Direct involvement of macrophages in destruction of beta-cells leading to development of diabetes in virus-infected mice.

abstract：:In this study we examined the effect of experimental diabetes and of treatment with an aldose reductase inhibitor on the level of sulfation of glomerular basement membrane (GBM) heparan sulfate, the principal glycosaminoglycan in this extracellular matrix. Glycosaminoglycans were isolated from GBM purified from contro...

journal_title：Diabetes

authors： Cohen MP,Klepser H,Wu VY

更新日期：1988-10-01 00:00:00

abstract：:The ATP-sensitive potassium channel, K(ATP) channel, a functional complex of the sulfonylurea receptor 1, SUR1, and an inward rectifier potassium channel subunit, Kir6.2, regulates insulin secretion in the pancreas. Mutations in both the Kir6.2 and SUR1 genes are associated with persistent hyperinsulinemic hypoglycemi...

journal_title：Diabetes

authors： Shyng SL,Ferrigni T,Shepard JB,Nestorowicz A,Glaser B,Permutt MA,Nichols CG

更新日期：1998-07-01 00:00:00

abstract：:The appearance of type 1 diabetes (T1D)-associated autoantibodies is the first and only measurable parameter to predict progression toward T1D in genetically susceptible individuals. However, autoantibodies indicate an active autoimmune reaction, wherein the immune tolerance is already broken. Therefore, there is a cl...

journal_title：Diabetes

authors： Kallionpää H,Somani J,Tuomela S,Ullah U,de Albuquerque R,Lönnberg T,Komsi E,Siljander H,Honkanen J,Härkönen T,Peet A,Tillmann V,Chandra V,Anagandula MK,Frisk G,Otonkoski T,Rasool O,Lund R,Lähdesmäki H,Knip M,Lahes

更新日期：2019-10-01 00:00:00

abstract：:We previously showed that pancreatic beta-cells express a neuronal isoform of nitric oxide synthase (nNOS) that controls insulin secretion by exerting two enzymatic activities: nitric oxide (NO) production and cytochrome c reductase activity. We now bring evidence that two inhibitors of nNOS, N-omega-nitro-l-arginine ...

journal_title：Diabetes

authors： Lajoix AD,Pugnière M,Roquet F,Mani JC,Dietz S,Linck N,Faurie F,Ribes G,Petit P,Gross R

更新日期：2004-06-01 00:00:00

abstract：:Acute elevations of plasma free fatty acid (FFA) levels augment glucose-stimulated insulin secretion (GSIS). Prolonged elevations of FFA levels reportedly impair GSIS, but no one has previously compared GSIS after prolonged exposure to saturated or unsaturated fat. Rats received a low-fat diet (Low-Fat) or one enriche...

journal_title：Diabetes

authors： Dobbins RL,Szczepaniak LS,Myhill J,Tamura Y,Uchino H,Giacca A,McGarry JD

更新日期：2002-06-01 00:00:00

abstract：:Flow-mediated remodeling of resistance arteries is essential for revascularization in ischemic diseases, but this is impaired in diabetes. We hypothesized that breaking advanced glycation end product (AGE) cross-links could improve remodeling in mesenteric resistance arteries in Zucker diabetic fatty (ZDF) rats compar...

journal_title：Diabetes

authors： Freidja ML,Tarhouni K,Toutain B,Fassot C,Loufrani L,Henrion D

更新日期：2012-06-01 00:00:00

abstract：:Genetics, epigenetics, and environment may together affect the susceptibility for type 2 diabetes (T2D). Our aim was to dissect molecular mechanisms underlying T2D using genome-wide expression and DNA methylation data in adipose tissue from monozygotic twin pairs discordant for T2D and independent case-control cohorts...

journal_title：Diabetes

authors： Nilsson E,Jansson PA,Perfilyev A,Volkov P,Pedersen M,Svensson MK,Poulsen P,Ribel-Madsen R,Pedersen NL,Almgren P,Fadista J,Rönn T,Klarlund Pedersen B,Scheele C,Vaag A,Ling C

更新日期：2014-09-01 00:00:00

abstract：:Precise timing of the teratogenic period in diabetic pregnancy is of clinical importance since correction of the glucose intolerance during this period may protect the offspring from malformations. An experimental approach to elucidate this problem with regard to skeletal development was made in groups of pregnant str...

journal_title：Diabetes

authors： Eriksson UJ,Dahlström E,Hellerström C

更新日期：1983-12-01 00:00:00

abstract：:The current study investigated the fate of a [U-(13)C]palmitate tracer extracted by forearm muscle in type 2 diabetic and control subjects. We studied seven healthy lean male subjects and seven obese male subjects with type 2 diabetes using the forearm muscle balance technique with continuous intravenous infusion of t...

journal_title：Diabetes

authors： Blaak EE,Wagenmakers AJ

更新日期：2002-03-01 00:00:00

abstract：:Class IIa histone deacetylases (HDACs), such as HDAC4, HDAC5, and HDAC7, provide critical mechanisms for regulating glucose homeostasis. Here we report that HDAC9, another class IIa HDAC, regulates hepatic gluconeogenesis via deacetylation of a Forkhead box O (FoxO) family transcription factor, FoxO1, together with HD...

journal_title：Diabetes

authors： Chen J,Wang N,Dong M,Guo M,Zhao Y,Zhuo Z,Zhang C,Chi X,Pan Y,Jiang J,Tang H,Niu J,Yang D,Li Z,Han X,Wang Q,Chen X

更新日期：2015-12-01 00:00:00

abstract：:Rats with classic Goldblatt (two-kidney) hypertension had diabetes induced by streptozotocin. After four months of diabetes, glomeruli of the unclipped kidney of hypertensive diabetic rats had markedly increased diabetic changes, including mesangial matrix thickening and mesangial immunoglobulin (IgG and IgM) and comp...

journal_title：Diabetes

authors： Mauer SM,Steffes MW,Azar S,Sandberg SK,Brown DM

更新日期：1978-07-01 00:00:00

abstract：OBJECTIVE:Heart failure is a major cause of mortality in diabetes and may be causally associated with altered metabolism. Recent reports indicate a role of inflammation in peripheral insulin resistance, but the impact of inflammation on cardiac metabolism is unknown. We investigated the effects of diet-induced obesity ...

journal_title：Diabetes

authors： Ko HJ,Zhang Z,Jung DY,Jun JY,Ma Z,Jones KE,Chan SY,Kim JK

更新日期：2009-11-01 00:00:00

abstract：:Because skeletal muscle plays a major role in glucose disposal, it may be the primary site of insulin resistance in non-insulin-dependent diabetes mellitus (NIDDM). Rates of glycogen synthesis (GS), glucose utilization via glycolysis, glycolytic utilization (GU), and glucose transport (GT) were studied in epitrochlear...

journal_title：Diabetes

authors： Karl IE,Gavin JR 3rd,Levy J

更新日期：1990-09-01 00:00:00

abstract：:This article is divided into two parts. A retrospective overview summarizes some of the work that provided the framework and tools of the more recent studies. The five novel areas of research are related to the indirect effects of insulin. Regulation of plasma glucose is of central importance in health and diabetes. U...

journal_title：Diabetes

authors： Vranic M

更新日期：1992-09-01 00:00:00

abstract：:To clarify the relationship between abnormality of sorbitol and/or myo-inositol metabolism caused by hyperglycemia and diabetic macroangiopathy, we investigated the effects of high glucose concentrations and epalrestat, an aldose reductase inhibitor, on the metabolism of sorbitol and myo-inositol in cultured rabbit ao...

journal_title：Diabetes

authors： Sakakibara F,Hotta N,Koh N,Sakamoto N

更新日期：1993-11-01 00:00:00

abstract：:Oxidative stress may contribute to the pathogenesis of diabetic nephropathy. However, the detailed molecular mechanism remains uncertain. Here, we report oxidative mitochondrial DNA (mtDNA) damage and accumulation of mtDNA with a 4,834-bp deletion in kidney of streptozotocin-induced diabetic rats. At 8 weeks after the...

journal_title：Diabetes

authors： Kakimoto M,Inoguchi T,Sonta T,Yu HY,Imamura M,Etoh T,Hashimoto T,Nawata H

更新日期：2002-05-01 00:00:00

abstract：:Pancreatic beta-cells are more sensitive to several toxins (e.g., streptozotocin, alloxan, cytokines) than the other three endocrine cell types in the islets of Langerhans. Cytokine-induced free radicals in beta-cells may be involved in beta-cell-specific destruction in type 1 diabetes. To investigate if this sensitiv...

journal_title：Diabetes

authors： Nielsen K,Karlsen AE,Deckert M,Madsen OD,Serup P,Mandrup-Poulsen T,Nerup J

更新日期：1999-12-01 00:00:00

abstract：:This study assessed the site of increased glucose uptake resulting from insulin inhalation, quantified its effect under steady-state glucose concentrations, and identified the time to onset of effect. Human insulin was administered to 13 beagles via inhalation (Exubera [insulin human (rDNA origin)] Inhalation Powder; ...

journal_title：Diabetes

authors： Edgerton DS,Cherrington AD,Williams P,Neal DW,Scott M,Bowen L,Wilson W,Hobbs CH,Leach C,Kuo MC,Strack TR

更新日期：2006-12-01 00:00:00

abstract：:As part of an ongoing search for susceptibility loci for NIDDM, we tested 19 genes whose products are implicated in insulin secretion or action for linkage with NIDDM. Loci included the G-protein-coupled inwardly rectifying potassium channels expressed in beta-cells (KCNJ3 and KCNJ7), glucagon (GCG), glucokinase regul...

journal_title：Diabetes

authors： Vionnet N,Hani EH,Lesage S,Philippi A,Hager J,Varret M,Stoffel M,Tanizawa Y,Chiu KC,Glaser B,Permutt MA,Passa P,Demenais F,Froguel P

更新日期：1997-06-01 00:00:00

abstract：:Considerable evidence implicates cellular senescence in the biology of aging and chronic disease. Diet and exercise are determinants of healthy aging; however, the extent to which they affect the behavior and accretion of senescent cells within distinct tissues is not clear. Here we tested the hypothesis that exercise...

journal_title：Diabetes

authors： Schafer MJ,White TA,Evans G,Tonne JM,Verzosa GC,Stout MB,Mazula DL,Palmer AK,Baker DJ,Jensen MD,Torbenson MS,Miller JD,Ikeda Y,Tchkonia T,van Deursen JM,Kirkland JL,LeBrasseur NK

更新日期：2016-06-01 00:00:00

abstract：:Evidence from animal models suggests that natural killer (NK) cells can be important players in the development of type 1 diabetes, although data in humans are still sparse. We studied the frequency and activation state of blood NK cells at different stages of human type 1 diabetes, and whether genetic or phenotypic N...

journal_title：Diabetes

authors： Rodacki M,Svoren B,Butty V,Besse W,Laffel L,Benoist C,Mathis D

更新日期：2007-01-01 00:00:00

abstract：:Successful islet transplantation depends on the infusion of sufficiently large quantities of islets, but only a fraction of transplanted islets can survive and become engrafted, and yet the underlying mechanism remains unclear. In this study, we examined the effect of sirolimus, a key component of the immunosuppressiv...

journal_title：Diabetes

authors： Zhang N,Su D,Qu S,Tse T,Bottino R,Balamurugan AN,Xu J,Bromberg JS,Dong HH

更新日期：2006-09-01 00:00:00

abstract：:Rat pancreatic islets were incubated in vitro with L-[4,5-3H]leucine or with L-[2,3-3H]tryptophan in Krebs-Ringer bicarbonate buffer, containing 0, 5, or 20 mM glucose. Incorporation of labeled amino acids in islet cells was evaluated quantitatively by a validated radioautographic procedure. Incorporation of labeled l...

journal_title：Diabetes

authors： Logothetopoulos J,Jain K

更新日期：1980-10-01 00:00:00

abstract：:The introduction of 13C magnetic resonance spectroscopy (MRS) has enabled noninvasive measurement of muscle glycogen synthesis in humans. Conclusions based on measurements by the MRS technique assume that glucose metabolism in gastrocnemius muscle is representative for all skeletal muscles and thus can be extrapolated...

journal_title：Diabetes

authors： Serlie MJ,de Haan JH,Tack CJ,Verberne HJ,Ackermans MT,Heerschap A,Sauerwein HP

更新日期：2005-05-01 00:00:00

abstract：:When fed a high-energy (HE) diet, diabetes-prone (DP) Psammomys obesus develop type 2 diabetes with altered glucose-stimulated insulin secretion (GSIS). Beta-cell stimulus-secretion coupling was investigated in islets isolated from DP P. obesus fed a low-energy (LE) diet (DP-LE) and after 5 days on a HE diet (DP-HE). ...

journal_title：Diabetes

authors： Pertusa JA,Nesher R,Kaiser N,Cerasi E,Henquin JC,Jonas JC

更新日期：2002-08-01 00:00:00

abstract：:Glucokinase is a critical component of the physiological glucose sensor found in cell types that are responsive to changes in plasma glucose levels. The acute regulation of glucokinase activity has been shown to occur via a regulatory protein found in liver parenchymal cells (Van Schaftingen E, Detheux M, Da Cunha MV....

journal_title：Diabetes

authors： Mookhtiar KA,Kalinowski SS,Brown KS,Tsay YH,Smith-Monroy C,Robinson GW

更新日期：1996-12-01 00:00:00

abstract：:ATP is known to be coreleased with insulin from pancreatic beta-cells. To monitor insulin secretion from single beta-cells, a single beta-cell was surrounded in culture by Fura 2-loaded calf pulmonary artery endothelium (CPAE) cells, which can detect the ATP. CPAE cells did not respond with an elevation in cytoplasmic...

journal_title：Diabetes

authors： Kuromi H,Mizuno N,Seino S

更新日期：1995-10-01 00:00:00

abstract：:The preferential channeling of different fuels to fat and changes in the transcription profile of adipose tissue and skeletal muscle are poorly understood processes involved in the pathogenesis of obesity and insulin resistance. Carbohydrate and lipid metabolism may play relevant roles in this context. Freely moving l...

journal_title：Diabetes

authors： Fabris R,Nisoli E,Lombardi AM,Tonello C,Serra R,Granzotto M,Cusin I,Rohner-Jeanrenaud F,Federspil G,Carruba MO,Vettor R

更新日期：2001-03-01 00:00:00

abstract：:Recent evidence supports the strong overlap between genes implicated in monogenic diabetes and susceptibility to type 2 diabetes. Transient neonatal diabetes mellitus (TNDM) is a rare disorder associated with overexpression of genes at a paternally expressed imprinted locus on chromosome 6q24. There are two overlappin...

journal_title：Diabetes

authors： Gloyn AL,Mackay DJ,Weedon MN,McCarthy MI,Walker M,Hitman G,Knight BA,Owen KR,Hattersley AT,Frayling TM

更新日期：2006-08-01 00:00:00

abstract：:This study examined the suitability of commercial U.S.P. insulin as a bacterial growth medium. Purified port insulin (Iletin II, Eli Lilly & Co., Indianapolis, Indiana) was inoculated with approximately 500,000 bacteria per ml of: (1) Staphylococcus epidermidis, (2) Staphylococcus aureus, or (3) Escherichia coli. All ...

journal_title：Diabetes

authors： Schade DS,Eaton RP

更新日期：1982-01-01 00:00:00