New alpha 2-adrenergic blocker (DG-5128) improves insulin secretion and in vivo glucose disposal in NIDDM patients.

abstract：:Different degrees of beta-cell failure and apoptosis are present in type 1 and type 2 diabetes. It has been recently suggested that high glucose-induced beta-cell apoptosis in type 2 diabetes shares a final common pathway with type 1 diabetes, involving interleukin-1beta (IL-1beta) production by beta-cells, nuclear fa...

journal_title：Diabetes

authors： Welsh N,Cnop M,Kharroubi I,Bugliani M,Lupi R,Marchetti P,Eizirik DL

更新日期：2005-11-01 00:00:00

abstract：:The interaction of insulin with the vascular endothelium was studied using bovine aortic endothelial cells in monolayer cultures. Confluent cell cultures exhibited specific binding of 125I-insulin to high- and low-affinity cell surface receptor sites. Binding was reversible, saturable, and accompanied by internalizati...

journal_title：Diabetes

authors： Kaiser N,Vlodavsky I,Tur-Sinai A,Fuks Z,Cerasi E

更新日期：1982-12-01 00:00:00

abstract：OBJECTIVE:Genome-wide association studies have identified several variants within the MTNR1B locus that are associated with fasting plasma glucose (FPG) and type 2 diabetes. We refined the association signal by direct genotyping and examined for associations of the variant displaying the most independent effect on FPG ...

journal_title：Diabetes

authors： Sparsø T,Bonnefond A,Andersson E,Bouatia-Naji N,Holmkvist J,Wegner L,Grarup N,Gjesing AP,Banasik K,Cavalcanti-Proença C,Marchand M,Vaxillaire M,Charpentier G,Jarvelin MR,Tichet J,Balkau B,Marre M,Lévy-Marchal C,Faerch

更新日期：2009-06-01 00:00:00

abstract：:The early renal growth in streptozotocin (STZ)-induced diabetic rats is preceded by a transient rise in renal tissue insulin-like growth factor (IGF)-I concentration. Administration of the long-acting somatostatin analog octreotide to STZ diabetic rats inhibits the early increase in kidney IGF-I and the increase in ki...

journal_title：Diabetes

authors： Raz I,Rubinger D,Popovtzer M,Grønbaek H,Weiss O,Flyvbjerg A

更新日期：1998-06-01 00:00:00

abstract：:To investigate the effects of insulin on platelets in obesity and in non-insulin-dependent diabetes mellitus (NIDDM)--classic insulin-resistant states--we determined ADP-induced platelet aggregation and platelet cGMP (guanosine 3',5'-cyclic monophosphate) content in platelet-rich plasma obtained from nine obese subjec...

journal_title：Diabetes

authors： Trovati M,Mularoni EM,Burzacca S,Ponziani MC,Massucco P,Mattiello L,Piretto V,Cavalot F,Anfossi G

更新日期：1995-11-01 00:00:00

abstract：:A polymorphism in the interleukin 12B gene was recently reported to be strongly associated with type 1 diabetes in 422 Australian and British families. We analyzed the same polymorphism in 470 Italian type 1 diabetic patients and 544 matched control subjects and found no evidence of association with the disease. ...

journal_title：Diabetes

authors： Nisticò L,Giorgi G,Giordano M,Galgani A,Petrone A,D'Alfonso S,Federici M,Di Mario U,Pozzilli P,Buzzetti R,Cascino I

更新日期：2002-05-01 00:00:00

abstract：:In vivo studies were undertaken in rats to provide evidence of the neural nature, tentative localization and mode of excitation of the insulin-sensitive central nervous system (CSN) glucoregulator center. In rats under light barbiturate anesthesia minute amounts of insulin injected into the carotid artery resulted in ...

journal_title：Diabetes

authors： Szabo O,Szabo AJ

更新日期：1975-04-01 00:00:00

abstract：OBJECTIVE:Regulation of obesity development is an important issue to prevent metabolic syndromes. Gene-disrupted mice of phospholipase Cδ1 (PLCδ1), a key enzyme of phosphoinositide turnover, seemed to show leanness. Here we examined whether and how PLCδ1 is involved in obesity. RESEARCH DESIGN AND METHODS:Weight gain,...

journal_title：Diabetes

authors： Hirata M,Suzuki M,Ishii R,Satow R,Uchida T,Kitazumi T,Sasaki T,Kitamura T,Yamaguchi H,Nakamura Y,Fukami K

更新日期：2011-07-01 00:00:00

abstract：:We previously reported a syndrome of severe hyperinsulinemia and early-onset hypertension in three patients with dominant-negative mutations in the nuclear hormone receptor peroxisome proliferator-activated receptor (PPAR)-gamma. We now report the results of further detailed pathophysiological evaluation of these subj...

journal_title：Diabetes

authors： Savage DB,Tan GD,Acerini CL,Jebb SA,Agostini M,Gurnell M,Williams RL,Umpleby AM,Thomas EL,Bell JD,Dixon AK,Dunne F,Boiani R,Cinti S,Vidal-Puig A,Karpe F,Chatterjee VK,O'Rahilly S

更新日期：2003-04-01 00:00:00

abstract：:Direct methods for measuring the secretion rate of insulin are too cumbersome for clinical application. Since C-peptide is secreted in an equimolar ratio with insulin and is excreted into the urine, measuring the urinary excretion rate of C-peptide (U-C) could serve as an indicator of its secretion rate (SR-C) if its ...

journal_title：Diabetes

authors： Meistas MT,Rendell M,Margolis S,Kowarski AA

更新日期：1982-05-01 00:00:00

abstract：:This cross-sectional study evaluated the relationship between 1) functional and structural measurements of neurodegeneration in the initial stages of diabetic retinopathy (DR) and 2) the presence of neurodegeneration and early microvascular impairment. We analyzed baseline data of 449 patients with type 2 diabetes enr...

journal_title：Diabetes

authors： Santos AR,Ribeiro L,Bandello F,Lattanzio R,Egan C,Frydkjaer-Olsen U,García-Arumí J,Gibson J,Grauslund J,Harding SP,Lang GE,Massin P,Midena E,Scanlon P,Aldington SJ,Simão S,Schwartz C,Ponsati B,Porta M,Costa MÂ,Her

更新日期：2017-09-01 00:00:00

abstract：:Obesity is characterized by adipose tissue (AT) macrophage (ATM) accumulation, which promotes AT inflammation and dysfunction. Toll-like receptor 4 (TLR4) deficiency attenuates AT inflammation in obesity but does not impede the accumulation of ATMs. The purpose of the current study was to determine whether TLR4 defici...

journal_title：Diabetes

authors： Orr JS,Puglisi MJ,Ellacott KL,Lumeng CN,Wasserman DH,Hasty AH

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:Progranulin is an important molecule in inflammatory response. Chronic inflammation is frequently associated with central obesity and associated disturbances; however, the role of circulating progranulin in human obesity, type 2 diabetes, and dyslipidemia is unknown. RESEARCH DESIGN AND METHODS:For the measu...

journal_title：Diabetes

authors： Youn BS,Bang SI,Klöting N,Park JW,Lee N,Oh JE,Pi KB,Lee TH,Ruschke K,Fasshauer M,Stumvoll M,Blüher M

更新日期：2009-03-01 00:00:00

abstract：:Type 1 diabetes results from chronic autoimmune destruction of insulin-producing β-cells within pancreatic islets. Although insulin is a critical self-antigen in animal models of autoimmune diabetes, due to extremely limited access to pancreas samples, little is known about human antigenic targets for islet-infiltrati...

journal_title：Diabetes

authors： Michels AW,Landry LG,McDaniel KA,Yu L,Campbell-Thompson M,Kwok WW,Jones KL,Gottlieb PA,Kappler JW,Tang Q,Roep BO,Atkinson MA,Mathews CE,Nakayama M

更新日期：2017-03-01 00:00:00

abstract：:Children with permanent diabetes are usually assumed to have type 1 diabetes. It has recently been shown that there are genetic subgroups of diabetes that are often diagnosed during the neonatal period but may present later. A recent Italian study proposed that type 1 diabetes is rare before 6 months of age. We aimed ...

journal_title：Diabetes

authors： Edghill EL,Dix RJ,Flanagan SE,Bingley PJ,Hattersley AT,Ellard S,Gillespie KM

更新日期：2006-06-01 00:00:00

abstract：:The pretreatment of isolated islets of Langerhans with concanavalin A (Con A) completely blocks alloxan from suppressing the insulin release response to glucose. The lectin itself inhibits insulin secretion. This effect is dose dependent and reversible. Con A, however, has no protective action against the inhibition o...

journal_title：Diabetes

authors： Virji MA,Steffes MW,Estensen RD

更新日期：1984-02-01 00:00:00

abstract：:Metabolic interactions between glucose and amino acids were studied with isolated rat islets using glucose utilization and lactate formation as indicators. Certain amino acids (8-10 mM) are capable of greatly stimulating lactate formation from 5mM glucose. On a molar basis L-isoleucine is the most potent stimulator in...

journal_title：Diabetes

authors： Pace CS,Ellerman J,Hover BA,Stillings SN,Matschinsky FM

更新日期：1975-05-01 00:00:00

abstract：:The contribution of dietary amino acids and endogenous hyperinsulinemia to prandial protein anabolism still has not been established. To this end, leucine estimates ([1-14C]leucine infusion, plasma alpha-ketoisocaproic acid [KIC] specific activity [SA] as precursor pool SA) of whole-body protein kinetics and fractiona...

journal_title：Diabetes

authors： Volpi E,Lucidi P,Cruciani G,Monacchia F,Reboldi G,Brunetti P,Bolli GB,De Feo P

更新日期：1996-09-01 00:00:00

abstract：OBJECTIVE:Klotho is an antiaging hormone present in the kidney that extends the lifespan, regulates kidney function, and modulates cellular responses to oxidative stress. We investigated whether Klotho levels and signaling modulate inflammation in diabetic kidneys. RESEARCH DESIGN AND METHODS:Renal Klotho expression w...

journal_title：Diabetes

authors： Zhao Y,Banerjee S,Dey N,LeJeune WS,Sarkar PS,Brobey R,Rosenblatt KP,Tilton RG,Choudhary S

更新日期：2011-07-01 00:00:00

abstract：:In type 1 diabetes, a lifelong autoimmune disease, T cells infiltrate the islets and the exocrine pancreas in high numbers. CD8+ T cells are the main cell type found in the insulitic lesion, and CD8+ T cells reactive against beta cell antigens have been detected in the periphery and in the pancreas of subjects with sh...

journal_title：Diabetes

authors： Rodriguez-Calvo T,Krogvold L,Amirian N,Dahl-Jørgensen K,von Herrath M

更新日期：2021-01-07 00:00:00

abstract：:Hyperglycemia-triggered vascular abnormalities are the most serious complications of diabetes mellitus (DM). The major cause of vascular dysfunction in DM is endothelial injury and dysfunction associated with the reduced number and dysfunction of endothelial progenitor cells (EPCs). A major challenge is to identify ke...

journal_title：Diabetes

authors： Yao Y,Li Y,Song Q,Hu C,Xie W,Xu C,Chen Q,Wang QK

更新日期：2019-08-01 00:00:00

abstract：:Insulin is a short-lived species in the circulatory system. After binding to its receptor sites and transmission of its biological signals, bound insulin undergoes receptor-mediated endocytosis and consequent degradation. An inactive insulin derivative that is not recognized by the receptor has a longer circulation li...

journal_title：Diabetes

authors： Gershonov E,Shechter Y,Fridkin M

更新日期：1999-07-01 00:00:00

abstract：:Diabetes results from an inadequate mass of functional beta-cells. Such inadequacy could result from loss of beta-cells due to an immune assault or the inability to compensate for insulin resistance. Thus, mechanisms that regulate the number of beta-cells will be key to understanding both the pathogenesis of diabetes ...

journal_title：Diabetes

authors： Georgia S,Bhushan A

更新日期：2006-11-01 00:00:00

abstract：:The receptor-type protein tyrosine kinases in murine pancreatic islets were screened to identify possible growth/differentiation factors in pancreatic beta-cells. The analysis revealed that insulin receptor-related receptor (IRR) is highly expressed in the islets as well as in several highly differentiated beta-cell l...

journal_title：Diabetes

authors： Hirayama I,Tamemoto H,Yokota H,Kubo SK,Wang J,Kuwano H,Nagamachi Y,Takeuchi T,Izumi T

更新日期：1999-06-01 00:00:00

abstract：:Diabetic nephropathy is a major complication of diabetes and a leading cause of end-stage renal diseases in the U.S. Pigment epithelium-derived factor (PEDF) is a potent angiogenic inhibitor that has been extensively studied in diabetic retinopathy. Recently, we reported that PEDF is expressed at high levels in normal...

journal_title：Diabetes

authors： Wang JJ,Zhang SX,Mott R,Knapp RR,Cao W,Lau K,Ma JX

更新日期：2006-06-01 00:00:00

abstract：:We reported earlier that β-cell-specific overexpression of glutathione peroxidase (GPx)-1 significantly ameliorated hyperglycemia in diabetic db/db mice and prevented glucotoxicity-induced deterioration of β-cell mass and function. We have now ascertained whether early treatment of Zucker diabetic fatty (ZDF) rats wit...

journal_title：Diabetes

authors： Mahadevan J,Parazzoli S,Oseid E,Hertzel AV,Bernlohr DA,Vallerie SN,Liu CQ,Lopez M,Harmon JS,Robertson RP

更新日期：2013-10-01 00:00:00

abstract：:Mammalian erythrocytes have been shown to bind, but not to respond to, physiologic doses of insulin. Insulin binding was studied in normal rat erythrocytes and erythroblastic leukemic (EBL) cells by standard 125I-insulin competitive binding assays. EBL cells exhibited marked insulin degradation, which was time, temper...

journal_title：Diabetes

authors： Galbraith RA,Wise C,Buse MG

更新日期：1980-07-01 00:00:00

abstract：:IDDM results from immune-mediated destruction of insulin-producing pancreatic beta-cells in individuals genetically susceptible for the disease. There is evidence that the 65-kDa isoform of GAD plays a critical role in the induction of autoimmune diabetes in NOD mice. In humans, it is still unclear when and to what be...

journal_title：Diabetes

authors： Roll U,Christie MR,Füchtenbusch M,Payton MA,Hawkes CJ,Ziegler AG

更新日期：1996-07-01 00:00:00

abstract：:Linkage results suggest that the region of chromosome 7 containing the leptin gene cosegregates with extreme obesity; however, leptin coding region mutations are rare. To investigate whether the leptin flanking sequence and/or a larger 40-cM region (7q22.1-7q35) contributes to obesity, we genotyped individuals from 20...

journal_title：Diabetes

authors： Li WD,Li D,Wang S,Zhang S,Zhao H,Price RA

更新日期：2003-06-01 00:00:00

abstract：:Glucagon-like peptide 1 (GLP-1) is a potent glucose-lowering agent of potential interest for the treatment of type 2 diabetes. To evaluate actions of NN2211, a long-acting GLP-1 derivative, we examined 11 patients with type 2 diabetes, age 59 +/- 7 years (mean +/- SD), BMI 28.9 +/- 3.0 kg/m(2), HbA(1c) 6.5 +/- 0.6%, i...

journal_title：Diabetes

authors： Juhl CB,Hollingdal M,Sturis J,Jakobsen G,Agersø H,Veldhuis J,Pørksen N,Schmitz O

更新日期：2002-02-01 00:00:00