Immunohistochemical study of prostacyclin-stimulating factor (PSF) in the diabetic and atherosclerotic human coronary artery.

abstract：:Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) is a transcriptional coactivator implicated in transcriptional programs of hepatic gluconeogenesis, oxidative phosphorylation, and insulin release by beta-cells. To study associations of the PGC-1alpha gene locus with carbohydrate metabolism an...

journal_title：Diabetes

authors： Oberkofler H,Linnemayr V,Weitgasser R,Klein K,Xie M,Iglseder B,Krempler F,Paulweber B,Patsch W

更新日期：2004-05-01 00:00:00

abstract：:Abdominal visceral fat (AVF), abdominal subcutaneous fat (ASF), and abdominal total fat (ATF) were measured using a computed tomography scan, both before (baseline) and after (post) a 20-week endurance exercise training protocol in the HERITAGE Family Study. Each of the baseline and response (post minus baseline) meas...

journal_title：Diabetes

authors： Rice T,Chagnon YC,Pérusse L,Borecki IB,Ukkola O,Rankinen T,Gagnon J,Leon AS,Skinner JS,Wilmore JH,Bouchard C,Rao DC

更新日期：2002-03-01 00:00:00

abstract：OBJECTIVE:Reactive oxygen species (ROS) is one of most important factors in impaired metabolism secretion coupling in pancreatic β-cells. We recently reported that elevated ROS production and impaired ATP production at high glucose in diabetic Goto-Kakizaki (GK) rat islets are effectively ameliorated by Src inhibition,...

journal_title：Diabetes

authors： Mukai E,Fujimoto S,Sato H,Oneyama C,Kominato R,Sato Y,Sasaki M,Nishi Y,Okada M,Inagaki N

更新日期：2011-01-01 00:00:00

abstract：:Pancreatic islets contain enzyme activity which catalyzes the phosphorylation by MgATP of cardiac, skeletal, or smooth muscle myosin light chains. The enzyme is activated by calcium (Ka = 10 microM) and calmodulin (Ka = 2 nM) and inhibited by trifluoperazine (Ki = 10 microM), a known inhibitor of calmodulin and of ins...

journal_title：Diabetes

authors： MacDonald MJ,Kowluru A

更新日期：1982-06-01 00:00:00

abstract：OBJECTIVE:To examine associations of neonatal adiposity with maternal glucose levels and cord serum C-peptide in a multicenter multinational study, the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study, thereby assessing the Pederson hypothesis linking maternal glycemia and fetal hyperinsulinemia to neonatal adi...

journal_title：Diabetes

authors： HAPO Study Cooperative Research Group.

更新日期：2009-02-01 00:00:00

abstract：:Increased abdominal obesity has been related to lower insulin sensitivity (SI), independent of overall obesity, but it has been suggested that this relationship may be weaker in non-whites. In the Insulin Resistance and Atherosclerosis Study (IRAS), SI was estimated using a minimal model analysis of the frequently sam...

journal_title：Diabetes

authors： Karter AJ,Mayer-Davis EJ,Selby JV,D'Agostino RB Jr,Haffner SM,Sholinsky P,Bergman R,Saad MF,Hamman RF

更新日期：1996-11-01 00:00:00

abstract：:Although recent studies show that adipose tissue macrophages (ATMs) participate in the inflammatory changes in obesity and contribute to insulin resistance, the properties of these cells are not well understood. We hypothesized that ATMs recruited to adipose tissue during a high-fat diet have unique inflammatory prope...

journal_title：Diabetes

authors： Lumeng CN,Deyoung SM,Bodzin JL,Saltiel AR

更新日期：2007-01-01 00:00:00

abstract：:To explain the contradictory data on the secretion of prostacyclin (PGI2) in clinical and experimental diabetes, we have investigated the effect of each of the major metabolic abnormalities in uncontrolled diabetes on vascular PGI2 synthesis. An increase in fatty acid concentrations caused a dose-dependent inhibition ...

journal_title：Diabetes

authors： Jeremy JY,Mikhailidis DP,Dandona P

更新日期：1983-03-01 00:00:00

abstract：:We have shown previously that palmitate treatment of C2C12 skeletal muscle myotubes causes inhibition of the protein kinase B (PKB) pathway and hence reduces insulin-stimulated glycogen synthesis through the elevation of intracellular ceramide levels. Ceramide is known to activate both atypical protein kinase C (aPKC)...

journal_title：Diabetes

authors： Cazzolli R,Carpenter L,Biden TJ,Schmitz-Peiffer C

更新日期：2001-10-01 00:00:00

abstract：:The relationship between plasma C-peptide and the frequency and severity of diabetic retinopathy was examined in a population-based study in Wisconsin in 1984-1986. Individuals with younger- (n = 835) and older- (n = 940) onset diabetes were included. C-peptide was measured by radioimmunoassay with Heding's M1230 anti...

journal_title：Diabetes

authors： Klein R,Moss SE,Klein BE,Davis MD,DeMets DL

更新日期：1990-11-01 00:00:00

abstract：OBJECTIVE:Islet-reactive CD8(+) T-cells play a key role in the pathogenesis of type 1 diabetes in the NOD mouse. The predominant T-cell specificities change over time, but whether similar shifts also occur after clinical diagnosis and insulin treatment in type 1 diabetic patients is unknown. RESEARCH DESIGN AND METHOD...

journal_title：Diabetes

authors： Martinuzzi E,Novelli G,Scotto M,Blancou P,Bach JM,Chaillous L,Bruno G,Chatenoud L,van Endert P,Mallone R

更新日期：2008-05-01 00:00:00

abstract：:Type 1 diabetes (T1D) remains a major health problem worldwide, with a steadily rising incidence yet no cure. Phosphoinositide 3-kinase-γ (PI3Kγ), a member of a family of lipid kinases expressed primarily in leukocytes, has been the subject of substantial research for its role in inflammatory diseases. However, the ro...

journal_title：Diabetes

authors： Azzi J,Moore RF,Elyaman W,Mounayar M,El Haddad N,Yang S,Jurewicz M,Takakura A,Petrelli A,Fiorina P,Ruckle T,Abdi R

更新日期：2012-06-01 00:00:00

abstract：:We have biochemically treated (periodate, borohydride, neuraminidase, organic solvents) frozen sections of human pancreas and studied the reactivity of islet-cell-antibody-positive human sera and monoclonal antibodies. The autoantigen of pancreatic sections has the properties of sialic acid containing glycolipid. ...

journal_title：Diabetes

authors： Nayak RC,Omar MA,Rabizadeh A,Srikanta S,Eisenbarth GS

更新日期：1985-06-01 00:00:00

abstract：:Fibroblast growth factor 21 (FGF21) is increasingly recognized as an important metabolic regulator of glucose homeostasis. Here, we conducted an exome-chip association analysis by genotyping 5,169 Chinese individuals from a community-based cohort and two clinic-based cohorts. A custom Asian exome-chip was used to dete...

journal_title：Diabetes

authors： Cheung CYY,Tang CS,Xu A,Lee CH,Au KW,Xu L,Fong CHY,Kwok KHM,Chow WS,Woo YC,Yuen MMA,Cherny SS,Hai J,Cheung BMY,Tan KCB,Lam TH,Tse HF,Sham PC,Lam KSL

更新日期：2017-06-01 00:00:00

abstract：:The stimulatory effect of the sodium ionophore, veratridine (10, 25 and 50 microM), on glucagon and insulin secretion was investigated using monolayer cultures of newborn rat pancreas. The results suggest that intracellular accumulation of sodium modulates hormone secretion from both alpha- and beta-cells. The action ...

journal_title：Diabetes

authors： Kawazu S,Ikeuchi M,Kikuchi M,Kanazawa Y,Fujimoto WY,Kosaka K

更新日期：1981-05-01 00:00:00

abstract：:We have suggested that altered maternal metabolism may affect the subsequent anthropometric and neuropsychological development of children who were in utero during disturbances in maternal fuel economy. This study reports the physical growth through 8 yr of age and the neuropsychological development through 4 yr of ag...

journal_title：Diabetes

authors： Silverman BL,Rizzo T,Green OC,Cho NH,Winter RJ,Ogata ES,Richards GE,Metzger BE

更新日期：1991-12-01 00:00:00

abstract：:Recently, missense mutations upstream of preproinsulin's signal peptide (SP) cleavage site were reported to cause mutant INS gene-induced diabetes of youth (MIDY). Our objective was to understand the molecular pathogenesis using metabolic labeling and assays of proinsulin export and insulin and C-peptide production to...

journal_title：Diabetes

authors： Liu M,Lara-Lemus R,Shan SO,Wright J,Haataja L,Barbetti F,Guo H,Larkin D,Arvan P

更新日期：2012-04-01 00:00:00

abstract：:We examined the metabolic characteristics that attend the development of type 2 diabetes (T2DM) in 441 impaired glucose tolerance (IGT) subjects who participated in the ACT NOW Study and had complete end-of-study metabolic measurements. Subjects were randomized to receive pioglitazone (PGZ; 45 mg/day) or placebo and w...

journal_title：Diabetes

authors： Defronzo RA,Tripathy D,Schwenke DC,Banerji M,Bray GA,Buchanan TA,Clement SC,Gastaldelli A,Henry RR,Kitabchi AE,Mudaliar S,Ratner RE,Stentz FB,Musi N,Reaven PD,ACT NOW Study.

更新日期：2013-11-01 00:00:00

abstract：:Although many studies using rodent islets and insulinoma cell lines have been performed to determine the role of insulin in the regulation of islet function, the autocrine effect of insulin on insulin gene expression is still controversial, and no consensus has yet been achieved. Because very little is known about the...

journal_title：Diabetes

authors： Muller D,Huang GC,Amiel S,Jones PM,Persaud SJ

更新日期：2006-10-01 00:00:00

abstract：:Impaired wound healing is one of the main causes of diabetic foot ulcerations. However, the exact mechanism of delayed wound healing in diabetes is not fully understood. Long noncoding RNAs (lncRNAs) are widely involved in a variety of biological processes and diseases, including diabetes and its associated complicati...

journal_title：Diabetes

authors： Hu M,Wu Y,Yang C,Wang X,Wang W,Zhou L,Zeng T,Zhou J,Wang C,Lao G,Yan L,Ren M

更新日期：2020-10-01 00:00:00

abstract：:Pancreatic beta-cells are more sensitive to several toxins (e.g., streptozotocin, alloxan, cytokines) than the other three endocrine cell types in the islets of Langerhans. Cytokine-induced free radicals in beta-cells may be involved in beta-cell-specific destruction in type 1 diabetes. To investigate if this sensitiv...

journal_title：Diabetes

authors： Nielsen K,Karlsen AE,Deckert M,Madsen OD,Serup P,Mandrup-Poulsen T,Nerup J

更新日期：1999-12-01 00:00:00

abstract：OBJECTIVE:Leptin released from adipocytes plays a key role in the control of food intake, energy balance, and glucose homeostasis. In addition to its central action, leptin directly affects pancreatic beta-cells, inhibiting insulin secretion, and, thus, modulating glucose homeostasis. However, despite the importance of...

journal_title：Diabetes

authors： Tudurí E,Marroquí L,Soriano S,Ropero AB,Batista TM,Piquer S,López-Boado MA,Carneiro EM,Gomis R,Nadal A,Quesada I

更新日期：2009-07-01 00:00:00

abstract：:Type 2 diabetes (T2D) is associated with vascular dysfunction. We hypothesized that increased nuclear factor-κB (NF-κB) signaling contributes to vascular dysfunction in T2D. We treated type 2 diabetic (db(-)/db(-)) and control (db(-)/db(+)) mice with two NF-κB inhibitors (6 mg/kg dehydroxymethylepoxyquinomicin twice a...

journal_title：Diabetes

authors： Kassan M,Choi SK,Galán M,Bishop A,Umezawa K,Trebak M,Belmadani S,Matrougui K

更新日期：2013-06-01 00:00:00

abstract：:A single administration of complete Freund's adjuvant (CFA), type 1 carrageenan (Car), or silica 7, 2, and 2 days, respectively, before infection with a low dose (1 x 10(2) plaque-forming units/mouse) of encephalomyocarditis D (EMC-D) virus resulted in a significant increase in the incidence of diabetes in SJL/J mice ...

journal_title：Diabetes

authors： Baek HS,Yoon JW

更新日期：1991-12-01 00:00:00

abstract：:Brain dopaminergic pathways play a major role in the control of movement. Absence of the murine dopamine D2 receptor gene (drd2) produces bradykinesia and hypothermia. A Ser311Cys mutation of the human DRD2 produces a marked functional impairment of the receptor and is associated with higher BMI in some populations. W...

journal_title：Diabetes

authors： Tataranni PA,Baier L,Jenkinson C,Harper I,Del Parigi A,Bogardus C

更新日期：2001-04-01 00:00:00

abstract：:Monolayer cultures of islet B-cells were established from neonatal rat pancreas. Serum-free media conditioned by these cultures for 72 h were concentrated and fractionated on Sephadex G-50 at acid pH into a high-molecular-weight pool containing binding protein for insulin-like growth factors (IGFs) and a low-molecular...

journal_title：Diabetes

authors： Romanus JA,Rabinovitch A,Rechler MM

更新日期：1985-07-01 00:00:00

abstract：:Amylin, a 37-amino acid peptide hormone co-secreted with insulin, potently governs the rate of gastric emptying. Hypoglycemia, in the absence of agents such as amylin, is reported to accelerate gastric emptying. We asked whether hypoglycemia had a similar action on gastric emptying in the presence of amylin. In prelim...

journal_title：Diabetes

authors： Gedulin BR,Young AA

更新日期：1998-01-01 00:00:00

abstract：:Prolonged near-physiological pulsatile insulin infusion has a greater hypoglycemic effect than continuous insulin infusion. We have previously shown that continuous hyperinsulinemia induces insulin insensitivity. This study examines the mechanisms responsible for the greater hypoglycemic effect of pulsatile insulin ad...

journal_title：Diabetes

authors： Ward GM,Walters JM,Aitken PM,Best JD,Alford FP

更新日期：1990-04-01 00:00:00

abstract：:Membrane glycoprotein plasma cell 1 (PC-1) has been shown to be increased in type 2 diabetes and involved in insulin resistance through inhibiting the insulin receptor tyrosine kinase, which was demonstrated using cultured breast cancer cells. However, other reports have shown contradictory results in Chinese hamster ...

journal_title：Diabetes

authors： Sakoda H,Ogihara T,Anai M,Funaki M,Inukai K,Katagiri H,Fukushima Y,Onishi Y,Ono H,Yazaki Y,Kikuchi M,Oka Y,Asano T

更新日期：1999-07-01 00:00:00

abstract：:We have reported previously that chronic and systemic administration of a streptococcal preparation (OK-432), an inducer of TNF, or of recombinant hTNF prevented the development of IDDM in the two animal models of IDDM-NOD mice and BB rats. In this study, we examined the effect of LT, which is structurally and functio...

journal_title：Diabetes

authors： Seino H,Takahashi K,Satoh J,Zhu XP,Sagara M,Masuda T,Nobunaga T,Funahashi I,Kajikawa T,Toyota T

更新日期：1993-03-01 00:00:00