Calcium-calmodulin-dependent myosin phosphorylation by pancreatic islets.

abstract：OBJECTIVE:Aggregation of human amylin/islet amyloid polypeptide (hA/hIAPP) into small soluble beta-sheet-containing oligomers is linked to islet beta-cell degeneration and the pathogenesis of type 2 diabetes. Here, we used tetracycline, which modifies hA/hIAPP oligomerization, to probe mechanisms whereby hA/hIAPP cause...

journal_title：Diabetes

authors： Aitken JF,Loomes KM,Scott DW,Reddy S,Phillips AR,Prijic G,Fernando C,Zhang S,Broadhurst R,L'Huillier P,Cooper GJ

更新日期：2010-01-01 00:00:00

abstract：:Eight dogs with previously established kidney allografts, immunosuppressed with cyclosporin A, received islet allografts from their respective original kidney donors. The median islet-graft functional survival was only 10.5 days, significantly less than for six similarly immunosuppressed dogs receiving only islet allo...

journal_title：Diabetes

authors： Guy AJ,Griffin SM,Alderson D,Farndon JR

更新日期：1989-01-01 00:00:00

abstract：:Clinical studies indicate that significant loss of functional islet mass occurs in the peritransplant period. Islets are injured as a result of detrimental effects of brain death, pancreas preservation, islet isolation, hypoxia, hyperglycemia, and immune-mediated events. In addition, recent studies demonstrated that i...

journal_title：Diabetes

authors： Contreras JL,Eckstein C,Smyth CA,Bilbao G,Vilatoba M,Ringland SE,Young C,Thompson JA,Fernández JA,Griffin JH,Eckhoff DE

更新日期：2004-11-01 00:00:00

abstract：:Patients with diabetes are at an increased risk for developing corneal disorders, often as a result of surgical and nonsurgical trauma. This study investigated whether intensive treatment of diabetes with the goal of maintaining blood glucose concentrations close to the normal range could ameliorate the delayed cornea...

journal_title：Diabetes

authors： Zagon IS,Sassani JW,McLaughlin PJ

更新日期：2006-04-01 00:00:00

abstract：:The mechanisms of marked increase in plasma leptin soon after ventromedial hypothalamus (VMH) lesions were investigated. Although rats did not gain body weight or parametrial fat-pad mass 24 h after the operation, the acute VMH-lesioned rats exhibited substantial five- and fourfold increases in plasma leptin levels co...

journal_title：Diabetes

authors： Suga A,Hirano T,Kageyama H,Kashiba M,Oka J,Osaka T,Namba Y,Tsuji M,Miura M,Adachi M,Inoue S

更新日期：1999-10-01 00:00:00

abstract：:We have suggested that altered maternal metabolism may affect the subsequent anthropometric and neuropsychological development of children who were in utero during disturbances in maternal fuel economy. This study reports the physical growth through 8 yr of age and the neuropsychological development through 4 yr of ag...

journal_title：Diabetes

authors： Silverman BL,Rizzo T,Green OC,Cho NH,Winter RJ,Ogata ES,Richards GE,Metzger BE

更新日期：1991-12-01 00:00:00

abstract：:Islet antigens associated with type 1 diabetes include a recently identified protein tyrosine phosphatase-like molecule IA-2, which contains the intracellular fragment IA-2ic. To determine whether combinations of antibodies including those to IA-2 characterize and predict type 1 diabetes, we studied antibodies to IA-2...

journal_title：Diabetes

authors： Hawa M,Rowe R,Lan MS,Notkins AL,Pozzilli P,Christie MR,Leslie RD

更新日期：1997-08-01 00:00:00

abstract：:When fed a high-energy (HE) diet, diabetes-prone (DP) Psammomys obesus develop type 2 diabetes with altered glucose-stimulated insulin secretion (GSIS). Beta-cell stimulus-secretion coupling was investigated in islets isolated from DP P. obesus fed a low-energy (LE) diet (DP-LE) and after 5 days on a HE diet (DP-HE). ...

journal_title：Diabetes

authors： Pertusa JA,Nesher R,Kaiser N,Cerasi E,Henquin JC,Jonas JC

更新日期：2002-08-01 00:00:00

abstract：:The objective of the study was to examine the potential differential effect of insulin and acipimox (both of which reduce free fatty acid [FFA] availability) on VLDL apolipoprotein (apo) B metabolism. We studied eight healthy men (age 40 +/- 4 years, BMI 25.8 +/- 0.9 kg/m2, plasma triglycerides 1.30 +/- 0.12 mmol/l) a...

journal_title：Diabetes

authors： Malmström R,Packard CJ,Caslake M,Bedford D,Stewart P,Yki-Järvinen H,Shepherd J,Taskinen MR

更新日期：1998-05-01 00:00:00

abstract：:Halofenate has been shown previously to lower triglycerides in dyslipidemic subjects. In addition, significant decreases in fasting plasma glucose were observed but only in type 2 diabetic patients. We hypothesized that halofenate might be an insulin sensitizer, and we present data to suggest that halofenate is a sele...

journal_title：Diabetes

authors： Allen T,Zhang F,Moodie SA,Clemens LE,Smith A,Gregoire F,Bell A,Muscat GE,Gustafson TA

更新日期：2006-09-01 00:00:00

abstract：:The transmission behavior of insulin-dependent juvenile diabetes mellitus (JDM) has been studied with respect to its frequency in the relatives of JDM probands and its possible linkage to the HLA complex. Mathematical analysis shows that under a single locus hypothesis a very restricted range of incidence rates is pos...

journal_title：Diabetes

authors： Suarez B,Hodge SE,Reich T

更新日期：1979-06-01 00:00:00

abstract：:Toxin from the scorpion Leiurus quinquestriatus was used to release norepinephrine from sympathetic nerve endings in the perfused rat pancrease. Addition of toxin, 10 mug./ml., to perfusate containing 0.3 mg./ml. glucose caused a large increase in release of norepinephrine and glucagon. Glucagon secretion was suppress...

journal_title：Diabetes

authors： Johnson DG,Ensinck JW

更新日期：1976-08-01 00:00:00

abstract：:We identified a heterozygous missense mutation that substituted aspartic acid (GAC) for alanine (GCC) at codon 1048 of the insulin receptor gene in a patient who displayed typical symptoms of Type A syndrome of insulin resistance. The proband's mother and younger brother were also found to be heterozygous for the muta...

journal_title：Diabetes

authors： Haruta T,Takata Y,Iwanishi M,Maegawa H,Imamura T,Egawa K,Itazu T,Kobayashi M

更新日期：1993-12-01 00:00:00

abstract：OBJECTIVE:We sought to examine the molecular mechanisms underlying permanenent neonatal diabetes mellitus (PNDM) in a patient with a heterozygous de novo L225P mutation in the L0 region of the sulfonylurea receptor (SUR)1, the regulatory subunit of the pancreatic ATP-sensitive K(+) channel (K(ATP) channel). RESEARCH D...

journal_title：Diabetes

authors： Masia R,De Leon DD,MacMullen C,McKnight H,Stanley CA,Nichols CG

更新日期：2007-05-01 00:00:00

abstract：:Antibodies to islet cell proteins detected as 37,000 and 40,000 M(r), tryptic fragments (37- and 40-kDa antigens) are strongly associated with progression to IDDM. The 40-kDa antigen has recently been identified as the tyrosine phosphatase-like protein IA-2 (ICA512) whereas the 37-kDa antigen has been suggested to be ...

journal_title：Diabetes

authors： Hawkes CJ,Wasmeier C,Christie MR,Hutton JC

更新日期：1996-09-01 00:00:00

abstract：:Numerous reports have confirmed the presence of islet cell antibodies in diabetic patients. These are found mostly in newly diagnosed insulin-dependent diabetic patients and in patients who have autoimmune polyendocrine disorders. Antibodies to beta cells, somatostatin, and glucagon-producing cells have been described...

journal_title：Diabetes

authors： Kaldany A

更新日期：1979-02-01 00:00:00

abstract：:Beta,beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) consists of a nonmetabolizable long-chain fatty acid designed to probe the effect exerted by fatty acids on insulin sensitivity. The effect of MEDICA 16 was evaluated in insulin-resistant Zucker (fa/fa) rats in terms of liver, muscle, and adipose tissue re...

journal_title：Diabetes

authors： Mayorek N,Kalderon B,Itach E,Bar-Tana J

更新日期：1997-12-01 00:00:00

abstract：:We conducted autosomal genome scans to map loci for metabolic syndrome (MES) and related traits in the Hong Kong Family Diabetes Study. We selected 55 families with 137 affected members (121 affected relative pairs) for nonparametric linkage analysis on MES. We also selected 179 families with 897 members (2,127 relati...

journal_title：Diabetes

authors： Ng MC,So WY,Lam VK,Cockram CS,Bell GI,Cox NJ,Chan JC

更新日期：2004-10-01 00:00:00

abstract：:Under diabetic conditions, the Maillard reaction facilitates the production of reactive oxygen species, and the activity of antioxidant enzymes such as Cu,Zn-superoxide dismutase is decreased, resulting in a remarkable increase of oxidative stress. The oxidative stress attacks DNA, lipids, and proteins and is also tho...

journal_title：Diabetes

authors： Taniguchi N,Kaneto H,Asahi M,Takahashi M,Wenyi C,Higashiyama S,Fujii J,Suzuki K,Kayanoki Y

更新日期：1996-07-01 00:00:00

abstract：:Although diabetes is the most common cause of end-stage renal disease (ESRD) worldwide, most people with diabetic nephropathy will never develop ESRD but will instead die of cardiovascular (CV) disease (CVD). The first evidence of kidney injury in diabetes is often microalbuminuria, itself also an independent risk mar...

journal_title：Diabetes

authors： Siddiqi FS,Advani A

更新日期：2013-11-01 00:00:00

abstract：:A recent study has demonstrated secondary amyloidosis in dogs treated with continuous intravenous insulin infusion. Since elevated levels of serum amyloid A protein (SAA) and diminished amyloid fibril degrading activity (AFDA) are associated with amyloidosis, we measured SAA and AFDA in ten type I diabetics treated wi...

journal_title：Diabetes

authors： Koivisto VA,Teppo AM,Maury CP,Taskinen MR

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:In humans, it is unclear if insulin resistance at the monocyte level is associated with atherosclerosis in vivo. Here we have studied first-degree relatives of patients with type 2 diabetes to investigate whether a reduction in components of the insulin signal transduction pathways, such as the insulin recept...

journal_title：Diabetes

authors： Cardellini M,Menghini R,Luzi A,Davato F,Cardolini I,D'Alfonso R,Gentileschi P,Rizza S,Marini MA,Porzio O,Lauro D,Sbraccia P,Lauro R,Federici M

更新日期：2011-12-01 00:00:00

abstract：:Hypothalamic "metabolic-sensing" neurons sense glucose and fatty acids (FAs) and play an integral role in the regulation of glucose, energy homeostasis, and the development of obesity and diabetes. Using pharmacologic agents, we previously found that ~50% of these neurons responded to oleic acid (OA) by using the FA t...

journal_title：Diabetes

authors： Le Foll C,Dunn-Meynell A,Musatov S,Magnan C,Levin BE

更新日期：2013-08-01 00:00:00

abstract：:Heart rate and RR variation (the standard deviation of the mean RR interval for a 5-min period) were evaluated as measurements of cardiac parasympathetic nervous system activity in fasting supine diabetic (N = 22) and comparable age normal (N = 22) subjects. The rate of breathing did not effect heart rate, but was inv...

journal_title：Diabetes

authors： Pfeifer MA,Cook D,Brodsky J,Tice D,Reenan A,Swedine S,Halter JB,Porte D Jr

更新日期：1982-04-01 00:00:00

abstract：:The responsiveness of the isolated perfused rat liver to different metabolic effects of insulin was investigated during recycling perfusion. Infusion of porcine insulin at rates of 6, 9, 16 and 33 mU/hr. resulted in stable perfusate insulin levels averaging 41, 72, 120 and 229 muU/ml., respectively. Since the portal v...

journal_title：Diabetes

authors： Mondon CE,Dolkas CB,Olefsky JM,Reaven GM

更新日期：1975-02-01 00:00:00

abstract：OBJECTIVE:Visceral obesity and elevated plasma free fatty acids are predisposing factors for type 2 diabetes. Chronic exposure to these lipids is detrimental for pancreatic beta-cells, resulting in reduced insulin content, defective insulin secretion, and apoptosis. We investigated the involvement in this phenomenon of...

journal_title：Diabetes

authors： Lovis P,Roggli E,Laybutt DR,Gattesco S,Yang JY,Widmann C,Abderrahmani A,Regazzi R

更新日期：2008-10-01 00:00:00

abstract：:We studied the functional consequences of an enhanced polyol pathway activity, elicited with galactose feeding, on the peripheral nerve of transgenic mice expressing human aldose reductase. Nontransgenic littermate mice were used as controls. With a quantitative immunoassay, the expression level of human aldose reduct...

journal_title：Diabetes

authors： Yagihashi S,Yamagishi S,Wada R,Sugimoto K,Baba M,Wong HG,Fujimoto J,Nishimura C,Kokai Y

更新日期：1996-01-01 00:00:00

abstract：:The TaqIB cholesteryl ester transfer protein (CETP) gene polymorphism (B1B2) is a determinant of HDL cholesterol in nondiabetic populations. Remarkably, this gene effect appears to be modified by environmental factors. We evaluated the effect of this polymorphism on HDL cholesterol levels and on the lipoprotein respon...

journal_title：Diabetes

authors： Dullaart RP,Hoogenberg K,Riemens SC,Groener JE,van Tol A,Sluiter WJ,Stulp BK

更新日期：1997-12-01 00:00:00

abstract：OBJECTIVE:Metformin can decrease adiposity and ameliorate obesity-related comorbid conditions, including abnormalities in glucose homeostasis in adolescents, but there are few data evaluating the efficacy of metformin among younger children. Our objective was to determine whether metformin treatment causes weight loss ...

journal_title：Diabetes

authors： Yanovski JA,Krakoff J,Salaita CG,McDuffie JR,Kozlosky M,Sebring NG,Reynolds JC,Brady SM,Calis KA

更新日期：2011-02-01 00:00:00

abstract：:Mammalian erythrocytes have been shown to bind, but not to respond to, physiologic doses of insulin. Insulin binding was studied in normal rat erythrocytes and erythroblastic leukemic (EBL) cells by standard 125I-insulin competitive binding assays. EBL cells exhibited marked insulin degradation, which was time, temper...

journal_title：Diabetes

authors： Galbraith RA,Wise C,Buse MG

更新日期：1980-07-01 00:00:00