Islet cell DNA is a target of inflammatory attack by nitric oxide.

abstract：:In an effort to better understand the phenomenon of lipotoxicity in human beta-cells, we evaluated the effects of 48-h preculture with 1.0 or 2.0 mmol/l free fatty acid (FFA) (2:1 oleate to palmitate) on the function and survival of isolated human islets and investigated some of the possible mechanisms. Compared with ...

journal_title：Diabetes

authors： Lupi R,Dotta F,Marselli L,Del Guerra S,Masini M,Santangelo C,Patané G,Boggi U,Piro S,Anello M,Bergamini E,Mosca F,Di Mario U,Del Prato S,Marchetti P

更新日期：2002-05-01 00:00:00

abstract：:These studies of a rat model for non-insulin-dependent diabetes mellitus (NIDDM) were performed to determine whether hyperglycemia occurs when capacity to synthesize insulin is exceeded. The neonatal streptozocin (STZ)-treated rat has acute hyperglycemia with marked destruction of pancreatic beta-cells, followed by gr...

journal_title：Diabetes

authors： Giddings SJ,Orland MJ,Weir GC,Bonner-Weir S,Permutt MA

更新日期：1985-03-01 00:00:00

abstract：:The effect of cerebral intraventricular insulin on pancreatic insulin secretion was investigated. An extracorporeal pancreatic blood circuit was established after laparotomy to monitor blood flow and insulin concentration directly from the superior pancreaticoduodenal vein. Phentolamine was infused throughout (0.2 mg....

journal_title：Diabetes

authors： Chen M,Woods SC,Porte D Jr

更新日期：1975-10-01 00:00:00

abstract：:Phorbol esters translocatively activate and subsequently downregulate protein kinase C and insulin-stimulated glucose uptake in rat adipocytes. This study examined the possibility that other translocative activators of protein kinase C in rat adipocytes, e.g., insulin and glucose, provoke similar downregulating effect...

journal_title：Diabetes

authors： Ishizuka T,Cooper DR,Arnold T,Hernandez H,Farese RV

更新日期：1991-10-01 00:00:00

abstract：:Islet β-cells adapt to insulin resistance through increased insulin secretion and expansion. Type 2 diabetes typically occurs when prolonged insulin resistance exceeds the adaptive capacity of β-cells. Our prior screening efforts led to the discovery that adenosine kinase (ADK) inhibitors stimulate β-cell replication....

journal_title：Diabetes

authors： Navarro G,Abdolazimi Y,Zhao Z,Xu H,Lee S,Armstrong NA,Annes JP

更新日期：2017-07-01 00:00:00

abstract：:MDL 29311, an analogue of probucol, administered to rats as a 1% dietary admixture for 2 wk before and 5 days after intravenous injection of 40 mg/kg of ALX significantly (P < 0.05) reduced plasma glucose (6.9 +/- 0.3 vs. 19.2 +/- 1.3 mM) and serum triglyceride (0.17 +/- 0.01 vs. 1.82 +/- 0.39 mM) levels in overnight-...

journal_title：Diabetes

authors： Johnson MB,Heineke EW,Rhinehart BL,Sheetz MJ,Barnhart RL,Robinson KM

更新日期：1993-08-01 00:00:00

abstract：:Enterovirus infections, implicated in the pathogenesis of type 1 diabetes in a number of studies, may precipitate the symptoms of clinical diabetes and play a role in the initiation of the beta-cell damaging process. The aim of this study was to evaluate whether cellular immune responses to enterovirus antigens are ab...

journal_title：Diabetes

authors： Juhela S,Hyöty H,Roivainen M,Härkönen T,Putto-Laurila A,Simell O,Ilonen J

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVE:Recent genome-wide association studies (GWASs) related common variants in the interleukin-6 (Il-6) receptor (IL6R) gene to plasma C-reactive protein (CRP) concentrations. Because IL6R variants were previously associated with IL-6 levels, we tested whether the associations with CRP were independent of IL-6 and...

journal_title：Diabetes

authors： Qi L,Rifai N,Hu FB

更新日期：2009-01-01 00:00:00

abstract：:Prophylactic insulin can prevent diabetes in the BB rat. We evaluated its use to prevent adoptive transfer of diabetes by activated splenocytes. ConA-activated spleen cells from acutely diabetic BB rats were divided into two equal aliquots and injected intravenously in paired diabetes-prone BB rat littermates. At the ...

journal_title：Diabetes

authors： Bertrand S,De Paepe M,Vigeant C,Yale JF

更新日期：1992-10-01 00:00:00

abstract：:Large glucagon immunoreactive substances, extracted from the fetal bovine pancreas and separated by gel filtration in the presence of 6 M guanidinium-hydrochloride, were submitted to lectin-sepharose affinity column chromatograph. Gel-filtered peak I (approximately 45 K delta) and peak II (approximately 10 K delta) in...

journal_title：Diabetes

authors： Tung AK,Cockburn E,Siu KP

更新日期：1982-11-01 00:00:00

abstract：:Molecular mechanisms underlying lipolysis, as defined by mobilization of fatty acids from adipose tissue, are not fully understood. A database search for enzymes with alpha/beta hydrolase folds, the GXSXG motif for serine esterase and the His-Gly dipeptide motif, has provided a previously unannotated gene that is indu...

journal_title：Diabetes

authors： Okazaki H,Igarashi M,Nishi M,Tajima M,Sekiya M,Okazaki S,Yahagi N,Ohashi K,Tsukamoto K,Amemiya-Kudo M,Matsuzaka T,Shimano H,Yamada N,Aoki J,Morikawa R,Takanezawa Y,Arai H,Nagai R,Kadowaki T,Osuga J,Ishibashi S

更新日期：2006-07-01 00:00:00

abstract：:A pancreatic alpha-like cell line has been established from a glucagonoma arising in transgenic mice expressing a hybrid gene consisting of the rat glucagon-promoter sequence fused to the sequence encoding the SV40 T-antigen oncoprotein. The alpha-tumor cell 1 (alpha TC1) line maintained many characteristics of differ...

journal_title：Diabetes

authors： Powers AC,Efrat S,Mojsov S,Spector D,Habener JF,Hanahan D

更新日期：1990-04-01 00:00:00

abstract：:Hepatic Notch signaling is inappropriately activated in obese/insulin-resistant mouse models. Genetic or pharmacologic inhibition of hepatic Notch signaling in obese mice simultaneously improves glucose tolerance and reduces hepatic triglyceride content. As such, we predicted that Notch signaling in human liver would ...

journal_title：Diabetes

authors： Valenti L,Mendoza RM,Rametta R,Maggioni M,Kitajewski C,Shawber CJ,Pajvani UB

更新日期：2013-12-01 00:00:00

abstract：:Myoblasts from human skeletal muscle were isolated from needle biopsy samples of vastus lateralis and fused to differentiated multinucleated myotubes. Specific high-affinity insulin and insulin-like growth factor I (IGF-I) binding, glucose transporter proteins GLUT1 and GLUT4, glycogen synthase and pyruvate dehydrogen...

journal_title：Diabetes

authors： Henry RR,Abrams L,Nikoulina S,Ciaraldi TP

更新日期：1995-08-01 00:00:00

abstract：:In early 1988, a colony of GK rats was started in Paris with progenitors issued from F35 of the original colony reported by Goto and Kakisaki. When studied longitudinally up to 8 mo, GK rats showed as early as 1 mo (weaning) significantly higher basal plasma glucose (9 mM) and insulin levels (doubled), altered glucose...

journal_title：Diabetes

authors： Portha B,Serradas P,Bailbé D,Suzuki K,Goto Y,Giroix MH

更新日期：1991-04-01 00:00:00

abstract：OBJECTIVE:We evaluated the impact on diabetes-related intermediary traits of common novel type 2 diabetes-associated variants in the JAZF1 (rs864745), CDC123/CAMK1D (rs12779790), TSPAN8 (rs7961581), THADA (rs7578597), ADAMTS9 (rs4607103), and NOTCH2 (rs10923931) loci, which were recently identified by meta-analysis of ...

journal_title：Diabetes

authors： Grarup N,Andersen G,Krarup NT,Albrechtsen A,Schmitz O,Jørgensen T,Borch-Johnsen K,Hansen T,Pedersen O

更新日期：2008-09-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor (PPAR)gamma is a key transcription factor facilitating fat deposition in adipose tissue through its proadipogenic and lipogenic actions. Human patients with dominant-negative mutations in PPARgamma display lipodystrophy and extreme insulin resistance. For this reason it was c...

journal_title：Diabetes

authors： Gray SL,Nora ED,Grosse J,Manieri M,Stoeger T,Medina-Gomez G,Burling K,Wattler S,Russ A,Yeo GS,Chatterjee VK,O'Rahilly S,Voshol PJ,Cinti S,Vidal-Puig A

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVE:We sought to examine the molecular mechanisms underlying permanenent neonatal diabetes mellitus (PNDM) in a patient with a heterozygous de novo L225P mutation in the L0 region of the sulfonylurea receptor (SUR)1, the regulatory subunit of the pancreatic ATP-sensitive K(+) channel (K(ATP) channel). RESEARCH D...

journal_title：Diabetes

authors： Masia R,De Leon DD,MacMullen C,McKnight H,Stanley CA,Nichols CG

更新日期：2007-05-01 00:00:00

abstract：:Diurnal variation in insulin sensitivity in patients with NIDDM has long been suspected but has been difficult to document mainly because of the interdependence of changes in glucose and insulin. Stable serum insulin levels during hyperglycemic clamping in patients with NIDDM in the present study provided the opportun...

journal_title：Diabetes

authors： Boden G,Chen X,Urbain JL

更新日期：1996-08-01 00:00:00

abstract：:Exposure of the isolated, glucose-perfused rat heart to buffer containing 0.4 mM tolbutamide resulted in significant changes in both energy metabolism and myocardial contractility. In the nondiabetic, tolbutamide mediated only small increases in mechanical function at low atrial filling pressure, but this effect incre...

journal_title：Diabetes

authors： Tan BH,Wilson GL,Schaffer SW

更新日期：1984-12-01 00:00:00

abstract：:We evaluated the effectiveness of a more potent and longer-acting somatostatin analogue (SMS 201-995) as an adjunct to insulin therapy, in a double-blind placebo-controlled randomized study of 26 C-peptide-negative type I (insulin-dependent) diabetic patients (20 women, 6 men, aged 22-40 yr) on their conventional drug...

journal_title：Diabetes

authors： Osei K,O'Dorisio TM,Malarkey WB,Craig EL,Cataland S

更新日期：1989-06-01 00:00:00

abstract：:In pancreatic beta-cells, glucose metabolism signals insulin secretion by altering the cellular array of messenger molecules. ATP is particularly important, given its role in regulating cation channel activity, exocytosis, and events dependent upon its hydrolysis. Uncoupling protein (UCP)-2 is proposed to catalyze a m...

journal_title：Diabetes

authors： Chan CB,De Leo D,Joseph JW,McQuaid TS,Ha XF,Xu F,Tsushima RG,Pennefather PS,Salapatek AM,Wheeler MB

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVE:FUT2 encodes the α(1,2) fucosyltransferase that determines blood group secretor status. Homozygotes (A/A) for the common nonsense mutation rs601338A>G (W143X) are nonsecretors and are unable to express histo-blood group antigens in secretions and on mucosal surfaces. This mutation has been reported to provide...

journal_title：Diabetes

authors： Smyth DJ,Cooper JD,Howson JM,Clarke P,Downes K,Mistry T,Stevens H,Walker NM,Todd JA

更新日期：2011-11-01 00:00:00

abstract：:Precise timing of the teratogenic period in diabetic pregnancy is of clinical importance since correction of the glucose intolerance during this period may protect the offspring from malformations. An experimental approach to elucidate this problem with regard to skeletal development was made in groups of pregnant str...

journal_title：Diabetes

authors： Eriksson UJ,Dahlström E,Hellerström C

更新日期：1983-12-01 00:00:00

abstract：:Nonhuman primate models of gestational diabetes have produced fetopathies most similar to those of the human infant of the mother with gestational diabetes (IGDM). Fetal hyperglycemia, hyperinsulinemia, macrosomia, selective organomegaly, intrauterine death, and placental hyperplasia are hallmarks of the fetopathy of ...

journal_title：Diabetes

authors： Susa JB,Schwartz R

更新日期：1985-06-01 00:00:00

abstract：:Clinical studies indicate that significant loss of functional islet mass occurs in the peritransplant period. Islets are injured as a result of detrimental effects of brain death, pancreas preservation, islet isolation, hypoxia, hyperglycemia, and immune-mediated events. In addition, recent studies demonstrated that i...

journal_title：Diabetes

authors： Contreras JL,Eckstein C,Smyth CA,Bilbao G,Vilatoba M,Ringland SE,Young C,Thompson JA,Fernández JA,Griffin JH,Eckhoff DE

更新日期：2004-11-01 00:00:00

abstract：OBJECTIVE:To evaluate whether healthy or diabetic adult mice can tolerate an extreme loss of pancreatic α-cells and how this sudden massive depletion affects β-cell function and blood glucose homeostasis. RESEARCH DESIGN AND METHODS:We generated a new transgenic model allowing near-total α-cell removal specifically in...

journal_title：Diabetes

authors： Thorel F,Damond N,Chera S,Wiederkehr A,Thorens B,Meda P,Wollheim CB,Herrera PL

更新日期：2011-11-01 00:00:00

abstract：:The kinin B1 receptor (B1R) plays a role in inflammatory and metabolic processes. B1R deletion (B1-/-) protects mice from diet-induced obesity and improves insulin and leptin sensitivity. In contrast, genetic reconstitution of B1R exclusively in adipose tissue reverses the lean phenotype of B1-/- mice. To study the ce...

journal_title：Diabetes

authors： Sales VM,Gonçalves-Zillo T,Castoldi A,Burgos M,Branquinho J,Batista C,Oliveira V,Silva E,Castro CHM,Câmara N,Mori MA,Pesquero JB

更新日期：2019-08-01 00:00:00

abstract：:Members of the tumor necrosis factor receptor superfamily play an important role in the initiation, expansion, and termination of an immune response. It has recently been demonstrated that one member of this family, CD30, plays a central role in maintaining peripheral tolerance by controlling the expansion of autoreac...

journal_title：Diabetes

authors： Siegmund T,Armitage N,Wicker LS,Peterson LB,Todd JA,Lyons PA

更新日期：2000-09-01 00:00:00

abstract：:The effects of glucose and diabetes on the high-affinity lofentanil-displaceable opiate-receptor binding in mouse brain membranes were studied to determine if the attenuation of opiate actions by hyperglycemia previously observed in our laboratory was due to a modification of receptor affinity or number. With membrane...

journal_title：Diabetes

authors： Brase DA,Han YH,Dewey WL

更新日期：1987-10-01 00:00:00