Abstract:
:The soluble plant fiber psyllium significantly reduced fasting glucose and total cholesterol levels in the C57BL/KsJ db/db diabetic mouse relative to placebo-fed mice. Insulin levels were significantly higher in psyllium-fed than placebo-fed animals, indicating this fiber may delay the progression of diabetes in the animal model. High-density lipoprotein cholesterol levels rose moderately in both psyllium- and placebo-fed animals during the study, whereas triglyceride levels remained unchanged in both groups. Psyllium's effect on glycemic, lipid, and hormone parameters was not explained by weight loss or reduced food intake; these were similar in psyllium- and placebo-fed animals during the study. Our results show that psyllium fiber can beneficially moderate glycemic and lipid parameters in the db/db diabetes model.
journal_name
Diabetesjournal_title
Diabetesauthors
Watters K,Blaisdell Pdoi
10.2337/diab.38.12.1528subject
Has Abstractpub_date
1989-12-01 00:00:00pages
1528-33issue
12eissn
0012-1797issn
1939-327Xjournal_volume
38pub_type
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