：:The plasma and tissue concentration of ascorbic acid (AA) is reduced in diabetes. This study was designed to investigate the mechanism and significance of this phenomenon. The low plasma AA concentration of diabetic rats can be normalized by dietary AA supplement (20-40 mg/day), a dosage approximately equal to the max...

journal_title：Diabetes

authors： McLennan S,Yue DK,Fisher E,Capogreco C,Heffernan S,Ross GR,Turtle JR

更新日期：1988-03-01 00:00:00

abstract：:Large glucagon immunoreactive substances, extracted from the fetal bovine pancreas and separated by gel filtration in the presence of 6 M guanidinium-hydrochloride, were submitted to lectin-sepharose affinity column chromatograph. Gel-filtered peak I (approximately 45 K delta) and peak II (approximately 10 K delta) in...

journal_title：Diabetes

authors： Tung AK,Cockburn E,Siu KP

更新日期：1982-11-01 00:00:00

abstract：:Impaired effectiveness of glucose to suppress endogenous glucose production (EGP) is an important cause of worsening hyperglycemia in type 2 diabetes. Elevated free fatty acids (FFAs) may impair glucose effectiveness via several mechanisms, including rapid changes in metabolic fluxes and/or more gradual changes in gen...

journal_title：Diabetes

authors： Kishore P,Tonelli J,Koppaka S,Fratila C,Bose A,Lee DE,Reddy K,Hawkins M

更新日期：2006-06-01 00:00:00

abstract：:Obesity and type 2 diabetes are emerging global epidemics associated with chronic, low-grade inflammation. A characteristic feature of type 2 diabetes is delayed wound healing, which increases the risk of recurrent infections, tissue necrosis, and limb amputation. In health, inflammation is actively resolved by endoge...

journal_title：Diabetes

authors： Tang Y,Zhang MJ,Hellmann J,Kosuri M,Bhatnagar A,Spite M

更新日期：2013-02-01 00:00:00

abstract：:The significance of the portohepatic glucosensors for counterregulation in deep hypoglycemia (i.e., glycemia < 2.8 mM) was studied in chronically cannulated male mongrel dogs in the conscious state. A total of 16 experiments were carried out on 6 dogs using the liver clamp technique under hyperinsulinemic conditions (...

journal_title：Diabetes

authors： Hamilton-Wessler M,Bergman RN,Halter JB,Watanabe RM,Donovan CM

更新日期：1994-08-01 00:00:00

abstract：:Advanced glycation end-products (AGEs) may play an important role in the pathogenesis and progression of cardiovascular and renal complications of diabetes. Four putative AGE receptors (RAGEs), AGE-R1, AGE-R2, and AGE-R3 have been described. In this study, we scanned the sequence of the genes encoding these AGE recept...

journal_title：Diabetes

authors： Poirier O,Nicaud V,Vionnet N,Raoux S,Tarnow L,Vlassara H,Parving HH,Cambien F

更新日期：2001-05-01 00:00:00

abstract：:Liver X receptors (LXRs) are important regulators of cholesterol and lipid metabolism and are also involved in glucose metabolism. However, the functional role of LXRs in human skeletal muscle is at present unknown. This study demonstrates that chronic ligand activation of LXRs by a synthetic LXR agonist increases the...

journal_title：Diabetes

authors： Kase ET,Wensaas AJ,Aas V,Højlund K,Levin K,Thoresen GH,Beck-Nielsen H,Rustan AC,Gaster M

更新日期：2005-04-01 00:00:00

abstract：:Islet transplantation is a potential treatment for type 1 diabetes, but the shortage of donor organs limits its routine application. As potential donor animals, we generated transgenic pigs expressing LEA29Y, a high-affinity variant of the T-cell costimulation inhibitor CTLA-4Ig, under the control of the porcine insul...

journal_title：Diabetes

authors： Klymiuk N,van Buerck L,Bähr A,Offers M,Kessler B,Wuensch A,Kurome M,Thormann M,Lochner K,Nagashima H,Herbach N,Wanke R,Seissler J,Wolf E

更新日期：2012-06-01 00:00:00

abstract：:The BB rat spontaneously develops autoimmune abnormalities such as insulin-dependent diabetes mellitus and thyroiditis. The autoimmunity of the BB rat is controlled in part by genes of the major histocompatibility complex (MHC), known as the RT1 complex in the rat, and accumulating evidence suggests the involvement of...

journal_title：Diabetes

authors： Holowachuk EW,Greer MK,Martin DR

更新日期：1988-12-01 00:00:00

abstract：:Exogenous ghrelin reduces glucose-stimulated insulin secretion and endogenous ghrelin protects against hypoglycemia during starvation. Islet ε-cells produce ghrelin and δ-cells express growth hormone secretagogue receptor (GHSR), suggesting the possibility of a paracrine mechanism for islet ghrelin to reach high local...

journal_title：Diabetes

authors： Gray SM,Niu J,Zhang A,Svendsen B,Campbell JE,D'Alessio DA,Tong J

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:To examine whether the inflammatory phenotype found in obese and diabetic individuals is preserved in isolated, cultured myocytes and to assess the effectiveness of pharmacological AMP-activated protein kinase (AMPK) activation upon the attenuation of inflammation in these myocytes. RESEARCH DESIGN AND METHO...

journal_title：Diabetes

authors： Green CJ,Pedersen M,Pedersen BK,Scheele C

更新日期：2011-11-01 00:00:00

abstract：:A cohort of 372 insulin-dependent diabetic children, diagnosed between October 1949 and December 1960, were followed-up until December 1976 by the same team of physicians. At the time of diagnosis all patients were under 16 yr of age and were given standardized treatment which did not change from 1949 to 1976. The the...

journal_title：Diabetes

authors： Lestradet H,Papoz L,Hellouin de Menibus C,Levavasseur F,Besse J,Billaud L,Battistelli F,Tric P,Lestradet F

更新日期：1981-03-01 00:00:00

abstract：:A reduced thermic effect of glucose in non-insulin-dependent diabetes mellitus (NIDDM) has been previously reported. To investigate whether this defect is related to 1) a decreased rate of glucose storage, 2) a reduced energy cost of glucose storage, or 3) a defect in the sympathetically mediated component of thermoge...

journal_title：Diabetes

authors： Ravussin E,Zawadzki JK

更新日期：1987-12-01 00:00:00

abstract：:Diabetic cardiomyopathy is characterized by reduced cardiac contractility due to direct changes in heart muscle function independent of vascular disease. An important contributor to contractile dysfunction in the diabetic state is an impaired sarcoplasmic reticulum (SR) function, leading to disturbed intracellular cal...

journal_title：Diabetes

authors： Trost SU,Belke DD,Bluhm WF,Meyer M,Swanson E,Dillmann WH

更新日期：2002-04-01 00:00:00

abstract：:Monocyte-to-macrophage differentiation is a critical event that accentuates atherosclerosis by promoting an inflammatory environment within the vessel wall. In this study, we investigated the molecular mechanisms responsible for monocyte-to-macrophage differentiation and, subsequently, the effect of metformin in regre...

journal_title：Diabetes

authors： Vasamsetti SB,Karnewar S,Kanugula AK,Thatipalli AR,Kumar JM,Kotamraju S

更新日期：2015-06-01 00:00:00

abstract：:Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) has been implicated in the control of blood glucose by its potent effect on expression and signaling of various nuclear receptors. To understand the role of COUP-TFII in glucose homeostasis, conditional COUP-TFII-deficient mice were generated and ...

journal_title：Diabetes

authors： Bardoux P,Zhang P,Flamez D,Perilhou A,Lavin TA,Tanti JF,Hellemans K,Gomas E,Godard C,Andreelli F,Buccheri MA,Kahn A,Le Marchand-Brustel Y,Burcelin R,Schuit F,Vasseur-Cognet M

更新日期：2005-05-01 00:00:00

abstract：:Fetal hyperinsulinemia causes fetal arterial hypoxia because fetal O2 use increases, whereas the supply of O2 to the fetus does not. To find which of the fetal tissues accounts for such an increase in fetal O2 use, we examined the effect of plasma hyperinsulinemia on O2, glucose, and lactate use by the hindquarters of...

journal_title：Diabetes

authors： Milley JR,Papacostas JS

更新日期：1989-05-01 00:00:00

abstract：:To evaluate the correlation between heat-shock protein (HSP) and insulitis, we compared lymphocyte proliferative response to Mycobacterium leprae HSP65 of NOD mice with that of I-E alpha d transgenic NOD (I-E+NOD) mice, which show no insulitis. We found that splenocytes from 15-week-old NOD mice showed a more marked p...

journal_title：Diabetes

authors： Shimada A,Kasatani T,Takei I,Maruyama T,Nomaguchi H,Ozawa Y,Ishii M,Kasuga A,Tashiro F,Miyazaki J,Yamamura K,Saruta T

更新日期：1996-02-01 00:00:00

abstract：:To assess the relationship between beta-cell function and the level and duration of hyperglycemia during generalized beta-cell impairment, we studied the effects of acute and prolonged infusion of somatostatin in seven normal men. Twenty minutes after beginning an acute infusion of somatostatin (200 microgram/h) plus ...

journal_title：Diabetes

authors： Ward WK,Halter JB,Best JD,Beard JC,Porte D Jr

更新日期：1983-10-01 00:00:00

abstract：:During epidemiologic investigations of vascular complications of diabetes in Warsaw the habit of cigarette smoking was analyzed in the subjects studied (4,530 diabetics). It was found that in the group of diabetics the number of ex-smokers was much greater (p less than 0.01) and that of present smokers lower (p less t...

journal_title：Diabetes

authors： Czyzyk A,Królewski AS

更新日期：1976-08-01 00:00:00