Low production capacity of interleukin-10 associates with the metabolic syndrome and type 2 diabetes : the Leiden 85-Plus Study.

abstract：:Hyperglycemia upon hospital admission in patients with ST-segment elevation myocardial infarction (STEMI) occurs frequently and is associated with adverse outcomes. It is, however, unsettled as to whether an elevated blood glucose level is the cause or consequence of increased myocardial damage. In addition, whether t...

journal_title：Diabetes

authors： Lønborg J,Vejlstrup N,Kelbæk H,Nepper-Christensen L,Jørgensen E,Helqvist S,Holmvang L,Saunamäki K,Bøtker HE,Kim WY,Clemmensen P,Treiman M,Engstrøm T

更新日期：2014-07-01 00:00:00

abstract：:Diabetic hearts exhibit decreased responsiveness to stimulation by beta-adrenoreceptor (beta-AR) agonists. This decrease in activity may be due to changes in expression and/or signaling of beta-AR. Recently we showed that right atrial strips from 14-week streptozotocin (STZ)-induced diabetic rat hearts exhibit decreas...

journal_title：Diabetes

authors： Dinçer UD,Bidasee KR,Güner S,Tay A,Ozçelikay AT,Altan VM

更新日期：2001-02-01 00:00:00

abstract：:Akt is critical in insulin-induced metabolism of glucose and lipids. To investigate functions induced by hepatic Akt activation, a constitutively active Akt, NH(2)-terminally myristoylation signal-attached Akt (myr-Akt), was overexpressed in the liver by injecting its adenovirus into mice. Hepatic myr-Akt overexpressi...

journal_title：Diabetes

authors： Ono H,Shimano H,Katagiri H,Yahagi N,Sakoda H,Onishi Y,Anai M,Ogihara T,Fujishiro M,Viana AY,Fukushima Y,Abe M,Shojima N,Kikuchi M,Yamada N,Oka Y,Asano T

更新日期：2003-12-01 00:00:00

abstract：:We investigated the mechanism of heterogeneous nuclear ribonucleoprotein F (hnRNP F) renoprotective action in a type 2 diabetes (T2D) mouse model (db/db). Immortalized rat renal proximal tubular cells (IRPTCs) and kidneys from humans with T2D were also studied. The db/db mice developed hyperglycemia, oxidative stress,...

journal_title：Diabetes

authors： Lo CS,Shi Y,Chenier I,Ghosh A,Wu CH,Cailhier JF,Ethier J,Lattouf JB,Filep JG,Ingelfinger JR,Zhang SL,Chan JSD

更新日期：2017-07-01 00:00:00

abstract：:Eight manufacturing facilities participating in the National Institutes of Health-sponsored Clinical Islet Transplantation (CIT) Consortium jointly developed and implemented a harmonized process for the manufacture of allogeneic purified human pancreatic islet (PHPI) product evaluated in a phase 3 trial in subjects wi...

journal_title：Diabetes

authors： Ricordi C,Goldstein JS,Balamurugan AN,Szot GL,Kin T,Liu C,Czarniecki CW,Barbaro B,Bridges ND,Cano J,Clarke WR,Eggerman TL,Hunsicker LG,Kaufman DB,Khan A,Lafontant DE,Linetsky E,Luo X,Markmann JF,Naji A,Korsgren O

更新日期：2016-11-01 00:00:00

abstract：:Hyperglycemia-induced oxidative stress is detrimental for endothelial cells, contributing to the vascular complications of diabetes. The mitochondrial permeability transition pore (PTP) is an oxidative stress-sensitive channel involved in cell death; therefore, we have examined its potential role in endothelial cells ...

journal_title：Diabetes

authors： Detaille D,Guigas B,Chauvin C,Batandier C,Fontaine E,Wiernsperger N,Leverve X

更新日期：2005-07-01 00:00:00

abstract：:Type 1 diabetes is a major histocompatibility complex (MHC) class II-associated autoimmune disease mediated by beta-cell-specific T-cells and characterized by circulating autoantibodies to beta-cell molecules. In the BB/Wor diabetes-prone (DP) rat, type 1 diabetes develops spontaneously with an incidence of >90%. BB d...

journal_title：Diabetes

authors： Ellerman KE,Like AA

更新日期：1999-05-01 00:00:00

abstract：:The allelic forms of the human leukocyte antigen (HLA)-DQ beta-chain (DQB1) have been recognized as the best markers of insulin-dependent diabetes mellitus (IDDM) susceptibility. We describe a method that allows the recognition of these DQB1 alleles without the use of either allele-specific oligonucleotide probes or r...

journal_title：Diabetes

authors： Trucco G,Fritsch R,Giorda R,Trucco M

更新日期：1989-12-01 00:00:00

abstract：:Insulin and glucagon release and insulin sensitivity were investigated in patients with glucokinase deficiency. Five subjects with a missense mutation (Glu256Lys) were studied. They were compared with six healthy subjects with low insulin response but normal glucose tolerance. Insulin and glucagon levels were measured...

journal_title：Diabetes

authors： Wajngot A,Alvarsson M,Glaser A,Efendic S,Luthman H,Grill V

更新日期：1994-12-01 00:00:00

abstract：:Under diabetic conditions, the Maillard reaction facilitates the production of reactive oxygen species, and the activity of antioxidant enzymes such as Cu,Zn-superoxide dismutase is decreased, resulting in a remarkable increase of oxidative stress. The oxidative stress attacks DNA, lipids, and proteins and is also tho...

journal_title：Diabetes

authors： Taniguchi N,Kaneto H,Asahi M,Takahashi M,Wenyi C,Higashiyama S,Fujii J,Suzuki K,Kayanoki Y

更新日期：1996-07-01 00:00:00

abstract：:Neonatal female rat pups that were raised artificially on a high-carbohydrate (HC) milk formula during their suckling period developed hyperinsulinemia immediately, maintained chronic hyperinsulinemia in the postweaning period on laboratory diet, and developed obesity in adulthood. Pups (second-generation HC [2-HC]) b...

journal_title：Diabetes

authors： Srinivasan M,Aalinkeel R,Song F,Patel MS

更新日期：2003-04-01 00:00:00

abstract：:In evaluating therapeutic interventions aimed at preventing diabetic neuropathy, choosing a suitable measure of neural function is difficult, partly because the relation between most available objective measures and the development of symptomatic neuropathy (SN) is unclear. Using data from 67 diabetic patients, we dev...

journal_title：Diabetes

authors： Weinberg CR,Pfeifer MA

更新日期：1986-08-01 00:00:00

abstract：:African Americans are at increased risk of type 2 diabetes and many diabetes complications. We have carried out a genome-wide scan for African American type 2 diabetes using 638 affected sibling pairs (ASPs) from 247 families ascertained through impaired renal function to identify type 2 diabetes loci in this high-ris...

journal_title：Diabetes

authors： Sale MM,Freedman BI,Langefeld CD,Williams AH,Hicks PJ,Colicigno CJ,Beck SR,Brown WM,Rich SS,Bowden DW

更新日期：2004-03-01 00:00:00

abstract：:GAD autoantibodies (GADAs) are sensitive markers of islet autoimmunity and type 1 diabetes. They form the basis of robust prediction models and are widely used for the recruitment of subjects at high risk of type 1 diabetes to prevention trials. However, GADAs are also found in many individuals at low risk of diabetes...

journal_title：Diabetes

authors： Williams AJ,Lampasona V,Schlosser M,Mueller PW,Pittman DL,Winter WE,Akolkar B,Wyatt R,Brigatti C,Krause S,Achenbach P,Participating Laboratories.

更新日期：2015-09-01 00:00:00

abstract：:Dynamic aspects of whole body alanine and glycine metabolism have been explored in insulin-dependent (type I) diabetic subjects. Using a primed, continuous intravenous (i.v.) infusion of [2H3]alanine and [15N]glycine given simultaneously with [1-13C]leucine, whole body alanine and glycine fluxes and their rates of de ...

journal_title：Diabetes

authors： Robert JJ,Beaufrere B,Koziet J,Desjeux JF,Bier DM,Young VR,Lestradet H

更新日期：1985-01-01 00:00:00

abstract：:Increased pancreas mass and glucagon-positive adenomas have been suggested to be a risk associated with sitagliptin or exenatide therapy in humans. Novo Nordisk has conducted extensive toxicology studies, including data on pancreas weight and histology, in Cynomolgus monkeys dosed with two different human glucagon-lik...

journal_title：Diabetes

authors： Gotfredsen CF,Mølck AM,Thorup I,Nyborg NC,Salanti Z,Knudsen LB,Larsen MO

更新日期：2014-07-01 00:00:00

abstract：:Current evidence suggests that reactive oxygen species (ROS) may participate in the destruction of pancreatic beta-cells leading to type 1 diabetes. Genetic factors pre-disposing individual susceptibility to type 1 diabetes might therefore include those affecting the efficacy of ROS metabolism. In a direct in vivo tes...

journal_title：Diabetes

authors： Kubisch HM,Wang J,Bray TM,Phillips JP

更新日期：1997-10-01 00:00:00

abstract：:Twelve type I (insulin-dependent) diabetic subjects in stable metabolic control for at least 3 mo received a controlled diet containing 50% carbohydrate, 35% fat, and 15% protein. Calorie intake varied from 1800 to 2200 calories, depending on individual needs. Part of the polyunsaturated omega-6 fatty acids (omega 6FA...

journal_title：Diabetes

authors： Rillaerts EG,Engelmann GJ,Van Camp KM,De Leeuw I

更新日期：1989-11-01 00:00:00

abstract：:Type 1 diabetes results from chronic autoimmune destruction of insulin-producing β-cells within pancreatic islets. Although insulin is a critical self-antigen in animal models of autoimmune diabetes, due to extremely limited access to pancreas samples, little is known about human antigenic targets for islet-infiltrati...

journal_title：Diabetes

authors： Michels AW,Landry LG,McDaniel KA,Yu L,Campbell-Thompson M,Kwok WW,Jones KL,Gottlieb PA,Kappler JW,Tang Q,Roep BO,Atkinson MA,Mathews CE,Nakayama M

更新日期：2017-03-01 00:00:00

abstract：:Fibroblast growth factors (FGFs) and their receptors (FGFRs) are key signaling molecules for pancreas development. Although FGFR3 is a crucial developmental gene, acting as a negative regulator of bone formation, its participation remains unexplored in pancreatic organogenesis. We found that FGFR3 was expressed in the...

journal_title：Diabetes

authors： Arnaud-Dabernat S,Kritzik M,Kayali AG,Zhang YQ,Liu G,Ungles C,Sarvetnick N

更新日期：2007-01-01 00:00:00

abstract：:Glucagon and its partner insulin are dually linked in both their secretion from islet cells and their action in the liver. Glucagon signaling increases hepatic glucose output, and hyperglucagonemia is partly responsible for the hyperglycemia in diabetes, making glucagon an attractive target for therapeutic interventio...

journal_title：Diabetes

authors： Dean ED

更新日期：2020-04-01 00:00:00

abstract：:To evaluate the role of splanchnic and peripheral tissues in the disposal of an oral glucose load, splanchnic exchange of glucose, lactate, pyruvate, glycerol and amino acids was determined in ten healthy subjects in the basal state and for three hours following the oral ingestion of 100 gm. of glucose. Following glu...

journal_title：Diabetes

authors： Felig P,Wahren J,Hendler R

更新日期：1975-05-01 00:00:00

abstract：:We used mouse genetics to model how polygenic thresholds for the transition from impaired glucose tolerance (IGT) to NIDDM are reached. NON/Lt and NZO/Hl are inbred mouse strains selected for IGT and polygenic obesity, respectively. Their F1 male progeny consistently developed NIDDM. Genetic analysis of F2 males from ...

journal_title：Diabetes

authors： Leiter EH,Reifsnyder PC,Flurkey K,Partke HJ,Junger E,Herberg L

更新日期：1998-08-01 00:00:00

abstract：:We have shown previously that palmitate treatment of C2C12 skeletal muscle myotubes causes inhibition of the protein kinase B (PKB) pathway and hence reduces insulin-stimulated glycogen synthesis through the elevation of intracellular ceramide levels. Ceramide is known to activate both atypical protein kinase C (aPKC)...

journal_title：Diabetes

authors： Cazzolli R,Carpenter L,Biden TJ,Schmitz-Peiffer C

更新日期：2001-10-01 00:00:00

abstract：:The effect of diabetes control on the activities of hydroxymethylglutaryl-CoA reductase (HMG-CoA reductase), cholesterol acyltransferase (ACAT), and phenol 2-monooxygenase, the major enzymes regulating cholesterol metabolism, was determined in alloxan-induced diabetic rabbits, and the results obtained were correlated ...

journal_title：Diabetes

authors： O'Meara NM,Devery RA,Owens D,Collins PB,Johnson AH,Tomkin GH

更新日期：1990-05-01 00:00:00

abstract：:In vivo voltammetry was used to measure the synaptic release of rat striatal dopamine and serotonin after the administration of the amino acid L-tryptophan to streptozocin-induced diabetic rats. Dopamine and serotonin release from rat striatum was studied at a short-term or acute (3-day) interval and a long-term or ch...

journal_title：Diabetes

authors： Broderick PA,Jacoby JH

更新日期：1988-07-01 00:00:00

abstract：:Fetuin-A interferes with insulin action in animal studies, but data on fetuin-A and diabetes risk in humans are sparse and the role of nonalcoholic fatty liver disease in this association is unknown. From 2000 to 2006, we prospectively identified 470 matched incident diabetes case-control pairs in the Nurses' Health S...

journal_title：Diabetes

authors： Sun Q,Cornelis MC,Manson JE,Hu FB

更新日期：2013-01-01 00:00:00

abstract：:Peptidic glucagon antagonists have been shown to lower blood glucose levels in diabetic models (1-3), but attempts to identify small molecular weight glucagon receptor-binding antagonists have met with little success. Skyrin, a fungal bisanthroquinone, exhibits functional glucagon antagonism by uncoupling the glucagon...

journal_title：Diabetes

authors： Parker JC,McPherson RK,Andrews KM,Levy CB,Dubins JS,Chin JE,Perry PV,Hulin B,Perry DA,Inagaki T,Dekker KA,Tachikawa K,Sugie Y,Treadway JL

更新日期：2000-12-01 00:00:00

abstract：:MDL 29311, an analogue of probucol, administered to rats as a 1% dietary admixture for 2 wk before and 5 days after intravenous injection of 40 mg/kg of ALX significantly (P < 0.05) reduced plasma glucose (6.9 +/- 0.3 vs. 19.2 +/- 1.3 mM) and serum triglyceride (0.17 +/- 0.01 vs. 1.82 +/- 0.39 mM) levels in overnight-...

journal_title：Diabetes

authors： Johnson MB,Heineke EW,Rhinehart BL,Sheetz MJ,Barnhart RL,Robinson KM

更新日期：1993-08-01 00:00:00

abstract：:Microinflammation is a common major mechanism in the pathogenesis of diabetic vascular complications, including diabetic nephropathy. Macrophage scavenger receptor-A (SR-A) is a multifunctional receptor expressed on macrophages. This study aimed to determine the role of SR-A in diabetic nephropathy using SR-A-deficien...

journal_title：Diabetes

authors： Usui HK,Shikata K,Sasaki M,Okada S,Matsuda M,Shikata Y,Ogawa D,Kido Y,Nagase R,Yozai K,Ohga S,Tone A,Wada J,Takeya M,Horiuchi S,Kodama T,Makino H

更新日期：2007-02-01 00:00:00