Reduced early insulin secretion in the etiology of type 2 diabetes mellitus in Pima Indians.

Abstract:

:We report the results of cross-sectional, prospective, and longitudinal studies identifying etiologic metabolic factors in the susceptibility to type 2 diabetes mellitus of the Pima Indians of Arizona, whose prevalence and incidence rates of the disease are the highest in the world. Diabetic Pima Indians are metabolically prototypic, with obesity, insulin resistance, a reduced acute insulin response to glucose, and increased endogenous glucose production. Cross-sectional studies show that the acute insulin response is absent in diabetic subjects and lower in impaired than in normal glucose-tolerant subjects. Prospective studies using proportional hazards analyses indicate that insulin resistance and a relatively low acute insulin response predict diabetes independently of age, gender, and each other, with obesity increasing susceptibility by worsening one or both predictors. Longitudinal studies show that glucose tolerance deteriorates as the degree of obesity increases due to worsening insulin resistance and decreases in early insulin secretion. Furthermore, since the children of diabetic pregnancies are at much greater risk of developing diabetes at a young age than those of nondiabetic pregnancies, the diabetic uterine environment may induce insulin resistance and/or reduced insulin secretion: early evidence confirms that adult normal glucose-tolerant offspring show a substantially decreased acute insulin response--the clearest demonstration yet of an environmental condition increasing susceptibility to type 2 diabetes mellitus. However, the genetic determinants require elucidation: correlation of the acute insulin response with the age of parental diabetes onset in fathers as well as mothers indicates a mechanism independent of the diabetic uterine environment.

journal_name

Diabetes

journal_title

Diabetes

authors

Bogardus C,Tataranni PA

doi

10.2337/diabetes.51.2007.s262

subject

Has Abstract

pub_date

2002-02-01 00:00:00

pages

S262-4

eissn

0012-1797

issn

1939-327X

journal_volume

51 Suppl 1

pub_type

杂志文章,评审

相关文献

DIABETES文献大全
  • Evidence of a causal relationship between adiponectin levels and insulin sensitivity: a Mendelian randomization study.

    abstract::The adipocyte-secreted protein adiponectin is associated with insulin sensitivity in observational studies. We aimed to evaluate whether this relationship is causal using a Mendelian randomization approach. In a sample of Swedish men aged 71 years (n = 942) from the Uppsala Longitudinal Study of Adult Men (ULSAM), ins...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db12-0935

    authors: Gao H,Fall T,van Dam RM,Flyvbjerg A,Zethelius B,Ingelsson E,Hägg S

    更新日期:2013-04-01 00:00:00

  • Deciphering the Plasma Proteome of Type 2 Diabetes.

    abstract::With an estimated prevalence of 463 million affected, type 2 diabetes represents a major challenge to health care systems worldwide. Analyzing the plasma proteomes of individuals with type 2 diabetes may illuminate hitherto unknown functional mechanisms underlying disease pathology. We assessed the associations betwee...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db20-0296

    authors: Elhadad MA,Jonasson C,Huth C,Wilson R,Gieger C,Matias P,Grallert H,Graumann J,Gailus-Durner V,Rathmann W,von Toerne C,Hauck SM,Koenig W,Sinner MF,Oprea TI,Suhre K,Thorand B,Hveem K,Peters A,Waldenberger M

    更新日期:2020-12-01 00:00:00

  • Preservation of morphology, insulin biosynthesis, and insulin release in cryopreserved human fetal pancreas.

    abstract::Human fetal pancreatic glands were obtained from 12 consecutive prostaglandin-induced abortions. Explants cultured for 1 day were frozen at 0.3 degree C/min in a 1 M DMSO-containing medium and stored at -196 degrees C. After storage for 3-4 mo the frozen material was rapidly thawed and cultured 1 day before being test...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.31.3.238

    authors: Sandler S,Andersson A,Hellerström C,Petersson B,Swenne I,Björkén C,Groth CG

    更新日期:1982-03-01 00:00:00

  • Induction of the ChREBPβ Isoform Is Essential for Glucose-Stimulated β-Cell Proliferation.

    abstract::Carbohydrate-responsive element-binding protein (ChREBP) is a glucose-sensing transcription factor required for glucose-stimulated proliferation of pancreatic β-cells in rodents and humans. The full-length isoform (ChREBPα) has a low glucose inhibitory domain (LID) that restrains the transactivation domain when glucos...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db15-0239

    authors: Zhang P,Kumar A,Katz LS,Li L,Paulynice M,Herman MA,Scott DK

    更新日期:2015-12-01 00:00:00

  • Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus.

    abstract::The decline of leptin (Ob protein) concentrations during fasting is implicated as a signal for increasing the expression of the orexigenic peptide neuropeptide Y (NPY) in the hypothalamus. To test the hypothesis that the effects of food intake on arcuate nucleus NPY activation are mediated by leptin, we performed simu...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diabetes.48.4.828

    authors: Baskin DG,Breininger JF,Schwartz MW

    更新日期:1999-04-01 00:00:00

  • Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity.

    abstract::Although recent studies show that adipose tissue macrophages (ATMs) participate in the inflammatory changes in obesity and contribute to insulin resistance, the properties of these cells are not well understood. We hypothesized that ATMs recruited to adipose tissue during a high-fat diet have unique inflammatory prope...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db06-1076

    authors: Lumeng CN,Deyoung SM,Bodzin JL,Saltiel AR

    更新日期:2007-01-01 00:00:00

  • Female rats do not exhibit free fatty acid-induced insulin resistance.

    abstract::It is well described that excessive lipid metabolism can cause insulin resistance in both animals and humans, and this has been implicated as a causative factor in the development of insulin resistance and type 2 diabetes in humans. Recently, we have shown that intravenous lipid emulsion (liposyn) infusion during a 12...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diabetes.51.6.1907

    authors: Hevener A,Reichart D,Janez A,Olefsky J

    更新日期:2002-06-01 00:00:00

  • Glucosylated collagen is antigenic.

    abstract::Sera from rats inoculated with in vitro glucosylated rat skin acid-soluble collagen were evaluated for specific antibody response using the enzyme-linked immunosorbent assay. The data indicate that the altered protein is capable of eliciting the production of antibodies, but unmodified collagen is not. The specificity...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.32.12.1182

    authors: Bassiouny AR,Rosenberg H,McDonald TL

    更新日期:1983-12-01 00:00:00

  • Vascular endothelial growth factor activates nuclear factor-kappaB and induces monocyte chemoattractant protein-1 in bovine retinal endothelial cells.

    abstract::Vascular endothelial growth factor (VEGF) has been suggested to play a role in the pathogenesis of diabetic vascular complications. In the present study, we investigated whether expression of monocyte chemoattractant protein-1 (MCP-1), a chemokine that has been proposed to recruit leukocytes to sites of inflammation, ...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diabetes.48.5.1131

    authors: Marumo T,Schini-Kerth VB,Busse R

    更新日期:1999-05-01 00:00:00

  • Hormone-sensitive lipase, the rate-limiting enzyme in triglyceride hydrolysis, is expressed and active in beta-cells.

    abstract::Triglycerides in the beta-cell may be important for stimulus-secretion coupling, through provision of a lipid-derived signal, and for pathogenetic events in NIDDM, where lipids may adversely affect beta-cell function. In adipose tissues, hormone-sensitive lipase (HSL) is rate-limiting in triglyceride hydrolysis. Here,...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diabetes.48.1.228

    authors: Mulder H,Holst LS,Svensson H,Degerman E,Sundler F,Ahrén B,Rorsman P,Holm C

    更新日期:1999-01-01 00:00:00

  • The effect of aminoguanidine and tolrestat on glucose toxicity in bovine retinal capillary pericytes.

    abstract::Cultured bovine retinal capillary pericytes (BRP) were used to investigate the effect of an aldose reductase inhibitor, tolrestat, and an inhibitor of advanced glycation end products (AGE) formation, aminoguanidine, on glucose toxicity. Glucose at high concentration reduced the replicative activity of pericytes in a d...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.43.6.758

    authors: Chibber R,Molinatti PA,Wong JS,Mirlees D,Kohner EM

    更新日期:1994-06-01 00:00:00

  • Growth Hormone Control of Hepatic Lipid Metabolism.

    abstract::In humans, low levels of growth hormone (GH) and its mediator, IGF-1, associate with hepatic lipid accumulation. In mice, congenital liver-specific ablation of the GH receptor (GHR) results in reductions in circulating IGF-1 and hepatic steatosis, associated with systemic insulin resistance. Due to the intricate relat...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db16-0649

    authors: Liu Z,Cordoba-Chacon J,Kineman RD,Cronstein BN,Muzumdar R,Gong Z,Werner H,Yakar S

    更新日期:2016-12-01 00:00:00

  • MDL 29311. Antioxidant with marked lipid- and glucose-lowering activity in diabetic rats and mice.

    abstract::MDL 29311, an analogue of probucol, administered to rats as a 1% dietary admixture for 2 wk before and 5 days after intravenous injection of 40 mg/kg of ALX significantly (P < 0.05) reduced plasma glucose (6.9 +/- 0.3 vs. 19.2 +/- 1.3 mM) and serum triglyceride (0.17 +/- 0.01 vs. 1.82 +/- 0.39 mM) levels in overnight-...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.42.8.1179

    authors: Johnson MB,Heineke EW,Rhinehart BL,Sheetz MJ,Barnhart RL,Robinson KM

    更新日期:1993-08-01 00:00:00

  • Studies on the regulation of insulin binding by liver plasma membranes from Zucker fatty rats.

    abstract::The hyperinsulinemia of obese rodents has been associated with a reduced number of hepatic insulin receptors except in hepatocytes from fatty Zucker rats. We isolated liver plasma membranes from 10-11-wk-old lean and fatty Zucker rats, some of which were injected with streptozotocin 2--4 wk earlier. We have determined...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.31.10.867

    authors: Clark JB,Keen S,Clark CM Jr

    更新日期:1982-10-01 00:00:00

  • Genetics of NIDDM in France: studies with 19 candidate genes in affected sib pairs.

    abstract::As part of an ongoing search for susceptibility loci for NIDDM, we tested 19 genes whose products are implicated in insulin secretion or action for linkage with NIDDM. Loci included the G-protein-coupled inwardly rectifying potassium channels expressed in beta-cells (KCNJ3 and KCNJ7), glucagon (GCG), glucokinase regul...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.46.6.1062

    authors: Vionnet N,Hani EH,Lesage S,Philippi A,Hager J,Varret M,Stoffel M,Tanizawa Y,Chiu KC,Glaser B,Permutt MA,Passa P,Demenais F,Froguel P

    更新日期:1997-06-01 00:00:00

  • Invariant natural killer T-cell control of type 1 diabetes: a dendritic cell genetic decision of a silver bullet or Russian roulette.

    abstract:OBJECTIVE:In part, activation of invariant natural killer T (iNKT)-cells with the superagonist alpha-galactosylceramide (alpha-GalCer) inhibits the development of T-cell-mediated autoimmune type 1 diabetes in NOD mice by inducing the downstream differentiation of antigen-presenting dendritic cells (DCs) to an immunotol...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db09-1116

    authors: Driver JP,Scheuplein F,Chen YG,Grier AE,Wilson SB,Serreze DV

    更新日期:2010-02-01 00:00:00

  • Downregulation of protein kinase C and insulin-stimulated 2-deoxyglucose uptake in rat adipocytes by phorbol esters, glucose, and insulin.

    abstract::Phorbol esters translocatively activate and subsequently downregulate protein kinase C and insulin-stimulated glucose uptake in rat adipocytes. This study examined the possibility that other translocative activators of protein kinase C in rat adipocytes, e.g., insulin and glucose, provoke similar downregulating effect...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.40.10.1274

    authors: Ishizuka T,Cooper DR,Arnold T,Hernandez H,Farese RV

    更新日期:1991-10-01 00:00:00

  • Perifusion and culture of human fetal pancreas.

    abstract::Human fetal pancreas has been obtained after the therapeutic termination of pregnancy with prostaglandin F2 alpha. Pancreatic explants were studied in a perifusion system and maintained in organ culture for up to 3 wk. Insulin biosynthesis was stimulated by glucose; however, the incorporation of 3H-L-leucine into proi...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.29.1.s57

    authors: Maitland JE,Parry DG,Turtle JR

    更新日期:1980-01-01 00:00:00

  • Identification of tyrosine phosphatase 2(256-760) construct as a new, sensitive marker for the detection of islet autoimmunity in type 2 diabetic patients: the non-insulin requiring autoimmune diabetes (NIRAD) study 2.

    abstract:OBJECTIVE:The presence of autoantibodies to islet antigens GAD and/or tyrosine phosphatase 2 (IA-2) in type 2 diabetic patients (latent autoimmune diabetes in adults [LADA]) identifies subjects at high risk to develop insulin dependency. The aim of this study was to dissect humoral anti-IA-2 immune response in Caucasia...

    journal_title:Diabetes

    pub_type: 杂志文章,多中心研究

    doi:10.2337/db07-0874

    authors: Tiberti C,Giordano C,Locatelli M,Bosi E,Bottazzo GF,Buzzetti R,Cucinotta D,Galluzzo A,Falorni A,Dotta F

    更新日期:2008-05-01 00:00:00

  • Human Type 1 Diabetes Is Characterized by an Early, Marked, Sustained, and Islet-Selective Loss of Sympathetic Nerves.

    abstract::In humans, the glucagon response to moderate-to-marked insulin-induced hypoglycemia (IIH) is largely mediated by the autonomic nervous system. Because this glucagon response is impaired early in type 1 diabetes, we sought to determine if these patients, like animal models of autoimmune diabetes, have an early and seve...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db16-0284

    authors: Mundinger TO,Mei Q,Foulis AK,Fligner CL,Hull RL,Taborsky GJ Jr

    更新日期:2016-08-01 00:00:00

  • In Vivo Enrichment of Diabetogenic T Cells.

    abstract::Dysfunctional T cells can mediate autoimmunity, but the inaccessibility of autoimmune tissues and the rarity of autoimmune T cells in the blood hinder their study. We describe a method to enrich and harvest autoimmune T cells in vivo by using a biomaterial scaffold loaded with protein antigens. In model antigen system...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db16-0946

    authors: Thelin MA,Kissler S,Vigneault F,Watters AL,White D,Koshy ST,Vermillion SA,Mooney DJ,Serwold T,Ali OA

    更新日期:2017-08-01 00:00:00

  • TLR9 Deficiency in B Cells Promotes Immune Tolerance via Interleukin-10 in a Type 1 Diabetes Mouse Model.

    abstract::Toll-like receptor 9 (TLR9) is highly expressed in B cells, and B cells are important in the pathogenesis of type 1 diabetes (T1D) development. However, the intrinsic effect of TLR9 in B cells on β-cell autoimmunity is not known. To fill this knowledge gap, we generated NOD mice with a B-cell-specific deficiency of TL...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db20-0373

    authors: Sha S,Pearson JA,Peng J,Hu Y,Huang J,Xing Y,Zhang L,Zhu Y,Zhao H,Wong FS,Chen L,Wen L

    更新日期:2021-02-01 00:00:00

  • Lifestyle and Metformin Ameliorate Insulin Sensitivity Independently of the Genetic Burden of Established Insulin Resistance Variants in Diabetes Prevention Program Participants.

    abstract::Large genome-wide association studies of glycemic traits have identified genetics variants that are associated with insulin resistance (IR) in the general population. It is unknown whether people with genetic enrichment for these IR variants respond differently to interventions that aim to improve insulin sensitivity....

    journal_title:Diabetes

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2337/db15-0950

    authors: Hivert MF,Christophi CA,Franks PW,Jablonski KA,Ehrmann DA,Kahn SE,Horton ES,Pollin TI,Mather KJ,Perreault L,Barrett-Connor E,Knowler WC,Florez JC,Diabetes Prevention Program Research Group.

    更新日期:2016-02-01 00:00:00

  • Abnormal erythrocyte charge in diabetes mellitus. Link with microalbuminuria.

    abstract::The anionic charge on the surface of the erythrocyte and the erythrocyte membrane content of sialic acid and acid glycosaminoglycans (GAGs) were evaluated in insulin-dependent diabetic patients who had albumin excretion rates less than 300 mg/24 h. In these subjects a statistically significant reduction of erythrocyte...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.37.6.745

    authors: Gambaro G,Baggio B,Cicerello E,Mastrosimone S,Marzaro G,Borsatti A,Crepaldi G

    更新日期:1988-06-01 00:00:00

  • Muscle glycogen synthesis and disposition of infused glucose in humans with reduced rates of insulin-mediated carbohydrate storage.

    abstract::Six men with a low rate of insulin-stimulated, non-oxidative carbohydrate disposal (storage) and six with a high storage rate were recruited for study of the fate of insulin-stimulated glucose uptake. [3-3H]glucose was infused before and during a 4-h hyperinsulinemic euglycemic clamp procedure in a dosage regimen desi...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.37.3.303

    authors: Young AA,Bogardus C,Wolfe-Lopez D,Mott DM

    更新日期:1988-03-01 00:00:00

  • Delayed Intervention With Pyridoxamine Improves Metabolic Function and Prevents Adipose Tissue Inflammation and Insulin Resistance in High-Fat Diet-Induced Obese Mice.

    abstract::Obesity is associated with an increased risk for the development of type 2 diabetes and vascular complications. Advanced glycation end products are increased in adipose tissue and have been associated with insulin resistance, vascular dysfunction, and inflammation of adipose tissue. Here, we report that delayed interv...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db15-1390

    authors: Maessen DE,Brouwers O,Gaens KH,Wouters K,Cleutjens JP,Janssen BJ,Miyata T,Stehouwer CD,Schalkwijk CG

    更新日期:2016-04-01 00:00:00

  • Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reduces fasting and postprandial glycemia in type 2 diabetes.

    abstract::Glucagon-like peptide 1 (GLP-1) is a potent glucose-lowering agent of potential interest for the treatment of type 2 diabetes. To evaluate actions of NN2211, a long-acting GLP-1 derivative, we examined 11 patients with type 2 diabetes, age 59 +/- 7 years (mean +/- SD), BMI 28.9 +/- 3.0 kg/m(2), HbA(1c) 6.5 +/- 0.6%, i...

    journal_title:Diabetes

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diabetes.51.2.424

    authors: Juhl CB,Hollingdal M,Sturis J,Jakobsen G,Agersø H,Veldhuis J,Pørksen N,Schmitz O

    更新日期:2002-02-01 00:00:00

  • Parasympathetic blockade attenuates augmented pancreatic polypeptide but not insulin secretion in Pima Indians.

    abstract::There is evidence from animal models of obesity and type 2 diabetes that increased parasympathetic vagal input to the pancreas contributes to hyperinsulinemia. Compared with Caucasians, Pima Indians have a high risk of type 2 diabetes and exhibit marked hyperinsulinemia and elevated plasma levels of pancreatic polypep...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diabetes.53.3.663

    authors: Vozarova de Courten B,Weyer C,Stefan N,Horton M,DelParigi A,Havel P,Bogardus C,Tataranni PA

    更新日期:2004-03-01 00:00:00

  • Life-table analysis of progression to diabetes of anti-insulin autoantibody-positive relatives of individuals with type I diabetes.

    abstract::Cytoplasmic islet cell antibody-negative (ICA-; less than 20 Juvenile Diabetes Foundation units, n = 1670) and ICA+ (n = 42) first-degree relatives of type I (insulin-dependent) diabetic individuals were studied for competitive insulin autoantibodies (CIAAs) with a radioassay. Overall, 3.7% of first-degree relatives (...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.38.10.1320

    authors: Ziegler AG,Ziegler R,Vardi P,Jackson RA,Soeldner JS,Eisenbarth GS

    更新日期:1989-10-01 00:00:00

  • Bioactives of Artemisia dracunculus L. mitigate the role of ceramides in attenuating insulin signaling in rat skeletal muscle cells.

    abstract::Ectopic lipids in peripheral tissues have been implicated in attenuating insulin action in vivo. The botanical extract of Artemisia dracunculus L. (PMI 5011) improves insulin action, yet the precise mechanism is not known. We sought to determine whether the mechanism by which PMI 5011 improves insulin signaling is thr...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db11-0396

    authors: Obanda DN,Hernandez A,Ribnicky D,Yu Y,Zhang XH,Wang ZQ,Cefalu WT

    更新日期:2012-03-01 00:00:00