Abstract:
:Current evidence suggests that reactive oxygen species (ROS) may participate in the destruction of pancreatic beta-cells leading to type 1 diabetes. Genetic factors pre-disposing individual susceptibility to type 1 diabetes might therefore include those affecting the efficacy of ROS metabolism. In a direct in vivo test of this hypothesis, we have generated strains of mice carrying transgenes that supplement basal levels of the radical-scavenging enzyme Cu/Zn superoxide dismutase in the pancreas via directed expression in beta-cells. Expression of these transgenes significantly enhances resistance to alloxan-induced diabetogenesis above that of control animals, thereby providing direct in vivo evidence that genetic variation in ROS metabolism can affect susceptibility to oxidative stress-mediated diabetogenesis.
journal_name
Diabetesjournal_title
Diabetesauthors
Kubisch HM,Wang J,Bray TM,Phillips JPdoi
10.2337/diabetes.46.10.1563subject
Has Abstractpub_date
1997-10-01 00:00:00pages
1563-6issue
10eissn
0012-1797issn
1939-327Xjournal_volume
46pub_type
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