Abstract:
:The apolipoprotein E (apoE) phenotype and allele frequencies were examined in type II (non-insulin-dependent) diabetic patients with normolipidemia (n = 134) and hypercholesterolemia (type IIa hyperlipoproteinemia, n = 35; type IIb hyperlipoproteinemia, n = 42). The frequencies of apoE4-present phenotypes (apoE4/3, apoE4/4, and apoE4/2) were highest in the type IIa group (51.4%), followed by the type IIb group (38.1%) and the normolipidemic group (16.4%), respectively, whereas the frequency of the most common phenotype, apoE3/3, was lowest in the type IIa group (48.6%), followed by the type IIb group (61.9%) and the normolipidemic group (79.9%), respectively. There were significant differences in the apoE phenotype frequencies between the normolipidemic group and the type IIa and IIb groups. The frequency of the epsilon 4 allele was significantly higher in the type IIa (28.6%) and IIb (20.2%) groups than in the normolipidemic group (8.9%), whereas the frequency of the epsilon 3 allele was significantly lower in the type IIa (71.4%) and IIb (78.6%) groups than in the normolipidemic group (89.2%). The frequency of the epsilon 2 allele tended to be lower in diabetic patients with hypercholesterolemia. In addition, these frequencies were also examined in nondiabetic subjects (n = 59). The frequency of the epsilon 4 allele tended to be higher in hypercholesterolemic diabetic subjects (24.1%) than in hypercholesterolemic nondiabetic subjects (15.3%). These data suggest that diabetic patients with the epsilon 4 allele may be more susceptible to hypercholesterolemia than diabetic patients without the epsilon 4 allele and possibly nondiabetic subjects with the epsilon 4 allele, although the underlying mechanism is unknown.
journal_name
Diabetesjournal_title
Diabetesauthors
Eto M,Watanabe K,Iwashima Y,Morikawa A,Chonan N,Oshima E,Sekiguchi M,Ishii Kdoi
10.2337/diab.36.11.1301subject
Has Abstractpub_date
1987-11-01 00:00:00pages
1301-6issue
11eissn
0012-1797issn
1939-327Xjournal_volume
36pub_type
杂志文章相关文献
DIABETES文献大全abstract::In type 2 diabetes, impaired insulin-induced Akt/endothelial nitric oxide synthase (eNOS) signaling may decrease the vascular relaxation response. Previously, we reported that this response was negatively regulated by G protein-coupled receptor kinase 2 (GRK2). In this study, we investigated whether/how in aortas from...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db11-1729
更新日期:2012-08-01 00:00:00
abstract::Circulating branched-chain amino acids (BCAAs) associate with insulin resistance and type 2 diabetes. 3-Hydroxyisobutyrate (3-HIB) is a catabolic intermediate of the BCAA valine. In this study, we show that in a cohort of 4,942 men and women, circulating 3-HIB is elevated according to levels of hyperglycemia and estab...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db19-1174
更新日期:2020-09-01 00:00:00
abstract::A corpus of evidence suggests that T-helper type 1 (Th1)-dependent cellular immunity plays a pivotal role in the pathogenesis of autoimmune diabetes. This study was intended to find ways to prevent the development of NOD diabetes using a neutralizing anti-interleukin (IL)-12 antibody (C17.8) that inhibits Thl cell dif...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.49.12.1998
更新日期:2000-12-01 00:00:00
abstract::Hexokinase (HK) II plays an important role in intracellular glucose metabolism by catalyzing the conversion of glucose to glucose-6-phosphate. HKII is considered to be a promising candidate gene for non-insulin-dependent diabetes mellitus (NIDDM) and insulin resistance. Therefore, we investigated the frequency of vari...
journal_title:Diabetes
pub_type: 临床试验,杂志文章
doi:10.2337/diab.44.3.330
更新日期:1995-03-01 00:00:00
abstract::Hepatocyte nuclear factor 4alpha (HNF4A), the gene for the maturity-onset diabetes of the young type 1 monogenic form of type 2 diabetes, is within the type 2 diabetes-linked region on chromosome 20q12-q13.1 and, consequently, is a positional candidate gene for type 2 diabetes in the general population. Previous studi...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.54.4.1185
更新日期:2005-04-01 00:00:00
abstract:OBJECTIVE:C57Bl/6 mice develop obesity and mild hyperglycemia when fed a high-fat diet (HFD). Although diet-induced obesity (DIO) is a widely studied model of type 2 diabetes, little is known about beta-cell failure in these mice. RESEARCH DESIGN AND METHODS:DIO mice were separated in two groups according to body weig...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db09-1452
更新日期:2010-09-01 00:00:00
abstract::Low-dose antithymocyte globulin (ATG) plus pegylated granulocyte colony-stimulating factor (G-CSF) preserves β-cell function for at least 12 months in type 1 diabetes. Herein, we describe metabolic and immunological parameters 24 months following treatment. Patients with established type 1 diabetes (duration 4-24 mont...
journal_title:Diabetes
pub_type: 杂志文章,随机对照试验
doi:10.2337/db16-0823
更新日期:2016-12-01 00:00:00
abstract::The primary objective of this study was to assess whether the topical administration of two neuroprotective drugs (brimonidine and somatostatin) could prevent or arrest retinal neurodysfunction in patients with type 2 diabetes. For this purpose, adults aged between 45 and 75 years with a diabetes duration ≥5 years and...
journal_title:Diabetes
pub_type: 杂志文章,随机对照试验
doi:10.2337/db18-0682
更新日期:2019-02-01 00:00:00
abstract::Insulin levels in humans were measured by a new assay, the isotope dilution assay (IDA), based on stable isotope dilution mass spectrometry. A known amount of a deuterated analog of insulin was used as an internal standard and added to the serum samples before sample processing. After isolation by immunoaffinity chrom...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.46.1.44
更新日期:1997-01-01 00:00:00
abstract::Growth hormone (GH) and IGFs have a long distinguished history in diabetes, with possible participation in the development of renal complications. The implicated effect of GH in diabetic end-stage organ damage may be mediated by growth hormone receptor (GHR) or postreceptor events in GH signal transduction. The presen...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.51.7.2270
更新日期:2002-07-01 00:00:00
abstract::GLUT2 glucose transporter mRNA has been shown to be underexpressed in pancreatic islets of numerous animal models of non-insulin-dependent diabetes mellitus (NIDDM). It has been proposed that this molecular defect contributes to the pathogenesis of diabetes, although information concerning the expression of GLUT2 in h...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.44.12.1369
更新日期:1995-12-01 00:00:00
abstract::The effect of combined antisense oligonucleotides (AS-oligos) against overexpression of extracellular matrix (ECM) components, fibronectin, laminin, and collagen IV and on cell monolayer permeability was examined in rat microvascular endothelial cells (RMECs) grown in high glucose medium and on retinal vascular permea...
journal_title:Diabetes
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:Many of the effects of angiotensin (Ang) II are mediated through specific plasma membrane receptors. However, Ang II also elicits biological effects from the interior of the cell (intracrine), some of which are not inhibited by Ang receptor blockers (ARBs). Recent in vitro studies have identified high glucose...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db08-0805
更新日期:2008-12-01 00:00:00
abstract::Although ATP-binding cassette transporter A1 (ABCA1) is well known for its role in cholesterol efflux and HDL formation, it is expressed in various tissues, where it may have different functions. Because hypoalphalipoproteinemia is highly prevalent in Mexico, we screened the ABCA1 coding sequence in Mexican individual...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db06-0905
更新日期:2007-07-01 00:00:00
abstract::Alzheimer disease and type 2 diabetes are characterized by increased prevalence with aging, a genetic predisposition, and comparable pathological features in the islet and brain (amyloid derived from amyloid beta protein in the brain in Alzheimer disease and islet amyloid derived from islet amyloid polypeptide in the ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.53.2.474
更新日期:2004-02-01 00:00:00
abstract:OBJECTIVE:To evaluate the extent of pancreatic β-cell function in a large number of insulin-dependent diabetic patients with a disease duration of 50 years or longer (Medalists). RESEARCH DESIGN AND METHODS:Characterization of clinical and biochemical parameters and β-cell function of 411 Medalists with correlation wi...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db10-0676
更新日期:2010-11-01 00:00:00
abstract::Obesity is associated with an increased risk for the development of type 2 diabetes and vascular complications. Advanced glycation end products are increased in adipose tissue and have been associated with insulin resistance, vascular dysfunction, and inflammation of adipose tissue. Here, we report that delayed interv...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db15-1390
更新日期:2016-04-01 00:00:00
abstract::Type 1 diabetes studies consistently generate data showing islet β-cell dysfunction and T cell-mediated anti-β-cell-specific autoimmunity. To explore the pathogenesis, we interrogated the β-cell transcriptomes from donors with and without type 1 diabetes using both bulk-sorted and single β-cells. Consistent with immun...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db18-0686
更新日期:2019-05-01 00:00:00
abstract::Large glucagon immunoreactive substances, extracted from the fetal bovine pancreas and separated by gel filtration in the presence of 6 M guanidinium-hydrochloride, were submitted to lectin-sepharose affinity column chromatograph. Gel-filtered peak I (approximately 45 K delta) and peak II (approximately 10 K delta) in...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diacare.31.11.1002
更新日期:1982-11-01 00:00:00
abstract::Type 2 diabetes is characterized by islet amyloid deposits, which are primarily composed of the amyloidogenic human form of islet amyloid polypeptide (IAPP, amylin). The mechanism of islet amyloido-genesis is not known, but other products (e.g., apolipoprotein E and perlecan) contained within islet amyloid may be nece...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.48.10.1962
更新日期:1999-10-01 00:00:00
abstract::As part of an ongoing search for susceptibility genes in obese families, we performed linkage analyses in 101 French families between qualitative and quantitative traits related to morbid obesity and polymorphisms located in or near 15 candidate genes whose products are involved in body weight regulation. These includ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.48.2.398
更新日期:1999-02-01 00:00:00
abstract:OBJECTIVE:Digenic causes of human disease are rarely reported. Insulin via its receptor, which is encoded by INSR, plays a key role in both metabolic and growth signaling pathways. Heterozygous INSR mutations are the most common cause of monogenic insulin resistance. However, growth retardation is only reported with ho...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db09-0787
更新日期:2009-12-01 00:00:00
abstract::Successful islet transplantation depends on the infusion of sufficiently large quantities of islets, but only a fraction of transplanted islets can survive and become engrafted, and yet the underlying mechanism remains unclear. In this study, we examined the effect of sirolimus, a key component of the immunosuppressiv...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db06-0173
更新日期:2006-09-01 00:00:00
abstract::We report a genomewide linkage analysis of a large consanguineous family segregating autosomal recessively inherited neonatal diabetes and the identification of a novel neonatal diabetes locus. Neonatal diabetes was characterized by low levels of circulating C-peptide with very low to undetectable levels of insulin in...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.52.10.2636
更新日期:2003-10-01 00:00:00
abstract::Human CD5+ B lymphocytes produce autoantibodies that bind to self- and exogenous antigens. Extremely high percentages of CD5+ B lymphocytes are present in the fetal and newborn periods, whereas they constitute only a minority of B lymphocytes in healthy adults. Increased percentages of circulating CD5+ lymphocytes hav...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.40.10.1314
更新日期:1991-10-01 00:00:00
abstract::Rats with chronic streptozotocin (SZ) diabetes develop dilatation of the alimentary tract, loss of fecal consistency, and autonomic neuropathy involving unmyelinated axons of the extrinsic innervation of the small bowel. Diabetic autonomic neuropathy involving the ileal mesenteric nerves is characterized by modest to ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.32.6.532
更新日期:1983-06-01 00:00:00
abstract::To test the general applicability of the hypothesis that diabetes mellitus causes increased polyol pathway activity, decreased tissue free myo-inositol, and resultant pathological changes in tissues susceptible to the ravages of diabetes, we measured glucose, sorbitol, and myo-inositol with quantitative histochemical ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.39.10.1305
更新日期:1990-10-01 00:00:00
abstract::Exercise bypasses insulin resistance to increase glucose uptake in skeletal muscle and therefore represents an important alternative to stimulate glucose uptake in insulin-resistant muscle. Both Rac1 and AMPK have been shown to partly regulate contraction-stimulated muscle glucose uptake, but whether those two signali...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db16-1138
更新日期:2017-06-01 00:00:00
abstract::Insulin receptors on viable rat adipocytes were affinity-labeled using a biologically active and photosensitive analogue of insulin, 125I-B2(2-nitro, 4 azidophenylacetyl)-des-PheB1-insulin (125I-NAPA-DP-insulin). The radiolabeled proteins were identified by SDS polyacrylamide gel electrophoresis and autoradiography. B...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.32.11.1001
更新日期:1983-11-01 00:00:00
abstract::Patients with non-insulin-dependent diabetes mellitus (NIDDM) who have chronic hyperglycemia lose acute incremental insulin responses to glucose but are able to briskly respond to other beta-cell secretagogues. To investigate whether this is a defect specific for glucose or represents a more general phenomenon, we mea...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.35.12.1314
更新日期:1986-12-01 00:00:00