Abstract:
:The large Maf family of basic leucine-zipper-containing transcription factors are known regulators of key developmental and functional processes in various cell types, including pancreatic islets. Here, we demonstrate that within the adult pancreas, MafB is only expressed in islet alpha-cells and contributes to cell type-specific expression of the glucagon gene through activation of a conserved control element found between nucleotides -77 to -51. MafB was also shown to be expressed in developing alpha- and beta-cells as well as in proliferating hormone-negative cells during pancreatogenesis. In addition, MafB expression is maintained in the insulin(+) and glucagon(+) cells remaining in mice lacking either the Pax4 or Pax6 developmental regulators, implicating a potentially early role for MafB in gene regulation during islet cell development. These results indicate that MafB is not only important to islet alpha-cell function but may also be involved in regulating genes required in both endocrine alpha- and beta-cell differentiation.
journal_name
Diabetesjournal_title
Diabetesauthors
Artner I,Le Lay J,Hang Y,Elghazi L,Schisler JC,Henderson E,Sosa-Pineda B,Stein Rdoi
10.2337/diabetes.55.02.06.db05-0946subject
Has Abstractpub_date
2006-02-01 00:00:00pages
297-304issue
2eissn
0012-1797issn
1939-327Xpii
55/2/297journal_volume
55pub_type
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