Modulation of growth hormone signal transduction in kidneys of streptozotocin-induced diabetic animals: effect of a growth hormone receptor antagonist.

abstract：OBJECTIVE:Evidence links the hypothalamic fatty acid synthase (FAS) pathway to the regulation of food intake and body weight. This includes pharmacological inhibitors that potently reduce feeding and body weight. The mammalian target of rapamycin (mTOR) is an intracellular fuel sensor whose activity in the hypothalamus...

journal_title：Diabetes

authors： Proulx K,Cota D,Woods SC,Seeley RJ

更新日期：2008-12-01 00:00:00

abstract：:To assess the relationship between beta-cell function and the level and duration of hyperglycemia during generalized beta-cell impairment, we studied the effects of acute and prolonged infusion of somatostatin in seven normal men. Twenty minutes after beginning an acute infusion of somatostatin (200 microgram/h) plus ...

journal_title：Diabetes

authors： Ward WK,Halter JB,Best JD,Beard JC,Porte D Jr

更新日期：1983-10-01 00:00:00

abstract：:Near normal glucoregulation was maintained in 10 patients with insulin-dependent (type I) diabetes mellitus for 6 wk with preprogrammed continuous subcutaneous insulin infusion using a portable battery-powered infusion pump (CSII). This form of therapy resulted in a statistically significant increase in motor nerve co...

journal_title：Diabetes

authors： Pietri A,Ehle AL,Raskin P

更新日期：1980-08-01 00:00:00

abstract：OBJECTIVE:Most pancreatic endocrine cells derive from Ptf1a-expressing progenitor cells. In humans, nonsense mutations in Ptf1a have recently been identified as a cause of permanent neonatal diabetes associated with pancreatic agenesis. The death of Ptf1a-null mice soon after birth has not allowed further insight into ...

journal_title：Diabetes

authors： Fukuda A,Kawaguchi Y,Furuyama K,Kodama S,Horiguchi M,Kuhara T,Kawaguchi M,Terao M,Doi R,Wright CV,Hoshino M,Chiba T,Uemoto S

更新日期：2008-09-01 00:00:00

abstract：:To treat insulin lipoatrophy, small amounts of dexamethasone (4 micrograms/unit) were added to insulin injections in nine patients. Six cases showed significant improvement of dexamethasone-treated sites over that of control sites in six months. With the continued use of dexamethasone-containing insulin, they remained...

journal_title：Diabetes

authors： Kumar O,Miller L,Mehtalia S

更新日期：1977-04-01 00:00:00

abstract：:In this study, 92% of patients' serums known to contain antibodies against islet cells, including the Juvenile Diabetes Foundation provisional reference serum, had antibodies reacting with gastrointestinal carcinoid tumors. Twelve percent of the control serums from healthy individuals bound to carcinoid cells, and 2% ...

journal_title：Diabetes

authors： Miettinen A,Holthöfer H,Kontiainen S,Miettinen M,Andersson LC

更新日期：1989-05-01 00:00:00

abstract：:Current pharmacological options for type 2 diabetes do not cure the disease. Despite the availability of multiple drug classes that modulate glycemia effectively and minimize long-term complications, these agents do not reverse pathogenesis, and in practice they are not selected to correct the molecular profile specif...

journal_title：Diabetes

authors： Florez JC

更新日期：2017-07-01 00:00:00

abstract：:The isolated rat liver perfused for 12 hours at pH 7.10 with a suspension of bovine erythrocytes in Krebs-Ringer bicarbonate buffer containing 3 per cent bovine serum albumin has been used as a test system to study effects of glucagon and of dexamethasone in the presence and absence of insulin on net biosynthesis of r...

journal_title：Diabetes

authors： Miller LL

更新日期：1976-01-01 00:00:00

abstract：:Increased susceptibility of LDL to oxidation has been shown to be associated with the presence of coronary heart disease and may account for the accelerated vascular disease seen in diabetes. The response of LDL to in vitro oxidative stress has been proposed as a measure of the predisposition of LDL to the in vivo sub...

journal_title：Diabetes

authors： Jenkins AJ,Klein RL,Chassereau CN,Hermayer KL,Lopes-Virella MF

更新日期：1996-06-01 00:00:00

abstract：:To investigate the temporal relationship of diabetes-induced renal growth and its associated metabolic alterations to the early development of renal hyperfunction, parallel functional and metabolic studies were performed shortly after the onset of diabetes in rats. Hyperglycemia and hypoinsulinemia were evident 18 h a...

journal_title：Diabetes

authors： Cortes P,Dumler F,Goldman J,Levin NW

更新日期：1987-01-01 00:00:00

abstract：:Both impaired glucose tolerance (IGT) (as defined by the 1985 World Health Organization criteria) and impaired fasting glucose (IFG) (as defined by the 1997 American Diabetes Association criteria) represent intermediate metabolic states between normal and diabetic glucose homeostasis. Cardiovascular disease may be rel...

journal_title：Diabetes

authors： Festa A,D'Agostino R Jr,Hanley AJ,Karter AJ,Saad MF,Haffner SM

更新日期：2004-06-01 00:00:00

abstract：:Monocyte-to-macrophage differentiation is a critical event that accentuates atherosclerosis by promoting an inflammatory environment within the vessel wall. In this study, we investigated the molecular mechanisms responsible for monocyte-to-macrophage differentiation and, subsequently, the effect of metformin in regre...

journal_title：Diabetes

authors： Vasamsetti SB,Karnewar S,Kanugula AK,Thatipalli AR,Kumar JM,Kotamraju S

更新日期：2015-06-01 00:00:00

abstract：:Protein kinase C (PKC) has been suggested as a mediator of insulin's effect on glucose transport, and PKC-mediated modulation of tyrosine kinase activity in the insulin receptor has been implicated in regulating the insulin sensitivity of tissues. Because skeletal muscle is a major target of insulin action, we examine...

journal_title：Diabetes

authors： Sowell MO,Treutelaar MK,Burant CF,Buse MG

更新日期：1988-05-01 00:00:00

abstract：:The exposure of primary cultures of hepatocytes to insulin. 10(-8) M, for 16 h results in a decrease in high affinity insulin binding with no alterations in lower affinity binding. This is reflected in a decrease in the sensitivity, but normal responsiveness, of cultured hepatocytes to the acute effect of insulin on t...

journal_title：Diabetes

authors： Amatruda JM,Newmeyer HW,Chang CL

更新日期：1982-02-01 00:00:00

abstract：:It has been proposed that p38 mitogen-activated protein kinase (MAPK) isoforms sensitive to the pyridinylimidazole compounds SB 203580 and SB 202190 may participate in the acute insulin-dependent activation of glucose transporters recruited to the plasma membrane of adipocytes and skeletal muscle. Here, we explore whe...

journal_title：Diabetes

authors： Turban S,Beardmore VA,Carr JM,Sakamoto K,Hajduch E,Arthur JS,Hundal HS

更新日期：2005-11-01 00:00:00

abstract：:Mutations in the NeuroD/BETA2 gene have been shown to associate with type 2 diabetes. In the present study, we examined mutations in the NeuroD/BETA2 gene for association with either type 1 or 2 diabetes. Three variants were identified in patients with type 2 diabetes: Ala45Thr (allelic frequency 0.36, 95% CI 0.31-0.4...

journal_title：Diabetes

authors： Hansen L,Jensen JN,Urioste S,Petersen HV,Pociot F,Eiberg H,Kristiansen OP,Hansen T,Serup P,Nerup J,Pedersen O

更新日期：2000-05-01 00:00:00

abstract：:The phenomenon of a discrepancy between glycated hemoglobin levels and other indicators of average glycemia may be due to many factors but can be measured as the glycation gap (GGap). This GGap is associated with differences in complications in patients with diabetes and may possibly be explained by dissimilarities in...

journal_title：Diabetes

authors： Dunmore SJ,Al-Derawi AS,Nayak AU,Narshi A,Nevill AM,Hellwig A,Majebi A,Kirkham P,Brown JE,Singh BM

更新日期：2018-01-01 00:00:00

abstract：:Insulin requirements for meals were measured in eight insulin-dependent diabetic patients, using a closed-loop insulin infusion system. Patients required more insulin for breakfast than for an isocaloric lunch (35.7 +/- 5.5 mU/kcal/3 h versus 26.9 +/- 5.1 mU/kcal/3 h, P less than 0.02) or an isocaloric supper (35.7 +/...

journal_title：Diabetes

authors： Nestler JE,Gebhart SS,Blackard WG

更新日期：1984-03-01 00:00:00

abstract：OBJECTIVE:In mammals, proper storage and distribution of lipids in and between tissues is essential for the maintenance of energy homeostasis. In contrast, aberrantly high levels of triglycerides in the blood ("hypertriglyceridemia") represent a hallmark of the metabolic syndrome and type 2 diabetes. As hypertriglyceri...

journal_title：Diabetes

authors： Narvekar P,Berriel Diaz M,Krones-Herzig A,Hardeland U,Strzoda D,Stöhr S,Frohme M,Herzig S

更新日期：2009-05-01 00:00:00

abstract：:Exposure of the isolated, glucose-perfused rat heart to buffer containing 0.4 mM tolbutamide resulted in significant changes in both energy metabolism and myocardial contractility. In the nondiabetic, tolbutamide mediated only small increases in mechanical function at low atrial filling pressure, but this effect incre...

journal_title：Diabetes

authors： Tan BH,Wilson GL,Schaffer SW

更新日期：1984-12-01 00:00:00

abstract：:Ghrelin, an endogenous ligand for growth hormone secretagogue (GHS) receptor originally isolated from the stomach, occurs in the hypothalamic arcuate nucleus and may play a role in energy homeostasis. Synthetic GHSs have activated the hypothalamic arcuate neurons containing neuropeptide Y (NPY), suggesting the involve...

journal_title：Diabetes

authors： Shintani M,Ogawa Y,Ebihara K,Aizawa-Abe M,Miyanaga F,Takaya K,Hayashi T,Inoue G,Hosoda K,Kojima M,Kangawa K,Nakao K

更新日期：2001-02-01 00:00:00

abstract：:Insulin antibodies are known to interfere with the radioimmunoassay of insulin. We tested intravenous glucose tolerance on 25 insulin autoantibody-positive (IAA+) patients and 25 IAA- controls, who were matched for sex, age, and body mass index, to establish if IAA could also interfere with insulin assay. Insulin cont...

journal_title：Diabetes

authors： Armitage M,Wilkin T,Wood P,Casey C,Loveless R

更新日期：1988-10-01 00:00:00

abstract：:Glucose controls islet beta-cell mass and function at least in part through the phosphatidylinositol 3-kinase (PI3K)/Akt pathway downstream of insulin signaling. The Foxo proteins, transcription factors known in other tissues to be negatively regulated by Akt activation, affect proliferation and metabolism. In this st...

journal_title：Diabetes

authors： Martinez SC,Cras-Méneur C,Bernal-Mizrachi E,Permutt MA

更新日期：2006-06-01 00:00:00

abstract：:Insulin-dependent diabetes mellitus (IDDM) involves the destruction of the insulin-producing cells in the islets of Langerhans. One possible cure is by transplanting the islet cells; however, transplanted islets, even between identical twins, are subject to autoimmune destruction by the disease process, resulting in d...

journal_title：Diabetes

authors： Wang T,Singh B,Warnock GL,Rajotte RV

更新日期：1992-01-01 00:00:00

abstract：:Mammalian erythrocytes have been shown to bind, but not to respond to, physiologic doses of insulin. Insulin binding was studied in normal rat erythrocytes and erythroblastic leukemic (EBL) cells by standard 125I-insulin competitive binding assays. EBL cells exhibited marked insulin degradation, which was time, temper...

journal_title：Diabetes

authors： Galbraith RA,Wise C,Buse MG

更新日期：1980-07-01 00:00:00

abstract：OBJECTIVE:Sarco-endoplasmic reticulum Ca(2+)-ATPase 2b (SERCA2b) and SERCA3 pump Ca(2+) in the endoplasmic reticulum (ER) of pancreatic β-cells. We studied their role in the control of the free ER Ca(2+) concentration ([Ca(2+)](ER)) and the role of SERCA3 in the control of insulin secretion and ER stress. RESEARCH DES...

journal_title：Diabetes

authors： Ravier MA,Daro D,Roma LP,Jonas JC,Cheng-Xue R,Schuit FC,Gilon P

更新日期：2011-10-01 00:00:00

abstract：:The adipocyte-derived hormone adiponectin seems to protect from insulin resistance, a key factor in the pathogenesis of type 2 diabetes. Genome-wide scans have mapped a susceptibility locus for type 2 diabetes and the metabolic syndrome to chromosome 3q27, where the adiponectin gene is located. A common silent T-G exc...

journal_title：Diabetes

authors： Stumvoll M,Tschritter O,Fritsche A,Staiger H,Renn W,Weisser M,Machicao F,Häring H

更新日期：2002-01-01 00:00:00

abstract：:Blood-retinal barrier (BRB) breakdown is a hallmark of diabetic retinopathy, but the molecular changes that cause this pathology are unclear. Occludin is a transmembrane component of interendothelial tight junctions that may regulate permeability at the BRB. In this study, we examined the effects of vascular endotheli...

journal_title：Diabetes

authors： Antonetti DA,Barber AJ,Khin S,Lieth E,Tarbell JM,Gardner TW

更新日期：1998-12-01 00:00:00

abstract：:p21(cip1), a regulatory molecule upstream of the G(1/0) checkpoint, is increased in beta-cells in response to mitogenic stimulation. Whereas p21(cip1) can variably stimulate or inhibit cell cycle progression, in vitro studies suggest that p21(cip1) acts as an inhibitor in the pancreatic beta-cell. To determine the fun...

journal_title：Diabetes

authors： Cozar-Castellano I,Haught M,Stewart AF

更新日期：2006-12-01 00:00:00

abstract：:Many common genetic polymorphisms are associated with glycemic traits and type 2 diabetes (T2D), but knowledge about genetic determinants of glycemic traits in pregnancy is limited. We tested genetic variants known to be associated with glycemic traits and T2D in the general population for associations with glycemic t...

journal_title：Diabetes

authors： Powe CE,Nodzenski M,Talbot O,Allard C,Briggs C,Leya MV,Perron P,Bouchard L,Florez JC,Scholtens DM,Lowe WL Jr,Hivert MF

更新日期：2018-12-01 00:00:00