Abstract:
:Nonhuman primate models of gestational diabetes have produced fetopathies most similar to those of the human infant of the mother with gestational diabetes (IGDM). Fetal hyperglycemia, hyperinsulinemia, macrosomia, selective organomegaly, intrauterine death, and placental hyperplasia are hallmarks of the fetopathy of the IGDM. The chronic infusion of insulin into the fetus of a normal pregnant rhesus monkey results in fetal hyperinsulinemia with normal to low plasma metabolic substrate concentrations. Under these conditions, fetal hyperinsulinemia is sufficient to cause fetal growth and hormone changes observed in the human IGDM. Our studies provide evidence that the soft tissue hyperplasia in the fetal macrosomia syndromes in humans and nonhuman primates in which fetal hyperinsulinemia is observed is the direct result of that chronic in utero hyperinsulinemia.
journal_name
Diabetesjournal_title
Diabetesauthors
Susa JB,Schwartz Rdoi
10.2337/diab.34.2.s36subject
Has Abstractpub_date
1985-06-01 00:00:00pages
36-41eissn
0012-1797issn
1939-327Xjournal_volume
34 Suppl 2pub_type
杂志文章相关文献
DIABETES文献大全abstract::The kinetics of in vivo insulin-mediated glucose uptake in human obesity have not been previously studied. To examine this, we used the glucose-clamp technique to measure whole-body and leg muscle glucose uptake in seven lean and six obese men during hyperinsulinemia (approximately 2000 pM) at four glucose levels (app...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.39.8.965
更新日期:1990-08-01 00:00:00
abstract::Cardiovascular diseases are the leading cause of morbidity and mortality in diabetes. Lipoprotein lipase (LPL), a major secretory product of macrophages, has been suggested to play a key role in the development of atherosclerosis. In the present study, we evaluated the effect of high glucose on macrophage LPL mRNA exp...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.47.3.431
更新日期:1998-03-01 00:00:00
abstract::Insulin resistance is of pathogenic importance in several common human disorders including type 2 diabetes, hypertension, obesity and hyperlipidemia, but the underlying mechanisms are unknown. The spontaneously hypertensive rat (SHR) is a model of these human insulin resistance syndromes. Quantitative trait loci (QTLs...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.49.12.2222
更新日期:2000-12-01 00:00:00
abstract::Diurnal variation in insulin sensitivity in patients with NIDDM has long been suspected but has been difficult to document mainly because of the interdependence of changes in glucose and insulin. Stable serum insulin levels during hyperglycemic clamping in patients with NIDDM in the present study provided the opportun...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.45.8.1044
更新日期:1996-08-01 00:00:00
abstract::We explored the role of reactive oxygen species (ROS) in the pathogenesis of muscle insulin resistance. We assessed insulin action in vivo with a hyperinsulinemic-euglycemic clamp in mice expressing a mitochondrial-targeted catalase (MCAT) that were fed regular chow (RC) or a high-fat diet (HFD) or underwent an acute ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db16-1334
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:Insufficient development of a new intra-islet capillary network after transplantation may be one contributing factor to the failure of islet grafts in clinical transplantation. The present study tested the hypothesis that the angiostatic factor thrombospondin-1 (TSP-1), which is normally present in islets, re...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db07-0724
更新日期:2008-07-01 00:00:00
abstract::The Na+-pumping activity of the erythrocyte plasma membrane in diabetic subjects was studied together with the lipid composition. Insulin-dependent diabetes mellitus (IDDM) patients (n = 25) were divided into young (28.1 +/- 7.4 yr old, mean +/- SD; n = 16) and old (7.17 +/- 9.8 yr old; n = 10) subjects; the age of no...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.38.7.825
更新日期:1989-07-01 00:00:00
abstract::Nonhuman primates have been used for a variety of studies on diabetes mellitus. Spontaneous, natural forms of diabetes have been well documented in several species; there are limited data on numerous other species that indicate diabetes or a diabetes-like syndrome. The causes and manifestations of spontaneous diabetes...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.31.1.s37
更新日期:1982-01-01 00:00:00
abstract::The paucity of animal models exhibiting full pathology of diabetic retinopathy (DR) has impeded understanding of the pathogenesis of DR and the development of therapeutic interventions. Here, we investigated whether hyperhexosemic marmosets (Callithrix jacchus) develop characteristic retinal vascular lesions including...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db14-0866
更新日期:2015-07-01 00:00:00
abstract::Data is accumulating indicating that impaired insulin action predisposes to increased vascular smooth muscle (VSM) tone, the hallmark of hypertension associated with diabetes. During the last several years, it has been established that VSM is an insulin-sensitive tissue like skeletal muscle and adipocytes. Investigato...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.45.3.s47
更新日期:1996-07-01 00:00:00
abstract::The underlying pathophysiology of the metabolic syndrome is the subject of debate, with both insulin resistance and obesity considered as important factors. We evaluated the differential effects of insulin resistance and central body fat distribution in determining the metabolic syndrome as defined by the National Cho...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.53.8.2087
更新日期:2004-08-01 00:00:00
abstract::Plasma glucagon response to glucose in diabetic subjects was observed before and after treatment. In normal subjects, plasma glucagon concentrations decreased substantially after an oral glucose load. In all diabetic patients before treatment, plasma glucagon was not suppressed and rather tended to rise paradoxically ...
journal_title:Diabetes
pub_type: 临床试验,杂志文章
doi:10.2337/diab.27.12.1145
更新日期:1978-12-01 00:00:00
abstract::The fa-gene was transferred from the Zucker rat (13 M strain) to the Wistar Kyoto (WKY) rat. The survey, performed at the 10th generation of backcrossing, showed that Wistar fatty rats (fa/fa), a congenic strain of WKY, developed obesity and obesity-related features, such as hyperinsulinemia and hyperlipemia, in the s...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.30.12.1045
更新日期:1981-12-01 00:00:00
abstract::Because skeletal muscle plays a major role in glucose disposal, it may be the primary site of insulin resistance in non-insulin-dependent diabetes mellitus (NIDDM). Rates of glycogen synthesis (GS), glucose utilization via glycolysis, glycolytic utilization (GU), and glucose transport (GT) were studied in epitrochlear...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.39.9.1106
更新日期:1990-09-01 00:00:00
abstract::Subjects with overt non-insulin-dependent diabetes mellitus (NIDDM) were studied in comparison to obese nondiabetic control subjects and patients with subclinical diabetes. Pancreatic insulin secretion rates were measured by deconvolution of peripheral C-peptide over a 24-h period while subjects consumed an isocaloric...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.43.7.871
更新日期:1994-07-01 00:00:00
abstract::High glucose concentrations such as are seen in diabetes mellitus are known to have deleterious effects on cells, but the pathways by which glucose induces these effects are unknown. One hypothesis is that metabolism of glucose to glucosamine might be involved. For example, it has been shown that glucosamine is more p...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.42.9.1289
更新日期:1993-09-01 00:00:00
abstract::It is suggested that the maternal transmission of islet autoantibodies increases the risk of autoimmune diabetes in mice. The aim of this study was to determine whether fetal exposure to islet autoantibodies modified the risk of type 1 diabetes in humans. Islet autoantibodies were measured at birth in 720 offspring of...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.53.1.1
更新日期:2004-01-01 00:00:00
abstract::Highly angiogenic bone marrow mononuclear cell-derived spheroids (BM-spheroids), formed by selective proliferation of the CD31+CD14+CD34+ monocyte subset via three-dimensional (3D) culture, have had robust angiogenetic capacity in rodent syngeneic renal subcapsular islet transplantation. We wondered whether the effica...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db17-0705
更新日期:2018-03-01 00:00:00
abstract::Thymocytes from adult BB rats can adoptively transfer autoimmune diabetes to athymic recipients. It is also known that the development of BB rat T-cells is recapitulated in adult thymus organ cultures (ATOCs). Based on these observations, we tested the hypothesis that cells capable of the adoptive transfer of diabetes...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.50.5.972
更新日期:2001-05-01 00:00:00
abstract::Cysteamine (300 mg/kg) administered subcutaneously depletes pancreatic somatostatin to 36% of control levels, but does not alter pancreatic insulin or glucagon content. Although perfusion of pancreata from normal animals with glucose (300 mg/dl) markedly stimulated somatostatin release, pancreata from cysteamine-treat...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.32.4.377
更新日期:1983-04-01 00:00:00
abstract::Fetuin-A interferes with insulin action in animal studies, but data on fetuin-A and diabetes risk in humans are sparse and the role of nonalcoholic fatty liver disease in this association is unknown. From 2000 to 2006, we prospectively identified 470 matched incident diabetes case-control pairs in the Nurses' Health S...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db12-0372
更新日期:2013-01-01 00:00:00
abstract::The significance of the portohepatic glucosensors for counterregulation in deep hypoglycemia (i.e., glycemia < 2.8 mM) was studied in chronically cannulated male mongrel dogs in the conscious state. A total of 16 experiments were carried out on 6 dogs using the liver clamp technique under hyperinsulinemic conditions (...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.43.8.1052
更新日期:1994-08-01 00:00:00
abstract:OBJECTIVE:We tested the hypothesis that adrenergic activation, cholinergic activation, or both, mediate the effect of recent antecedent hypoglycemia to reduce the sympathoadrenal response to subsequent hypoglycemia, the key feature of hypoglycemia-associated autonomic failure in diabetes, in humans. RESEARCH DESIGN AN...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db10-1374
更新日期:2011-02-01 00:00:00
abstract::This study was undertaken to test two assumptions critical for use of [2-14C]acetate to measure gluconeogenesis in vivo. For the assumption that incorporation into glucose of products of [14C]acetate metabolism does not affect the distribution of label within the glucose molecule, we infused [2-14C]acetate in 17 healt...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.42.5.732
更新日期:1993-05-01 00:00:00
abstract::Prophylactic insulin can prevent diabetes in the BB rat. We evaluated its use to prevent adoptive transfer of diabetes by activated splenocytes. ConA-activated spleen cells from acutely diabetic BB rats were divided into two equal aliquots and injected intravenously in paired diabetes-prone BB rat littermates. At the ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.41.10.1273
更新日期:1992-10-01 00:00:00
abstract::Islet β-cells adapt to insulin resistance through increased insulin secretion and expansion. Type 2 diabetes typically occurs when prolonged insulin resistance exceeds the adaptive capacity of β-cells. Our prior screening efforts led to the discovery that adenosine kinase (ADK) inhibitors stimulate β-cell replication....
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db16-0816
更新日期:2017-07-01 00:00:00
abstract::Two weeks after intraportal transplantation of 2,000 neonatal pancreatic islets, recipient rats completely recovered from streptozotocin-induced diabetes. The reversal of diabetes could be documented by the normalization of blood glucose levels, by a restored weight gain, by normal glucagon and insulin levels in blood...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.43.11.1345
更新日期:1994-11-01 00:00:00
abstract::In diabetic subjects, polyol pathway activity might inhibit neutrophil function and cause nerve damage. The effects of ponalrestat, an aldose reductase inhibitor, were assessed on neutrophil intracellular killing of Escherichia coli and on autonomic function in diabetic subjects in a randomized double-blind, placebo-c...
journal_title:Diabetes
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diab.42.2.336
更新日期:1993-02-01 00:00:00
abstract:OBJECTIVE:High-fat diet (HFD)-induced adipose tissue inflammation is a critical feature of diet-induced insulin resistance (IR); however, the contribution of interleukin-1 receptor I (IL-1RI)-mediated signals to this phenotype has not been defined. We hypothesized that lack of IL-1RI may ameliorate HFD-induced IR by at...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db10-1278
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:The aim of the current study was to evaluate the long-term effects of leptin on glucose metabolism, diabetes complications, and life span in an insulin-dependent diabetes model, the Akita mouse. RESEARCH DESIGN AND METHODS:We cross-mated Akita mice with leptin-expressing transgenic (LepTg) mice to produce Ak...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db10-1795
更新日期:2011-09-01 00:00:00