Abstract:
:The neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) is ubiquitously distributed in both the central and peripheral nervous systems and exerts a variety of effects. PACAP is a neuropeptide in pancreatic islets, where it has been suggested as a parasympathetic and sensory neurotransmitter. PACAP stimulates insulin secretion in a glucose-dependent manner, by an effect executed mainly through augmenting the formation of cAMP and stimulating the uptake of calcium. Accumulating evidence in animal studies points to a physiological importance of PACAP in the regulation of the insulin response to feeding. This review summarizes the current knowledge of islet actions and mechanisms and the function of PACAP.
journal_name
Diabetesjournal_title
Diabetesauthors
Filipsson K,Kvist-Reimer M,Ahrén Bdoi
10.2337/diabetes.50.9.1959subject
Has Abstractpub_date
2001-09-01 00:00:00pages
1959-69issue
9eissn
0012-1797issn
1939-327Xjournal_volume
50pub_type
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