Intrinsic differences in adipocyte precursor cells from different white fat depots.

Abstract:

:Obesity and body fat distribution are important risk factors for the development of type 2 diabetes and metabolic syndrome. Evidence has accumulated that this risk is related to intrinsic differences in behavior of adipocytes in different fat depots. In the current study, we demonstrate that adipocyte precursor cells (APCs) isolated from visceral and subcutaneous white adipose depots of mice have distinct patterns of gene expression, differentiation potential, and response to environmental and genetic influences. APCs derived from subcutaneous fat differentiate well in the presence of classical induction cocktail, whereas those from visceral fat differentiate poorly but can be induced to differentiate by addition of bone morphogenetic protein (BMP)-2 or BMP-4. This difference correlates with major differences in gene expression signature between subcutaneous and visceral APCs. The number of APCs is higher in obesity-prone C57BL/6 mice than obesity-resistant 129 mice, and the number in both depots is increased by up to 270% by exposure of mice to high-fat diet. Thus, APCs from visceral and subcutaneous depots are dynamic populations, which have intrinsic differences in gene expression, differentiation properties, and responses to environmental/genetic factors. Regulation of these populations may provide a new target for the treatment and prevention of obesity and its metabolic complications.

journal_name

Diabetes

journal_title

Diabetes

authors

Macotela Y,Emanuelli B,Mori MA,Gesta S,Schulz TJ,Tseng YH,Kahn CR

doi

10.2337/db11-1753

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

1691-9

issue

7

eissn

0012-1797

issn

1939-327X

pii

db11-1753

journal_volume

61

pub_type

杂志文章

相关文献

DIABETES文献大全
  • ZnT8 is a major CD8+ T cell-recognized autoantigen in pediatric type 1 diabetes.

    abstract::Type 1 diabetes results from the destruction of β-cells by an autoimmune T-cell response assisted by antigen-presenting B cells producing autoantibodies. CD8(+) T-cell responses against islet cell antigens, thought to play a central role in diabetes pathogenesis, can be monitored using enzyme-linked immunosorbent spot...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db12-0071

    authors: Énée É,Kratzer R,Arnoux JB,Barilleau E,Hamel Y,Marchi C,Beltrand J,Michaud B,Chatenoud L,Robert JJ,van Endert P

    更新日期:2012-07-01 00:00:00

  • The rat T-cell surface protein RT6 is associated with src family tyrosine kinases and generates an activation signal.

    abstract::RT6 is a glycosyl-phosphatidylinositol-linked surface molecule present on most mature rat T-cells. RT6+ T-cells can prevent the expression of autoimmune diabetes in the BB rat, but the mechanism is unknown. Because cross-linking of other glycosyl-phosphatidylinositol-linked T-cell proteins is known to activate T-cells...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.45.10.1419

    authors: Rigby MR,Bortell R,Greiner DL,Czech MP,Klarlund JK,Mordes JP,Rossini AA

    更新日期:1996-10-01 00:00:00

  • Diverse roles of K(ATP) channels learned from Kir6.2 genetically engineered mice.

    abstract::The regulation of insulin secretion from pancreatic beta-cells depends critically on the activities of their plasma membrane ion channels. ATP-sensitive K+ channels (K(ATP) channels) are present in many cells and regulate a variety of cellular functions by coupling cell metabolism with membrane potential. The activity...

    journal_title:Diabetes

    pub_type: 杂志文章,评审

    doi:10.2337/diabetes.49.3.311

    authors: Seino S,Iwanaga T,Nagashima K,Miki T

    更新日期:2000-03-01 00:00:00

  • The metabolically obese, normal-weight individual revisited.

    abstract::Nearly 20 years ago, it was suggested that individuals exist who are not obese on the basis of height and weight, but who, like people with overt obesity, are hyperinsulinemic, insulin-resistant, and predisposed to type 2 diabetes, hypertriglyceridemia, and premature coronary heart disease. Since then it has become in...

    journal_title:Diabetes

    pub_type: 杂志文章,评审

    doi:10.2337/diabetes.47.5.699

    authors: Ruderman N,Chisholm D,Pi-Sunyer X,Schneider S

    更新日期:1998-05-01 00:00:00

  • Islet-Expressed CXCL10 Promotes Autoimmune Destruction of Islet Isografts in Mice With Type 1 Diabetes.

    abstract::Type 1 diabetes (T1D) results from the autoimmune destruction of insulin-producing β-cells in the pancreas. Thereby, the chemokine CXC-motif ligand 10 (CXCL10) plays an important role in the recruitment of autoaggressive lymphocytes to the islets of Langerhans. Transplantation of isolated islets as a promising therapy...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db16-0547

    authors: Bender C,Christen S,Scholich K,Bayer M,Pfeilschifter JM,Hintermann E,Christen U

    更新日期:2017-01-01 00:00:00

  • Cellular Origins of Beige Fat Cells Revisited.

    abstract::Activated beige adipocytes have therapeutic potential due to their ability to improve glucose and lipid homeostasis. To date, the origin of beige adipocytes remains enigmatic. Whether beige cells arise through de novo differentiation from resident precursors or through reprogramming of mature white adipocytes has been...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db19-0308

    authors: Shao M,Wang QA,Song A,Vishvanath L,Busbuso NC,Scherer PE,Gupta RK

    更新日期:2019-10-01 00:00:00

  • Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice.

    abstract:OBJECTIVE:To evaluate whether healthy or diabetic adult mice can tolerate an extreme loss of pancreatic α-cells and how this sudden massive depletion affects β-cell function and blood glucose homeostasis. RESEARCH DESIGN AND METHODS:We generated a new transgenic model allowing near-total α-cell removal specifically in...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db11-0876

    authors: Thorel F,Damond N,Chera S,Wiederkehr A,Thorens B,Meda P,Wollheim CB,Herrera PL

    更新日期:2011-11-01 00:00:00

  • Dysregulation of Nrf2/Keap1 Redox Pathway in Diabetes Affects Multipotency of Stromal Cells.

    abstract::The molecular and cellular level reaches of the metabolic dysregulations that characterize diabetes are yet to be fully discovered. As mechanisms underlying management of reactive oxygen species (ROS) gain interest as crucial factors in cell integrity, questions arise about the role of redox cues in the regulation and...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db18-0232

    authors: Rabbani PS,Soares MA,Hameedi SG,Kadle RL,Mubasher A,Kowzun M,Ceradini DJ

    更新日期:2019-01-01 00:00:00

  • Myocardial loss of IRS1 and IRS2 causes heart failure and is controlled by p38α MAPK during insulin resistance.

    abstract::Cardiac failure is a major cause of death in patients with type 2 diabetes, but the molecular mechanism that links diabetes to heart failure remains unclear. Insulin resistance is a hallmark of type 2 diabetes, and insulin receptor substrates 1 and 2 (IRS1 and IRS2) are the major insulin-signaling components regulatin...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db13-0095

    authors: Qi Y,Xu Z,Zhu Q,Thomas C,Kumar R,Feng H,Dostal DE,White MF,Baker KM,Guo S

    更新日期:2013-11-01 00:00:00

  • Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: II. Immunologic analysis.

    abstract::Recently, we identified in normally type 1 diabetes-prone NOD/LtJ mice a spontaneous new leptin receptor (LEPR) mutation (designated Lepr(db-5J)) producing juvenile obesity, hyperglycemia, hyperinsulinemia, and hyperleptinemia. This early type 2 diabetes syndrome suppressed intra-islet insulitis and permitted spontane...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:

    authors: Lee CH,Chen YG,Chen J,Reifsnyder PC,Serreze DV,Clare-Salzler M,Rodriguez M,Wasserfall C,Atkinson MA,Leiter EH

    更新日期:2006-01-01 00:00:00

  • Effect of tolbutamide on myocardial metabolism and mechanical performance of the diabetic rat.

    abstract::Exposure of the isolated, glucose-perfused rat heart to buffer containing 0.4 mM tolbutamide resulted in significant changes in both energy metabolism and myocardial contractility. In the nondiabetic, tolbutamide mediated only small increases in mechanical function at low atrial filling pressure, but this effect incre...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.33.12.1138

    authors: Tan BH,Wilson GL,Schaffer SW

    更新日期:1984-12-01 00:00:00

  • Foxo1 links hyperglycemia to LDL oxidation and endothelial nitric oxide synthase dysfunction in vascular endothelial cells.

    abstract:OBJECTIVE:Atherosclerotic cardiovascular disease is the leading cause of death among people with diabetes. Generation of oxidized LDLs and reduced nitric oxide (NO) availability because of endothelial NO synthase (eNOS) dysfunction are critical events in atherosclerotic plaque formation. Biochemical mechanism leading f...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db09-0167

    authors: Tanaka J,Qiang L,Banks AS,Welch CL,Matsumoto M,Kitamura T,Ido-Kitamura Y,DePinho RA,Accili D

    更新日期:2009-10-01 00:00:00

  • The functional state of sympathetic nerves in spontaneously diabetic mice.

    abstract::I investigated biochemical parameters of sympathetic nerve function in spontaneously diabetic mice(C57 BL/KsJdb/db) and in their lean littermates. The concentration of norepinephrine (NE) in organs innervated by sympathetic nerves was significantly reduced in the heart, kidney, and salivary glands of mice (24 weeks ol...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.27.10.969

    authors: Giachetti A

    更新日期:1978-10-01 00:00:00

  • Inhibition of N-acetylheparosan deacetylase in diabetic rats.

    abstract::The effects on N-acetylheparosan deacetylase (N-deacetylase) activity exerted by poorly and well-regulated diabetes and variation of genetic background were investigated in insulin-treated streptozocin-induced diabetic rats of two different strains (H and U). N-deacetylase plays a key role in heparan sulfate biosynthe...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.40.11.1449

    authors: Kofoed-Enevoldsen A,Eriksson UJ

    更新日期:1991-11-01 00:00:00

  • Nutrition and somatomedin. XXVI. Molecular regulation of IGF-I by insulin in cultured rat hepatocytes.

    abstract::Although decreased levels of circulating insulinlike growth factor I (IGF-I) and hepatic IGF-I mRNA in diabetic animal models support a role for insulin in IGF-I regulation, it has been difficult to study the effects of insulin in vitro. Few immortal cell lines exhibit hormone-responsive production of IGF-I, and studi...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.40.11.1525

    authors: Phillips LS,Goldstein S,Pao CI

    更新日期:1991-11-01 00:00:00

  • Perifusion and culture of human fetal pancreas.

    abstract::Human fetal pancreas has been obtained after the therapeutic termination of pregnancy with prostaglandin F2 alpha. Pancreatic explants were studied in a perifusion system and maintained in organ culture for up to 3 wk. Insulin biosynthesis was stimulated by glucose; however, the incorporation of 3H-L-leucine into proi...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.29.1.s57

    authors: Maitland JE,Parry DG,Turtle JR

    更新日期:1980-01-01 00:00:00

  • Molecular determinants of regulated exocytosis.

    abstract::Regulated exocytosis forms the basis for many intercellular signaling processes, for example, in hormone secretion or neurotransmitter release. During regulated exocytosis, the membrane of a secretory vesicle fuses with the plasma membrane in a tightly controlled reaction that is most often triggered by calcium. Recen...

    journal_title:Diabetes

    pub_type: 杂志文章,评审

    doi:10.2337/diabetes.51.2007.s3

    authors: Gerber SH,Südhof TC

    更新日期:2002-02-01 00:00:00

  • Diabetes, Pancreatogenic Diabetes, and Pancreatic Cancer.

    abstract::The relationships between diabetes and pancreatic ductal adenocarcinoma (PDAC) are complex. Longstanding type 2 diabetes (T2DM) is a risk factor for pancreatic cancer, but increasing epidemiological data point to PDAC as also a cause of diabetes due to unknown mechanisms. New-onset diabetes is of particular interest t...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db16-1477

    authors: Andersen DK,Korc M,Petersen GM,Eibl G,Li D,Rickels MR,Chari ST,Abbruzzese JL

    更新日期:2017-05-01 00:00:00

  • Liver-specific loss of lipolysis-stimulated lipoprotein receptor triggers systemic hyperlipidemia in mice.

    abstract:OBJECTIVE:In mammals, proper storage and distribution of lipids in and between tissues is essential for the maintenance of energy homeostasis. In contrast, aberrantly high levels of triglycerides in the blood ("hypertriglyceridemia") represent a hallmark of the metabolic syndrome and type 2 diabetes. As hypertriglyceri...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db08-1184

    authors: Narvekar P,Berriel Diaz M,Krones-Herzig A,Hardeland U,Strzoda D,Stöhr S,Frohme M,Herzig S

    更新日期:2009-05-01 00:00:00

  • Ebselen treatment prevents islet apoptosis, maintains intranuclear Pdx-1 and MafA levels, and preserves β-cell mass and function in ZDF rats.

    abstract::We reported earlier that β-cell-specific overexpression of glutathione peroxidase (GPx)-1 significantly ameliorated hyperglycemia in diabetic db/db mice and prevented glucotoxicity-induced deterioration of β-cell mass and function. We have now ascertained whether early treatment of Zucker diabetic fatty (ZDF) rats wit...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db13-0357

    authors: Mahadevan J,Parazzoli S,Oseid E,Hertzel AV,Bernlohr DA,Vallerie SN,Liu CQ,Lopez M,Harmon JS,Robertson RP

    更新日期:2013-10-01 00:00:00

  • Adenovirus-mediated XIAP gene transfer reverses the negative effects of immunosuppressive drugs on insulin secretion and cell viability of isolated human islets.

    abstract::Immunosuppressive drugs are routinely used to provide tolerance after whole pancreas and islet cell transplantations. While they are essential in inhibiting graft rejection, little is known about their effect on islet function and beta-cell viability. In this study, we report that tacrolimus, sirolimus, and mycophenol...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diabetes.54.2.424

    authors: Hui H,Khoury N,Zhao X,Balkir L,D'Amico E,Bullotta A,Nguyen ED,Gambotto A,Perfetti R

    更新日期:2005-02-01 00:00:00

  • Modulation of growth hormone signal transduction in kidneys of streptozotocin-induced diabetic animals: effect of a growth hormone receptor antagonist.

    abstract::Growth hormone (GH) and IGFs have a long distinguished history in diabetes, with possible participation in the development of renal complications. The implicated effect of GH in diabetic end-stage organ damage may be mediated by growth hormone receptor (GHR) or postreceptor events in GH signal transduction. The presen...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diabetes.51.7.2270

    authors: Thirone AC,Scarlett JA,Gasparetti AL,Araujo EP,Lima MH,Carvalho CR,Velloso LA,Saad MJ

    更新日期:2002-07-01 00:00:00

  • Otopetrin 1 protects mice from obesity-associated metabolic dysfunction through attenuating adipose tissue inflammation.

    abstract::Chronic low-grade inflammation is emerging as a pathogenic link between obesity and metabolic disease. Persistent immune activation in white adipose tissue (WAT) impairs insulin sensitivity and systemic metabolism, in part, through the actions of proinflammatory cytokines. Whether obesity engages an adaptive mechanism...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db13-1139

    authors: Wang GX,Cho KW,Uhm M,Hu CR,Li S,Cozacov Z,Xu AE,Cheng JX,Saltiel AR,Lumeng CN,Lin JD

    更新日期:2014-04-01 00:00:00

  • Islet graft assessment in the Edmonton Protocol: implications for predicting long-term clinical outcome.

    abstract::The success of the Edmonton Protocol for islet transplantation has provided new hope in the treatment of type 1 diabetes. This study reports on the assessment of 83 human islet grafts transplanted using the Edmonton Protocol since 1999. Cellular composition, as assessed by immunohistochemistry, showed a lower islet pu...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diabetes.53.12.3107

    authors: Street CN,Lakey JR,Shapiro AM,Imes S,Rajotte RV,Ryan EA,Lyon JG,Kin T,Avila J,Tsujimura T,Korbutt GS

    更新日期:2004-12-01 00:00:00

  • Deranged insulin-secretory dynamics in offspring of two diabetic parents after double stimulation with intravenous glucose.

    abstract::Nine offspring of two diabetic parents and 18 normals were studied with two intravenous glucose loads (o.5 gm./kg. body weight), 60 minutes apart. By thus stressing the beta cell, subtle defects could be identified in the prediabetics: (1) An inverse relationship between insulin peak response and insulin concentration...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.26.12.1184

    authors: Koncz L,Soeldner JS,Otto H,Smith TM,Gleason RE

    更新日期:1977-12-01 00:00:00

  • Decreased cardiac glutathione peroxidase levels and enhanced mandibular apoptosis in malformed embryos of diabetic rats.

    abstract:OBJECTIVE:To characterize normal and malformed embryos within the same litters from control and diabetic rats for expression of genes related to metabolism of reactive oxygen species (ROS) or glucose as well as developmental genes. RESEARCH DESIGN AND METHODS:Embryos from nondiabetic and streptozotocin-induced diabeti...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db08-0830

    authors: Wentzel P,Gäreskog M,Eriksson UJ

    更新日期:2008-12-01 00:00:00

  • Investigation of insulin sensitivity in treated subjects with ketosis-prone diabetes mellitus.

    abstract::Two similar intravenous infucion techniques have been utilized to investigate insulin sensitivity in young subjects with recent-onset ketosis-prone diabetes mellitus. All subjects presented initially with mild to moderately severe ketoacidosis and had been treated with daily insulin therapy for two to eight weeks at t...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.26.4.278

    authors: Ginsberg HN

    更新日期:1977-04-01 00:00:00

  • Divergent pathways of gene expression are activated by the RAGE ligands S100b and AGE-BSA.

    abstract::Activation of the receptor for advanced glycation end products (RAGE) reportedly triggers a variety of proinflammatory responses. However, our previous work revealed that RAGE-binding AGEs free of endotoxin were incapable of inducing vascular cell adhesion molecule-1 (VCAM-1) or tumor necrosis factor-alpha (TNF-alpha)...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diabetes.53.3.743

    authors: Valencia JV,Mone M,Zhang J,Weetall M,Buxton FP,Hughes TE

    更新日期:2004-03-01 00:00:00

  • Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats.

    abstract::Hypogonadotropism is a common feature of uncontrolled diabetes, for which the ultimate mechanism remains to be elucidated. Kisspeptins, ligands of G protein-coupled receptor 54 (GPR54) encoded by the KiSS-1 gene, have recently emerged as major gatekeepers of the gonadotropic axis. Alteration in the hypothalamic KiSS-1...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db05-1584

    authors: Castellano JM,Navarro VM,Fernández-Fernández R,Roa J,Vigo E,Pineda R,Dieguez C,Aguilar E,Pinilla L,Tena-Sempere M

    更新日期:2006-09-01 00:00:00

  • Virus-induced diabetes in autoimmune New Zealand mice.

    abstract::Infection of autoimmune New Zealand mice with the D variant of encephalomyocarditis (EMC) virus results in beta-cell damage and clinical diabetes. The induction of diabetes in parental NZB and NZW strains was independent of sex. However, the susceptibility to virus-induced diabetes in their F1 offspring was sex depend...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.32.8.755

    authors: Yoon JW,Melez KA,Smathers PA,Archer JA,Steinberg AD

    更新日期:1983-08-01 00:00:00