Antibodies against gastrointestinal carcinoid tumors in IDDM.

abstract：:An A-to-G transition in the mitochondrial tRNALeu(UUR) gene at base pair 3243 has been shown to be associated with the maternally transmitted clinical phenotype of NIDDM and sensorineural hearing loss in white and Japanese pedigrees. We have detected this mutation in 25 of 50 tested members of five white French pedigr...

journal_title：Diabetes

authors： Velho G,Byrne MM,Clément K,Sturis J,Pueyo ME,Blanché H,Vionnet N,Fiet J,Passa P,Robert JJ,Polonsky KS,Froguel P

更新日期：1996-04-01 00:00:00

abstract：:Cyclic nucleotide phosphodiesterase (PDE) 3B plays an important role in the antilipolytic action of insulin and, thereby, the release of fatty acids from adipocytes. Increased concentrations of circulating fatty acids as a result of elevated or unrestrained lipolysis cause insulin resistance. The lipolytic action of t...

journal_title：Diabetes

authors： Mei J,Holst LS,Landström TR,Holm C,Brindley D,Manganiello V,Degerman E

更新日期：2002-03-01 00:00:00

abstract：:The effect of Ca2+ and calmodulin has been studied on adenylate cyclase activity in homogenates of rat islets of Langerhans. EGTA had a stimulatory effect on the enzyme in accord with the known inhibitory effect of Ca2+. In contrast, the addition of Ca2+ together with calmodulin is stimulatory and demonstrates the exi...

journal_title：Diabetes

authors： Sharp GW,Wiedenkeller DE,Kaelin D,Siegel EG,Wollheim CB

更新日期：1980-01-01 00:00:00

abstract：:The possible influence of diabetes on the higher mnestic and cognitive functions has been investigated. The P300 wave latency, an endogenous electrophysiological event, was explored and compared with the multimodal short-latency evoked potential (EP) recordings (visual [VEP], brainstem auditory [BAEP], and median and ...

journal_title：Diabetes

authors： Pozzessere G,Valle E,de Crignis S,Cordischi VM,Fattapposta F,Rizzo PA,Pietravalle P,Cristina G,Morano S,di Mario U

更新日期：1991-08-01 00:00:00

abstract：:Evaluation of the existence of a diurnal pattern of glucose tolerance after mixed meals is important to inform a closed-loop system of treatment for insulin requiring diabetes. We studied 20 healthy volunteers with normal fasting glucose (4.8 ± 0.1 mmol/L) and HbA(1c) (5.2 ± 0.0%) to determine such a pattern in nondia...

journal_title：Diabetes

authors： Saad A,Dalla Man C,Nandy DK,Levine JA,Bharucha AE,Rizza RA,Basu R,Carter RE,Cobelli C,Kudva YC,Basu A

更新日期：2012-11-01 00:00:00

abstract：:The clinical features of the experimental hyperosmolar diabetic (EHD) rat model resemble those seen in the human syndrome--extreme hyperglycemia without ketoacidosis is common to both. The absence of ketoacidosis in the syndrome has been ascribed to both substrate (free fatty acid) deficiency and to interference with ...

journal_title：Diabetes

authors： Gordon EE,Duga J

更新日期：1975-03-01 00:00:00

abstract：:Compartmentalization of kinases and phosphatases is a key determinant in the specificity of second messenger-mediated signaling events. Localization of the cAMP-dependent protein kinase (PKA) and other signaling enzymes is mediated by interaction with A-kinase anchoring proteins (AKAPs). This study focused on recent a...

journal_title：Diabetes

authors： Alto N,Carlisle Michel JJ,Dodge KL,Langeberg LK,Scott JD

更新日期：2002-12-01 00:00:00

abstract：:EPHX2 (encoding soluble epoxide hydrolase [sEH]) converts biologically active epoxyeicosatrienoic acids (EETs), anti-inflammatory and profibrinolytic effectors, into the less biologically active metabolites, dihydroxyeicostrienoic acids. We sought to characterize the expression and the function of EPHX2 in diabetic co...

journal_title：Diabetes

authors： Sun H,Lee P,Yan C,Gao N,Wang J,Fan X,Yu FS

更新日期：2018-06-01 00:00:00

abstract：:The rapid conversion of glucose to sorbitol by aldose reductase and the consequent hyperosmolarity of the cytoplasm has been shown to be the primary cause of the so-called "sugar" or "osmotic" cataract in many animal lenses. It is not as clear, however, that hyperosmolarity is the principal factor in the etiology of c...

journal_title：Diabetes

authors： Barnett PA,González RG,Chylack LT Jr,Cheng HM

更新日期：1986-04-01 00:00:00

abstract：:Hyperinsulinemia was produced in fetal rhesus monkeys for 21 days in the last third of gestation by subcutaneous pork insulin injected at 19 U a day. Plasma insulin concentrations in treated fetuses (N = 4) were 3525 microU/ml. There was no difference in paired pre- and post-treatment fetal plasma glucose concentratio...

journal_title：Diabetes

authors： McCormick KL,Susa JB,Widness JA,Singer DB,Adamsons K,Schwartz R

更新日期：1979-12-01 00:00:00

abstract：OBJECTIVE:The gut environment modulates the pathogenesis of type 1 diabetes (T1D), but how it affects autoimmunity toward pancreatic β-cells, a self-tissue located outside the intestine, is still unclear. In the small intestine, lamina propria dendritic cells (LPDCs) induce peripheral differentiation of FoxP3(+) regula...

journal_title：Diabetes

authors： Badami E,Sorini C,Coccia M,Usuelli V,Molteni L,Bolla AM,Scavini M,Mariani A,King C,Bosi E,Falcone M

更新日期：2011-08-01 00:00:00

abstract：:Alzheimer disease and type 2 diabetes are characterized by increased prevalence with aging, a genetic predisposition, and comparable pathological features in the islet and brain (amyloid derived from amyloid beta protein in the brain in Alzheimer disease and islet amyloid derived from islet amyloid polypeptide in the ...

journal_title：Diabetes

authors： Janson J,Laedtke T,Parisi JE,O'Brien P,Petersen RC,Butler PC

更新日期：2004-02-01 00:00:00

abstract：:Rhesus monkeys frequently develop obesity and insulin resistance followed by type 2 diabetes when allowed free access to chow. This insulin resistance is partly due to defective glucose transport into skeletal muscle. In this study, we examined signaling factors required for insulin-stimulated glucose transport in mus...

journal_title：Diabetes

authors： Standaert ML,Ortmeyer HK,Sajan MP,Kanoh Y,Bandyopadhyay G,Hansen BC,Farese RV

更新日期：2002-10-01 00:00:00

abstract：:This genome-wide search for susceptibility genes to type 2 diabetes/impaired glucose homeostasis (IGH) was performed on a relatively homogeneous Chinese sample with a total number of 257 pedigrees and 385 affected sibpairs. Two regions showed significant linkage to type 2 diabetes/IGH in the Chinese. The region showin...

journal_title：Diabetes

authors： Xiang K,Wang Y,Zheng T,Jia W,Li J,Chen L,Shen K,Wu S,Lin X,Zhang G,Wang C,Wang S,Lu H,Fang Q,Shi Y,Zhang R,Xu J,Weng Q

更新日期：2004-01-01 00:00:00

abstract：:Hyperglycemia-induced oxidative stress is detrimental for endothelial cells, contributing to the vascular complications of diabetes. The mitochondrial permeability transition pore (PTP) is an oxidative stress-sensitive channel involved in cell death; therefore, we have examined its potential role in endothelial cells ...

journal_title：Diabetes

authors： Detaille D,Guigas B,Chauvin C,Batandier C,Fontaine E,Wiernsperger N,Leverve X

更新日期：2005-07-01 00:00:00

abstract：:We examined the hypothesis that imprinted genes may affect the propensity to type 2 diabetes and obesity in Pima Indians. Multipoint variance component methods were used to assess linkage of BMI (kg/m(2)) and age-adjusted diabetes to loci derived from either father (LOD(FA)) or mother (LOD(MO)) in a genome-wide scan. ...

journal_title：Diabetes

authors： Lindsay RS,Kobes S,Knowler WC,Bennett PH,Hanson RL

更新日期：2001-12-01 00:00:00

abstract：:Extracellular ATP (eATP) activates T cells by engaging the P2X7R receptor. We identified two loss-of-function P2X7R mutations that are protective against type 1 diabetes (T1D) and thus hypothesized that eATP/P2X7R signaling may represent an early step in T1D onset. Specifically, we observed that in patients with newly...

journal_title：Diabetes

authors： Tezza S,Ben Nasr M,D'Addio F,Vergani A,Usuelli V,Falzoni S,Bassi R,Dellepiane S,Fotino C,Rossi C,Maestroni A,Solini A,Corradi D,Giani E,Mameli C,Bertuzzi F,Pezzolesi MG,Wasserfall CH,Atkinson MA,Füchtbauer EM,Rico

更新日期：2018-10-01 00:00:00

abstract：:The transmission behavior of insulin-dependent juvenile diabetes mellitus (JDM) has been studied with respect to its frequency in the relatives of JDM probands and its possible linkage to the HLA complex. Mathematical analysis shows that under a single locus hypothesis a very restricted range of incidence rates is pos...

journal_title：Diabetes

authors： Suarez B,Hodge SE,Reich T

更新日期：1979-06-01 00:00:00

abstract：:It has been suggested that the metabolic syndrome and type 2 diabetes are manifestations of the inflammatory host response. This host response is orchestrated by the production of pro- and anti-inflammatory cytokines that are under genetic control. We therefore hypothesized that a low production capacity of interleuki...

journal_title：Diabetes

authors： van Exel E,Gussekloo J,de Craen AJ,Frölich M,Bootsma-Van Der Wiel A,Westendorp RG,Leiden 85 Plus Study.

更新日期：2002-04-01 00:00:00

abstract：:Diabetes mellitus (DM) is associated with increased plasma levels of arginine-vasopressin (AVP), which may aggravate hyperglycemia and nephropathy. However, the mechanisms by which DM may cause the increased AVP levels are not known. Electrophysiological recordings in supraoptic nucleus (SON) slices from streptozotoci...

journal_title：Diabetes

authors： Kim YB,Kim WB,Jung WW,Jin X,Kim YS,Kim B,Han HC,Block GD,Colwell CS,Kim YI

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:On the basis of the role of activin A in inflammation, atherogenesis, and glucose homeostasis, we investigated whether activin A could be related to glucometabolic abnormalities in patients with acute myocardial infarction (MI). RESEARCH DESIGN AND METHODS:Activin A measurement and oral glucose tolerance tes...

journal_title：Diabetes

authors： Andersen GØ,Ueland T,Knudsen EC,Scholz H,Yndestad A,Sahraoui A,Smith C,Lekva T,Otterdal K,Halvorsen B,Seljeflot I,Aukrust P

更新日期：2011-05-01 00:00:00

abstract：:Obesity is associated with an increase in the fractional contribution of gluconeogenesis (GNG) to glucose production. We tested if this was related to the altered protein metabolism in obesity. GNG(PEP) (via phosphoenol pyruvate [PEP]) was measured after a 17-h fast using the deuterated water method and 2H nuclear mag...

journal_title：Diabetes

authors： Chevalier S,Burgess SC,Malloy CR,Gougeon R,Marliss EB,Morais JA

更新日期：2006-03-01 00:00:00

abstract：:The relationship between the levels of circulating thyroid hormones and the action of insulin on adipose tissue was investigated in 6 hypothyroid patients and 6 hyperthyroid patients, all untreated, and 8 healthy control subjects. All were matched for age, body weight, and fat cell size. Gluteal s.c. adipose tissue wa...

journal_title：Diabetes

authors： Arner P,Bolinder J,Wennlund A,Ostman J

更新日期：1984-04-01 00:00:00

abstract：:Expression of GLUTs in rat peripheral nerve was first studied at the mRNA level with Northern transfer analysis with cDNAs specific for GLUT1, GLUT2, GLUT3, and GLUT4. GLUT1 mRNA was the only GLUT mRNA detectable in rat sciatic nerve. In situ hybridization localized this mRNA to the perineurium and to some endo- and e...

journal_title：Diabetes

authors： Muona P,Sollberg S,Peltonen J,Uitto J

更新日期：1992-12-01 00:00:00

abstract：:Experiments in rodents suggest that hypothalamic insulin signaling essentially contributes to the acute control of peripheral glucose homeostasis. Against this background, we investigated in healthy humans whether intranasal (IN) insulin, which is known to effectively reach the brain compartment, impacts systemic gluc...

journal_title：Diabetes

authors： Ott V,Lehnert H,Staub J,Wönne K,Born J,Hallschmid M

更新日期：2015-03-01 00:00:00

abstract：:Diabetic hearts exhibit decreased responsiveness to stimulation by beta-adrenoreceptor (beta-AR) agonists. This decrease in activity may be due to changes in expression and/or signaling of beta-AR. Recently we showed that right atrial strips from 14-week streptozotocin (STZ)-induced diabetic rat hearts exhibit decreas...

journal_title：Diabetes

authors： Dinçer UD,Bidasee KR,Güner S,Tay A,Ozçelikay AT,Altan VM

更新日期：2001-02-01 00:00:00

abstract：:Mutations in the NeuroD/BETA2 gene have been shown to associate with type 2 diabetes. In the present study, we examined mutations in the NeuroD/BETA2 gene for association with either type 1 or 2 diabetes. Three variants were identified in patients with type 2 diabetes: Ala45Thr (allelic frequency 0.36, 95% CI 0.31-0.4...

journal_title：Diabetes

authors： Hansen L,Jensen JN,Urioste S,Petersen HV,Pociot F,Eiberg H,Kristiansen OP,Hansen T,Serup P,Nerup J,Pedersen O

更新日期：2000-05-01 00:00:00

abstract：:Insulin is a short-lived species in the circulatory system. After binding to its receptor sites and transmission of its biological signals, bound insulin undergoes receptor-mediated endocytosis and consequent degradation. An inactive insulin derivative that is not recognized by the receptor has a longer circulation li...

journal_title：Diabetes

authors： Gershonov E,Shechter Y,Fridkin M

更新日期：1999-07-01 00:00:00

abstract：:To elucidate the precise significance of pancreatic A-cell hypersecretion in the pathogenesis of diabetes mellitus, the change in the immunoreactive glucagon (IRG) response to intravenous arginine was studied in both nonobese, hypoinsulinemic non-insulin-dependent (NIDDM) and insulin-dependent diabetic (IDDM) subjects...

journal_title：Diabetes

authors： Kawamori R,Shichiri M,Kikuchi M,Yamasaki Y,Abe H

更新日期：1980-09-01 00:00:00

abstract：:The aim of this randomized double-blind study was to compare the within-subject variability of the glucose-lowering effect of a novel insulin analog, insulin detemir, with that of insulin glargine and NPH insulin in people with type 1 diabetes. Fifty-four subjects (32 males and 22 females, age 38 +/- 10 years [mean +/...

journal_title：Diabetes

authors： Heise T,Nosek L,Rønn BB,Endahl L,Heinemann L,Kapitza C,Draeger E

更新日期：2004-06-01 00:00:00