Abstract:
:Cysteamine (300 mg/kg) administered subcutaneously depletes pancreatic somatostatin to 36% of control levels, but does not alter pancreatic insulin or glucagon content. Although perfusion of pancreata from normal animals with glucose (300 mg/dl) markedly stimulated somatostatin release, pancreata from cysteamine-treated animals failed to secrete somatostatin in response to glucose. Cysteamine treatment was without effect on insulin and glucagon release under the conditions tested. The isolated perfused pancreas from the cysteamine-treated rat provides a model for further investigations into regulation of islet hormone release in the absence of stimulated somatostatin release.
journal_name
Diabetesjournal_title
Diabetesauthors
Sorenson RL,Grouse LH,Elde RPdoi
10.2337/diab.32.4.377subject
Has Abstractpub_date
1983-04-01 00:00:00pages
377-9issue
4eissn
0012-1797issn
1939-327Xjournal_volume
32pub_type
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